Symptomatic efficacy of rasagiline monotherapy in early Parkinson's disease: post-hoc analyses from the ADAGIO trial.
Identifieur interne : 000030 ( PubMed/Corpus ); précédent : 000029; suivant : 000031Symptomatic efficacy of rasagiline monotherapy in early Parkinson's disease: post-hoc analyses from the ADAGIO trial.
Auteurs : Joseph Jankovic ; Elijahu Berkovich ; Eli Eyal ; Eduardo TolosaSource :
- Parkinsonism & related disorders ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Indans, Neuroprotective Agents.
- drug effects : Motor Activity.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Cohort Studies, Double-Blind Method, Female, Humans, Male.
Abstract
The ADAGIO study included a large cohort of patients with early PD (baseline total-UPDRS = 20) who were initially randomized to rasagiline and placebo, thereby allowing analyses of symptomatic efficacy.
DOI: 10.1016/j.parkreldis.2014.02.024
PubMed: 24637126
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pubmed:24637126Le document en format XML
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<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation><nlm:affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Dept of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: josephj@bcm.tmc.edu.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Berkovich, Elijahu" sort="Berkovich, Elijahu" uniqKey="Berkovich E" first="Elijahu" last="Berkovich">Elijahu Berkovich</name>
<affiliation><nlm:affiliation>Teva Pharmaceutical Industries Ltd, Petach Tikva, Israel.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Eyal, Eli" sort="Eyal, Eli" uniqKey="Eyal E" first="Eli" last="Eyal">Eli Eyal</name>
<affiliation><nlm:affiliation>Teva Pharmaceutical Industries Ltd, Petach Tikva, Israel.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<affiliation><nlm:affiliation>Neurology Service, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Catalonia, Spain.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Symptomatic efficacy of rasagiline monotherapy in early Parkinson's disease: post-hoc analyses from the ADAGIO trial.</title>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation><nlm:affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Dept of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: josephj@bcm.tmc.edu.</nlm:affiliation>
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<author><name sortKey="Berkovich, Elijahu" sort="Berkovich, Elijahu" uniqKey="Berkovich E" first="Elijahu" last="Berkovich">Elijahu Berkovich</name>
<affiliation><nlm:affiliation>Teva Pharmaceutical Industries Ltd, Petach Tikva, Israel.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Eyal, Eli" sort="Eyal, Eli" uniqKey="Eyal E" first="Eli" last="Eyal">Eli Eyal</name>
<affiliation><nlm:affiliation>Teva Pharmaceutical Industries Ltd, Petach Tikva, Israel.</nlm:affiliation>
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<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<affiliation><nlm:affiliation>Neurology Service, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Catalonia, Spain.</nlm:affiliation>
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<series><title level="j">Parkinsonism & related disorders</title>
<idno type="e-ISSN">1873-5126</idno>
<imprint><date when="2014" type="published">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cohort Studies</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Indans (therapeutic use)</term>
<term>Male</term>
<term>Motor Activity (drug effects)</term>
<term>Neuroprotective Agents (therapeutic use)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Indans</term>
<term>Neuroprotective Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Activity</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cohort Studies</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">The ADAGIO study included a large cohort of patients with early PD (baseline total-UPDRS = 20) who were initially randomized to rasagiline and placebo, thereby allowing analyses of symptomatic efficacy.</div>
</front>
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<DateCreated><Year>2014</Year>
<Month>05</Month>
<Day>19</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>01</Month>
<Day>14</Day>
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<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>20</Volume>
<Issue>6</Issue>
<PubDate><Year>2014</Year>
<Month>Jun</Month>
</PubDate>
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<Title>Parkinsonism & related disorders</Title>
<ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation>
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<ArticleTitle>Symptomatic efficacy of rasagiline monotherapy in early Parkinson's disease: post-hoc analyses from the ADAGIO trial.</ArticleTitle>
<Pagination><MedlinePgn>640-3</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2014.02.024</ELocationID>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The ADAGIO study included a large cohort of patients with early PD (baseline total-UPDRS = 20) who were initially randomized to rasagiline and placebo, thereby allowing analyses of symptomatic efficacy.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Post-hoc analyses comparing the efficacy of rasagiline 1 mg/day (n = 288) versus placebo (n = 588) on key symptoms at 36 weeks, and on total-UPDRS scores over 72 weeks (completer population: rasagiline 1 mg/day n = 221, placebo n = 392) were performed.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Treatment with rasagiline resulted in significantly better tremor, bradykinesia, rigidity and postural-instability-gait-difficulty scores at week 36 versus placebo. Whereas the placebo group experienced progressive deterioration from baseline (2.6 UPDRS points at week 36), patients in the rasagiline group were maintained at baseline values at week 60 (UPDRS-change of 0.3 points). At week 72, patients who had received continuous monotherapy with rasagiline experienced a worsening of only 1.6 points.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Treatment with rasagiline maintained motor function to baseline values for at least a year with significant benefits observed in all key PD motor symptoms.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jankovic</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Dept of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: josephj@bcm.tmc.edu.</Affiliation>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2014</Year>
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<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Parkinsonism Relat Disord</MedlineTA>
<NlmUniqueID>9513583</NlmUniqueID>
<ISSNLinking>1353-8020</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>003N66TS6T</RegistryNumber>
<NameOfSubstance UI="C031967">rasagiline</NameOfSubstance>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Monotherapy</Keyword>
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