JankovicV1, PascalFrancis, Corpus, bibRecord, 000157

Postural control in Parkinson's disease after unilateral posteroventral pallidotomy

Identifieur interne : 000157 ( PascalFrancis/Corpus ); précédent : 000156; suivant : 000158

Postural control in Parkinson's disease after unilateral posteroventral pallidotomy

Auteurs : Deborah Roberts ; Averell Overby ; Joseph Jankovic ; Sharon Olson ; Eugene Lai ; J Krauss ; Robert Grossman

Source :

Brain [ 0006-8950 ] ; 2000.

RBID : Pascal:00-0487652

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Chirurgie, Ajustement postural, Traitement, Homme, Pallidotomie.

English descriptors

KwdEn :
- Human, Parkinson disease, Postural fitting, Surgery, Treatment.

Abstract

Postural control changes were studied in 27 patients with Parkinson's disease after unilateral posteroventral pallidotomy (PVP). Patients were evaluated before PVP and at 3, 6 and 12 months post-PVP, both off' and on' parkinsonian medications, with selected evaluation tools representing functional performance, functional balance and posturographic components of balance. The majority of variables in the off' state were significantly improved at 3 months post-PVP. Improvement was maintained at 6 months but had declined for some variables by the 12 month follow-up. Standing up from a chair (P = 0.009), the balance and gait sections of the Performance-Oriented Assessment (P ≤ 0.0004), and the limits of stability (LOS) posturography variables (P < 0.0005) of the average time to reach a target, the number of targets missed and the initial excursion distance to the target (P = 0.029) retained significant improvement at the 12 month follow-up. When the patients were in the on' state, LOS posturography variables of average time to target, average path length deviation, and the number of targets missed were the only variables significantly improved at 3 months post-PVP (P = -0.013) and this improvement was maintained at 12 months post-PVP (P = 0.012-0.041). Unilateral PVP improves axial symptoms of Parkinson's disease involved in functional performance such as gait disturbance as well as improving postural stability in the 'off' state. Generally, the maximum improvement is seen at 3 months post-PVP with many variables remaining significantly improved at 12 months post-PVP. Axial dyskinesias in the on' state are also significantly reduced with the improvement maintained at 12 months post-PVP. These findings suggest that unilateral pallidotomy is not only effective in abolishing levodopa-induced dyskinesias, but that it also improves the axial signs of Parkinson's disease.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`02`	`1`		`@1 OVERBY (Averell)`
A11	`03`	`1`		`@1 JANKOVIC (Joseph)`
A11	`04`	`1`		`@1 OLSON (Sharon)`
A11	`05`	`1`		`@1 LAI (Eugene C.)`
A11	`06`	`1`		`@1 KRAUSS (J. K.)`
A11	`07`	`1`		`@1 GROSSMAN (Robert)`
A14	`01`			`@1 Texas Woman's University, Baylor College of Medicine @2 Houston, Texas @3 USA @Z 1 aut. @Z 4 aut.`
A14	`02`			`@1 Ohio University @2 Athens, Ohio @3 USA @Z 2 aut.`
A14	`03`			`@1 Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine @2 Houston, Texas @3 USA @Z 3 aut. @Z 5 aut.`
A14	`04`			`@1 Department of Neurology, Baylor College of Medicine @2 Houston, Texas @3 USA @Z 3 aut. @Z 5 aut.`
A14	`05`			`@1 Department of Neurosurgery, Baylor College of Medicine @2 Houston, Texas @3 USA @Z 6 aut. @Z 7 aut.`
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C01	`01`		`ENG`	@0 Postural control changes were studied in 27 patients with Parkinson's disease after unilateral posteroventral pallidotomy (PVP). Patients were evaluated before PVP and at 3, 6 and 12 months post-PVP, both off' and on' parkinsonian medications, with selected evaluation tools representing functional performance, functional balance and posturographic components of balance. The majority of variables in the off' state were significantly improved at 3 months post-PVP. Improvement was maintained at 6 months but had declined for some variables by the 12 month follow-up. Standing up from a chair (P = 0.009), the balance and gait sections of the Performance-Oriented Assessment (P ≤ 0.0004), and the limits of stability (LOS) posturography variables (P < 0.0005) of the average time to reach a target, the number of targets missed and the initial excursion distance to the target (P = 0.029) retained significant improvement at the 12 month follow-up. When the patients were in the on' state, LOS posturography variables of average time to target, average path length deviation, and the number of targets missed were the only variables significantly improved at 3 months post-PVP (P = -0.013) and this improvement was maintained at 12 months post-PVP (P = 0.012-0.041). Unilateral PVP improves axial symptoms of Parkinson's disease involved in functional performance such as gait disturbance as well as improving postural stability in the 'off' state. Generally, the maximum improvement is seen at 3 months post-PVP with many variables remaining significantly improved at 12 months post-PVP. Axial dyskinesias in the on' state are also significantly reduced with the improvement maintained at 12 months post-PVP. These findings suggest that unilateral pallidotomy is not only effective in abolishing levodopa-induced dyskinesias, but that it also improves the axial signs of Parkinson's disease.
C02	`01`	`X`		`@0 002B17G`
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C03	`02`	`X`	`ENG`	`@0 Surgery @5 04`
C03	`02`	`X`	`SPA`	`@0 Cirugía @5 04`
C03	`03`	`X`	`FRE`	`@0 Ajustement postural @5 07`
C03	`03`	`X`	`ENG`	`@0 Postural fitting @5 07`
C03	`03`	`X`	`SPA`	`@0 Ajuste postural @5 07`
C03	`04`	`X`	`FRE`	`@0 Traitement @5 17`
C03	`04`	`X`	`ENG`	`@0 Treatment @5 17`
C03	`04`	`X`	`SPA`	`@0 Tratamiento @5 17`
C03	`05`	`X`	`FRE`	`@0 Homme @5 20`
C03	`05`	`X`	`ENG`	`@0 Human @5 20`
C03	`05`	`X`	`SPA`	`@0 Hombre @5 20`
C03	`06`	`X`	`FRE`	`@0 Pallidotomie @4 INC @5 86`
C07	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 37`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Encéphale pathologie @5 39`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
N21				`@1 325`

Format Inist (serveur)

NO :	PASCAL 00-0487652 INIST
ET :	Postural control in Parkinson's disease after unilateral posteroventral pallidotomy
AU :	ROBERTS-WARRIOR (Deborah); OVERBY (Averell); JANKOVIC (Joseph); OLSON (Sharon); LAI (Eugene C.); KRAUSS (J. K.); GROSSMAN (Robert)
AF :	Texas Woman's University, Baylor College of Medicine/Houston, Texas/Etats-Unis (1 aut., 4 aut.); Ohio University/Athens, Ohio/Etats-Unis (2 aut.); Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine/Houston, Texas/Etats-Unis (3 aut., 5 aut.); Department of Neurology, Baylor College of Medicine/Houston, Texas/Etats-Unis (3 aut., 5 aut.); Department of Neurosurgery, Baylor College of Medicine/Houston, Texas/Etats-Unis (6 aut., 7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Brain; ISSN 0006-8950; Royaume-Uni; Da. 2000; Vol. 123; No. p.10; Pp. 2141-2149; Bibl. 1 p.1/4
LA :	Anglais
EA :	Postural control changes were studied in 27 patients with Parkinson's disease after unilateral posteroventral pallidotomy (PVP). Patients were evaluated before PVP and at 3, 6 and 12 months post-PVP, both off' and on' parkinsonian medications, with selected evaluation tools representing functional performance, functional balance and posturographic components of balance. The majority of variables in the off' state were significantly improved at 3 months post-PVP. Improvement was maintained at 6 months but had declined for some variables by the 12 month follow-up. Standing up from a chair (P = 0.009), the balance and gait sections of the Performance-Oriented Assessment (P ≤ 0.0004), and the limits of stability (LOS) posturography variables (P < 0.0005) of the average time to reach a target, the number of targets missed and the initial excursion distance to the target (P = 0.029) retained significant improvement at the 12 month follow-up. When the patients were in the on' state, LOS posturography variables of average time to target, average path length deviation, and the number of targets missed were the only variables significantly improved at 3 months post-PVP (P = -0.013) and this improvement was maintained at 12 months post-PVP (P = 0.012-0.041). Unilateral PVP improves axial symptoms of Parkinson's disease involved in functional performance such as gait disturbance as well as improving postural stability in the 'off' state. Generally, the maximum improvement is seen at 3 months post-PVP with many variables remaining significantly improved at 12 months post-PVP. Axial dyskinesias in the on' state are also significantly reduced with the improvement maintained at 12 months post-PVP. These findings suggest that unilateral pallidotomy is not only effective in abolishing levodopa-induced dyskinesias, but that it also improves the axial signs of Parkinson's disease.
CC :	002B17G
FD :	Parkinson maladie; Chirurgie; Ajustement postural; Traitement; Homme; Pallidotomie
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative
ED :	Parkinson disease; Surgery; Postural fitting; Treatment; Human
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease
SD :	Parkinson enfermedad; Cirugía; Ajuste postural; Tratamiento; Hombre
LO :	INIST-998.354000092209490150
ID :	00-0487652

Links to Exploration step

Pascal:00-0487652

Le document en format XML

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<front><div type="abstract" xml:lang="en">Postural control changes were studied in 27 patients with Parkinson's disease after unilateral posteroventral pallidotomy (PVP). Patients were evaluated before PVP and at 3, 6 and 12 months post-PVP, both off' and on' parkinsonian medications, with selected evaluation tools representing functional performance, functional balance and posturographic components of balance. The majority of variables in the off' state were significantly improved at 3 months post-PVP. Improvement was maintained at 6 months but had declined for some variables by the 12 month follow-up. Standing up from a chair (P = 0.009), the balance and gait sections of the Performance-Oriented Assessment (P ≤ 0.0004), and the limits of stability (LOS) posturography variables (P < 0.0005) of the average time to reach a target, the number of targets missed and the initial excursion distance to the target (P = 0.029) retained significant improvement at the 12 month follow-up. When the patients were in the on' state, LOS posturography variables of average time to target, average path length deviation, and the number of targets missed were the only variables significantly improved at 3 months post-PVP (P = -0.013) and this improvement was maintained at 12 months post-PVP (P = 0.012-0.041). Unilateral PVP improves axial symptoms of Parkinson's disease involved in functional performance such as gait disturbance as well as improving postural stability in the 'off' state. Generally, the maximum improvement is seen at 3 months post-PVP with many variables remaining significantly improved at 12 months post-PVP. Axial dyskinesias in the on' state are also significantly reduced with the improvement maintained at 12 months post-PVP. These findings suggest that unilateral pallidotomy is not only effective in abolishing levodopa-induced dyskinesias, but that it also improves the axial signs of Parkinson's disease.</div>
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<server><NO>PASCAL 00-0487652 INIST</NO>
<ET>Postural control in Parkinson's disease after unilateral posteroventral pallidotomy</ET>
<AU>ROBERTS-WARRIOR (Deborah); OVERBY (Averell); JANKOVIC (Joseph); OLSON (Sharon); LAI (Eugene C.); KRAUSS (J. K.); GROSSMAN (Robert)</AU>
<AF>Texas Woman's University, Baylor College of Medicine/Houston, Texas/Etats-Unis (1 aut., 4 aut.); Ohio University/Athens, Ohio/Etats-Unis (2 aut.); Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine/Houston, Texas/Etats-Unis (3 aut., 5 aut.); Department of Neurology, Baylor College of Medicine/Houston, Texas/Etats-Unis (3 aut., 5 aut.); Department of Neurosurgery, Baylor College of Medicine/Houston, Texas/Etats-Unis (6 aut., 7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Brain; ISSN 0006-8950; Royaume-Uni; Da. 2000; Vol. 123; No. p.10; Pp. 2141-2149; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>Postural control changes were studied in 27 patients with Parkinson's disease after unilateral posteroventral pallidotomy (PVP). Patients were evaluated before PVP and at 3, 6 and 12 months post-PVP, both off' and on' parkinsonian medications, with selected evaluation tools representing functional performance, functional balance and posturographic components of balance. The majority of variables in the off' state were significantly improved at 3 months post-PVP. Improvement was maintained at 6 months but had declined for some variables by the 12 month follow-up. Standing up from a chair (P = 0.009), the balance and gait sections of the Performance-Oriented Assessment (P ≤ 0.0004), and the limits of stability (LOS) posturography variables (P < 0.0005) of the average time to reach a target, the number of targets missed and the initial excursion distance to the target (P = 0.029) retained significant improvement at the 12 month follow-up. When the patients were in the on' state, LOS posturography variables of average time to target, average path length deviation, and the number of targets missed were the only variables significantly improved at 3 months post-PVP (P = -0.013) and this improvement was maintained at 12 months post-PVP (P = 0.012-0.041). Unilateral PVP improves axial symptoms of Parkinson's disease involved in functional performance such as gait disturbance as well as improving postural stability in the 'off' state. Generally, the maximum improvement is seen at 3 months post-PVP with many variables remaining significantly improved at 12 months post-PVP. Axial dyskinesias in the on' state are also significantly reduced with the improvement maintained at 12 months post-PVP. These findings suggest that unilateral pallidotomy is not only effective in abolishing levodopa-induced dyskinesias, but that it also improves the axial signs of Parkinson's disease.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Chirurgie; Ajustement postural; Traitement; Homme; Pallidotomie</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative</FG>
<ED>Parkinson disease; Surgery; Postural fitting; Treatment; Human</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease</EG>
<SD>Parkinson enfermedad; Cirugía; Ajuste postural; Tratamiento; Hombre</SD>
<LO>INIST-998.354000092209490150</LO>
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Postural control in Parkinson's disease after unilateral posteroventral pallidotomy

Postural control in Parkinson's disease after unilateral posteroventral pallidotomy

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