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Differential diagnosis of Parkinson's disease and the parkinsonism plus syndromes.

Identifieur interne : 000090 ( Ncbi/Curation ); précédent : 000089; suivant : 000091

Differential diagnosis of Parkinson's disease and the parkinsonism plus syndromes.

Auteurs : M. Stacy ; Joseph Jankovic [États-Unis]

Source :

RBID : pubmed:1584178

English descriptors

Abstract

Although Parkinson's disease (PD) is thought to represent a specific clinical-pathologic entity, up to 20% of patients diagnosed as having PD will have another disorder at autopsy. Furthermore, pathologic features typically associated with PD can also be observed in patients with other neurodegenerative disorders. This article attempts to point out the difficulties in differentiating PD from progressive supranuclear palsy and other parkinsonism plus syndromes and various causes of parkinsonism associated with cognitive changes. The clinical and pathologic differentiation of these disorders are discussed. These disorders are usually associated with postsynaptic receptor changes and therefore levodopa and dopamine agonists provide limited benefit.

PubMed: 1584178

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M. Stacy
<affiliation>
<nlm:affiliation>Department of Neurology, University of Missouri, School of Medicine, Columbia.</nlm:affiliation>
<wicri:noCountry code="subField">Columbia</wicri:noCountry>
</affiliation>

Le document en format XML

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<title xml:lang="en">Differential diagnosis of Parkinson's disease and the parkinsonism plus syndromes.</title>
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<term>Alzheimer Disease (diagnosis)</term>
<term>Basal Ganglia Diseases (diagnosis)</term>
<term>Dementia (diagnosis)</term>
<term>Diagnosis, Differential</term>
<term>Humans</term>
<term>Parkinson Disease (classification)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Supranuclear Palsy, Progressive (diagnosis)</term>
<term>Syndrome</term>
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<term>Parkinson Disease</term>
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<term>Alzheimer Disease</term>
<term>Basal Ganglia Diseases</term>
<term>Dementia</term>
<term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
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<div type="abstract" xml:lang="en">Although Parkinson's disease (PD) is thought to represent a specific clinical-pathologic entity, up to 20% of patients diagnosed as having PD will have another disorder at autopsy. Furthermore, pathologic features typically associated with PD can also be observed in patients with other neurodegenerative disorders. This article attempts to point out the difficulties in differentiating PD from progressive supranuclear palsy and other parkinsonism plus syndromes and various causes of parkinsonism associated with cognitive changes. The clinical and pathologic differentiation of these disorders are discussed. These disorders are usually associated with postsynaptic receptor changes and therefore levodopa and dopamine agonists provide limited benefit.</div>
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