Differential diagnosis of Parkinson's disease and the parkinsonism plus syndromes.
Identifieur interne : 000309 ( PubMed/Corpus ); précédent : 000308; suivant : 000310Differential diagnosis of Parkinson's disease and the parkinsonism plus syndromes.
Auteurs : M. Stacy ; J. JankovicSource :
- Neurologic clinics [ 0733-8619 ] ; 1992.
English descriptors
- KwdEn :
- MESH :
- classification : Parkinson Disease.
- diagnosis : Alzheimer Disease, Basal Ganglia Diseases, Dementia, Parkinson Disease, Supranuclear Palsy, Progressive.
- Diagnosis, Differential, Humans, Syndrome.
Abstract
Although Parkinson's disease (PD) is thought to represent a specific clinical-pathologic entity, up to 20% of patients diagnosed as having PD will have another disorder at autopsy. Furthermore, pathologic features typically associated with PD can also be observed in patients with other neurodegenerative disorders. This article attempts to point out the difficulties in differentiating PD from progressive supranuclear palsy and other parkinsonism plus syndromes and various causes of parkinsonism associated with cognitive changes. The clinical and pathologic differentiation of these disorders are discussed. These disorders are usually associated with postsynaptic receptor changes and therefore levodopa and dopamine agonists provide limited benefit.
PubMed: 1584178
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Jankovic</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1584178</idno><idno type="pmid">1584178</idno><idno type="wicri:Area/PubMed/Corpus">000309</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Differential diagnosis of Parkinson's disease and the parkinsonism plus syndromes.</title><author><name sortKey="Stacy, M" sort="Stacy, M" uniqKey="Stacy M" first="M" last="Stacy">M. Stacy</name><affiliation><nlm:affiliation>Department of Neurology, University of Missouri, School of Medicine, Columbia.</nlm:affiliation></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J. Jankovic</name></author></analytic><series><title level="j">Neurologic clinics</title><idno type="ISSN">0733-8619</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (diagnosis)</term><term>Basal Ganglia Diseases (diagnosis)</term><term>Dementia (diagnosis)</term><term>Diagnosis, Differential</term><term>Humans</term><term>Parkinson Disease (classification)</term><term>Parkinson Disease (diagnosis)</term><term>Supranuclear Palsy, Progressive (diagnosis)</term><term>Syndrome</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term><term>Basal Ganglia Diseases</term><term>Dementia</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Diagnosis, Differential</term><term>Humans</term><term>Syndrome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although Parkinson's disease (PD) is thought to represent a specific clinical-pathologic entity, up to 20% of patients diagnosed as having PD will have another disorder at autopsy. Furthermore, pathologic features typically associated with PD can also be observed in patients with other neurodegenerative disorders. This article attempts to point out the difficulties in differentiating PD from progressive supranuclear palsy and other parkinsonism plus syndromes and various causes of parkinsonism associated with cognitive changes. The clinical and pathologic differentiation of these disorders are discussed. These disorders are usually associated with postsynaptic receptor changes and therefore levodopa and dopamine agonists provide limited benefit.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">1584178</PMID><DateCreated><Year>1992</Year><Month>06</Month><Day>17</Day></DateCreated><DateCompleted><Year>1992</Year><Month>06</Month><Day>17</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0733-8619</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>2</Issue><PubDate><Year>1992</Year><Month>May</Month></PubDate></JournalIssue><Title>Neurologic clinics</Title><ISOAbbreviation>Neurol Clin</ISOAbbreviation></Journal><ArticleTitle>Differential diagnosis of Parkinson's disease and the parkinsonism plus syndromes.</ArticleTitle><Pagination><MedlinePgn>341-59</MedlinePgn></Pagination><Abstract><AbstractText>Although Parkinson's disease (PD) is thought to represent a specific clinical-pathologic entity, up to 20% of patients diagnosed as having PD will have another disorder at autopsy. 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