Epigenetic mechanisms in Parkinson's disease.
Identifieur interne : 000483 ( Ncbi/Checkpoint ); précédent : 000482; suivant : 000484Epigenetic mechanisms in Parkinson's disease.
Auteurs : Ya Feng [République populaire de Chine] ; Joseph Jankovic [États-Unis] ; Yun Wu [République populaire de Chine]Source :
- Journal of the neurological sciences ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Histones, RNA, Untranslated.
- epidemiology : Parkinson Disease.
- genetics : DNA Methylation, Epigenesis, Genetic, Parkinson Disease.
- Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Humans, Male, Risk Factors.
Abstract
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD has been considered to result from a complex interaction between genetic and environmental factors, but the nature of the relationship between the two chief modifiers remains to be elucidated. There is a growing body of evidence supporting the role of epigenetics in the development and progression of many neurodegenerative diseases including PD. Epigenetic modification refers to changes in gene expression or function without changes in DNA sequence, which mainly includes DNA methylation, post-modifications of histone, and non-coding RNAs. In this review, we will focus on the abnormal epigenetic modifications involved in the pathogenesis of PD and their implications for the development of future diagnostic and therapeutic strategies.
DOI: 10.1016/j.jns.2014.12.017
PubMed: 25553963
Affiliations:
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<series><title level="j">Journal of the neurological sciences</title>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is the second most common age-related neurodegenerative disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD has been considered to result from a complex interaction between genetic and environmental factors, but the nature of the relationship between the two chief modifiers remains to be elucidated. There is a growing body of evidence supporting the role of epigenetics in the development and progression of many neurodegenerative diseases including PD. Epigenetic modification refers to changes in gene expression or function without changes in DNA sequence, which mainly includes DNA methylation, post-modifications of histone, and non-coding RNAs. In this review, we will focus on the abnormal epigenetic modifications involved in the pathogenesis of PD and their implications for the development of future diagnostic and therapeutic strategies.</div>
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