Epigenetic mechanisms in Parkinson's disease.
Identifieur interne : 000017 ( PubMed/Curation ); précédent : 000016; suivant : 000018Epigenetic mechanisms in Parkinson's disease.
Auteurs : Ya Feng [République populaire de Chine] ; Joseph Jankovic [États-Unis] ; Yun Wu [République populaire de Chine]Source :
- Journal of the neurological sciences ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Histones, RNA, Untranslated.
- epidemiology : Parkinson Disease.
- genetics : DNA Methylation, Epigenesis, Genetic, Parkinson Disease.
- Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Humans, Male, Risk Factors.
Abstract
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD has been considered to result from a complex interaction between genetic and environmental factors, but the nature of the relationship between the two chief modifiers remains to be elucidated. There is a growing body of evidence supporting the role of epigenetics in the development and progression of many neurodegenerative diseases including PD. Epigenetic modification refers to changes in gene expression or function without changes in DNA sequence, which mainly includes DNA methylation, post-modifications of histone, and non-coding RNAs. In this review, we will focus on the abnormal epigenetic modifications involved in the pathogenesis of PD and their implications for the development of future diagnostic and therapeutic strategies.
DOI: 10.1016/j.jns.2014.12.017
PubMed: 25553963
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<author><name sortKey="Feng, Ya" sort="Feng, Ya" uniqKey="Feng Y" first="Ya" last="Feng">Ya Feng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.</nlm:affiliation>
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<wicri:regionArea>Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080</wicri:regionArea>
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<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
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<author><name sortKey="Wu, Yun Cheng" sort="Wu, Yun Cheng" uniqKey="Wu Y" first="Yun" last="Wu">Yun Wu</name>
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<term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genetic Predisposition to Disease</term>
<term>Histones (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (genetics)</term>
<term>RNA, Untranslated (genetics)</term>
<term>Risk Factors</term>
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<term>Epigenesis, Genetic</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genetic Predisposition to Disease</term>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is the second most common age-related neurodegenerative disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD has been considered to result from a complex interaction between genetic and environmental factors, but the nature of the relationship between the two chief modifiers remains to be elucidated. There is a growing body of evidence supporting the role of epigenetics in the development and progression of many neurodegenerative diseases including PD. Epigenetic modification refers to changes in gene expression or function without changes in DNA sequence, which mainly includes DNA methylation, post-modifications of histone, and non-coding RNAs. In this review, we will focus on the abnormal epigenetic modifications involved in the pathogenesis of PD and their implications for the development of future diagnostic and therapeutic strategies.</div>
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<Abstract><AbstractText>Parkinson's disease (PD) is the second most common age-related neurodegenerative disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD has been considered to result from a complex interaction between genetic and environmental factors, but the nature of the relationship between the two chief modifiers remains to be elucidated. There is a growing body of evidence supporting the role of epigenetics in the development and progression of many neurodegenerative diseases including PD. Epigenetic modification refers to changes in gene expression or function without changes in DNA sequence, which mainly includes DNA methylation, post-modifications of histone, and non-coding RNAs. In this review, we will focus on the abnormal epigenetic modifications involved in the pathogenesis of PD and their implications for the development of future diagnostic and therapeutic strategies.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation>
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