JankovicV1, Ncbi, Checkpoint, bibRecord, 000341

Clinical heterogeneity in patients with early-stage Parkinson’s disease: a cluster analysis*

Identifieur interne : 000341 ( Ncbi/Checkpoint ); précédent : 000340; suivant : 000342

Clinical heterogeneity in patients with early-stage Parkinson’s disease: a cluster analysis*

Auteurs : Ping Liu [République populaire de Chine] ; Tao Feng [République populaire de Chine] ; Yong Wang [République populaire de Chine] ; Xuan Zhang [République populaire de Chine] ; Biao Chen [République populaire de Chine]

Source :

Journal of Zhejiang University. Science. B [ 1673-1581 ] ; 2011.

RBID : PMC:3167902

Abstract

The aim of this study was to investigate the clinical heterogeneity of Parkinson’s disease (PD) among a cohort of Chinese patients in early stages. Clinical data on demographics, motor variables, motor phenotypes, disease progression, global cognitive function, depression, apathy, sleep quality, constipation, fatigue, and L-dopa complications were collected from 138 Chinese PD subjects in early stages (Hoehn and Yahr stages 1–3). The PD subject subtypes were classified using k-means cluster analysis according to the clinical data from five to three-cluster consecutively. Kappa statistical analysis was performed to evaluate the consistency among different subtype solutions. The cluster analysis indicated four main subtypes: the non-tremor dominant subtype (NTD, n=28, 20.3%), rapid disease progression subtype (RDP, n=7, 5.1%), young-onset subtype (YO, n=50, 36.2%), and tremor dominant subtype (TD, n=53, 38.4%). Overall, 78.3% (108/138) of subjects were always classified between the same three groups (52 always in TD, 7 in RDP, and 49 in NTD), and 98.6% (136/138) between five- and four-cluster solutions. However, subjects classified as NTD in the four-cluster analysis were dispersed into different subtypes in the three-cluster analysis, with low concordance between four- and three-cluster solutions (kappa value=−0.139, P=0.001). This study defines clinical heterogeneity of PD patients in early stages using a data-driven approach. The subtypes generated by the four-cluster solution appear to exhibit ideal internal cohesion and external isolation.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167902

DOI: 10.1631/jzus.B1100069
PubMed: 21887844
PubMed Central: 3167902

Affiliations:

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PMC:3167902

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>The aim of this study was to investigate the clinical heterogeneity of Parkinson’s disease (PD) among a cohort of Chinese patients in early stages. Clinical data on demographics, motor variables, motor phenotypes, disease progression, global cognitive function, depression, apathy, sleep quality, constipation, fatigue, and L-dopa complications were collected from 138 Chinese PD subjects in early stages (Hoehn and Yahr stages 1–3). The PD subject subtypes were classified using <italic>k</italic>
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Clinical heterogeneity in patients with early-stage Parkinson’s disease: a cluster analysis*

Clinical heterogeneity in patients with early-stage Parkinson’s disease: a cluster analysis*

Source :

Abstract

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