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Significant Linkage of Parkinson Disease to Chromosome 2q36-37

Identifieur interne : 001359 ( Main/Merge ); précédent : 001358; suivant : 001360

Significant Linkage of Parkinson Disease to Chromosome 2q36-37

Auteurs : Nathan Pankratz ; William Nichols ; Sean Uniacke ; Cheryl Halter ; Alice Rudolph [États-Unis] ; Cliff Shults ; P Conneally ; Tatiana Foroud

Source :

American Journal of Human Genetics [ 0002-9297 ] ; 2003.

RBID : PMC:1180337

Abstract

Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this subset of 65 pedigrees generated a LOD score of 5.1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180337

PubMed: 12638082
PubMed Central: 1180337

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PMC:1180337

Le document en format XML

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<affiliation><nlm:aff id="N0x9463f40.0x98d39e0">Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis;</nlm:aff>
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<author><name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William" last="Nichols">William Nichols</name>
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<author><name sortKey="Rudolph, Alice" sort="Rudolph, Alice" uniqKey="Rudolph A" first="Alice" last="Rudolph">Alice Rudolph</name>
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<author><name sortKey="Shults, Cliff" sort="Shults, Cliff" uniqKey="Shults C" first="Cliff" last="Shults">Cliff Shults</name>
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<author><name sortKey="Conneally, P Michael" sort="Conneally, P Michael" uniqKey="Conneally P" first="P" last="Conneally">P Conneally</name>
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<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
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<wicri:noCountry code="subfield">Indianapolis</wicri:noCountry>
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<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<affiliation><nlm:aff id="N0x9463f40.0x98d39e0">Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis;</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p>Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this subset of 65 pedigrees generated a LOD score of 5.1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.</p>
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Significant Linkage of Parkinson Disease to Chromosome 2q36-37

Significant Linkage of Parkinson Disease to Chromosome 2q36-37

Source :

Abstract

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