Significant Linkage of Parkinson Disease to Chromosome 2q36-37
Identifieur interne : 000056 ( Ncbi/Curation ); précédent : 000055; suivant : 000057Significant Linkage of Parkinson Disease to Chromosome 2q36-37
Auteurs : Nathan Pankratz ; William Nichols ; Sean Uniacke ; Cheryl Halter ; Alice Rudolph [États-Unis] ; Cliff Shults ; P Conneally ; Tatiana ForoudSource :
- American Journal of Human Genetics [ 0002-9297 ] ; 2003.
Abstract
Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this subset of 65 pedigrees generated a LOD score of 5.1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.
Url:
PubMed: 12638082
PubMed Central: 1180337
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Nathan Pankratz<affiliation><nlm:aff id="N0x9463f40.0x98d39e0">Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis;</nlm:aff>
<wicri:noCountry code="subfield">Indianapolis</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="N0x9463f40.0x98d39e0">Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati;</nlm:aff>
<wicri:noCountry code="subfield">Cincinnati</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="N0x9463f40.0x98d39e0">Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati;</nlm:aff>
<wicri:noCountry code="subfield">Cincinnati</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="N0x9463f40.0x98d39e0">Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis;</nlm:aff>
<wicri:noCountry code="subfield">Indianapolis</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="N0x9463f40.0x98d39e0">Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis;</nlm:aff>
<wicri:noCountry code="subfield">Indianapolis</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="N0x9463f40.0x98d39e0">Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis;</nlm:aff>
<wicri:noCountry code="subfield">Indianapolis</wicri:noCountry>
</affiliation>
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<front><div type="abstract" xml:lang="en"><p>Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this subset of 65 pedigrees generated a LOD score of 5.1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.</p>
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