Mutations in the novel protein PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions
Identifieur interne : 000222 ( Main/Merge ); précédent : 000221; suivant : 000223Mutations in the novel protein PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions
Auteurs : Hsien Lee ; Yong Huang ; Nadine Bruneau [France] ; Patrice Roll [France] ; Elisha Roberson ; Mark Hermann ; Emily Quinn ; James Maas ; Robert Edwards ; Tetsuo Ashizawa [États-Unis] ; Betul Baykan ; Kailash Bhatia ; Susan Bressman ; Michiko Bruno ; Ewout Brunt ; Roberto Caraballo [Argentine] ; Bernard Echenne [France] ; Natalio Fejerman [Argentine] ; Steve Frucht ; Christina Gurnett [États-Unis] ; Edouard Hirsch [France] ; Henry Houlden ; Joseph Jankovic [États-Unis] ; Wei Lee [Singapour] ; David Lynch ; Shehla Mohamed ; Ulrich Müller [Allemagne] ; Mark Nespeca ; David Renner ; Jacques Rochette ; Gabrielle Rudolf [France] ; Shinji Saiki ; Bing Soong [Taïwan] ; Kathryn Swoboda ; Sam Tucker ; Nicholas Wood ; Michael Hanna ; Anne Bowcock ; Pierre Szepetowski [France] ; Ying Fu ; Louis PtáSource :
- Cell reports ; 2011.
Abstract
Paroxysmal Kinesigenic Dyskinesia with Infantile Convulsions (PKD/IC) is an episodic movement disorder with autosomal dominant inheritance and high penetrance, but the causative gene is unknown. We have now identified four truncating mutations involving the
Url:
DOI: 10.1016/j.celrep.2011.11.001
PubMed: 22832103
PubMed Central: 3334308
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PMC:3334308Le document en format XML
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<author><name sortKey="Lee, Hsien Yang" sort="Lee, Hsien Yang" uniqKey="Lee H" first="Hsien" last="Lee">Hsien Lee</name>
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<author><name sortKey="Huang, Yong" sort="Huang, Yong" uniqKey="Huang Y" first="Yong" last="Huang">Yong Huang</name>
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<author><name sortKey="Quinn, Emily" sort="Quinn, Emily" uniqKey="Quinn E" first="Emily" last="Quinn">Emily Quinn</name>
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<author><name sortKey="Maas, James" sort="Maas, James" uniqKey="Maas J" first="James" last="Maas">James Maas</name>
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<author><name sortKey="Edwards, Robert" sort="Edwards, Robert" uniqKey="Edwards R" first="Robert" last="Edwards">Robert Edwards</name>
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<author><name sortKey="Ashizawa, Tetsuo" sort="Ashizawa, Tetsuo" uniqKey="Ashizawa T" first="Tetsuo" last="Ashizawa">Tetsuo Ashizawa</name>
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<author><name sortKey="Baykan, Betul" sort="Baykan, Betul" uniqKey="Baykan B" first="Betul" last="Baykan">Betul Baykan</name>
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<author><name sortKey="Bhatia, Kailash" sort="Bhatia, Kailash" uniqKey="Bhatia K" first="Kailash" last="Bhatia">Kailash Bhatia</name>
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<author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
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<author><name sortKey="Bruno, Michiko K" sort="Bruno, Michiko K" uniqKey="Bruno M" first="Michiko" last="Bruno">Michiko Bruno</name>
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<author><name sortKey="Brunt, Ewout R" sort="Brunt, Ewout R" uniqKey="Brunt E" first="Ewout" last="Brunt">Ewout Brunt</name>
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<author><name sortKey="Caraballo, Roberto" sort="Caraballo, Roberto" uniqKey="Caraballo R" first="Roberto" last="Caraballo">Roberto Caraballo</name>
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<author><name sortKey="Echenne, Bernard" sort="Echenne, Bernard" uniqKey="Echenne B" first="Bernard" last="Echenne">Bernard Echenne</name>
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<author><name sortKey="Frucht, Steve" sort="Frucht, Steve" uniqKey="Frucht S" first="Steve" last="Frucht">Steve Frucht</name>
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<author><name sortKey="Gurnett, Christina A" sort="Gurnett, Christina A" uniqKey="Gurnett C" first="Christina" last="Gurnett">Christina Gurnett</name>
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</placeName>
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<author><name sortKey="Hirsch, Edouard" sort="Hirsch, Edouard" uniqKey="Hirsch E" first="Edouard" last="Hirsch">Edouard Hirsch</name>
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<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
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<author><name sortKey="Lee, Wei Ling" sort="Lee, Wei Ling" uniqKey="Lee W" first="Wei" last="Lee">Wei Lee</name>
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<author><name sortKey="Lynch, David R" sort="Lynch, David R" uniqKey="Lynch D" first="David" last="Lynch">David Lynch</name>
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<author><name sortKey="Mohamed, Shehla" sort="Mohamed, Shehla" uniqKey="Mohamed S" first="Shehla" last="Mohamed">Shehla Mohamed</name>
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</affiliation>
</author>
<author><name sortKey="Muller, Ulrich" sort="Muller, Ulrich" uniqKey="Muller U" first="Ulrich" last="Müller">Ulrich Müller</name>
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<author><name sortKey="Nespeca, Mark P" sort="Nespeca, Mark P" uniqKey="Nespeca M" first="Mark" last="Nespeca">Mark Nespeca</name>
<affiliation><nlm:aff id="A22">Pediatric Neurology Division, Rady Children’s Hospital San Diego, UCSD Department of Neuroscience, San Diego, California, 92123</nlm:aff>
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</affiliation>
</author>
<author><name sortKey="Renner, David" sort="Renner, David" uniqKey="Renner D" first="David" last="Renner">David Renner</name>
<affiliation><nlm:aff id="A23">Department of Neurology, University of Utah, Salt Lake City, Utah, 84132</nlm:aff>
<wicri:noCountry code="subfield">84132</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rochette, Jacques" sort="Rochette, Jacques" uniqKey="Rochette J" first="Jacques" last="Rochette">Jacques Rochette</name>
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</affiliation>
</author>
<author><name sortKey="Rudolf, Gabrielle" sort="Rudolf, Gabrielle" uniqKey="Rudolf G" first="Gabrielle" last="Rudolf">Gabrielle Rudolf</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie. Hôpitaux Universitaires de Strasbourg</wicri:regionArea>
</affiliation>
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<author><name sortKey="Saiki, Shinji" sort="Saiki, Shinji" uniqKey="Saiki S" first="Shinji" last="Saiki">Shinji Saiki</name>
<affiliation><nlm:aff id="A25">Department of Neurology, Kanazawa Medical University, Ishikawa, Japan, 920-0293</nlm:aff>
<wicri:noCountry code="subfield">920-0293</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Soong, Bing Wen" sort="Soong, Bing Wen" uniqKey="Soong B" first="Bing" last="Soong">Bing Soong</name>
<affiliation wicri:level="1"><nlm:aff id="A26">Department of Neurology, National Yang-Ming University School of Medicine and the Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, National Yang-Ming University School of Medicine and the Neurological Institute, Taipei Veterans General Hospital, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Swoboda, Kathryn J" sort="Swoboda, Kathryn J" uniqKey="Swoboda K" first="Kathryn" last="Swoboda">Kathryn Swoboda</name>
<affiliation><nlm:aff id="A23">Department of Neurology, University of Utah, Salt Lake City, Utah, 84132</nlm:aff>
<wicri:noCountry code="subfield">84132</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tucker, Sam" sort="Tucker, Sam" uniqKey="Tucker S" first="Sam" last="Tucker">Sam Tucker</name>
<affiliation><nlm:aff id="A19">Division of Neurology, Children’s Hospital of Philadelphia, Philadelphia, Pa. USA, 19104</nlm:aff>
<wicri:noCountry code="subfield">19104</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wood, Nicholas" sort="Wood, Nicholas" uniqKey="Wood N" first="Nicholas" last="Wood">Nicholas Wood</name>
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<wicri:noCountry code="subfield">WC1N 3BG</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hanna, Michael" sort="Hanna, Michael" uniqKey="Hanna M" first="Michael" last="Hanna">Michael Hanna</name>
<affiliation><nlm:aff id="A8">Institute of Neurology, University College London, London, WC1N 3BG</nlm:aff>
<wicri:noCountry code="subfield">WC1N 3BG</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A27">Senior Investigator of the International Paroxysmal Kinesigenic Dyskinesia/Infantile Convulsions Collaborative Working Group</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bowcock, Anne" sort="Bowcock, Anne" uniqKey="Bowcock A" first="Anne" last="Bowcock">Anne Bowcock</name>
<affiliation><nlm:aff id="A5">Division of Human Genetics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, 63110</nlm:aff>
<wicri:noCountry code="subfield">63110</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A27">Senior Investigator of the International Paroxysmal Kinesigenic Dyskinesia/Infantile Convulsions Collaborative Working Group</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Szepetowski, Pierre" sort="Szepetowski, Pierre" uniqKey="Szepetowski P" first="Pierre" last="Szepetowski">Pierre Szepetowski</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Institut de Neurobiologie de la Méditerranée, INMED. Inserm U901. Université de la Méditerranée. Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
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<affiliation><nlm:aff id="A27">Senior Investigator of the International Paroxysmal Kinesigenic Dyskinesia/Infantile Convulsions Collaborative Working Group</nlm:aff>
</affiliation>
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<author><name sortKey="Fu, Ying Hui" sort="Fu, Ying Hui" uniqKey="Fu Y" first="Ying" last="Fu">Ying Fu</name>
<affiliation><nlm:aff id="A1">Department of Neurology, UCSF, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A27">Senior Investigator of the International Paroxysmal Kinesigenic Dyskinesia/Infantile Convulsions Collaborative Working Group</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pta Ek, Louis J" sort="Pta Ek, Louis J" uniqKey="Pta Ek L" first="Louis" last="Ptá">Louis Ptá</name>
<affiliation><nlm:aff id="A1">Department of Neurology, UCSF, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Howard Hughes Medical Institute, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A27">Senior Investigator of the International Paroxysmal Kinesigenic Dyskinesia/Infantile Convulsions Collaborative Working Group</nlm:aff>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mutations in the novel protein PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions</title>
<author><name sortKey="Lee, Hsien Yang" sort="Lee, Hsien Yang" uniqKey="Lee H" first="Hsien" last="Lee">Hsien Lee</name>
<affiliation><nlm:aff id="A1">Department of Neurology, UCSF, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
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<author><name sortKey="Huang, Yong" sort="Huang, Yong" uniqKey="Huang Y" first="Yong" last="Huang">Yong Huang</name>
<affiliation><nlm:aff id="A1">Department of Neurology, UCSF, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Howard Hughes Medical Institute, San Francisco, California, 94158</nlm:aff>
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</affiliation>
</author>
<author><name sortKey="Bruneau, Nadine" sort="Bruneau, Nadine" uniqKey="Bruneau N" first="Nadine" last="Bruneau">Nadine Bruneau</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Institut de Neurobiologie de la Méditerranée, INMED. Inserm U901. Université de la Méditerranée. Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Neurobiologie de la Méditerranée, INMED. Inserm U901. Université de la Méditerranée. Marseille</wicri:regionArea>
<wicri:noRegion>INMED. Inserm U901. Université de la Méditerranée. Marseille</wicri:noRegion>
<wicri:noRegion>INMED. Inserm U901. Université de la Méditerranée. Marseille</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roll, Patrice" sort="Roll, Patrice" uniqKey="Roll P" first="Patrice" last="Roll">Patrice Roll</name>
<affiliation wicri:level="4"><nlm:aff id="A4">INSERM UMR_S910, Université de la Méditerranée, Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR_S910, Université de la Méditerranée, Marseille</wicri:regionArea>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université de la Méditerranée</orgName>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roberson, Elisha D O" sort="Roberson, Elisha D O" uniqKey="Roberson E" first="Elisha" last="Roberson">Elisha Roberson</name>
<affiliation><nlm:aff id="A5">Division of Human Genetics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, 63110</nlm:aff>
<wicri:noCountry code="subfield">63110</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hermann, Mark" sort="Hermann, Mark" uniqKey="Hermann M" first="Mark" last="Hermann">Mark Hermann</name>
<affiliation><nlm:aff id="A1">Department of Neurology, UCSF, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Quinn, Emily" sort="Quinn, Emily" uniqKey="Quinn E" first="Emily" last="Quinn">Emily Quinn</name>
<affiliation><nlm:aff id="A1">Department of Neurology, UCSF, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Howard Hughes Medical Institute, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Maas, James" sort="Maas, James" uniqKey="Maas J" first="James" last="Maas">James Maas</name>
<affiliation><nlm:aff id="A1">Department of Neurology, UCSF, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Edwards, Robert" sort="Edwards, Robert" uniqKey="Edwards R" first="Robert" last="Edwards">Robert Edwards</name>
<affiliation><nlm:aff id="A1">Department of Neurology, UCSF, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ashizawa, Tetsuo" sort="Ashizawa, Tetsuo" uniqKey="Ashizawa T" first="Tetsuo" last="Ashizawa">Tetsuo Ashizawa</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Neurology, University of Florida, Gainesville, Florida 32611</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baykan, Betul" sort="Baykan, Betul" uniqKey="Baykan B" first="Betul" last="Baykan">Betul Baykan</name>
<affiliation><nlm:aff id="A7">Department of Neurology, Istanbul University, Millet Cad 34390 Istanbul Turkey</nlm:aff>
<wicri:noCountry code="subfield">Millet Cad 34390 Istanbul Turkey</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bhatia, Kailash" sort="Bhatia, Kailash" uniqKey="Bhatia K" first="Kailash" last="Bhatia">Kailash Bhatia</name>
<affiliation><nlm:aff id="A8">Institute of Neurology, University College London, London, WC1N 3BG</nlm:aff>
<wicri:noCountry code="subfield">WC1N 3BG</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
<affiliation><nlm:aff id="A9">Department of Neurology, Beth Israel Medical Center, New York, New York, 10003</nlm:aff>
<wicri:noCountry code="subfield">10003</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bruno, Michiko K" sort="Bruno, Michiko K" uniqKey="Bruno M" first="Michiko" last="Bruno">Michiko Bruno</name>
<affiliation><nlm:aff id="A1">Department of Neurology, UCSF, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A10">Department of Neurology, The Queen’s Medical Center, Honolulu, Hawaii, 96813</nlm:aff>
<wicri:noCountry code="subfield">96813</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Brunt, Ewout R" sort="Brunt, Ewout R" uniqKey="Brunt E" first="Ewout" last="Brunt">Ewout Brunt</name>
<affiliation><nlm:aff id="A11">Department of Neurology, University Medical Centre Groningen, University of Groningen, The Netherlands, 9713 GZ</nlm:aff>
<wicri:noCountry code="subfield">9713 GZ</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Caraballo, Roberto" sort="Caraballo, Roberto" uniqKey="Caraballo R" first="Roberto" last="Caraballo">Roberto Caraballo</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Neurology, Juan P. Garrahan Pediatric Hospital, Combate de los Pozos 1881. CP 1245, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Department of Neurology, Juan P. Garrahan Pediatric Hospital, Combate de los Pozos 1881. CP 1245, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Echenne, Bernard" sort="Echenne, Bernard" uniqKey="Echenne B" first="Bernard" last="Echenne">Bernard Echenne</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Service de Neuropédiatrie, Hôpital Gui de Chauliac, Montpellier, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neuropédiatrie, Hôpital Gui de Chauliac, Montpellier</wicri:regionArea>
<placeName><settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fejerman, Natalio" sort="Fejerman, Natalio" uniqKey="Fejerman N" first="Natalio" last="Fejerman">Natalio Fejerman</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Neurology, Juan P. Garrahan Pediatric Hospital, Combate de los Pozos 1881. CP 1245, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Department of Neurology, Juan P. Garrahan Pediatric Hospital, Combate de los Pozos 1881. CP 1245, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frucht, Steve" sort="Frucht, Steve" uniqKey="Frucht S" first="Steve" last="Frucht">Steve Frucht</name>
<affiliation><nlm:aff id="A14">Movement Disorders Center, Mount Sinai Medical Center, New York, 10029</nlm:aff>
<wicri:noCountry code="subfield">10029</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gurnett, Christina A" sort="Gurnett, Christina A" uniqKey="Gurnett C" first="Christina" last="Gurnett">Christina Gurnett</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Neurology, Washington University School of Medicine, St Louis, MO 63110</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Department of Neurology, Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hirsch, Edouard" sort="Hirsch, Edouard" uniqKey="Hirsch E" first="Edouard" last="Hirsch">Edouard Hirsch</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Service de Neurologie. Hôpitaux Universitaires de Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie. Hôpitaux Universitaires de Strasbourg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Houlden, Henry" sort="Houlden, Henry" uniqKey="Houlden H" first="Henry" last="Houlden">Henry Houlden</name>
<affiliation><nlm:aff id="A8">Institute of Neurology, University College London, London, WC1N 3BG</nlm:aff>
<wicri:noCountry code="subfield">WC1N 3BG</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Parkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Parkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston</wicri:cityArea>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university" n="3">Baylor College of Medicine</orgName>
</affiliation>
</author>
<author><name sortKey="Lee, Wei Ling" sort="Lee, Wei Ling" uniqKey="Lee W" first="Wei" last="Lee">Wei Lee</name>
<affiliation wicri:level="1"><nlm:aff id="A18">National Neuroscience Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>National Neuroscience Institute</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lynch, David R" sort="Lynch, David R" uniqKey="Lynch D" first="David" last="Lynch">David Lynch</name>
<affiliation><nlm:aff id="A19">Division of Neurology, Children’s Hospital of Philadelphia, Philadelphia, Pa. USA, 19104</nlm:aff>
<wicri:noCountry code="subfield">19104</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mohamed, Shehla" sort="Mohamed, Shehla" uniqKey="Mohamed S" first="Shehla" last="Mohamed">Shehla Mohamed</name>
<affiliation><nlm:aff id="A20">Clinical Genetics, Guy’s Hospital, London, SE1 9RT</nlm:aff>
<wicri:noCountry code="subfield">SE1 9RT</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Muller, Ulrich" sort="Muller, Ulrich" uniqKey="Muller U" first="Ulrich" last="Müller">Ulrich Müller</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Institut für Humangenetik, Justus-Liebig-Universität, Giessen, Germany, D-35392</nlm:aff>
<country wicri:rule="zip">Allemagne</country>
<wicri:regionArea>Institut für Humangenetik, Justus-Liebig-Universität, Giessen, Germany, D-35392</wicri:regionArea>
<wicri:noRegion>35392</wicri:noRegion>
<wicri:noRegion>35392</wicri:noRegion>
<wicri:noRegion>D-35392</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nespeca, Mark P" sort="Nespeca, Mark P" uniqKey="Nespeca M" first="Mark" last="Nespeca">Mark Nespeca</name>
<affiliation><nlm:aff id="A22">Pediatric Neurology Division, Rady Children’s Hospital San Diego, UCSD Department of Neuroscience, San Diego, California, 92123</nlm:aff>
<wicri:noCountry code="subfield">92123</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Renner, David" sort="Renner, David" uniqKey="Renner D" first="David" last="Renner">David Renner</name>
<affiliation><nlm:aff id="A23">Department of Neurology, University of Utah, Salt Lake City, Utah, 84132</nlm:aff>
<wicri:noCountry code="subfield">84132</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rochette, Jacques" sort="Rochette, Jacques" uniqKey="Rochette J" first="Jacques" last="Rochette">Jacques Rochette</name>
<affiliation><nlm:aff id="A24">Service de Génétique-INSERM UMR 925 , Université de Picardie Jules Verne, Amiens 80036-France</nlm:aff>
<wicri:noCountry code="subfield">Amiens 80036-France</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rudolf, Gabrielle" sort="Rudolf, Gabrielle" uniqKey="Rudolf G" first="Gabrielle" last="Rudolf">Gabrielle Rudolf</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Service de Neurologie. Hôpitaux Universitaires de Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie. Hôpitaux Universitaires de Strasbourg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Saiki, Shinji" sort="Saiki, Shinji" uniqKey="Saiki S" first="Shinji" last="Saiki">Shinji Saiki</name>
<affiliation><nlm:aff id="A25">Department of Neurology, Kanazawa Medical University, Ishikawa, Japan, 920-0293</nlm:aff>
<wicri:noCountry code="subfield">920-0293</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Soong, Bing Wen" sort="Soong, Bing Wen" uniqKey="Soong B" first="Bing" last="Soong">Bing Soong</name>
<affiliation wicri:level="1"><nlm:aff id="A26">Department of Neurology, National Yang-Ming University School of Medicine and the Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, National Yang-Ming University School of Medicine and the Neurological Institute, Taipei Veterans General Hospital, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Swoboda, Kathryn J" sort="Swoboda, Kathryn J" uniqKey="Swoboda K" first="Kathryn" last="Swoboda">Kathryn Swoboda</name>
<affiliation><nlm:aff id="A23">Department of Neurology, University of Utah, Salt Lake City, Utah, 84132</nlm:aff>
<wicri:noCountry code="subfield">84132</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tucker, Sam" sort="Tucker, Sam" uniqKey="Tucker S" first="Sam" last="Tucker">Sam Tucker</name>
<affiliation><nlm:aff id="A19">Division of Neurology, Children’s Hospital of Philadelphia, Philadelphia, Pa. USA, 19104</nlm:aff>
<wicri:noCountry code="subfield">19104</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wood, Nicholas" sort="Wood, Nicholas" uniqKey="Wood N" first="Nicholas" last="Wood">Nicholas Wood</name>
<affiliation><nlm:aff id="A8">Institute of Neurology, University College London, London, WC1N 3BG</nlm:aff>
<wicri:noCountry code="subfield">WC1N 3BG</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hanna, Michael" sort="Hanna, Michael" uniqKey="Hanna M" first="Michael" last="Hanna">Michael Hanna</name>
<affiliation><nlm:aff id="A8">Institute of Neurology, University College London, London, WC1N 3BG</nlm:aff>
<wicri:noCountry code="subfield">WC1N 3BG</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A27">Senior Investigator of the International Paroxysmal Kinesigenic Dyskinesia/Infantile Convulsions Collaborative Working Group</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bowcock, Anne" sort="Bowcock, Anne" uniqKey="Bowcock A" first="Anne" last="Bowcock">Anne Bowcock</name>
<affiliation><nlm:aff id="A5">Division of Human Genetics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, 63110</nlm:aff>
<wicri:noCountry code="subfield">63110</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A27">Senior Investigator of the International Paroxysmal Kinesigenic Dyskinesia/Infantile Convulsions Collaborative Working Group</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Szepetowski, Pierre" sort="Szepetowski, Pierre" uniqKey="Szepetowski P" first="Pierre" last="Szepetowski">Pierre Szepetowski</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Institut de Neurobiologie de la Méditerranée, INMED. Inserm U901. Université de la Méditerranée. Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Neurobiologie de la Méditerranée, INMED. Inserm U901. Université de la Méditerranée. Marseille</wicri:regionArea>
<wicri:noRegion>INMED. Inserm U901. Université de la Méditerranée. Marseille</wicri:noRegion>
<wicri:noRegion>INMED. Inserm U901. Université de la Méditerranée. Marseille</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="A27">Senior Investigator of the International Paroxysmal Kinesigenic Dyskinesia/Infantile Convulsions Collaborative Working Group</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fu, Ying Hui" sort="Fu, Ying Hui" uniqKey="Fu Y" first="Ying" last="Fu">Ying Fu</name>
<affiliation><nlm:aff id="A1">Department of Neurology, UCSF, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A27">Senior Investigator of the International Paroxysmal Kinesigenic Dyskinesia/Infantile Convulsions Collaborative Working Group</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pta Ek, Louis J" sort="Pta Ek, Louis J" uniqKey="Pta Ek L" first="Louis" last="Ptá">Louis Ptá</name>
<affiliation><nlm:aff id="A1">Department of Neurology, UCSF, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Howard Hughes Medical Institute, San Francisco, California, 94158</nlm:aff>
<wicri:noCountry code="subfield">94158</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A27">Senior Investigator of the International Paroxysmal Kinesigenic Dyskinesia/Infantile Convulsions Collaborative Working Group</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell reports</title>
<idno type="e-ISSN">2211-1247</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p id="P2">Paroxysmal Kinesigenic Dyskinesia with Infantile Convulsions (PKD/IC) is an episodic movement disorder with autosomal dominant inheritance and high penetrance, but the causative gene is unknown. We have now identified four truncating mutations involving the <italic>PRRT2</italic>
gene in the vast majority (24/25) of well characterized families with PKD/IC. PRRT2 truncating mutations were also detected in 28 of 78 additional families. The <italic>PRRT2</italic>
gene encodes a proline-rich transmembrane protein of unknown function that has been reported to interact with the t-SNARE, SNAP25. PRRT2 localizes to axons but not to dendritic processes in primary neuronal culture and mutants associated with PKD/IC lead to dramatically reduced PRRT2 protein levels leading ultimately to neuronal hyperexcitability that manifests <italic>in vivo</italic>
as PKD/IC.</p>
</div>
</front>
</TEI>
</record>
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