Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy. Commentary
Identifieur interne : 001489 ( Main/Exploration ); précédent : 001488; suivant : 001490Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy. Commentary
Auteurs : Manjit Sanghera [États-Unis] ; Robert Grossman [États-Unis] ; Christopher Kalhorn [États-Unis] ; Winifred Hamiltor [États-Unis] ; William Ondo [États-Unis] ; Joseph Jankovic [États-Unis] ; Giovanni Broggi ; Kim Burchiel ; Louis Whitworth ; Roy BakaySource :
- Neurosurgery [ 0148-396X ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adolescent, Adult, Basal Ganglia (physiopathology), Basal Ganglia (surgery), Basal ganglion, Child, Dystonia, Dystonic Disorders (physiopathology), Dystonic Disorders (surgery), Electrophysiology, Female, Globus Pallidus (physiopathology), Globus Pallidus (surgery), Human, Humans, Intraoperative, Male, Middle Aged, Monitoring, Intraoperative, Neural Conduction (physiology), Neurons (physiology), Pallidum, Parkinson Disease (physiopathology), Parkinson Disease (surgery), Pathophysiology, Primary, Putamen (physiopathology), Putamen (surgery), Secondary, Surgery.
- MESH :
- physiology : Neural Conduction, Neurons.
- physiopathology : Basal Ganglia, Dystonic Disorders, Globus Pallidus, Parkinson Disease, Putamen.
- surgery : Basal Ganglia, Dystonic Disorders, Globus Pallidus, Parkinson Disease, Putamen.
- Adolescent, Adult, Child, Electrophysiology, Female, Humans, Male, Middle Aged, Monitoring, Intraoperative.
Abstract
OBJECTIVE: Basal ganglia neuronal activity in patients undergoing posteroventral pallidotomy (PVP) for the treatment of primary genetic, secondary, or idiopathic dystonia (DYS) was studied to gain a better understanding of the physiology of DYS. METHODS: intraoperative neurophysiological data recorded from 15 DYS patients were compared with those from 78 patients with Parkinson's disease (PD) who underwent PVP. RESULTS: Putamen neurons in both DYS and PD patients had low discharge rates. Globus pallidus extema (GPe) and globus pallidus interna (GPi) neurons in DYS patients had significantly lower discharge rates and more irregular discharge patterns than in PD patients GPe and GPi neurons displayed similar discharge rates and patterns in DYS, whereas in PD, the discharge rate of GPe neurons was lower than that of the GPi neurons. The discharge rate and pattern of GPe and GPi neurons in patients whose DYS was ameliorated by PVP were similar to those in DYS patients who did not benefit from PVP. No significant differences in the rate or pattern of neuronal discharge in patients with DYS of different causes were discernible PVP was most beneficial in patients with primary genetic DYS. Anesthesia with desflurane depressed the discharge rate of the GPe and GPi neurons, particularly in patients with PD. CONCLUSION: Significant differences in the rates and patterns of discharge of GPe and GPi neurons exist in DYS and PD. The findings are discussed with reference to the current model of the functional connections of the basal ganglia.
Affiliations:
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Commentary</title><author><name sortKey="Sanghera, Manjit K" sort="Sanghera, Manjit K" uniqKey="Sanghera M" first="Manjit" last="Sanghera">Manjit Sanghera</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Grossman, Robert G" sort="Grossman, Robert G" uniqKey="Grossman R" first="Robert" last="Grossman">Robert Grossman</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Kalhorn, Christopher G" sort="Kalhorn, Christopher G" uniqKey="Kalhorn C" first="Christopher" last="Kalhorn">Christopher Kalhorn</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Hamiltor, Winifred J" sort="Hamiltor, Winifred J" uniqKey="Hamiltor W" first="Winifred" last="Hamiltor">Winifred Hamiltor</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Broggi, Giovanni" sort="Broggi, Giovanni" uniqKey="Broggi G" first="Giovanni" last="Broggi">Giovanni Broggi</name></author><author><name sortKey="Burchiel, Kim J" sort="Burchiel, Kim J" uniqKey="Burchiel K" first="Kim" last="Burchiel">Kim Burchiel</name></author><author><name sortKey="Whitworth, Louis" sort="Whitworth, Louis" uniqKey="Whitworth L" first="Louis" last="Whitworth">Louis Whitworth</name></author><author><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy" last="Bakay">Roy Bakay</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0379032</idno><date when="2003">2003</date><idno type="stanalyst">PASCAL 03-0379032 INIST</idno><idno type="RBID">Pascal:03-0379032</idno><idno type="wicri:Area/PascalFrancis/Corpus">000108</idno><idno type="wicri:Area/PascalFrancis/Curation">000058</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000108</idno><idno type="wicri:doubleKey">0148-396X:2003:Sanghera M:basal:ganglia:neuronal</idno><idno type="wicri:Area/Main/Merge">001545</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:12762881</idno><idno type="wicri:Area/PubMed/Corpus">000220</idno><idno type="wicri:Area/PubMed/Curation">000220</idno><idno type="wicri:Area/PubMed/Checkpoint">000220</idno><idno type="wicri:Area/Ncbi/Merge">000059</idno><idno type="wicri:Area/Ncbi/Curation">000059</idno><idno type="wicri:Area/Ncbi/Checkpoint">000059</idno><idno type="wicri:doubleKey">0148-396X:2003:Sanghera M:basal:ganglia:neuronal</idno><idno type="wicri:Area/Main/Merge">001369</idno><idno type="wicri:Area/Main/Curation">001489</idno><idno type="wicri:Area/Main/Exploration">001489</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy. Commentary</title><author><name sortKey="Sanghera, Manjit K" sort="Sanghera, Manjit K" uniqKey="Sanghera M" first="Manjit" last="Sanghera">Manjit Sanghera</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Grossman, Robert G" sort="Grossman, Robert G" uniqKey="Grossman R" first="Robert" last="Grossman">Robert Grossman</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Kalhorn, Christopher G" sort="Kalhorn, Christopher G" uniqKey="Kalhorn C" first="Christopher" last="Kalhorn">Christopher Kalhorn</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Hamiltor, Winifred J" sort="Hamiltor, Winifred J" uniqKey="Hamiltor W" first="Winifred" last="Hamiltor">Winifred Hamiltor</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Broggi, Giovanni" sort="Broggi, Giovanni" uniqKey="Broggi G" first="Giovanni" last="Broggi">Giovanni Broggi</name></author><author><name sortKey="Burchiel, Kim J" sort="Burchiel, Kim J" uniqKey="Burchiel K" first="Kim" last="Burchiel">Kim Burchiel</name></author><author><name sortKey="Whitworth, Louis" sort="Whitworth, Louis" uniqKey="Whitworth L" first="Louis" last="Whitworth">Louis Whitworth</name></author><author><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy" last="Bakay">Roy Bakay</name></author></analytic><series><title level="j" type="main">Neurosurgery</title><title level="j" type="abbreviated">Neurosurgery</title><idno type="ISSN">0148-396X</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurosurgery</title><title level="j" type="abbreviated">Neurosurgery</title><idno type="ISSN">0148-396X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Basal Ganglia (physiopathology)</term><term>Basal Ganglia (surgery)</term><term>Basal ganglion</term><term>Child</term><term>Dystonia</term><term>Dystonic Disorders (physiopathology)</term><term>Dystonic Disorders (surgery)</term><term>Electrophysiology</term><term>Female</term><term>Globus Pallidus (physiopathology)</term><term>Globus Pallidus (surgery)</term><term>Human</term><term>Humans</term><term>Intraoperative</term><term>Male</term><term>Middle Aged</term><term>Monitoring, Intraoperative</term><term>Neural Conduction (physiology)</term><term>Neurons (physiology)</term><term>Pallidum</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Pathophysiology</term><term>Primary</term><term>Putamen (physiopathology)</term><term>Putamen (surgery)</term><term>Secondary</term><term>Surgery</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neural Conduction</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Dystonic Disorders</term><term>Globus Pallidus</term><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Basal Ganglia</term><term>Dystonic Disorders</term><term>Globus Pallidus</term><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Electrophysiology</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Monitoring, Intraoperative</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term><term>Primaire</term><term>Secondaire</term><term>Electrophysiologie</term><term>Noyau gris central</term><term>Pallidum</term><term>Chirurgie</term><term>Physiopathologie</term><term>Peropératoire</term><term>Homme</term><term>Pallidotomie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVE: Basal ganglia neuronal activity in patients undergoing posteroventral pallidotomy (PVP) for the treatment of primary genetic, secondary, or idiopathic dystonia (DYS) was studied to gain a better understanding of the physiology of DYS. METHODS: intraoperative neurophysiological data recorded from 15 DYS patients were compared with those from 78 patients with Parkinson's disease (PD) who underwent PVP. RESULTS: Putamen neurons in both DYS and PD patients had low discharge rates. Globus pallidus extema (GPe) and globus pallidus interna (GPi) neurons in DYS patients had significantly lower discharge rates and more irregular discharge patterns than in PD patients GPe and GPi neurons displayed similar discharge rates and patterns in DYS, whereas in PD, the discharge rate of GPe neurons was lower than that of the GPi neurons. The discharge rate and pattern of GPe and GPi neurons in patients whose DYS was ameliorated by PVP were similar to those in DYS patients who did not benefit from PVP. No significant differences in the rate or pattern of neuronal discharge in patients with DYS of different causes were discernible PVP was most beneficial in patients with primary genetic DYS. Anesthesia with desflurane depressed the discharge rate of the GPe and GPi neurons, particularly in patients with PD. CONCLUSION: Significant differences in the rates and patterns of discharge of GPe and GPi neurons exist in DYS and PD. The findings are discussed with reference to the current model of the functional connections of the basal ganglia.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><noCountry><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy" last="Bakay">Roy Bakay</name><name sortKey="Broggi, Giovanni" sort="Broggi, Giovanni" uniqKey="Broggi G" first="Giovanni" last="Broggi">Giovanni Broggi</name><name sortKey="Burchiel, Kim J" sort="Burchiel, Kim J" uniqKey="Burchiel K" first="Kim" last="Burchiel">Kim Burchiel</name><name sortKey="Whitworth, Louis" sort="Whitworth, Louis" uniqKey="Whitworth L" first="Louis" last="Whitworth">Louis Whitworth</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Sanghera, Manjit K" sort="Sanghera, Manjit K" uniqKey="Sanghera M" first="Manjit" last="Sanghera">Manjit Sanghera</name></region><name sortKey="Grossman, Robert G" sort="Grossman, Robert G" uniqKey="Grossman R" first="Robert" last="Grossman">Robert Grossman</name><name sortKey="Hamiltor, Winifred J" sort="Hamiltor, Winifred J" uniqKey="Hamiltor W" first="Winifred" last="Hamiltor">Winifred Hamiltor</name><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><name sortKey="Kalhorn, Christopher G" sort="Kalhorn, Christopher G" uniqKey="Kalhorn C" first="Christopher" last="Kalhorn">Christopher Kalhorn</name><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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