Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.
Identifieur interne : 001316 ( Main/Exploration ); précédent : 001315; suivant : 001317Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.
Auteurs : J Van [États-Unis] ; E Martin ; W Scott ; F. Zhang ; M Nance ; R Watts ; J Hubble ; J Haines ; W Koller ; K. Lyons ; R. Pahwa ; M Stern ; A. Colcher ; B Hiner ; Joseph Jankovic [États-Unis] ; W Ondo ; F Allen ; C Goetz ; G Small ; F. Mastaglia ; A Roses ; J Stajich ; M Booze ; K. Fujiwara ; R Gibson ; L Middleton ; B Scott ; M Pericak ; J VanceSource :
- Neurology ; 2003.
English descriptors
- KwdEn :
- Aged, Alleles, Arylamine N-Acetyltransferase (genetics), Chromosomes, Human, Pair 8 (genetics), Female, Gene Frequency, Genetic Linkage, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Isoenzymes (genetics), Male, Middle Aged, Parkinson Disease (enzymology), Parkinson Disease (genetics), Polymorphism, Genetic, Polymorphism, Single Nucleotide (genetics), Risk Assessment.
- MESH :
- chemical , genetics : Arylamine N-Acetyltransferase, Isoenzymes.
- enzymology : Parkinson Disease.
- genetics : Chromosomes, Human, Pair 8, Parkinson Disease, Polymorphism, Single Nucleotide.
- Aged, Alleles, Female, Gene Frequency, Genetic Linkage, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Assessment.
Abstract
Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).
PubMed: 12682333
Affiliations:
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Le document en format XML
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Zhang</name></author><author><name sortKey="Nance, M A" sort="Nance, M A" uniqKey="Nance M" first="M" last="Nance">M Nance</name></author><author><name sortKey="Watts, R L" sort="Watts, R L" uniqKey="Watts R" first="R" last="Watts">R Watts</name></author><author><name sortKey="Hubble, J P" sort="Hubble, J P" uniqKey="Hubble J" first="J" last="Hubble">J Hubble</name></author><author><name sortKey="Haines, J L" sort="Haines, J L" uniqKey="Haines J" first="J" last="Haines">J Haines</name></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W" last="Koller">W Koller</name></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K" last="Lyons">K. Lyons</name></author><author><name sortKey="Pahwa, R" sort="Pahwa, R" uniqKey="Pahwa R" first="R" last="Pahwa">R. Pahwa</name></author><author><name sortKey="Stern, M B" sort="Stern, M B" uniqKey="Stern M" first="M" last="Stern">M Stern</name></author><author><name sortKey="Colcher, A" sort="Colcher, A" uniqKey="Colcher A" first="A" last="Colcher">A. Colcher</name></author><author><name sortKey="Hiner, B C" sort="Hiner, B C" uniqKey="Hiner B" first="B" last="Hiner">B Hiner</name></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Ondo, W G" sort="Ondo, W G" uniqKey="Ondo W" first="W" last="Ondo">W Ondo</name></author><author><name sortKey="Allen, F H" sort="Allen, F H" uniqKey="Allen F" first="F" last="Allen">F Allen</name></author><author><name sortKey="Goetz, C G" sort="Goetz, C G" uniqKey="Goetz C" first="C" last="Goetz">C Goetz</name></author><author><name sortKey="Small, G W" sort="Small, G W" uniqKey="Small G" first="G" last="Small">G Small</name></author><author><name sortKey="Mastaglia, F" sort="Mastaglia, F" uniqKey="Mastaglia F" first="F" last="Mastaglia">F. Mastaglia</name></author><author><name sortKey="Roses, A D" sort="Roses, A D" uniqKey="Roses A" first="A" last="Roses">A Roses</name></author><author><name sortKey="Stajich, J M" sort="Stajich, J M" uniqKey="Stajich J" first="J" last="Stajich">J Stajich</name></author><author><name sortKey="Booze, M W" sort="Booze, M W" uniqKey="Booze M" first="M" last="Booze">M Booze</name></author><author><name sortKey="Fujiwara, K" sort="Fujiwara, K" uniqKey="Fujiwara K" first="K" last="Fujiwara">K. Fujiwara</name></author><author><name sortKey="Gibson, R A" sort="Gibson, R A" uniqKey="Gibson R" first="R" last="Gibson">R Gibson</name></author><author><name sortKey="Middleton, L T" sort="Middleton, L T" uniqKey="Middleton L" first="L" last="Middleton">L Middleton</name></author><author><name sortKey="Scott, B L" sort="Scott, B L" uniqKey="Scott B" first="B" last="Scott">B Scott</name></author><author><name sortKey="Pericak Vance, M A" sort="Pericak Vance, M A" uniqKey="Pericak Vance M" first="M" last="Pericak">M Pericak</name></author><author><name sortKey="Vance, J M" sort="Vance, J M" uniqKey="Vance J" first="J" last="Vance">J Vance</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12682333</idno><idno type="pmid">12682333</idno><idno type="wicri:Area/PubMed/Corpus">000221</idno><idno type="wicri:Area/PubMed/Curation">000221</idno><idno type="wicri:Area/PubMed/Checkpoint">000218</idno><idno type="wicri:Area/Ncbi/Merge">000057</idno><idno type="wicri:Area/Ncbi/Curation">000057</idno><idno type="wicri:Area/Ncbi/Checkpoint">000057</idno><idno type="wicri:Area/Main/Merge">001367</idno><idno type="wicri:Area/Main/Curation">001316</idno><idno type="wicri:Area/Main/Exploration">001316</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.</title><author><name sortKey="Van Der Walt, J M" sort="Van Der Walt, J M" uniqKey="Van Der Walt J" first="J" last="Van">J Van</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Martin, E R" sort="Martin, E R" uniqKey="Martin E" first="E" last="Martin">E Martin</name></author><author><name sortKey="Scott, W K" sort="Scott, W K" uniqKey="Scott W" first="W" last="Scott">W Scott</name></author><author><name sortKey="Zhang, F" sort="Zhang, F" uniqKey="Zhang F" first="F" last="Zhang">F. Zhang</name></author><author><name sortKey="Nance, M A" sort="Nance, M A" uniqKey="Nance M" first="M" last="Nance">M Nance</name></author><author><name sortKey="Watts, R L" sort="Watts, R L" uniqKey="Watts R" first="R" last="Watts">R Watts</name></author><author><name sortKey="Hubble, J P" sort="Hubble, J P" uniqKey="Hubble J" first="J" last="Hubble">J Hubble</name></author><author><name sortKey="Haines, J L" sort="Haines, J L" uniqKey="Haines J" first="J" last="Haines">J Haines</name></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W" last="Koller">W Koller</name></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K" last="Lyons">K. Lyons</name></author><author><name sortKey="Pahwa, R" sort="Pahwa, R" uniqKey="Pahwa R" first="R" last="Pahwa">R. Pahwa</name></author><author><name sortKey="Stern, M B" sort="Stern, M B" uniqKey="Stern M" first="M" last="Stern">M Stern</name></author><author><name sortKey="Colcher, A" sort="Colcher, A" uniqKey="Colcher A" first="A" last="Colcher">A. Colcher</name></author><author><name sortKey="Hiner, B C" sort="Hiner, B C" uniqKey="Hiner B" first="B" last="Hiner">B Hiner</name></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Ondo, W G" sort="Ondo, W G" uniqKey="Ondo W" first="W" last="Ondo">W Ondo</name></author><author><name sortKey="Allen, F H" sort="Allen, F H" uniqKey="Allen F" first="F" last="Allen">F Allen</name></author><author><name sortKey="Goetz, C G" sort="Goetz, C G" uniqKey="Goetz C" first="C" last="Goetz">C Goetz</name></author><author><name sortKey="Small, G W" sort="Small, G W" uniqKey="Small G" first="G" last="Small">G Small</name></author><author><name sortKey="Mastaglia, F" sort="Mastaglia, F" uniqKey="Mastaglia F" first="F" last="Mastaglia">F. Mastaglia</name></author><author><name sortKey="Roses, A D" sort="Roses, A D" uniqKey="Roses A" first="A" last="Roses">A Roses</name></author><author><name sortKey="Stajich, J M" sort="Stajich, J M" uniqKey="Stajich J" first="J" last="Stajich">J Stajich</name></author><author><name sortKey="Booze, M W" sort="Booze, M W" uniqKey="Booze M" first="M" last="Booze">M Booze</name></author><author><name sortKey="Fujiwara, K" sort="Fujiwara, K" uniqKey="Fujiwara K" first="K" last="Fujiwara">K. Fujiwara</name></author><author><name sortKey="Gibson, R A" sort="Gibson, R A" uniqKey="Gibson R" first="R" last="Gibson">R Gibson</name></author><author><name sortKey="Middleton, L T" sort="Middleton, L T" uniqKey="Middleton L" first="L" last="Middleton">L Middleton</name></author><author><name sortKey="Scott, B L" sort="Scott, B L" uniqKey="Scott B" first="B" last="Scott">B Scott</name></author><author><name sortKey="Pericak Vance, M A" sort="Pericak Vance, M A" uniqKey="Pericak Vance M" first="M" last="Pericak">M Pericak</name></author><author><name sortKey="Vance, J M" sort="Vance, J M" uniqKey="Vance J" first="J" last="Vance">J Vance</name></author></analytic><series><title level="j">Neurology</title><idno type="e-ISSN">1526-632X</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Arylamine N-Acetyltransferase (genetics)</term><term>Chromosomes, Human, Pair 8 (genetics)</term><term>Female</term><term>Gene Frequency</term><term>Genetic Linkage</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Isoenzymes (genetics)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (enzymology)</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Genetic</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Risk Assessment</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Arylamine N-Acetyltransferase</term><term>Isoenzymes</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 8</term><term>Parkinson Disease</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Female</term><term>Gene Frequency</term><term>Genetic Linkage</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term><term>Risk Assessment</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><noCountry><name sortKey="Allen, F H" sort="Allen, F H" uniqKey="Allen F" first="F" last="Allen">F Allen</name><name sortKey="Booze, M W" sort="Booze, M W" uniqKey="Booze M" first="M" last="Booze">M Booze</name><name sortKey="Colcher, A" sort="Colcher, A" uniqKey="Colcher A" first="A" last="Colcher">A. Colcher</name><name sortKey="Fujiwara, K" sort="Fujiwara, K" uniqKey="Fujiwara K" first="K" last="Fujiwara">K. Fujiwara</name><name sortKey="Gibson, R A" sort="Gibson, R A" uniqKey="Gibson R" first="R" last="Gibson">R Gibson</name><name sortKey="Goetz, C G" sort="Goetz, C G" uniqKey="Goetz C" first="C" last="Goetz">C Goetz</name><name sortKey="Haines, J L" sort="Haines, J L" uniqKey="Haines J" first="J" last="Haines">J Haines</name><name sortKey="Hiner, B C" sort="Hiner, B C" uniqKey="Hiner B" first="B" last="Hiner">B Hiner</name><name sortKey="Hubble, J P" sort="Hubble, J P" uniqKey="Hubble J" first="J" last="Hubble">J Hubble</name><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W" last="Koller">W Koller</name><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K" last="Lyons">K. Lyons</name><name sortKey="Martin, E R" sort="Martin, E R" uniqKey="Martin E" first="E" last="Martin">E Martin</name><name sortKey="Mastaglia, F" sort="Mastaglia, F" uniqKey="Mastaglia F" first="F" last="Mastaglia">F. Mastaglia</name><name sortKey="Middleton, L T" sort="Middleton, L T" uniqKey="Middleton L" first="L" last="Middleton">L Middleton</name><name sortKey="Nance, M A" sort="Nance, M A" uniqKey="Nance M" first="M" last="Nance">M Nance</name><name sortKey="Ondo, W G" sort="Ondo, W G" uniqKey="Ondo W" first="W" last="Ondo">W Ondo</name><name sortKey="Pahwa, R" sort="Pahwa, R" uniqKey="Pahwa R" first="R" last="Pahwa">R. Pahwa</name><name sortKey="Pericak Vance, M A" sort="Pericak Vance, M A" uniqKey="Pericak Vance M" first="M" last="Pericak">M Pericak</name><name sortKey="Roses, A D" sort="Roses, A D" uniqKey="Roses A" first="A" last="Roses">A Roses</name><name sortKey="Scott, B L" sort="Scott, B L" uniqKey="Scott B" first="B" last="Scott">B Scott</name><name sortKey="Scott, W K" sort="Scott, W K" uniqKey="Scott W" first="W" last="Scott">W Scott</name><name sortKey="Small, G W" sort="Small, G W" uniqKey="Small G" first="G" last="Small">G Small</name><name sortKey="Stajich, J M" sort="Stajich, J M" uniqKey="Stajich J" first="J" last="Stajich">J Stajich</name><name sortKey="Stern, M B" sort="Stern, M B" uniqKey="Stern M" first="M" last="Stern">M Stern</name><name sortKey="Vance, J M" sort="Vance, J M" uniqKey="Vance J" first="J" last="Vance">J Vance</name><name sortKey="Watts, R L" sort="Watts, R L" uniqKey="Watts R" first="R" last="Watts">R Watts</name><name sortKey="Zhang, F" sort="Zhang, F" uniqKey="Zhang F" first="F" last="Zhang">F. Zhang</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Van Der Walt, J M" sort="Van Der Walt, J M" uniqKey="Van Der Walt J" first="J" last="Van">J Van</name></region><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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