Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.
Identifieur interne : 000221 ( PubMed/Corpus ); précédent : 000220; suivant : 000222Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.
Auteurs : J Van ; E Martin ; W Scott ; F. Zhang ; M Nance ; R Watts ; J Hubble ; J Haines ; W Koller ; K. Lyons ; R. Pahwa ; M Stern ; A. Colcher ; B Hiner ; J. Jankovic ; W Ondo ; F Allen ; C Goetz ; G Small ; F. Mastaglia ; A Roses ; J Stajich ; M Booze ; K. Fujiwara ; R Gibson ; L Middleton ; B Scott ; M Pericak ; J VanceSource :
- Neurology ; 2003.
English descriptors
- KwdEn :
- Aged, Alleles, Arylamine N-Acetyltransferase (genetics), Chromosomes, Human, Pair 8 (genetics), Female, Gene Frequency, Genetic Linkage, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Isoenzymes (genetics), Male, Middle Aged, Parkinson Disease (enzymology), Parkinson Disease (genetics), Polymorphism, Genetic, Polymorphism, Single Nucleotide (genetics), Risk Assessment.
- MESH :
- chemical , genetics : Arylamine N-Acetyltransferase, Isoenzymes.
- enzymology : Parkinson Disease.
- genetics : Chromosomes, Human, Pair 8, Parkinson Disease, Polymorphism, Single Nucleotide.
- Aged, Alleles, Female, Gene Frequency, Genetic Linkage, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Assessment.
Abstract
Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).
PubMed: 12682333
Links to Exploration step
pubmed:12682333Le document en format XML
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<front><div type="abstract" xml:lang="en">Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).</div>
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<ArticleTitle>Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.</ArticleTitle>
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<Abstract><AbstractText>Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).</AbstractText>
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