The Trail Making Test in Prodromal Huntington Disease: Contributions of Disease Progression to Test Performance
Identifieur interne : 000210 ( Main/Exploration ); précédent : 000209; suivant : 000211The Trail Making Test in Prodromal Huntington Disease: Contributions of Disease Progression to Test Performance
Auteurs : Justin O [États-Unis] ; Leigh Beglinger [États-Unis] ; Megan Smith [États-Unis] ; James Mills [États-Unis] ; David Moser [États-Unis] ; Kelly Rowe [États-Unis] ; Douglas Langbehn [États-Unis] ; Kevin Duff [États-Unis] ; Julie Stout [Australie] ; Deborah Harrington [États-Unis] ; Noelle Carlozzi [États-Unis] ; Jane Paulsen [États-Unis]Source :
- Journal of clinical and experimental neuropsychology [ 1380-3395 ] ; 2011.
Abstract
We examined the Trail Making Test (TMT) in a sample of 767 participants with prodromal Huntington disease (prodromal HD) and 217 healthy comparisons to determine the contributions of motor, psychiatric, and cognitive changes to TMT scores. Eight traditional and derived TMT scores were also evaluated for their ability to differentiate prodromal participants closer to estimated age of diagnosis from those farther away and prodromal individuals from healthy comparisons. Results indicate that motor signs only mildly affected part A, and psychiatric symptoms did not affect either part. Tests of perceptual processing, visual scanning, and attention were primarily associated with part A, and executive functioning (response inhibition, set-shifting), processing speed, and working memory were associated with part B. Additionally, TMT scores differentiated between healthy comparisons and prodromal HD individuals as far as 9–15 years before estimated diagnosis. In participants manifesting prodromal motor signs and psychiatric symptoms, the TMT primarily measures cognition and is able to discriminate between groups based on health status and estimated time to diagnosis.
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DOI: 10.1080/13803395.2010.541228
PubMed: 21302170
PubMed Central: 3159183
Affiliations:
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City</wicri:cityArea></affiliation></author><author><name sortKey="Beglinger, Leigh J" sort="Beglinger, Leigh J" uniqKey="Beglinger L" first="Leigh" last="Beglinger">Leigh Beglinger</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Smith, Megan M" sort="Smith, Megan M" uniqKey="Smith M" first="Megan" last="Smith">Megan Smith</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Mills, James" sort="Mills, James" uniqKey="Mills J" first="James" last="Mills">James Mills</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Moser, David J" sort="Moser, David J" uniqKey="Moser D" first="David" last="Moser">David Moser</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Rowe, Kelly C" sort="Rowe, Kelly C" uniqKey="Rowe K" first="Kelly" 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xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Kessler Foundation Research Center, West Orange</wicri:cityArea></affiliation></author><author><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane" last="Paulsen">Jane Paulsen</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A7">Department of Psychology, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychology, The University of Iowa, Iowa City</wicri:cityArea></affiliation><affiliation 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J:the:trail:making</idno><idno type="wicri:Area/Main/Merge">000211</idno><idno type="wicri:Area/Main/Curation">000210</idno><idno type="wicri:Area/Main/Exploration">000210</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Trail Making Test in Prodromal Huntington Disease: Contributions of Disease Progression to Test Performance</title><author><name sortKey="O Ourke, Justin J F" sort="O Ourke, Justin J F" uniqKey="O Ourke J" first="Justin" last="O">Justin O</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Counseling Psychology, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Counseling Psychology, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Beglinger, Leigh J" sort="Beglinger, Leigh J" uniqKey="Beglinger L" first="Leigh" last="Beglinger">Leigh Beglinger</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Smith, Megan M" sort="Smith, Megan M" uniqKey="Smith M" first="Megan" last="Smith">Megan Smith</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Mills, James" sort="Mills, James" uniqKey="Mills J" first="James" last="Mills">James Mills</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Moser, David J" sort="Moser, David J" uniqKey="Moser D" first="David" last="Moser">David Moser</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Rowe, Kelly C" sort="Rowe, Kelly C" uniqKey="Rowe K" first="Kelly" last="Rowe">Kelly Rowe</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neuroscience, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Neuroscience, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Langbehn, Douglas R" sort="Langbehn, Douglas R" uniqKey="Langbehn D" first="Douglas" last="Langbehn">Douglas Langbehn</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Duff, Kevin" sort="Duff, Kevin" uniqKey="Duff K" first="Kevin" last="Duff">Kevin Duff</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie" last="Stout">Julie Stout</name><affiliation wicri:level="1"><nlm:aff id="A4">School of Psychology, Psychiatry, and Psychological Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychology, Psychiatry, and Psychological Medicine, Monash University, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Harrington, Deborah L" sort="Harrington, Deborah L" uniqKey="Harrington D" first="Deborah" last="Harrington">Deborah Harrington</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Radiology, University of California San Diego, San Diego, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Radiology, University of California San Diego, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Carlozzi, Noelle" sort="Carlozzi, Noelle" uniqKey="Carlozzi N" first="Noelle" last="Carlozzi">Noelle Carlozzi</name><affiliation wicri:level="2"><nlm:aff id="A6">Kessler Foundation Research Center, West Orange, NJ</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Kessler Foundation Research Center, West Orange</wicri:cityArea></affiliation></author><author><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane" last="Paulsen">Jane Paulsen</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychiatry, The University of Iowa, Iowa City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A7">Department of Psychology, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Psychology, The University of Iowa, Iowa City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A8">Department of Neurology, The University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Neurology, The University of Iowa, Iowa City</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of clinical and experimental neuropsychology</title><idno type="ISSN">1380-3395</idno><idno type="e-ISSN">1744-411X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We examined the Trail Making Test (TMT) in a sample of 767 participants with prodromal Huntington disease (prodromal HD) and 217 healthy comparisons to determine the contributions of motor, psychiatric, and cognitive changes to TMT scores. Eight traditional and derived TMT scores were also evaluated for their ability to differentiate prodromal participants closer to estimated age of diagnosis from those farther away and prodromal individuals from healthy comparisons. Results indicate that motor signs only mildly affected part A, and psychiatric symptoms did not affect either part. Tests of perceptual processing, visual scanning, and attention were primarily associated with part A, and executive functioning (response inhibition, set-shifting), processing speed, and working memory were associated with part B. Additionally, TMT scores differentiated between healthy comparisons and prodromal HD individuals as far as 9–15 years before estimated diagnosis. In participants manifesting prodromal motor signs and psychiatric symptoms, the TMT primarily measures cognition and is able to discriminate between groups based on health status and estimated time to diagnosis.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country><region><li>Californie</li><li>Iowa</li><li>New Jersey</li></region></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="O Ourke, Justin J F" sort="O Ourke, Justin J F" uniqKey="O Ourke J" first="Justin" last="O">Justin O</name></region><name sortKey="Beglinger, Leigh J" sort="Beglinger, Leigh J" uniqKey="Beglinger L" first="Leigh" last="Beglinger">Leigh Beglinger</name><name sortKey="Carlozzi, Noelle" sort="Carlozzi, Noelle" uniqKey="Carlozzi N" first="Noelle" last="Carlozzi">Noelle Carlozzi</name><name sortKey="Duff, Kevin" sort="Duff, Kevin" uniqKey="Duff K" first="Kevin" last="Duff">Kevin Duff</name><name sortKey="Harrington, Deborah L" sort="Harrington, Deborah L" uniqKey="Harrington D" first="Deborah" last="Harrington">Deborah Harrington</name><name sortKey="Langbehn, Douglas R" sort="Langbehn, Douglas R" uniqKey="Langbehn D" first="Douglas" last="Langbehn">Douglas Langbehn</name><name sortKey="Mills, James" sort="Mills, James" uniqKey="Mills J" first="James" last="Mills">James Mills</name><name sortKey="Moser, David J" sort="Moser, David J" uniqKey="Moser D" first="David" last="Moser">David Moser</name><name sortKey="O Ourke, Justin J F" sort="O Ourke, Justin J F" uniqKey="O Ourke J" first="Justin" last="O">Justin O</name><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane" last="Paulsen">Jane Paulsen</name><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane" last="Paulsen">Jane Paulsen</name><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane" last="Paulsen">Jane Paulsen</name><name sortKey="Rowe, Kelly C" sort="Rowe, Kelly C" uniqKey="Rowe K" first="Kelly" last="Rowe">Kelly Rowe</name><name sortKey="Rowe, Kelly C" sort="Rowe, Kelly C" uniqKey="Rowe K" first="Kelly" last="Rowe">Kelly Rowe</name><name sortKey="Smith, Megan M" sort="Smith, Megan M" uniqKey="Smith M" first="Megan" last="Smith">Megan Smith</name></country><country name="Australie"><noRegion><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie" last="Stout">Julie Stout</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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