The Trail Making Test in Prodromal Huntington Disease: Contributions of Disease Progression to Test Performance
Identifieur interne : 000216 ( Pmc/Corpus ); précédent : 000215; suivant : 000217The Trail Making Test in Prodromal Huntington Disease: Contributions of Disease Progression to Test Performance
Auteurs : Justin O ; Leigh Beglinger ; Megan Smith ; James Mills ; David Moser ; Kelly Rowe ; Douglas Langbehn ; Kevin Duff ; Julie Stout ; Deborah Harrington ; Noelle Carlozzi ; Jane PaulsenSource :
- Journal of clinical and experimental neuropsychology [ 1380-3395 ] ; 2011.
Abstract
We examined the Trail Making Test (TMT) in a sample of 767 participants with prodromal Huntington disease (prodromal HD) and 217 healthy comparisons to determine the contributions of motor, psychiatric, and cognitive changes to TMT scores. Eight traditional and derived TMT scores were also evaluated for their ability to differentiate prodromal participants closer to estimated age of diagnosis from those farther away and prodromal individuals from healthy comparisons. Results indicate that motor signs only mildly affected part A, and psychiatric symptoms did not affect either part. Tests of perceptual processing, visual scanning, and attention were primarily associated with part A, and executive functioning (response inhibition, set-shifting), processing speed, and working memory were associated with part B. Additionally, TMT scores differentiated between healthy comparisons and prodromal HD individuals as far as 9–15 years before estimated diagnosis. In participants manifesting prodromal motor signs and psychiatric symptoms, the TMT primarily measures cognition and is able to discriminate between groups based on health status and estimated time to diagnosis.
Url:
DOI: 10.1080/13803395.2010.541228
PubMed: 21302170
PubMed Central: 3159183
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