Variability and validity of polymorphism association studies in Parkinson's disease
Identifieur interne : 001912 ( Main/Curation ); précédent : 001911; suivant : 001913Variability and validity of polymorphism association studies in Parkinson's disease
Auteurs : E Tan [États-Unis] ; M Khajavi [États-Unis] ; J Thornby [États-Unis] ; S Nagamitsu [États-Unis] ; J Jankovic [États-Unis] ; T Ashizawa [États-Unis]Source :
- Neurology [ 0028-3878 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Apolipoproteins E (genetics), Arylamine N-Acetyltransferase (genetics), Carrier Proteins (genetics), Case-Control Studies, Catechol O-Methyltransferase (genetics), DNA, Mitochondrial (genetics), Dopamine Plasma Membrane Transport Proteins, Female, Gene, Gene Frequency, Genetic Linkage, Genetic Variation (genetics), Genetics, Glutathione Transferase (genetics), Human, Humans, Isoenzymes (genetics), Male, Membrane Glycoproteins, Membrane Transport Proteins, Metaanalysis, Monoamine Oxidase (genetics), Nerve Tissue Proteins, Parkinson Disease (genetics), Parkinson disease, Pathogenesis, Polymorphism, Polymorphism, Genetic (genetics), RNA, Transfer, Glu (genetics), Receptors, Dopamine D2 (genetics), Receptors, Dopamine D4, Reproducibility of Results, Risk factor, Validity, Variability.
- MESH :
- chemical , genetics : Apolipoproteins E, Arylamine N-Acetyltransferase, Carrier Proteins, Catechol O-Methyltransferase, DNA, Mitochondrial, Glutathione Transferase, Isoenzymes, Monoamine Oxidase, RNA, Transfer, Glu, Receptors, Dopamine D2.
- genetics : Genetic Variation, Parkinson Disease, Polymorphism, Genetic.
- Case-Control Studies, Dopamine Plasma Membrane Transport Proteins, Female, Gene Frequency, Genetic Linkage, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Receptors, Dopamine D4, Reproducibility of Results.
Abstract
Background: In recent years, interest in gene-environment interactions has spurred a great number of association studies on polymorphism of different genes. Objective: To review case-control studies of genetic polymorphisms in PD, and perform meta-analysis of individual gene polymorphism. Methods: The authors searched the Medline database (PubMed) for publications (English language) from January 1966 to November 1999 for association studies in PD. The key words used were "PD" and "polymorphism." The authors supplemented the search with relevant references quoted in these published articles. Those with four or more independent studies of a specific gene polymorphism were subjected to meta-analysis, with the exception of cytochrome-P450 enzyme polymorphisms, for which meta-analyses results were already available in the literature. Results: The authors identified 84 studies on 14 genes, including dopamine receptors (DRD2 and DRD4), dopamine transporter (DAT), monoamine oxidase (MAOA and MAOB), catecholO-methyltransferase (COMT), N-acetyltransferase 2 (NAT2), APOE, glutathione transferase (GSTT1, GSTM1, GSTP1, and GSTZ1), and mitochondrial genes (tRNAGlu and ND2). Four polymorphisms showed significant association with PD: slow acetylator genotypes of NAT2 (PD:control OR = 1.36), allele >188bp of the MAOB (GT)n polymorphism (OR = 2.58), the deletion allele of GSTT1 (OR = 1.34), and A4336G of tRNAGlu (OR = 3.0). No significant differences were found for the other genes. Conclusion: Significant associations with PD were found in polymorphisms of NAT2, MAOB, GSTT1, and tRNAGlu. Although significant association does not imply a causal relationship between the presence of the polymorphisms and PD pathogenesis, their pathophysiologic significance should be studied further.
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apolipoproteins E (genetics)</term>
<term>Arylamine N-Acetyltransferase (genetics)</term>
<term>Carrier Proteins (genetics)</term>
<term>Case-Control Studies</term>
<term>Catechol O-Methyltransferase (genetics)</term>
<term>DNA, Mitochondrial (genetics)</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Female</term>
<term>Gene</term>
<term>Gene Frequency</term>
<term>Genetic Linkage</term>
<term>Genetic Variation (genetics)</term>
<term>Genetics</term>
<term>Glutathione Transferase (genetics)</term>
<term>Human</term>
<term>Humans</term>
<term>Isoenzymes (genetics)</term>
<term>Male</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Metaanalysis</term>
<term>Monoamine Oxidase (genetics)</term>
<term>Nerve Tissue Proteins</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson disease</term>
<term>Pathogenesis</term>
<term>Polymorphism</term>
<term>Polymorphism, Genetic (genetics)</term>
<term>RNA, Transfer, Glu (genetics)</term>
<term>Receptors, Dopamine D2 (genetics)</term>
<term>Receptors, Dopamine D4</term>
<term>Reproducibility of Results</term>
<term>Risk factor</term>
<term>Validity</term>
<term>Variability</term>
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<term>Arylamine N-Acetyltransferase</term>
<term>Carrier Proteins</term>
<term>Catechol O-Methyltransferase</term>
<term>DNA, Mitochondrial</term>
<term>Glutathione Transferase</term>
<term>Isoenzymes</term>
<term>Monoamine Oxidase</term>
<term>RNA, Transfer, Glu</term>
<term>Receptors, Dopamine D2</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Variation</term>
<term>Parkinson Disease</term>
<term>Polymorphism, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Linkage</term>
<term>Humans</term>
<term>Male</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Nerve Tissue Proteins</term>
<term>Receptors, Dopamine D4</term>
<term>Reproducibility of Results</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Polymorphisme</term>
<term>Gène</term>
<term>Génétique</term>
<term>Variabilité</term>
<term>Validité</term>
<term>Métaanalyse</term>
<term>Pathogénie</term>
<term>Facteur risque</term>
<term>Homme</term>
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<front><div type="abstract" xml:lang="en">Background: In recent years, interest in gene-environment interactions has spurred a great number of association studies on polymorphism of different genes. Objective: To review case-control studies of genetic polymorphisms in PD, and perform meta-analysis of individual gene polymorphism. Methods: The authors searched the Medline database (PubMed) for publications (English language) from January 1966 to November 1999 for association studies in PD. The key words used were "PD" and "polymorphism." The authors supplemented the search with relevant references quoted in these published articles. Those with four or more independent studies of a specific gene polymorphism were subjected to meta-analysis, with the exception of cytochrome-P450 enzyme polymorphisms, for which meta-analyses results were already available in the literature. Results: The authors identified 84 studies on 14 genes, including dopamine receptors (DRD2 and DRD4), dopamine transporter (DAT), monoamine oxidase (MAOA and MAOB), catecholO-methyltransferase (COMT), N-acetyltransferase 2 (NAT2), APOE, glutathione transferase (GSTT1, GSTM1, GSTP1, and GSTZ1), and mitochondrial genes (tRNA<sup>Glu</sup>
and ND2). Four polymorphisms showed significant association with PD: slow acetylator genotypes of NAT2 (PD:control OR = 1.36), allele >188bp of the MAOB (GT)<sub>n</sub>
polymorphism (OR = 2.58), the deletion allele of GSTT1 (OR = 1.34), and A4336G of tRNA<sup>Glu</sup>
(OR = 3.0). No significant differences were found for the other genes. Conclusion: Significant associations with PD were found in polymorphisms of NAT2, MAOB, GSTT1, and tRNA<sup>Glu</sup>
. Although significant association does not imply a causal relationship between the presence of the polymorphisms and PD pathogenesis, their pathophysiologic significance should be studied further.</div>
</front>
</TEI>
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<author><name sortKey="Nagamitsu, S" sort="Nagamitsu, S" uniqKey="Nagamitsu S" first="S" last="Nagamitsu">S Nagamitsu</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
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<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
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<sZ>4 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ashizawa, T" sort="Ashizawa, T" uniqKey="Ashizawa T" first="T" last="Ashizawa">T Ashizawa</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
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<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Veterans Affairs Medical Center</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
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<sZ>4 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Texas</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Variability and validity of polymorphism association studies in Parkinson's disease</title>
<author><name sortKey="Tan, E K" sort="Tan, E K" uniqKey="Tan E" first="E" last="Tan">E Tan</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Khajavi, M" sort="Khajavi, M" uniqKey="Khajavi M" first="M" last="Khajavi">M Khajavi</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Veterans Affairs Medical Center</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thornby, J I" sort="Thornby, J I" uniqKey="Thornby J" first="J" last="Thornby">J Thornby</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Veterans Affairs Medical Center</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nagamitsu, S" sort="Nagamitsu, S" uniqKey="Nagamitsu S" first="S" last="Nagamitsu">S Nagamitsu</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Veterans Affairs Medical Center</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J Jankovic</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ashizawa, T" sort="Ashizawa, T" uniqKey="Ashizawa T" first="T" last="Ashizawa">T Ashizawa</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Veterans Affairs Medical Center</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2000">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gene</term>
<term>Genetics</term>
<term>Human</term>
<term>Metaanalysis</term>
<term>Parkinson disease</term>
<term>Pathogenesis</term>
<term>Polymorphism</term>
<term>Risk factor</term>
<term>Validity</term>
<term>Variability</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Polymorphisme</term>
<term>Gène</term>
<term>Génétique</term>
<term>Variabilité</term>
<term>Validité</term>
<term>Métaanalyse</term>
<term>Pathogénie</term>
<term>Facteur risque</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: In recent years, interest in gene-environment interactions has spurred a great number of association studies on polymorphism of different genes. Objective: To review case-control studies of genetic polymorphisms in PD, and perform meta-analysis of individual gene polymorphism. Methods: The authors searched the Medline database (PubMed) for publications (English language) from January 1966 to November 1999 for association studies in PD. The key words used were "PD" and "polymorphism." The authors supplemented the search with relevant references quoted in these published articles. Those with four or more independent studies of a specific gene polymorphism were subjected to meta-analysis, with the exception of cytochrome-P450 enzyme polymorphisms, for which meta-analyses results were already available in the literature. Results: The authors identified 84 studies on 14 genes, including dopamine receptors (DRD2 and DRD4), dopamine transporter (DAT), monoamine oxidase (MAOA and MAOB), catecholO-methyltransferase (COMT), N-acetyltransferase 2 (NAT2), APOE, glutathione transferase (GSTT1, GSTM1, GSTP1, and GSTZ1), and mitochondrial genes (tRNA<sup>Glu</sup>
and ND2). Four polymorphisms showed significant association with PD: slow acetylator genotypes of NAT2 (PD:control OR = 1.36), allele >188bp of the MAOB (GT)<sub>n</sub>
polymorphism (OR = 2.58), the deletion allele of GSTT1 (OR = 1.34), and A4336G of tRNA<sup>Glu</sup>
(OR = 3.0). No significant differences were found for the other genes. Conclusion: Significant associations with PD were found in polymorphisms of NAT2, MAOB, GSTT1, and tRNA<sup>Glu</sup>
. Although significant association does not imply a causal relationship between the presence of the polymorphisms and PD pathogenesis, their pathophysiologic significance should be studied further.</div>
</front>
</TEI>
</INIST>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Variability and validity of polymorphism association studies in Parkinson's disease.</title>
<author><name sortKey="Tan, E K" sort="Tan, E K" uniqKey="Tan E" first="E" last="Tan">E Tan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Baylor College of Medicine, Houston, Texas 77030</wicri:regionArea>
<wicri:noRegion>Texas 77030</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khajavi, M" sort="Khajavi, M" uniqKey="Khajavi M" first="M" last="Khajavi">M. Khajavi</name>
</author>
<author><name sortKey="Thornby, J I" sort="Thornby, J I" uniqKey="Thornby J" first="J" last="Thornby">J Thornby</name>
</author>
<author><name sortKey="Nagamitsu, S" sort="Nagamitsu, S" uniqKey="Nagamitsu S" first="S" last="Nagamitsu">S. Nagamitsu</name>
</author>
<author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name>
<affiliation><country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university" n="3">Baylor College of Medicine</orgName>
</affiliation>
</author>
<author><name sortKey="Ashizawa, T" sort="Ashizawa, T" uniqKey="Ashizawa T" first="T" last="Ashizawa">T. Ashizawa</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2000">2000</date>
<idno type="RBID">pubmed:10953187</idno>
<idno type="pmid">10953187</idno>
<idno type="wicri:Area/PubMed/Corpus">000261</idno>
<idno type="wicri:Area/PubMed/Curation">000261</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000250</idno>
<idno type="wicri:Area/Ncbi/Merge">000015</idno>
<idno type="wicri:Area/Ncbi/Curation">000015</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000015</idno>
<idno type="wicri:doubleKey">0028-3878:2000:Tan E:variability:and:validity</idno>
<idno type="wicri:Area/Main/Merge">001859</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Variability and validity of polymorphism association studies in Parkinson's disease.</title>
<author><name sortKey="Tan, E K" sort="Tan, E K" uniqKey="Tan E" first="E" last="Tan">E Tan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Baylor College of Medicine, Houston, Texas 77030</wicri:regionArea>
<wicri:noRegion>Texas 77030</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khajavi, M" sort="Khajavi, M" uniqKey="Khajavi M" first="M" last="Khajavi">M. Khajavi</name>
</author>
<author><name sortKey="Thornby, J I" sort="Thornby, J I" uniqKey="Thornby J" first="J" last="Thornby">J Thornby</name>
</author>
<author><name sortKey="Nagamitsu, S" sort="Nagamitsu, S" uniqKey="Nagamitsu S" first="S" last="Nagamitsu">S. Nagamitsu</name>
</author>
<author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name>
<affiliation><country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university" n="3">Baylor College of Medicine</orgName>
</affiliation>
</author>
<author><name sortKey="Ashizawa, T" sort="Ashizawa, T" uniqKey="Ashizawa T" first="T" last="Ashizawa">T. Ashizawa</name>
</author>
</analytic>
<series><title level="j">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2000" type="published">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apolipoproteins E (genetics)</term>
<term>Arylamine N-Acetyltransferase (genetics)</term>
<term>Carrier Proteins (genetics)</term>
<term>Case-Control Studies</term>
<term>Catechol O-Methyltransferase (genetics)</term>
<term>DNA, Mitochondrial (genetics)</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Linkage</term>
<term>Genetic Variation (genetics)</term>
<term>Glutathione Transferase (genetics)</term>
<term>Humans</term>
<term>Isoenzymes (genetics)</term>
<term>Male</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Monoamine Oxidase (genetics)</term>
<term>Nerve Tissue Proteins</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Genetic (genetics)</term>
<term>RNA, Transfer, Glu (genetics)</term>
<term>Receptors, Dopamine D2 (genetics)</term>
<term>Receptors, Dopamine D4</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term>
<term>Arylamine N-Acetyltransferase</term>
<term>Carrier Proteins</term>
<term>Catechol O-Methyltransferase</term>
<term>DNA, Mitochondrial</term>
<term>Glutathione Transferase</term>
<term>Isoenzymes</term>
<term>Monoamine Oxidase</term>
<term>RNA, Transfer, Glu</term>
<term>Receptors, Dopamine D2</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Variation</term>
<term>Parkinson Disease</term>
<term>Polymorphism, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Linkage</term>
<term>Humans</term>
<term>Male</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Nerve Tissue Proteins</term>
<term>Receptors, Dopamine D4</term>
<term>Reproducibility of Results</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In recent years, interest in gene-environment interactions has spurred a great number of association studies on polymorphism of different genes.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
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