Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease
Identifieur interne : 000030 ( Main/Curation ); précédent : 000029; suivant : 000031Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease
Auteurs : Scarlet Gallegos [Chili] ; Carla Pacheco [Chili] ; Christian Peters [Chili] ; Carlos Opazo [Australie] ; Luis Aguayo [Chili]Source :
- Frontiers in Neuroscience [ 1662-4548 ] ; 2015.
Abstract
Alpha-synuclein is a presynaptic protein expressed throughout the central nervous system, and it is the main component of Lewy bodies, one of the histopathological features of Parkinson's disease (PD) which is a progressive and irreversible neurodegenerative disorder. The conformational flexibility of α-synuclein allows it to adopt different conformations, i.e., bound to membranes or form aggregates, the oligomers are believed to be the more toxic species. In this review, we will focus on two major features of α-synuclein, transmission and toxicity, that could help to understand the pathological characteristics of PD. One important feature of α-synuclein is its ability to be transmitted from neuron to neuron using mechanisms such as endocytosis, plasma membrane penetration or through exosomes, thus propagating the Lewy body pathology to different brain regions thereby contributing to the progressiveness of PD. The second feature of α-synuclein is that it confers cytotoxicity to recipient cells, principally when it is in an oligomeric state. This form causes mitochondrial dysfunction, endoplasmic reticulum stress, oxidative stress, proteasome impairment, disruption of plasma membrane and pore formation that lead to apoptosis pathway activation and consequent cell death. The complexity of α-synuclein oligomerization and formation of toxic species could be a major factor for the irreversibility of PD and could also explain the lack of successful therapies to halt the disease.
Url:
DOI: 10.3389/fnins.2015.00059
PubMed: 25805964
PubMed Central: 4353246
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000323
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000323
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000016
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000494
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000494
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000494
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000030
Links to Exploration step
PMC:4353246Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease</title><author><name sortKey="Gallegos, Scarlet" sort="Gallegos, Scarlet" uniqKey="Gallegos S" first="Scarlet" last="Gallegos">Scarlet Gallegos</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Neurophysiology, Department of Physiology, University of Concepcion</institution><country>Concepcio, Chile</country></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Pacheco, Carla" sort="Pacheco, Carla" uniqKey="Pacheco C" first="Carla" last="Pacheco">Carla Pacheco</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Neurophysiology, Department of Physiology, University of Concepcion</institution><country>Concepcio, Chile</country></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Peters, Christian" sort="Peters, Christian" uniqKey="Peters C" first="Christian" last="Peters">Christian Peters</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Neurophysiology, Department of Physiology, University of Concepcion</institution><country>Concepcio, Chile</country></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Opazo, Carlos M" sort="Opazo, Carlos M" uniqKey="Opazo C" first="Carlos" last="Opazo">Carlos Opazo</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Oxidation Biology Laboratory, The Florey Institute of Neuroscience and Mental Health, University of Melbourne</institution><country>Melbourne, VIC, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Aguayo, Luis G" sort="Aguayo, Luis G" uniqKey="Aguayo L" first="Luis" last="Aguayo">Luis Aguayo</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Neurophysiology, Department of Physiology, University of Concepcion</institution><country>Concepcio, Chile</country></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25805964</idno><idno type="pmc">4353246</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353246</idno><idno type="RBID">PMC:4353246</idno><idno type="doi">10.3389/fnins.2015.00059</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000323</idno><idno type="wicri:Area/Pmc/Curation">000323</idno><idno type="wicri:Area/Pmc/Checkpoint">000016</idno><idno type="wicri:Area/Ncbi/Merge">000494</idno><idno type="wicri:Area/Ncbi/Curation">000494</idno><idno type="wicri:Area/Ncbi/Checkpoint">000494</idno><idno type="wicri:doubleKey">1662-4548:2015:Gallegos S:features:of:alpha</idno><idno type="wicri:Area/Main/Merge">000030</idno><idno type="wicri:Area/Main/Curation">000030</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease</title><author><name sortKey="Gallegos, Scarlet" sort="Gallegos, Scarlet" uniqKey="Gallegos S" first="Scarlet" last="Gallegos">Scarlet Gallegos</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Neurophysiology, Department of Physiology, University of Concepcion</institution><country>Concepcio, Chile</country></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Pacheco, Carla" sort="Pacheco, Carla" uniqKey="Pacheco C" first="Carla" last="Pacheco">Carla Pacheco</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Neurophysiology, Department of Physiology, University of Concepcion</institution><country>Concepcio, Chile</country></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Peters, Christian" sort="Peters, Christian" uniqKey="Peters C" first="Christian" last="Peters">Christian Peters</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Neurophysiology, Department of Physiology, University of Concepcion</institution><country>Concepcio, Chile</country></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Opazo, Carlos M" sort="Opazo, Carlos M" uniqKey="Opazo C" first="Carlos" last="Opazo">Carlos Opazo</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Oxidation Biology Laboratory, The Florey Institute of Neuroscience and Mental Health, University of Melbourne</institution><country>Melbourne, VIC, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Aguayo, Luis G" sort="Aguayo, Luis G" uniqKey="Aguayo L" first="Luis" last="Aguayo">Luis Aguayo</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Neurophysiology, Department of Physiology, University of Concepcion</institution><country>Concepcio, Chile</country></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Neuroscience</title><idno type="ISSN">1662-4548</idno><idno type="e-ISSN">1662-453X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Alpha-synuclein is a presynaptic protein expressed throughout the central nervous system, and it is the main component of Lewy bodies, one of the histopathological features of Parkinson's disease (PD) which is a progressive and irreversible neurodegenerative disorder. The conformational flexibility of α-synuclein allows it to adopt different conformations, i.e., bound to membranes or form aggregates, the oligomers are believed to be the more toxic species. In this review, we will focus on two major features of α-synuclein, transmission and toxicity, that could help to understand the pathological characteristics of PD. One important feature of α-synuclein is its ability to be transmitted from neuron to neuron using mechanisms such as endocytosis, plasma membrane penetration or through exosomes, thus propagating the Lewy body pathology to different brain regions thereby contributing to the progressiveness of PD. The second feature of α-synuclein is that it confers cytotoxicity to recipient cells, principally when it is in an oligomeric state. This form causes mitochondrial dysfunction, endoplasmic reticulum stress, oxidative stress, proteasome impairment, disruption of plasma membrane and pore formation that lead to apoptosis pathway activation and consequent cell death. The complexity of α-synuclein oligomerization and formation of toxic species could be a major factor for the irreversibility of PD and could also explain the lack of successful therapies to halt the disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aguayo, L G" uniqKey="Aguayo L">L. G. Aguayo</name></author><author><name sortKey="Parodi, J" uniqKey="Parodi J">J. Parodi</name></author><author><name sortKey="Sepulveda, F J" uniqKey="Sepulveda F">F. J. Sepúlveda</name></author><author><name sortKey="Opazo, C" uniqKey="Opazo C">C. Opazo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahn, K J" uniqKey="Ahn K">K. J. Ahn</name></author><author><name sortKey="Paik, S R" uniqKey="Paik S">S. R. Paik</name></author><author><name sortKey="Chung, K C" uniqKey="Chung K">K. C. Chung</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alvarez Erviti, L" uniqKey="Alvarez Erviti L">L. Alvarez-Erviti</name></author><author><name sortKey="Seow, Y" uniqKey="Seow Y">Y. Seow</name></author><author><name sortKey="Schapira, A H" uniqKey="Schapira A">A. H. Schapira</name></author><author><name sortKey="Gardiner, C" uniqKey="Gardiner C">C. Gardiner</name></author><author><name sortKey="Sargent, I L" uniqKey="Sargent I">I. L. Sargent</name></author><author><name sortKey="Wood, M J" uniqKey="Wood M">M. J. Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angot, E" uniqKey="Angot E">E. Angot</name></author><author><name sortKey="Brundin, P" uniqKey="Brundin P">P. Brundin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angot, E" uniqKey="Angot E">E. Angot</name></author><author><name sortKey="Steiner, J A" uniqKey="Steiner J">J. A. Steiner</name></author><author><name sortKey="Lema Tome, C M" uniqKey="Lema Tome C">C. M. Lema Tome</name></author><author><name sortKey="Ekstrom, P" uniqKey="Ekstrom P">P. Ekstrom</name></author><author><name sortKey="Mattsson, B" uniqKey="Mattsson B">B. Mattsson</name></author><author><name sortKey="Bjorklund, A" uniqKey="Bjorklund A">A. Bjorklund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Auluck, P K" uniqKey="Auluck P">P. K. Auluck</name></author><author><name sortKey="Caraveo, G" uniqKey="Caraveo G">G. Caraveo</name></author><author><name sortKey="Lindquist, S" uniqKey="Lindquist S">S. Lindquist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bellucci, A" uniqKey="Bellucci A">A. Bellucci</name></author><author><name sortKey="Zaltieri, M" uniqKey="Zaltieri M">M. Zaltieri</name></author><author><name sortKey="Navarria, L" uniqKey="Navarria L">L. Navarria</name></author><author><name sortKey="Grigoletto, J" uniqKey="Grigoletto J">J. Grigoletto</name></author><author><name sortKey="Missale, C" uniqKey="Missale C">C. Missale</name></author><author><name sortKey="Spano, P" uniqKey="Spano P">P. Spano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bendor, J T" uniqKey="Bendor J">J. T. Bendor</name></author><author><name sortKey="Logan, T P" uniqKey="Logan T">T. P. Logan</name></author><author><name sortKey="Edwards, R H" uniqKey="Edwards R">R. H. Edwards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bisaglia, M" uniqKey="Bisaglia M">M. Bisaglia</name></author><author><name sortKey="Mammi, S" uniqKey="Mammi S">S. Mammi</name></author><author><name sortKey="Bubacco, L" uniqKey="Bubacco L">L. Bubacco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brundin, P" uniqKey="Brundin P">P. Brundin</name></author><author><name sortKey="Li, J Y" uniqKey="Li J">J. Y. Li</name></author><author><name sortKey="Holton, J L" uniqKey="Holton J">J. L. Holton</name></author><author><name sortKey="Lindvall, O" uniqKey="Lindvall O">O. Lindvall</name></author><author><name sortKey="Revesz, T" uniqKey="Revesz T">T. Revesz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burre, J" uniqKey="Burre J">J. Burre</name></author><author><name sortKey="Sharma, M" uniqKey="Sharma M">M. Sharma</name></author><author><name sortKey="Tsetsenis, T" uniqKey="Tsetsenis T">T. Tsetsenis</name></author><author><name sortKey="Buchman, V" uniqKey="Buchman V">V. Buchman</name></author><author><name sortKey="Etherton, M R" uniqKey="Etherton M">M. R. Etherton</name></author><author><name sortKey="Sudhof, T C" uniqKey="Sudhof T">T. C. Sudhof</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chandra, S" uniqKey="Chandra S">S. Chandra</name></author><author><name sortKey="Fornai, F" uniqKey="Fornai F">F. Fornai</name></author><author><name sortKey="Kwon, H B" uniqKey="Kwon H">H. B. Kwon</name></author><author><name sortKey="Yazdani, U" uniqKey="Yazdani U">U. Yazdani</name></author><author><name sortKey="Atasoy, D" uniqKey="Atasoy D">D. Atasoy</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colla, E" uniqKey="Colla E">E. Colla</name></author><author><name sortKey="Coune, P" uniqKey="Coune P">P. Coune</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Pletnikova, O" uniqKey="Pletnikova O">O. Pletnikova</name></author><author><name sortKey="Troncoso, J C" uniqKey="Troncoso J">J. C. Troncoso</name></author><author><name sortKey="Iwatsubo, T" uniqKey="Iwatsubo T">T. Iwatsubo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colla, E" uniqKey="Colla E">E. Colla</name></author><author><name sortKey="Jensen, P H" uniqKey="Jensen P">P. H. Jensen</name></author><author><name sortKey="Pletnikova, O" uniqKey="Pletnikova O">O. Pletnikova</name></author><author><name sortKey="Troncoso, J C" uniqKey="Troncoso J">J. C. Troncoso</name></author><author><name sortKey="Glabe, C" uniqKey="Glabe C">C. Glabe</name></author><author><name sortKey="Lee, M K" uniqKey="Lee M">M., K. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costanzo, M" uniqKey="Costanzo M">M. Costanzo</name></author><author><name sortKey="Zurzolo, C" uniqKey="Zurzolo C">C. Zurzolo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danzer, K M" uniqKey="Danzer K">K. M. Danzer</name></author><author><name sortKey="Haasen, D" uniqKey="Haasen D">D. Haasen</name></author><author><name sortKey="Karow, A R" uniqKey="Karow A">A. R. Karow</name></author><author><name sortKey="Moussaud, S" uniqKey="Moussaud S">S. Moussaud</name></author><author><name sortKey="Habeck, M" uniqKey="Habeck M">M. Habeck</name></author><author><name sortKey="Giese, A" uniqKey="Giese A">A. Giese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danzer, K M" uniqKey="Danzer K">K. M. Danzer</name></author><author><name sortKey="Kranich, L R" uniqKey="Kranich L">L. R. Kranich</name></author><author><name sortKey="Ruf, W P" uniqKey="Ruf W">W. P. Ruf</name></author><author><name sortKey="Cagsal Getkin, O" uniqKey="Cagsal Getkin O">O. Cagsal-Getkin</name></author><author><name sortKey="Winslow, A R" uniqKey="Winslow A">A. R. Winslow</name></author><author><name sortKey="Zhu, L" uniqKey="Zhu L">L. Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danzer, K M" uniqKey="Danzer K">K. M. Danzer</name></author><author><name sortKey="Krebs, S K" uniqKey="Krebs S">S. K. Krebs</name></author><author><name sortKey="Wolff, M" uniqKey="Wolff M">M. Wolff</name></author><author><name sortKey="Birk, G" uniqKey="Birk G">G. Birk</name></author><author><name sortKey="Hengerer, B" uniqKey="Hengerer B">B. Hengerer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deleersnijder, A" uniqKey="Deleersnijder A">A. Deleersnijder</name></author><author><name sortKey="Gerard, M" uniqKey="Gerard M">M. Gerard</name></author><author><name sortKey="Debyser, Z" uniqKey="Debyser Z">Z. Debyser</name></author><author><name sortKey="Baekelandt, V" uniqKey="Baekelandt V">V. Baekelandt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desplats, P A" uniqKey="Desplats P">P. A. Desplats</name></author><author><name sortKey="Lee, H" uniqKey="Lee H">H. Lee</name></author><author><name sortKey="Eun Jin, B" uniqKey="Eun Jin B">B. Eun-Jin</name></author><author><name sortKey="Christina, P" uniqKey="Christina P">P. Christina</name></author><author><name sortKey="Edward, R" uniqKey="Edward R">R. Edward</name></author><author><name sortKey="Leslie, C" uniqKey="Leslie C">C. Leslie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doyle, K M" uniqKey="Doyle K">K. M. Doyle</name></author><author><name sortKey="Kennedy, D" uniqKey="Kennedy D">D. Kennedy</name></author><author><name sortKey="Gorman, A M" uniqKey="Gorman A">A. M. Gorman</name></author><author><name sortKey="Gupta, S" uniqKey="Gupta S">S. Gupta</name></author><author><name sortKey="Healy, S J" uniqKey="Healy S">S. J. Healy</name></author><author><name sortKey="Samali, A" uniqKey="Samali A">A. Samali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Agnaf, O M" uniqKey="El Agnaf O">O. M. El-Agnaf</name></author><author><name sortKey="Salem, S A" uniqKey="Salem S">S. A. Salem</name></author><author><name sortKey="Paleologou, K E" uniqKey="Paleologou K">K. E. Paleologou</name></author><author><name sortKey="Curran, M D" uniqKey="Curran M">M. D. Curran</name></author><author><name sortKey="Gibson, M J" uniqKey="Gibson M">M. J. Gibson</name></author><author><name sortKey="Court, J A" uniqKey="Court J">J. A. Court</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, L R" uniqKey="Feng L">L. R. Feng</name></author><author><name sortKey="Federoff, H J" uniqKey="Federoff H">H. J. Federoff</name></author><author><name sortKey="Vicini, S" uniqKey="Vicini S">S. Vicini</name></author><author><name sortKey="Maguire Zeiss, K A" uniqKey="Maguire Zeiss K">K. A. Maguire-Zeiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freundt, E C" uniqKey="Freundt E">E. C. Freundt</name></author><author><name sortKey="Maynard, N" uniqKey="Maynard N">N. Maynard</name></author><author><name sortKey="Clancy, E K" uniqKey="Clancy E">E. K. Clancy</name></author><author><name sortKey="Roy, S" uniqKey="Roy S">S. Roy</name></author><author><name sortKey="Bousset, L" uniqKey="Bousset L">L. Bousset</name></author><author><name sortKey="Sourigues, Y" uniqKey="Sourigues Y">Y. Sourigues</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frost, B" uniqKey="Frost B">B. Frost</name></author><author><name sortKey="Diamond, M I" uniqKey="Diamond M">M. I. Diamond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furukawa, K" uniqKey="Furukawa K">K. Furukawa</name></author><author><name sortKey="Matsuzaki Kobayashi, M" uniqKey="Matsuzaki Kobayashi M">M. Matsuzaki-Kobayashi</name></author><author><name sortKey="Hasegawa, T" uniqKey="Hasegawa T">T. Hasegawa</name></author><author><name sortKey="Kikuchi, A" uniqKey="Kikuchi A">A. Kikuchi</name></author><author><name sortKey="Sugeno, N" uniqKey="Sugeno N">N. Sugeno</name></author><author><name sortKey="Itoyama, Y" uniqKey="Itoyama Y">Y. Itoyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greten Harrison, B" uniqKey="Greten Harrison B">B. Greten-Harrison</name></author><author><name sortKey="Polydoro, M" uniqKey="Polydoro M">M. Polydoro</name></author><author><name sortKey="Morimoto Tomita, M" uniqKey="Morimoto Tomita M">M. Morimoto-Tomita</name></author><author><name sortKey="Diao, L" uniqKey="Diao L">L. Diao</name></author><author><name sortKey="Williams, A M" uniqKey="Williams A">A. M. Williams</name></author><author><name sortKey="Nie, E H" uniqKey="Nie E">E. H. Nie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansen, C" uniqKey="Hansen C">C. Hansen</name></author><author><name sortKey="Angot, E" uniqKey="Angot E">E. Angot</name></author><author><name sortKey="Bergstrom, A L" uniqKey="Bergstrom A">A. L. Bergstrom</name></author><author><name sortKey="Steiner, J A" uniqKey="Steiner J">J. A. Steiner</name></author><author><name sortKey="Pieri, L" uniqKey="Pieri L">L. Pieri</name></author><author><name sortKey="Paul, G" uniqKey="Paul G">G. Paul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hara, S" uniqKey="Hara S">S. Hara</name></author><author><name sortKey="Arawaka, S" uniqKey="Arawaka S">S. Arawaka</name></author><author><name sortKey="Sato, H" uniqKey="Sato H">H. Sato</name></author><author><name sortKey="Machiya, Y" uniqKey="Machiya Y">Y. Machiya</name></author><author><name sortKey="Cui, C" uniqKey="Cui C">C. Cui</name></author><author><name sortKey="Sasaki, A" uniqKey="Sasaki A">A. Sasaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Irwin, D J" uniqKey="Irwin D">D. J. Irwin</name></author><author><name sortKey="Lee, V M" uniqKey="Lee V">V. M. Lee</name></author><author><name sortKey="Trojanowski, J Q" uniqKey="Trojanowski J">J. Q. Trojanowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, N" uniqKey="Jain N">N. Jain</name></author><author><name sortKey="Bhasne, K" uniqKey="Bhasne K">K. Bhasne</name></author><author><name sortKey="Hemaswasthi, M" uniqKey="Hemaswasthi M">M. Hemaswasthi</name></author><author><name sortKey="Mukhopadhyay, S" uniqKey="Mukhopadhyay S">S. Mukhopadhyay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jang, A" uniqKey="Jang A">A. Jang</name></author><author><name sortKey="Lee, H" uniqKey="Lee H">H. Lee</name></author><author><name sortKey="Suk, J" uniqKey="Suk J">J. Suk</name></author><author><name sortKey="Jung, J" uniqKey="Jung J">J. Jung</name></author><author><name sortKey="Kim, K" uniqKey="Kim K">K. Kim</name></author><author><name sortKey="Lee, S" uniqKey="Lee S">S. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jang, H" uniqKey="Jang H">H. Jang</name></author><author><name sortKey="Zheng, J" uniqKey="Zheng J">J. Zheng</name></author><author><name sortKey="Nussinov, R" uniqKey="Nussinov R">R. Nussinov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J. Jankovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jucker, M" uniqKey="Jucker M">M. Jucker</name></author><author><name sortKey="Walker, L C" uniqKey="Walker L">L. C. Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Junn, E" uniqKey="Junn E">E. Junn</name></author><author><name sortKey="Mouradian, M M" uniqKey="Mouradian M">M., M. Mouradian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, H Y" uniqKey="Kim H">H. Y. Kim</name></author><author><name sortKey="Cho, M K" uniqKey="Cho M">M. K. Cho</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name></author><author><name sortKey="Maier, E" uniqKey="Maier E">E. Maier</name></author><author><name sortKey="Siebenhaar, C" uniqKey="Siebenhaar C">C. Siebenhaar</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosten, J" uniqKey="Kosten J">J. Kosten</name></author><author><name sortKey="Binolfi, A" uniqKey="Binolfi A">A. Binolfi</name></author><author><name sortKey="Stuiver, M" uniqKey="Stuiver M">M. Stuiver</name></author><author><name sortKey="Verzini, S" uniqKey="Verzini S">S. Verzini</name></author><author><name sortKey="Theillet, F X" uniqKey="Theillet F">F. X. Theillet</name></author><author><name sortKey="Bekei, B" uniqKey="Bekei B">B. Bekei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lashuel, H A" uniqKey="Lashuel H">H. A. Lashuel</name></author><author><name sortKey="Overk, C R" uniqKey="Overk C">C. R. Overk</name></author><author><name sortKey="Oueslati, A" uniqKey="Oueslati A">A. Oueslati</name></author><author><name sortKey="Masliah, E" uniqKey="Masliah E">E. Masliah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lavedan, C" uniqKey="Lavedan C">C. Lavedan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, C" uniqKey="Lee C">C. Lee</name></author><author><name sortKey="Yu, M H H" uniqKey="Yu M">M.-H. H. Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, H J" uniqKey="Lee H">H. J. Lee</name></author><author><name sortKey="Cho, E D" uniqKey="Cho E">E. D. Cho</name></author><author><name sortKey="Lee, K W" uniqKey="Lee K">K. W. Lee</name></author><author><name sortKey="Kim, J H" uniqKey="Kim J">J. H. Kim</name></author><author><name sortKey="Cho, S G" uniqKey="Cho S">S. G. Cho</name></author><author><name sortKey="Lee, S J" uniqKey="Lee S">S. J. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, H J" uniqKey="Lee H">H. J. Lee</name></author><author><name sortKey="Patel, S" uniqKey="Patel S">S. Patel</name></author><author><name sortKey="Lee, S J" uniqKey="Lee S">S. J. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, J Y" uniqKey="Li J">J. Y. Li</name></author><author><name sortKey="Englund, E" uniqKey="Englund E">E. Englund</name></author><author><name sortKey="Holton, J L" uniqKey="Holton J">J. L. Holton</name></author><author><name sortKey="Soulet, D" uniqKey="Soulet D">D. Soulet</name></author><author><name sortKey="Hagell, P" uniqKey="Hagell P">P. Hagell</name></author><author><name sortKey="Lees, A J" uniqKey="Lees A">A. J. Lees</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luk, K C" uniqKey="Luk K">K. C. Luk</name></author><author><name sortKey="Kehm, V" uniqKey="Kehm V">V. Kehm</name></author><author><name sortKey="Carroll, J" uniqKey="Carroll J">J. Carroll</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B. Zhang</name></author><author><name sortKey="O Brien, P" uniqKey="O Brien P">P. O'Brien</name></author><author><name sortKey="Trojanowski, J Q" uniqKey="Trojanowski J">J. Q. Trojanowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luk, K C" uniqKey="Luk K">K. C. Luk</name></author><author><name sortKey="Kehm, V M" uniqKey="Kehm V">V. M. Kehm</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B. Zhang</name></author><author><name sortKey="O Brien, P" uniqKey="O Brien P">P. O'Brien</name></author><author><name sortKey="Trojanowski, J Q" uniqKey="Trojanowski J">J. Q. Trojanowski</name></author><author><name sortKey="Lee, V M" uniqKey="Lee V">V. M. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luk, K C" uniqKey="Luk K">K. C. Luk</name></author><author><name sortKey="Song, C" uniqKey="Song C">C. Song</name></author><author><name sortKey="O Brien, P" uniqKey="O Brien P">P. O'Brien</name></author><author><name sortKey="Stieber, A" uniqKey="Stieber A">A. Stieber</name></author><author><name sortKey="Branch, J R" uniqKey="Branch J">J. R. Branch</name></author><author><name sortKey="Brunden, K R" uniqKey="Brunden K">K. R. Brunden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Masters, C S G" uniqKey="Masters C">C. S. G. Masters</name></author><author><name sortKey="Weiman, N A" uniqKey="Weiman N">N. A. Weiman</name></author><author><name sortKey="Multhaup, G" uniqKey="Multhaup G">G. Multhaup</name></author><author><name sortKey="Mcdonald, D L" uniqKey="Mcdonald D">D. L. McDonald</name></author><author><name sortKey="Beyreuther, K" uniqKey="Beyreuther K">K. Beyreuther</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mercuri, N B" uniqKey="Mercuri N">N. B. Mercuri</name></author><author><name sortKey="Bernardi, G" uniqKey="Bernardi G">G. Bernardi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moreno Gonzalez, I" uniqKey="Moreno Gonzalez I">I. Moreno-Gonzalez</name></author><author><name sortKey="Soto, C" uniqKey="Soto C">C. Soto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munch, C" uniqKey="Munch C">C. Munch</name></author><author><name sortKey="Bertolotti, A" uniqKey="Bertolotti A">A. Bertolotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Obeso, J A" uniqKey="Obeso J">J. A. Obeso</name></author><author><name sortKey="Rodriguez Oroz, M C" uniqKey="Rodriguez Oroz M">M. C. Rodriguez-Oroz</name></author><author><name sortKey="Goetz, C G" uniqKey="Goetz C">C. G. Goetz</name></author><author><name sortKey="Marin, C" uniqKey="Marin C">C. Marin</name></author><author><name sortKey="Kordower, J H" uniqKey="Kordower J">J. H. Kordower</name></author><author><name sortKey="Rodriguez, M" uniqKey="Rodriguez M">M. Rodriguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pacheco, C" uniqKey="Pacheco C">C. Pacheco</name></author><author><name sortKey="Morales, C" uniqKey="Morales C">C. Morales</name></author><author><name sortKey="Ramirez, E A" uniqKey="Ramirez E">E. A. Ramirez</name></author><author><name sortKey="Mu Oz, F J" uniqKey="Mu Oz F">F. J. Muñoz</name></author><author><name sortKey="Gallegos, S" uniqKey="Gallegos S">S. Gallegos</name></author><author><name sortKey="Caviedes, P" uniqKey="Caviedes P">P. Caviedes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parihar, M S" uniqKey="Parihar M">M. S. Parihar</name></author><author><name sortKey="Parihar, A" uniqKey="Parihar A">A. Parihar</name></author><author><name sortKey="Fujita, M" uniqKey="Fujita M">M. Fujita</name></author><author><name sortKey="Hashimoto, M" uniqKey="Hashimoto M">M. Hashimoto</name></author><author><name sortKey="Ghafourifar, P" uniqKey="Ghafourifar P">P. Ghafourifar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parihar, M S" uniqKey="Parihar M">M. S. Parihar</name></author><author><name sortKey="Parihar, A" uniqKey="Parihar A">A. Parihar</name></author><author><name sortKey="Fujita, M" uniqKey="Fujita M">M. Fujita</name></author><author><name sortKey="Hashimoto, M" uniqKey="Hashimoto M">M. Hashimoto</name></author><author><name sortKey="Ghafourifar, P" uniqKey="Ghafourifar P">P. Ghafourifar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parodi, J" uniqKey="Parodi J">J. Parodi</name></author><author><name sortKey="Sepulveda, F J" uniqKey="Sepulveda F">F. J. Sepúlveda</name></author><author><name sortKey="Roa, J" uniqKey="Roa J">J. Roa</name></author><author><name sortKey="Opazo, C" uniqKey="Opazo C">C. Opazo</name></author><author><name sortKey="Inestrosa, N C" uniqKey="Inestrosa N">N. C. Inestrosa</name></author><author><name sortKey="Aguayo, L G" uniqKey="Aguayo L">L. G. Aguayo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plotegher, N" uniqKey="Plotegher N">N. Plotegher</name></author><author><name sortKey="Greggio, E" uniqKey="Greggio E">E. Greggio</name></author><author><name sortKey="Bisaglia, M" uniqKey="Bisaglia M">M. Bisaglia</name></author><author><name sortKey="Bubacco, L" uniqKey="Bubacco L">L. Bubacco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ross, C A" uniqKey="Ross C">C. A. Ross</name></author><author><name sortKey="Poirier, M A" uniqKey="Poirier M">M. A. Poirier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sato, H" uniqKey="Sato H">H. Sato</name></author><author><name sortKey="Kato, T" uniqKey="Kato T">T. Kato</name></author><author><name sortKey="Arawaka, S" uniqKey="Arawaka S">S. Arawaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schapira, A H" uniqKey="Schapira A">A. H. Schapira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, F" uniqKey="Schmidt F">F. Schmidt</name></author><author><name sortKey="Levin, J" uniqKey="Levin J">J. Levin</name></author><author><name sortKey="Kamp, F" uniqKey="Kamp F">F. Kamp</name></author><author><name sortKey="Kretzschmar, H" uniqKey="Kretzschmar H">H. Kretzschmar</name></author><author><name sortKey="Giese, A" uniqKey="Giese A">A. Giese</name></author><author><name sortKey="Botzel, K" uniqKey="Botzel K">K. Botzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sepulveda, F J" uniqKey="Sepulveda F">F. J. Sepulveda</name></author><author><name sortKey="Fierro, H" uniqKey="Fierro H">H. Fierro</name></author><author><name sortKey="Fernandez, E" uniqKey="Fernandez E">E. Fernandez</name></author><author><name sortKey="Castillo, C" uniqKey="Castillo C">C. Castillo</name></author><author><name sortKey="Peoples, R W" uniqKey="Peoples R">R. W. Peoples</name></author><author><name sortKey="Opazo, C" uniqKey="Opazo C">C. Opazo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sepulveda, F J" uniqKey="Sepulveda F">F. J. Sepulveda</name></author><author><name sortKey="Parodi, J" uniqKey="Parodi J">J. Parodi</name></author><author><name sortKey="Peoples, R W" uniqKey="Peoples R">R. W. Peoples</name></author><author><name sortKey="Opazo, C" uniqKey="Opazo C">C. Opazo</name></author><author><name sortKey="Aguayo, L G" uniqKey="Aguayo L">L. G. Aguayo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, N" uniqKey="Singh N">N. Singh</name></author><author><name sortKey="Pillay, V" uniqKey="Pillay V">V. Pillay</name></author><author><name sortKey="Choonara, Y E" uniqKey="Choonara Y">Y. E. Choonara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, W W" uniqKey="Smith W">W. W. Smith</name></author><author><name sortKey="Jiang, H" uniqKey="Jiang H">H. Jiang</name></author><author><name sortKey="Pei, Z" uniqKey="Pei Z">Z. Pei</name></author><author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y. Tanaka</name></author><author><name sortKey="Morita, H" uniqKey="Morita H">H. Morita</name></author><author><name sortKey="Sawa, A" uniqKey="Sawa A">A. Sawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soto, C" uniqKey="Soto C">C. Soto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soto, C" uniqKey="Soto C">C. Soto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soto, C" uniqKey="Soto C">C. Soto</name></author><author><name sortKey="Satani, N" uniqKey="Satani N">N. Satani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steiner, J A" uniqKey="Steiner J">J. A. Steiner</name></author><author><name sortKey="Angot, E" uniqKey="Angot E">E. Angot</name></author><author><name sortKey="Brundin, P" uniqKey="Brundin P">P. Brundin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stockl, M T" uniqKey="Stockl M">M. T. Stockl</name></author><author><name sortKey="Zijlstra, N" uniqKey="Zijlstra N">N. Zijlstra</name></author><author><name sortKey="Subramaniam, V" uniqKey="Subramaniam V">V. Subramaniam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tarazi, F I" uniqKey="Tarazi F">F. I. Tarazi</name></author><author><name sortKey="Sahli, Z T" uniqKey="Sahli Z">Z. T. Sahli</name></author><author><name sortKey="Wolny, M" uniqKey="Wolny M">M. Wolny</name></author><author><name sortKey="Mousa, S A" uniqKey="Mousa S">S. A. Mousa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tosatto, L" uniqKey="Tosatto L">L. Tosatto</name></author><author><name sortKey="Andrighetti, A O" uniqKey="Andrighetti A">A. O. Andrighetti</name></author><author><name sortKey="Plotegher, N" uniqKey="Plotegher N">N. Plotegher</name></author><author><name sortKey="Antonini, V" uniqKey="Antonini V">V. Antonini</name></author><author><name sortKey="Tessari, I" uniqKey="Tessari I">I. Tessari</name></author><author><name sortKey="Ricci, L" uniqKey="Ricci L">L. Ricci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsigelny, I F" uniqKey="Tsigelny I">I. F. Tsigelny</name></author><author><name sortKey="Bar On, P" uniqKey="Bar On P">P. Bar-On</name></author><author><name sortKey="Sharikov, Y" uniqKey="Sharikov Y">Y. Sharikov</name></author><author><name sortKey="Crews, L" uniqKey="Crews L">L. Crews</name></author><author><name sortKey="Hashimoto, M" uniqKey="Hashimoto M">M. Hashimoto</name></author><author><name sortKey="Miller, M A" uniqKey="Miller M">M. A. Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsigelny, I F" uniqKey="Tsigelny I">I. F. Tsigelny</name></author><author><name sortKey="Sharikov, Y" uniqKey="Sharikov Y">Y. Sharikov</name></author><author><name sortKey="Wrasidlo, W" uniqKey="Wrasidlo W">W. Wrasidlo</name></author><author><name sortKey="Gonzalez, T" uniqKey="Gonzalez T">T. Gonzalez</name></author><author><name sortKey="Desplats, P A" uniqKey="Desplats P">P. A. Desplats</name></author><author><name sortKey="Crews, L" uniqKey="Crews L">L. Crews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ulmer, T S" uniqKey="Ulmer T">T. S. Ulmer</name></author><author><name sortKey="Bax, A" uniqKey="Bax A">A. Bax</name></author><author><name sortKey="Cole, N B" uniqKey="Cole N">N. B. Cole</name></author><author><name sortKey="Nussbaum, R L" uniqKey="Nussbaum R">R. L. Nussbaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volpicelli Daley, L A" uniqKey="Volpicelli Daley L">L. A. Volpicelli-Daley</name></author><author><name sortKey="Luk, K C" uniqKey="Luk K">K. C. Luk</name></author><author><name sortKey="Patel, T P" uniqKey="Patel T">T. P. Patel</name></author><author><name sortKey="Tanik, S A" uniqKey="Tanik S">S. A. Tanik</name></author><author><name sortKey="Riddle, D M" uniqKey="Riddle D">D. M. Riddle</name></author><author><name sortKey="Stieber, A" uniqKey="Stieber A">A. Stieber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, D G" uniqKey="Walker D">D. G. Walker</name></author><author><name sortKey="Lue, L F" uniqKey="Lue L">L. F. Lue</name></author><author><name sortKey="Adler, C H" uniqKey="Adler C">C. H. Adler</name></author><author><name sortKey="Shill, H A" uniqKey="Shill H">H. A. Shill</name></author><author><name sortKey="Caviness, J N" uniqKey="Caviness J">J. N. Caviness</name></author><author><name sortKey="Sabbagh, M N" uniqKey="Sabbagh M">M. N. Sabbagh</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/JankovicV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000030 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000030 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= JankovicV1
|flux= Main
|étape= Curation
|type= RBID
|clé= PMC:4353246
|texte= Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:25805964" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \
| NlmPubMed2Wicri -a JankovicV1
| This area was generated with Dilib version V0.6.19. |  |