Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease
Identifieur interne : 000494 ( Ncbi/Curation ); précédent : 000493; suivant : 000495Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease
Auteurs : Scarlet Gallegos [Chili] ; Carla Pacheco [Chili] ; Christian Peters [Chili] ; Carlos Opazo [Australie] ; Luis Aguayo [Chili]Source :
- Frontiers in Neuroscience [ 1662-4548 ] ; 2015.
Abstract
Alpha-synuclein is a presynaptic protein expressed throughout the central nervous system, and it is the main component of Lewy bodies, one of the histopathological features of Parkinson's disease (PD) which is a progressive and irreversible neurodegenerative disorder. The conformational flexibility of α-synuclein allows it to adopt different conformations, i.e., bound to membranes or form aggregates, the oligomers are believed to be the more toxic species. In this review, we will focus on two major features of α-synuclein, transmission and toxicity, that could help to understand the pathological characteristics of PD. One important feature of α-synuclein is its ability to be transmitted from neuron to neuron using mechanisms such as endocytosis, plasma membrane penetration or through exosomes, thus propagating the Lewy body pathology to different brain regions thereby contributing to the progressiveness of PD. The second feature of α-synuclein is that it confers cytotoxicity to recipient cells, principally when it is in an oligomeric state. This form causes mitochondrial dysfunction, endoplasmic reticulum stress, oxidative stress, proteasome impairment, disruption of plasma membrane and pore formation that lead to apoptosis pathway activation and consequent cell death. The complexity of α-synuclein oligomerization and formation of toxic species could be a major factor for the irreversibility of PD and could also explain the lack of successful therapies to halt the disease.
Url:
DOI: 10.3389/fnins.2015.00059
PubMed: 25805964
PubMed Central: 4353246
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<front><div type="abstract" xml:lang="en"><p>Alpha-synuclein is a presynaptic protein expressed throughout the central nervous system, and it is the main component of Lewy bodies, one of the histopathological features of Parkinson's disease (PD) which is a progressive and irreversible neurodegenerative disorder. The conformational flexibility of α-synuclein allows it to adopt different conformations, i.e., bound to membranes or form aggregates, the oligomers are believed to be the more toxic species. In this review, we will focus on two major features of α-synuclein, transmission and toxicity, that could help to understand the pathological characteristics of PD. One important feature of α-synuclein is its ability to be transmitted from neuron to neuron using mechanisms such as endocytosis, plasma membrane penetration or through exosomes, thus propagating the Lewy body pathology to different brain regions thereby contributing to the progressiveness of PD. The second feature of α-synuclein is that it confers cytotoxicity to recipient cells, principally when it is in an oligomeric state. This form causes mitochondrial dysfunction, endoplasmic reticulum stress, oxidative stress, proteasome impairment, disruption of plasma membrane and pore formation that lead to apoptosis pathway activation and consequent cell death. The complexity of α-synuclein oligomerization and formation of toxic species could be a major factor for the irreversibility of PD and could also explain the lack of successful therapies to halt the disease.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aguayo, L G" uniqKey="Aguayo L">L. G. Aguayo</name>
</author>
<author><name sortKey="Parodi, J" uniqKey="Parodi J">J. Parodi</name>
</author>
<author><name sortKey="Sepulveda, F J" uniqKey="Sepulveda F">F. J. Sepúlveda</name>
</author>
<author><name sortKey="Opazo, C" uniqKey="Opazo C">C. Opazo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ahn, K J" uniqKey="Ahn K">K. J. Ahn</name>
</author>
<author><name sortKey="Paik, S R" uniqKey="Paik S">S. R. Paik</name>
</author>
<author><name sortKey="Chung, K C" uniqKey="Chung K">K. C. Chung</name>
</author>
<author><name sortKey="Kim, J" uniqKey="Kim J">J. Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alvarez Erviti, L" uniqKey="Alvarez Erviti L">L. Alvarez-Erviti</name>
</author>
<author><name sortKey="Seow, Y" uniqKey="Seow Y">Y. Seow</name>
</author>
<author><name sortKey="Schapira, A H" uniqKey="Schapira A">A. H. Schapira</name>
</author>
<author><name sortKey="Gardiner, C" uniqKey="Gardiner C">C. Gardiner</name>
</author>
<author><name sortKey="Sargent, I L" uniqKey="Sargent I">I. L. Sargent</name>
</author>
<author><name sortKey="Wood, M J" uniqKey="Wood M">M. J. Wood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Angot, E" uniqKey="Angot E">E. Angot</name>
</author>
<author><name sortKey="Brundin, P" uniqKey="Brundin P">P. Brundin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Angot, E" uniqKey="Angot E">E. Angot</name>
</author>
<author><name sortKey="Steiner, J A" uniqKey="Steiner J">J. A. Steiner</name>
</author>
<author><name sortKey="Lema Tome, C M" uniqKey="Lema Tome C">C. M. Lema Tome</name>
</author>
<author><name sortKey="Ekstrom, P" uniqKey="Ekstrom P">P. Ekstrom</name>
</author>
<author><name sortKey="Mattsson, B" uniqKey="Mattsson B">B. Mattsson</name>
</author>
<author><name sortKey="Bjorklund, A" uniqKey="Bjorklund A">A. Bjorklund</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Auluck, P K" uniqKey="Auluck P">P. K. Auluck</name>
</author>
<author><name sortKey="Caraveo, G" uniqKey="Caraveo G">G. Caraveo</name>
</author>
<author><name sortKey="Lindquist, S" uniqKey="Lindquist S">S. Lindquist</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bellucci, A" uniqKey="Bellucci A">A. Bellucci</name>
</author>
<author><name sortKey="Zaltieri, M" uniqKey="Zaltieri M">M. Zaltieri</name>
</author>
<author><name sortKey="Navarria, L" uniqKey="Navarria L">L. Navarria</name>
</author>
<author><name sortKey="Grigoletto, J" uniqKey="Grigoletto J">J. Grigoletto</name>
</author>
<author><name sortKey="Missale, C" uniqKey="Missale C">C. Missale</name>
</author>
<author><name sortKey="Spano, P" uniqKey="Spano P">P. Spano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bendor, J T" uniqKey="Bendor J">J. T. Bendor</name>
</author>
<author><name sortKey="Logan, T P" uniqKey="Logan T">T. P. Logan</name>
</author>
<author><name sortKey="Edwards, R H" uniqKey="Edwards R">R. H. Edwards</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bisaglia, M" uniqKey="Bisaglia M">M. Bisaglia</name>
</author>
<author><name sortKey="Mammi, S" uniqKey="Mammi S">S. Mammi</name>
</author>
<author><name sortKey="Bubacco, L" uniqKey="Bubacco L">L. Bubacco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brundin, P" uniqKey="Brundin P">P. Brundin</name>
</author>
<author><name sortKey="Li, J Y" uniqKey="Li J">J. Y. Li</name>
</author>
<author><name sortKey="Holton, J L" uniqKey="Holton J">J. L. Holton</name>
</author>
<author><name sortKey="Lindvall, O" uniqKey="Lindvall O">O. Lindvall</name>
</author>
<author><name sortKey="Revesz, T" uniqKey="Revesz T">T. Revesz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burre, J" uniqKey="Burre J">J. Burre</name>
</author>
<author><name sortKey="Sharma, M" uniqKey="Sharma M">M. Sharma</name>
</author>
<author><name sortKey="Tsetsenis, T" uniqKey="Tsetsenis T">T. Tsetsenis</name>
</author>
<author><name sortKey="Buchman, V" uniqKey="Buchman V">V. Buchman</name>
</author>
<author><name sortKey="Etherton, M R" uniqKey="Etherton M">M. R. Etherton</name>
</author>
<author><name sortKey="Sudhof, T C" uniqKey="Sudhof T">T. C. Sudhof</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chandra, S" uniqKey="Chandra S">S. Chandra</name>
</author>
<author><name sortKey="Fornai, F" uniqKey="Fornai F">F. Fornai</name>
</author>
<author><name sortKey="Kwon, H B" uniqKey="Kwon H">H. B. Kwon</name>
</author>
<author><name sortKey="Yazdani, U" uniqKey="Yazdani U">U. Yazdani</name>
</author>
<author><name sortKey="Atasoy, D" uniqKey="Atasoy D">D. Atasoy</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Colla, E" uniqKey="Colla E">E. Colla</name>
</author>
<author><name sortKey="Coune, P" uniqKey="Coune P">P. Coune</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Pletnikova, O" uniqKey="Pletnikova O">O. Pletnikova</name>
</author>
<author><name sortKey="Troncoso, J C" uniqKey="Troncoso J">J. C. Troncoso</name>
</author>
<author><name sortKey="Iwatsubo, T" uniqKey="Iwatsubo T">T. Iwatsubo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Colla, E" uniqKey="Colla E">E. Colla</name>
</author>
<author><name sortKey="Jensen, P H" uniqKey="Jensen P">P. H. Jensen</name>
</author>
<author><name sortKey="Pletnikova, O" uniqKey="Pletnikova O">O. Pletnikova</name>
</author>
<author><name sortKey="Troncoso, J C" uniqKey="Troncoso J">J. C. Troncoso</name>
</author>
<author><name sortKey="Glabe, C" uniqKey="Glabe C">C. Glabe</name>
</author>
<author><name sortKey="Lee, M K" uniqKey="Lee M">M., K. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Costanzo, M" uniqKey="Costanzo M">M. Costanzo</name>
</author>
<author><name sortKey="Zurzolo, C" uniqKey="Zurzolo C">C. Zurzolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Danzer, K M" uniqKey="Danzer K">K. M. Danzer</name>
</author>
<author><name sortKey="Haasen, D" uniqKey="Haasen D">D. Haasen</name>
</author>
<author><name sortKey="Karow, A R" uniqKey="Karow A">A. R. Karow</name>
</author>
<author><name sortKey="Moussaud, S" uniqKey="Moussaud S">S. Moussaud</name>
</author>
<author><name sortKey="Habeck, M" uniqKey="Habeck M">M. Habeck</name>
</author>
<author><name sortKey="Giese, A" uniqKey="Giese A">A. Giese</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Danzer, K M" uniqKey="Danzer K">K. M. Danzer</name>
</author>
<author><name sortKey="Kranich, L R" uniqKey="Kranich L">L. R. Kranich</name>
</author>
<author><name sortKey="Ruf, W P" uniqKey="Ruf W">W. P. Ruf</name>
</author>
<author><name sortKey="Cagsal Getkin, O" uniqKey="Cagsal Getkin O">O. Cagsal-Getkin</name>
</author>
<author><name sortKey="Winslow, A R" uniqKey="Winslow A">A. R. Winslow</name>
</author>
<author><name sortKey="Zhu, L" uniqKey="Zhu L">L. Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Danzer, K M" uniqKey="Danzer K">K. M. Danzer</name>
</author>
<author><name sortKey="Krebs, S K" uniqKey="Krebs S">S. K. Krebs</name>
</author>
<author><name sortKey="Wolff, M" uniqKey="Wolff M">M. Wolff</name>
</author>
<author><name sortKey="Birk, G" uniqKey="Birk G">G. Birk</name>
</author>
<author><name sortKey="Hengerer, B" uniqKey="Hengerer B">B. Hengerer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deleersnijder, A" uniqKey="Deleersnijder A">A. Deleersnijder</name>
</author>
<author><name sortKey="Gerard, M" uniqKey="Gerard M">M. Gerard</name>
</author>
<author><name sortKey="Debyser, Z" uniqKey="Debyser Z">Z. Debyser</name>
</author>
<author><name sortKey="Baekelandt, V" uniqKey="Baekelandt V">V. Baekelandt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Desplats, P A" uniqKey="Desplats P">P. A. Desplats</name>
</author>
<author><name sortKey="Lee, H" uniqKey="Lee H">H. Lee</name>
</author>
<author><name sortKey="Eun Jin, B" uniqKey="Eun Jin B">B. Eun-Jin</name>
</author>
<author><name sortKey="Christina, P" uniqKey="Christina P">P. Christina</name>
</author>
<author><name sortKey="Edward, R" uniqKey="Edward R">R. Edward</name>
</author>
<author><name sortKey="Leslie, C" uniqKey="Leslie C">C. Leslie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doyle, K M" uniqKey="Doyle K">K. M. Doyle</name>
</author>
<author><name sortKey="Kennedy, D" uniqKey="Kennedy D">D. Kennedy</name>
</author>
<author><name sortKey="Gorman, A M" uniqKey="Gorman A">A. M. Gorman</name>
</author>
<author><name sortKey="Gupta, S" uniqKey="Gupta S">S. Gupta</name>
</author>
<author><name sortKey="Healy, S J" uniqKey="Healy S">S. J. Healy</name>
</author>
<author><name sortKey="Samali, A" uniqKey="Samali A">A. Samali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Agnaf, O M" uniqKey="El Agnaf O">O. M. El-Agnaf</name>
</author>
<author><name sortKey="Salem, S A" uniqKey="Salem S">S. A. Salem</name>
</author>
<author><name sortKey="Paleologou, K E" uniqKey="Paleologou K">K. E. Paleologou</name>
</author>
<author><name sortKey="Curran, M D" uniqKey="Curran M">M. D. Curran</name>
</author>
<author><name sortKey="Gibson, M J" uniqKey="Gibson M">M. J. Gibson</name>
</author>
<author><name sortKey="Court, J A" uniqKey="Court J">J. A. Court</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feng, L R" uniqKey="Feng L">L. R. Feng</name>
</author>
<author><name sortKey="Federoff, H J" uniqKey="Federoff H">H. J. Federoff</name>
</author>
<author><name sortKey="Vicini, S" uniqKey="Vicini S">S. Vicini</name>
</author>
<author><name sortKey="Maguire Zeiss, K A" uniqKey="Maguire Zeiss K">K. A. Maguire-Zeiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Freundt, E C" uniqKey="Freundt E">E. C. Freundt</name>
</author>
<author><name sortKey="Maynard, N" uniqKey="Maynard N">N. Maynard</name>
</author>
<author><name sortKey="Clancy, E K" uniqKey="Clancy E">E. K. Clancy</name>
</author>
<author><name sortKey="Roy, S" uniqKey="Roy S">S. Roy</name>
</author>
<author><name sortKey="Bousset, L" uniqKey="Bousset L">L. Bousset</name>
</author>
<author><name sortKey="Sourigues, Y" uniqKey="Sourigues Y">Y. Sourigues</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frost, B" uniqKey="Frost B">B. Frost</name>
</author>
<author><name sortKey="Diamond, M I" uniqKey="Diamond M">M. I. Diamond</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Furukawa, K" uniqKey="Furukawa K">K. Furukawa</name>
</author>
<author><name sortKey="Matsuzaki Kobayashi, M" uniqKey="Matsuzaki Kobayashi M">M. Matsuzaki-Kobayashi</name>
</author>
<author><name sortKey="Hasegawa, T" uniqKey="Hasegawa T">T. Hasegawa</name>
</author>
<author><name sortKey="Kikuchi, A" uniqKey="Kikuchi A">A. Kikuchi</name>
</author>
<author><name sortKey="Sugeno, N" uniqKey="Sugeno N">N. Sugeno</name>
</author>
<author><name sortKey="Itoyama, Y" uniqKey="Itoyama Y">Y. Itoyama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Greten Harrison, B" uniqKey="Greten Harrison B">B. Greten-Harrison</name>
</author>
<author><name sortKey="Polydoro, M" uniqKey="Polydoro M">M. Polydoro</name>
</author>
<author><name sortKey="Morimoto Tomita, M" uniqKey="Morimoto Tomita M">M. Morimoto-Tomita</name>
</author>
<author><name sortKey="Diao, L" uniqKey="Diao L">L. Diao</name>
</author>
<author><name sortKey="Williams, A M" uniqKey="Williams A">A. M. Williams</name>
</author>
<author><name sortKey="Nie, E H" uniqKey="Nie E">E. H. Nie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hansen, C" uniqKey="Hansen C">C. Hansen</name>
</author>
<author><name sortKey="Angot, E" uniqKey="Angot E">E. Angot</name>
</author>
<author><name sortKey="Bergstrom, A L" uniqKey="Bergstrom A">A. L. Bergstrom</name>
</author>
<author><name sortKey="Steiner, J A" uniqKey="Steiner J">J. A. Steiner</name>
</author>
<author><name sortKey="Pieri, L" uniqKey="Pieri L">L. Pieri</name>
</author>
<author><name sortKey="Paul, G" uniqKey="Paul G">G. Paul</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hara, S" uniqKey="Hara S">S. Hara</name>
</author>
<author><name sortKey="Arawaka, S" uniqKey="Arawaka S">S. Arawaka</name>
</author>
<author><name sortKey="Sato, H" uniqKey="Sato H">H. Sato</name>
</author>
<author><name sortKey="Machiya, Y" uniqKey="Machiya Y">Y. Machiya</name>
</author>
<author><name sortKey="Cui, C" uniqKey="Cui C">C. Cui</name>
</author>
<author><name sortKey="Sasaki, A" uniqKey="Sasaki A">A. Sasaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Irwin, D J" uniqKey="Irwin D">D. J. Irwin</name>
</author>
<author><name sortKey="Lee, V M" uniqKey="Lee V">V. M. Lee</name>
</author>
<author><name sortKey="Trojanowski, J Q" uniqKey="Trojanowski J">J. Q. Trojanowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jain, N" uniqKey="Jain N">N. Jain</name>
</author>
<author><name sortKey="Bhasne, K" uniqKey="Bhasne K">K. Bhasne</name>
</author>
<author><name sortKey="Hemaswasthi, M" uniqKey="Hemaswasthi M">M. Hemaswasthi</name>
</author>
<author><name sortKey="Mukhopadhyay, S" uniqKey="Mukhopadhyay S">S. Mukhopadhyay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jang, A" uniqKey="Jang A">A. Jang</name>
</author>
<author><name sortKey="Lee, H" uniqKey="Lee H">H. Lee</name>
</author>
<author><name sortKey="Suk, J" uniqKey="Suk J">J. Suk</name>
</author>
<author><name sortKey="Jung, J" uniqKey="Jung J">J. Jung</name>
</author>
<author><name sortKey="Kim, K" uniqKey="Kim K">K. Kim</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jang, H" uniqKey="Jang H">H. Jang</name>
</author>
<author><name sortKey="Zheng, J" uniqKey="Zheng J">J. Zheng</name>
</author>
<author><name sortKey="Nussinov, R" uniqKey="Nussinov R">R. Nussinov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J. Jankovic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jucker, M" uniqKey="Jucker M">M. Jucker</name>
</author>
<author><name sortKey="Walker, L C" uniqKey="Walker L">L. C. Walker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Junn, E" uniqKey="Junn E">E. Junn</name>
</author>
<author><name sortKey="Mouradian, M M" uniqKey="Mouradian M">M., M. Mouradian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, H Y" uniqKey="Kim H">H. Y. Kim</name>
</author>
<author><name sortKey="Cho, M K" uniqKey="Cho M">M. K. Cho</name>
</author>
<author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name>
</author>
<author><name sortKey="Maier, E" uniqKey="Maier E">E. Maier</name>
</author>
<author><name sortKey="Siebenhaar, C" uniqKey="Siebenhaar C">C. Siebenhaar</name>
</author>
<author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kosten, J" uniqKey="Kosten J">J. Kosten</name>
</author>
<author><name sortKey="Binolfi, A" uniqKey="Binolfi A">A. Binolfi</name>
</author>
<author><name sortKey="Stuiver, M" uniqKey="Stuiver M">M. Stuiver</name>
</author>
<author><name sortKey="Verzini, S" uniqKey="Verzini S">S. Verzini</name>
</author>
<author><name sortKey="Theillet, F X" uniqKey="Theillet F">F. X. Theillet</name>
</author>
<author><name sortKey="Bekei, B" uniqKey="Bekei B">B. Bekei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lashuel, H A" uniqKey="Lashuel H">H. A. Lashuel</name>
</author>
<author><name sortKey="Overk, C R" uniqKey="Overk C">C. R. Overk</name>
</author>
<author><name sortKey="Oueslati, A" uniqKey="Oueslati A">A. Oueslati</name>
</author>
<author><name sortKey="Masliah, E" uniqKey="Masliah E">E. Masliah</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lavedan, C" uniqKey="Lavedan C">C. Lavedan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, C" uniqKey="Lee C">C. Lee</name>
</author>
<author><name sortKey="Yu, M H H" uniqKey="Yu M">M.-H. H. Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, H J" uniqKey="Lee H">H. J. Lee</name>
</author>
<author><name sortKey="Cho, E D" uniqKey="Cho E">E. D. Cho</name>
</author>
<author><name sortKey="Lee, K W" uniqKey="Lee K">K. W. Lee</name>
</author>
<author><name sortKey="Kim, J H" uniqKey="Kim J">J. H. Kim</name>
</author>
<author><name sortKey="Cho, S G" uniqKey="Cho S">S. G. Cho</name>
</author>
<author><name sortKey="Lee, S J" uniqKey="Lee S">S. J. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, H J" uniqKey="Lee H">H. J. Lee</name>
</author>
<author><name sortKey="Patel, S" uniqKey="Patel S">S. Patel</name>
</author>
<author><name sortKey="Lee, S J" uniqKey="Lee S">S. J. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J Y" uniqKey="Li J">J. Y. Li</name>
</author>
<author><name sortKey="Englund, E" uniqKey="Englund E">E. Englund</name>
</author>
<author><name sortKey="Holton, J L" uniqKey="Holton J">J. L. Holton</name>
</author>
<author><name sortKey="Soulet, D" uniqKey="Soulet D">D. Soulet</name>
</author>
<author><name sortKey="Hagell, P" uniqKey="Hagell P">P. Hagell</name>
</author>
<author><name sortKey="Lees, A J" uniqKey="Lees A">A. J. Lees</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luk, K C" uniqKey="Luk K">K. C. Luk</name>
</author>
<author><name sortKey="Kehm, V" uniqKey="Kehm V">V. Kehm</name>
</author>
<author><name sortKey="Carroll, J" uniqKey="Carroll J">J. Carroll</name>
</author>
<author><name sortKey="Zhang, B" uniqKey="Zhang B">B. Zhang</name>
</author>
<author><name sortKey="O Brien, P" uniqKey="O Brien P">P. O'Brien</name>
</author>
<author><name sortKey="Trojanowski, J Q" uniqKey="Trojanowski J">J. Q. Trojanowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luk, K C" uniqKey="Luk K">K. C. Luk</name>
</author>
<author><name sortKey="Kehm, V M" uniqKey="Kehm V">V. M. Kehm</name>
</author>
<author><name sortKey="Zhang, B" uniqKey="Zhang B">B. Zhang</name>
</author>
<author><name sortKey="O Brien, P" uniqKey="O Brien P">P. O'Brien</name>
</author>
<author><name sortKey="Trojanowski, J Q" uniqKey="Trojanowski J">J. Q. Trojanowski</name>
</author>
<author><name sortKey="Lee, V M" uniqKey="Lee V">V. M. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luk, K C" uniqKey="Luk K">K. C. Luk</name>
</author>
<author><name sortKey="Song, C" uniqKey="Song C">C. Song</name>
</author>
<author><name sortKey="O Brien, P" uniqKey="O Brien P">P. O'Brien</name>
</author>
<author><name sortKey="Stieber, A" uniqKey="Stieber A">A. Stieber</name>
</author>
<author><name sortKey="Branch, J R" uniqKey="Branch J">J. R. Branch</name>
</author>
<author><name sortKey="Brunden, K R" uniqKey="Brunden K">K. R. Brunden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Masters, C S G" uniqKey="Masters C">C. S. G. Masters</name>
</author>
<author><name sortKey="Weiman, N A" uniqKey="Weiman N">N. A. Weiman</name>
</author>
<author><name sortKey="Multhaup, G" uniqKey="Multhaup G">G. Multhaup</name>
</author>
<author><name sortKey="Mcdonald, D L" uniqKey="Mcdonald D">D. L. McDonald</name>
</author>
<author><name sortKey="Beyreuther, K" uniqKey="Beyreuther K">K. Beyreuther</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mercuri, N B" uniqKey="Mercuri N">N. B. Mercuri</name>
</author>
<author><name sortKey="Bernardi, G" uniqKey="Bernardi G">G. Bernardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moreno Gonzalez, I" uniqKey="Moreno Gonzalez I">I. Moreno-Gonzalez</name>
</author>
<author><name sortKey="Soto, C" uniqKey="Soto C">C. Soto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munch, C" uniqKey="Munch C">C. Munch</name>
</author>
<author><name sortKey="Bertolotti, A" uniqKey="Bertolotti A">A. Bertolotti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Obeso, J A" uniqKey="Obeso J">J. A. Obeso</name>
</author>
<author><name sortKey="Rodriguez Oroz, M C" uniqKey="Rodriguez Oroz M">M. C. Rodriguez-Oroz</name>
</author>
<author><name sortKey="Goetz, C G" uniqKey="Goetz C">C. G. Goetz</name>
</author>
<author><name sortKey="Marin, C" uniqKey="Marin C">C. Marin</name>
</author>
<author><name sortKey="Kordower, J H" uniqKey="Kordower J">J. H. Kordower</name>
</author>
<author><name sortKey="Rodriguez, M" uniqKey="Rodriguez M">M. Rodriguez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pacheco, C" uniqKey="Pacheco C">C. Pacheco</name>
</author>
<author><name sortKey="Morales, C" uniqKey="Morales C">C. Morales</name>
</author>
<author><name sortKey="Ramirez, E A" uniqKey="Ramirez E">E. A. Ramirez</name>
</author>
<author><name sortKey="Mu Oz, F J" uniqKey="Mu Oz F">F. J. Muñoz</name>
</author>
<author><name sortKey="Gallegos, S" uniqKey="Gallegos S">S. Gallegos</name>
</author>
<author><name sortKey="Caviedes, P" uniqKey="Caviedes P">P. Caviedes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parihar, M S" uniqKey="Parihar M">M. S. Parihar</name>
</author>
<author><name sortKey="Parihar, A" uniqKey="Parihar A">A. Parihar</name>
</author>
<author><name sortKey="Fujita, M" uniqKey="Fujita M">M. Fujita</name>
</author>
<author><name sortKey="Hashimoto, M" uniqKey="Hashimoto M">M. Hashimoto</name>
</author>
<author><name sortKey="Ghafourifar, P" uniqKey="Ghafourifar P">P. Ghafourifar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parihar, M S" uniqKey="Parihar M">M. S. Parihar</name>
</author>
<author><name sortKey="Parihar, A" uniqKey="Parihar A">A. Parihar</name>
</author>
<author><name sortKey="Fujita, M" uniqKey="Fujita M">M. Fujita</name>
</author>
<author><name sortKey="Hashimoto, M" uniqKey="Hashimoto M">M. Hashimoto</name>
</author>
<author><name sortKey="Ghafourifar, P" uniqKey="Ghafourifar P">P. Ghafourifar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parodi, J" uniqKey="Parodi J">J. Parodi</name>
</author>
<author><name sortKey="Sepulveda, F J" uniqKey="Sepulveda F">F. J. Sepúlveda</name>
</author>
<author><name sortKey="Roa, J" uniqKey="Roa J">J. Roa</name>
</author>
<author><name sortKey="Opazo, C" uniqKey="Opazo C">C. Opazo</name>
</author>
<author><name sortKey="Inestrosa, N C" uniqKey="Inestrosa N">N. C. Inestrosa</name>
</author>
<author><name sortKey="Aguayo, L G" uniqKey="Aguayo L">L. G. Aguayo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Plotegher, N" uniqKey="Plotegher N">N. Plotegher</name>
</author>
<author><name sortKey="Greggio, E" uniqKey="Greggio E">E. Greggio</name>
</author>
<author><name sortKey="Bisaglia, M" uniqKey="Bisaglia M">M. Bisaglia</name>
</author>
<author><name sortKey="Bubacco, L" uniqKey="Bubacco L">L. Bubacco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ross, C A" uniqKey="Ross C">C. A. Ross</name>
</author>
<author><name sortKey="Poirier, M A" uniqKey="Poirier M">M. A. Poirier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sato, H" uniqKey="Sato H">H. Sato</name>
</author>
<author><name sortKey="Kato, T" uniqKey="Kato T">T. Kato</name>
</author>
<author><name sortKey="Arawaka, S" uniqKey="Arawaka S">S. Arawaka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schapira, A H" uniqKey="Schapira A">A. H. Schapira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schmidt, F" uniqKey="Schmidt F">F. Schmidt</name>
</author>
<author><name sortKey="Levin, J" uniqKey="Levin J">J. Levin</name>
</author>
<author><name sortKey="Kamp, F" uniqKey="Kamp F">F. Kamp</name>
</author>
<author><name sortKey="Kretzschmar, H" uniqKey="Kretzschmar H">H. Kretzschmar</name>
</author>
<author><name sortKey="Giese, A" uniqKey="Giese A">A. Giese</name>
</author>
<author><name sortKey="Botzel, K" uniqKey="Botzel K">K. Botzel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sepulveda, F J" uniqKey="Sepulveda F">F. J. Sepulveda</name>
</author>
<author><name sortKey="Fierro, H" uniqKey="Fierro H">H. Fierro</name>
</author>
<author><name sortKey="Fernandez, E" uniqKey="Fernandez E">E. Fernandez</name>
</author>
<author><name sortKey="Castillo, C" uniqKey="Castillo C">C. Castillo</name>
</author>
<author><name sortKey="Peoples, R W" uniqKey="Peoples R">R. W. Peoples</name>
</author>
<author><name sortKey="Opazo, C" uniqKey="Opazo C">C. Opazo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sepulveda, F J" uniqKey="Sepulveda F">F. J. Sepulveda</name>
</author>
<author><name sortKey="Parodi, J" uniqKey="Parodi J">J. Parodi</name>
</author>
<author><name sortKey="Peoples, R W" uniqKey="Peoples R">R. W. Peoples</name>
</author>
<author><name sortKey="Opazo, C" uniqKey="Opazo C">C. Opazo</name>
</author>
<author><name sortKey="Aguayo, L G" uniqKey="Aguayo L">L. G. Aguayo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singh, N" uniqKey="Singh N">N. Singh</name>
</author>
<author><name sortKey="Pillay, V" uniqKey="Pillay V">V. Pillay</name>
</author>
<author><name sortKey="Choonara, Y E" uniqKey="Choonara Y">Y. E. Choonara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, W W" uniqKey="Smith W">W. W. Smith</name>
</author>
<author><name sortKey="Jiang, H" uniqKey="Jiang H">H. Jiang</name>
</author>
<author><name sortKey="Pei, Z" uniqKey="Pei Z">Z. Pei</name>
</author>
<author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y. Tanaka</name>
</author>
<author><name sortKey="Morita, H" uniqKey="Morita H">H. Morita</name>
</author>
<author><name sortKey="Sawa, A" uniqKey="Sawa A">A. Sawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Soto, C" uniqKey="Soto C">C. Soto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Soto, C" uniqKey="Soto C">C. Soto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Soto, C" uniqKey="Soto C">C. Soto</name>
</author>
<author><name sortKey="Satani, N" uniqKey="Satani N">N. Satani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steiner, J A" uniqKey="Steiner J">J. A. Steiner</name>
</author>
<author><name sortKey="Angot, E" uniqKey="Angot E">E. Angot</name>
</author>
<author><name sortKey="Brundin, P" uniqKey="Brundin P">P. Brundin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stockl, M T" uniqKey="Stockl M">M. T. Stockl</name>
</author>
<author><name sortKey="Zijlstra, N" uniqKey="Zijlstra N">N. Zijlstra</name>
</author>
<author><name sortKey="Subramaniam, V" uniqKey="Subramaniam V">V. Subramaniam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tarazi, F I" uniqKey="Tarazi F">F. I. Tarazi</name>
</author>
<author><name sortKey="Sahli, Z T" uniqKey="Sahli Z">Z. T. Sahli</name>
</author>
<author><name sortKey="Wolny, M" uniqKey="Wolny M">M. Wolny</name>
</author>
<author><name sortKey="Mousa, S A" uniqKey="Mousa S">S. A. Mousa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tosatto, L" uniqKey="Tosatto L">L. Tosatto</name>
</author>
<author><name sortKey="Andrighetti, A O" uniqKey="Andrighetti A">A. O. Andrighetti</name>
</author>
<author><name sortKey="Plotegher, N" uniqKey="Plotegher N">N. Plotegher</name>
</author>
<author><name sortKey="Antonini, V" uniqKey="Antonini V">V. Antonini</name>
</author>
<author><name sortKey="Tessari, I" uniqKey="Tessari I">I. Tessari</name>
</author>
<author><name sortKey="Ricci, L" uniqKey="Ricci L">L. Ricci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsigelny, I F" uniqKey="Tsigelny I">I. F. Tsigelny</name>
</author>
<author><name sortKey="Bar On, P" uniqKey="Bar On P">P. Bar-On</name>
</author>
<author><name sortKey="Sharikov, Y" uniqKey="Sharikov Y">Y. Sharikov</name>
</author>
<author><name sortKey="Crews, L" uniqKey="Crews L">L. Crews</name>
</author>
<author><name sortKey="Hashimoto, M" uniqKey="Hashimoto M">M. Hashimoto</name>
</author>
<author><name sortKey="Miller, M A" uniqKey="Miller M">M. A. Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsigelny, I F" uniqKey="Tsigelny I">I. F. Tsigelny</name>
</author>
<author><name sortKey="Sharikov, Y" uniqKey="Sharikov Y">Y. Sharikov</name>
</author>
<author><name sortKey="Wrasidlo, W" uniqKey="Wrasidlo W">W. Wrasidlo</name>
</author>
<author><name sortKey="Gonzalez, T" uniqKey="Gonzalez T">T. Gonzalez</name>
</author>
<author><name sortKey="Desplats, P A" uniqKey="Desplats P">P. A. Desplats</name>
</author>
<author><name sortKey="Crews, L" uniqKey="Crews L">L. Crews</name>
</author>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Ulmer, T S" uniqKey="Ulmer T">T. S. Ulmer</name>
</author>
<author><name sortKey="Bax, A" uniqKey="Bax A">A. Bax</name>
</author>
<author><name sortKey="Cole, N B" uniqKey="Cole N">N. B. Cole</name>
</author>
<author><name sortKey="Nussbaum, R L" uniqKey="Nussbaum R">R. L. Nussbaum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Volpicelli Daley, L A" uniqKey="Volpicelli Daley L">L. A. Volpicelli-Daley</name>
</author>
<author><name sortKey="Luk, K C" uniqKey="Luk K">K. C. Luk</name>
</author>
<author><name sortKey="Patel, T P" uniqKey="Patel T">T. P. Patel</name>
</author>
<author><name sortKey="Tanik, S A" uniqKey="Tanik S">S. A. Tanik</name>
</author>
<author><name sortKey="Riddle, D M" uniqKey="Riddle D">D. M. Riddle</name>
</author>
<author><name sortKey="Stieber, A" uniqKey="Stieber A">A. Stieber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Walker, D G" uniqKey="Walker D">D. G. Walker</name>
</author>
<author><name sortKey="Lue, L F" uniqKey="Lue L">L. F. Lue</name>
</author>
<author><name sortKey="Adler, C H" uniqKey="Adler C">C. H. Adler</name>
</author>
<author><name sortKey="Shill, H A" uniqKey="Shill H">H. A. Shill</name>
</author>
<author><name sortKey="Caviness, J N" uniqKey="Caviness J">J. N. Caviness</name>
</author>
<author><name sortKey="Sabbagh, M N" uniqKey="Sabbagh M">M. N. Sabbagh</name>
</author>
</analytic>
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