Class-specific antibody responses in school children vaccinated with an A/Brazil/11/78 (H1N1)-like recombinant influenza virus prepared from the A/Leningrad/134/57 paediatric cold-adapted donor strain.
Identifieur interne : 000479 ( PubMed/Curation ); précédent : 000478; suivant : 000480Class-specific antibody responses in school children vaccinated with an A/Brazil/11/78 (H1N1)-like recombinant influenza virus prepared from the A/Leningrad/134/57 paediatric cold-adapted donor strain.
Auteurs : A N Slepushkin [Russie] ; P A Patriarca ; N P Obrosova-Serova ; M W Harmon ; L N Kupryashina ; S G Cheshik ; R B Vartanyan ; G I Alexandrova ; F I Polezhaev ; N I LonskayaSource :
- Vaccine [ 0264-410X ] ; 1988.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (analyse), Enfant, Humains, Immunoglobuline A (immunologie), Immunoglobuline G (immunologie), Recombinaison génétique, Sous-type H1N1 du virus de la grippe A, Spécificité des anticorps, Tests d'inhibition de l'hémagglutination, Vaccination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- analyse : Anticorps antiviraux.
- génétique : Virus de la grippe A.
- immunologie : Immunoglobuline A, Immunoglobuline G, Vaccins antigrippaux, Virus de la grippe A.
- Enfant, Humains, Recombinaison génétique, Sous-type H1N1 du virus de la grippe A, Spécificité des anticorps, Tests d'inhibition de l'hémagglutination, Vaccination.
English descriptors
- KwdEn :
- Antibodies, Viral (analysis), Antibody Specificity, Child, Hemagglutination Inhibition Tests, Humans, Immunoglobulin A (immunology), Immunoglobulin G (immunology), Influenza A Virus, H1N1 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Recombination, Genetic, Vaccination.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , analysis : Antibodies, Viral.
- chemical , immunology : Immunoglobulin A, Immunoglobulin G, Influenza Vaccines.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- Antibody Specificity, Child, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H1N1 Subtype, Recombination, Genetic, Vaccination.
Abstract
Forty-three school children from 8 to 11 years old were vaccinated intranasally with two doses of a paediatric attenuated influenza vaccine developed by reassortment between cold-adapted A/Leningrad/134/57(H2N2) and an A/Brazil/11/78(H1N1)-like strain. Two vaccine doses were administered 1 month apart in a randomized, blind, placebo-controlled study. Although the first vaccine dose had a low infectivity titre, overall 65% of children who received two doses of vaccine showed serological evidence of infection by HI tests. Serum IgA antibody responses against the vaccine strain were detected in nearly 50% of the vaccines and serum IgG antibody responses were detected in approximately equal to 40% by an enzyme immunoassay.
DOI: 10.1016/0264-410x(88)90009-6
PubMed: 3354254
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Serova, N P" sort="Obrosova Serova, N P" uniqKey="Obrosova Serova N" first="N P" last="Obrosova-Serova">N P Obrosova-Serova</name></author><author><name sortKey="Harmon, M W" sort="Harmon, M W" uniqKey="Harmon M" first="M W" last="Harmon">M W Harmon</name></author><author><name sortKey="Kupryashina, L N" sort="Kupryashina, L N" uniqKey="Kupryashina L" first="L N" last="Kupryashina">L N Kupryashina</name></author><author><name sortKey="Cheshik, S G" sort="Cheshik, S G" uniqKey="Cheshik S" first="S G" last="Cheshik">S G Cheshik</name></author><author><name sortKey="Vartanyan, R B" sort="Vartanyan, R B" uniqKey="Vartanyan R" first="R B" last="Vartanyan">R B Vartanyan</name></author><author><name sortKey="Alexandrova, G I" sort="Alexandrova, G I" uniqKey="Alexandrova G" first="G I" last="Alexandrova">G I Alexandrova</name></author><author><name sortKey="Polezhaev, F I" sort="Polezhaev, F I" uniqKey="Polezhaev F" first="F I" last="Polezhaev">F I Polezhaev</name></author><author><name 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uniqKey="Slepushkin A" first="A N" last="Slepushkin">A N Slepushkin</name><affiliation wicri:level="3"><nlm:affiliation>D.I Ivanovsky Institute of Virology, Academy of Medical Sciences of the USSR, Moscow.</nlm:affiliation><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName><wicri:orgArea>D.I Ivanovsky Institute of Virology, Academy of Medical Sciences of the USSR</wicri:orgArea></affiliation></author><author><name sortKey="Patriarca, P A" sort="Patriarca, P A" uniqKey="Patriarca P" first="P A" last="Patriarca">P A Patriarca</name></author><author><name sortKey="Obrosova Serova, N P" sort="Obrosova Serova, N P" uniqKey="Obrosova Serova N" first="N P" last="Obrosova-Serova">N P Obrosova-Serova</name></author><author><name sortKey="Harmon, M W" sort="Harmon, M W" uniqKey="Harmon M" first="M W" last="Harmon">M W Harmon</name></author><author><name sortKey="Kupryashina, L N" sort="Kupryashina, L N" uniqKey="Kupryashina L" first="L N" last="Kupryashina">L N Kupryashina</name></author><author><name sortKey="Cheshik, S G" sort="Cheshik, S G" uniqKey="Cheshik S" first="S G" last="Cheshik">S G Cheshik</name></author><author><name sortKey="Vartanyan, R B" sort="Vartanyan, R B" uniqKey="Vartanyan R" first="R B" last="Vartanyan">R B Vartanyan</name></author><author><name sortKey="Alexandrova, G I" sort="Alexandrova, G I" uniqKey="Alexandrova G" first="G I" last="Alexandrova">G I Alexandrova</name></author><author><name sortKey="Polezhaev, F I" sort="Polezhaev, F I" uniqKey="Polezhaev F" first="F I" last="Polezhaev">F I Polezhaev</name></author><author><name sortKey="Lonskaya, N I" sort="Lonskaya, N I" uniqKey="Lonskaya N" first="N I" last="Lonskaya">N I Lonskaya</name></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="1988" type="published">1988</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (analysis)</term><term>Antibody Specificity</term><term>Child</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Immunoglobulin A (immunology)</term><term>Immunoglobulin G (immunology)</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (immunology)</term><term>Recombination, Genetic</term><term>Vaccination</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (analyse)</term><term>Enfant</term><term>Humains</term><term>Immunoglobuline A (immunologie)</term><term>Immunoglobuline G (immunologie)</term><term>Recombinaison génétique</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Spécificité des anticorps</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccination</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (immunologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Immunoglobulin A</term><term>Immunoglobulin G</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Immunoglobuline A</term><term>Immunoglobuline G</term><term>Vaccins antigrippaux</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Antibody Specificity</term><term>Child</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Recombination, Genetic</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Enfant</term><term>Humains</term><term>Recombinaison génétique</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Spécificité des anticorps</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Forty-three school children from 8 to 11 years old were vaccinated intranasally with two doses of a paediatric attenuated influenza vaccine developed by reassortment between cold-adapted A/Leningrad/134/57(H2N2) and an A/Brazil/11/78(H1N1)-like strain. Two vaccine doses were administered 1 month apart in a randomized, blind, placebo-controlled study. Although the first vaccine dose had a low infectivity titre, overall 65% of children who received two doses of vaccine showed serological evidence of infection by HI tests. Serum IgA antibody responses against the vaccine strain were detected in nearly 50% of the vaccines and serum IgG antibody responses were detected in approximately equal to 40% by an enzyme immunoassay.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3354254</PMID><DateCompleted><Year>1988</Year><Month>04</Month><Day>28</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>28</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0264-410X</ISSN><JournalIssue CitedMedium="Print"><Volume>6</Volume><Issue>1</Issue><PubDate><Year>1988</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Class-specific antibody responses in school children vaccinated with an A/Brazil/11/78 (H1N1)-like recombinant influenza virus prepared from the A/Leningrad/134/57 paediatric cold-adapted donor strain.</ArticleTitle><Pagination><MedlinePgn>25-8</MedlinePgn></Pagination><Abstract><AbstractText>Forty-three school children from 8 to 11 years old were vaccinated intranasally with two doses of a paediatric attenuated influenza vaccine developed by reassortment between cold-adapted A/Leningrad/134/57(H2N2) and an A/Brazil/11/78(H1N1)-like strain. Two vaccine doses were administered 1 month apart in a randomized, blind, placebo-controlled study. Although the first vaccine dose had a low infectivity titre, overall 65% of children who received two doses of vaccine showed serological evidence of infection by HI tests. Serum IgA antibody responses against the vaccine strain were detected in nearly 50% of the vaccines and serum IgG antibody responses were detected in approximately equal to 40% by an enzyme immunoassay.</AbstractText></Abstract><AuthorList CompleteYN="N"><Author ValidYN="Y"><LastName>Slepushkin</LastName><ForeName>A N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>D.I Ivanovsky Institute of Virology, Academy of Medical Sciences of the USSR, Moscow.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patriarca</LastName><ForeName>P A</ForeName><Initials>PA</Initials></Author><Author ValidYN="Y"><LastName>Obrosova-Serova</LastName><ForeName>N P</ForeName><Initials>NP</Initials></Author><Author ValidYN="Y"><LastName>Harmon</LastName><ForeName>M W</ForeName><Initials>MW</Initials></Author><Author ValidYN="Y"><LastName>Kupryashina</LastName><ForeName>L N</ForeName><Initials>LN</Initials></Author><Author ValidYN="Y"><LastName>Cheshik</LastName><ForeName>S G</ForeName><Initials>SG</Initials></Author><Author ValidYN="Y"><LastName>Vartanyan</LastName><ForeName>R B</ForeName><Initials>RB</Initials></Author><Author ValidYN="Y"><LastName>Alexandrova</LastName><ForeName>G I</ForeName><Initials>GI</Initials></Author><Author ValidYN="Y"><LastName>Polezhaev</LastName><ForeName>F I</ForeName><Initials>FI</Initials></Author><Author ValidYN="Y"><LastName>Lonskaya</LastName><ForeName>N I</ForeName><Initials>NI</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007070">Immunoglobulin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000918" MajorTopicYN="N">Antibody Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006385" MajorTopicYN="N">Hemagglutination Inhibition Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007070" MajorTopicYN="N">Immunoglobulin A</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011995" MajorTopicYN="N">Recombination, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="Y">Vaccination</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1988</Year><Month>2</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1988</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1988</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3354254</ArticleId><ArticleId IdType="pii">0264-410X(88)90009-6</ArticleId><ArticleId IdType="doi">10.1016/0264-410x(88)90009-6</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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