Class-specific antibody responses in school children vaccinated with an A/Brazil/11/78 (H1N1)-like recombinant influenza virus prepared from the A/Leningrad/134/57 paediatric cold-adapted donor strain.
Identifieur interne : 000479 ( PubMed/Corpus ); précédent : 000478; suivant : 000480Class-specific antibody responses in school children vaccinated with an A/Brazil/11/78 (H1N1)-like recombinant influenza virus prepared from the A/Leningrad/134/57 paediatric cold-adapted donor strain.
Auteurs : A N Slepushkin ; P A Patriarca ; N P Obrosova-Serova ; M W Harmon ; L N Kupryashina ; S G Cheshik ; R B Vartanyan ; G I Alexandrova ; F I Polezhaev ; N I LonskayaSource :
- Vaccine [ 0264-410X ] ; 1988.
English descriptors
- KwdEn :
- Antibodies, Viral (analysis), Antibody Specificity, Child, Hemagglutination Inhibition Tests, Humans, Immunoglobulin A (immunology), Immunoglobulin G (immunology), Influenza A Virus, H1N1 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Recombination, Genetic, Vaccination.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , analysis : Antibodies, Viral.
- chemical , immunology : Immunoglobulin A, Immunoglobulin G, Influenza Vaccines.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- Antibody Specificity, Child, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H1N1 Subtype, Recombination, Genetic, Vaccination.
Abstract
Forty-three school children from 8 to 11 years old were vaccinated intranasally with two doses of a paediatric attenuated influenza vaccine developed by reassortment between cold-adapted A/Leningrad/134/57(H2N2) and an A/Brazil/11/78(H1N1)-like strain. Two vaccine doses were administered 1 month apart in a randomized, blind, placebo-controlled study. Although the first vaccine dose had a low infectivity titre, overall 65% of children who received two doses of vaccine showed serological evidence of infection by HI tests. Serum IgA antibody responses against the vaccine strain were detected in nearly 50% of the vaccines and serum IgG antibody responses were detected in approximately equal to 40% by an enzyme immunoassay.
DOI: 10.1016/0264-410x(88)90009-6
PubMed: 3354254
Links to Exploration step
pubmed:3354254Le document en format XML
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<author><name sortKey="Obrosova Serova, N P" sort="Obrosova Serova, N P" uniqKey="Obrosova Serova N" first="N P" last="Obrosova-Serova">N P Obrosova-Serova</name>
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<term>Influenza A virus (immunology)</term>
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<term>Influenza Vaccines (immunology)</term>
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<term>Hemagglutination Inhibition Tests</term>
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<front><div type="abstract" xml:lang="en">Forty-three school children from 8 to 11 years old were vaccinated intranasally with two doses of a paediatric attenuated influenza vaccine developed by reassortment between cold-adapted A/Leningrad/134/57(H2N2) and an A/Brazil/11/78(H1N1)-like strain. Two vaccine doses were administered 1 month apart in a randomized, blind, placebo-controlled study. Although the first vaccine dose had a low infectivity titre, overall 65% of children who received two doses of vaccine showed serological evidence of infection by HI tests. Serum IgA antibody responses against the vaccine strain were detected in nearly 50% of the vaccines and serum IgG antibody responses were detected in approximately equal to 40% by an enzyme immunoassay.</div>
</front>
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<Abstract><AbstractText>Forty-three school children from 8 to 11 years old were vaccinated intranasally with two doses of a paediatric attenuated influenza vaccine developed by reassortment between cold-adapted A/Leningrad/134/57(H2N2) and an A/Brazil/11/78(H1N1)-like strain. Two vaccine doses were administered 1 month apart in a randomized, blind, placebo-controlled study. Although the first vaccine dose had a low infectivity titre, overall 65% of children who received two doses of vaccine showed serological evidence of infection by HI tests. Serum IgA antibody responses against the vaccine strain were detected in nearly 50% of the vaccines and serum IgG antibody responses were detected in approximately equal to 40% by an enzyme immunoassay.</AbstractText>
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