H2N2V1, PubMed, Corpus, bibRecord, 000404

Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?

Identifieur interne : 000404 ( PubMed/Corpus ); précédent : 000403; suivant : 000405

Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?

Auteurs : D. Cotter ; N. Takei ; M. Farrell ; P. Sham ; P. Quinn ; C. Larkin ; J. Oxford ; R M Murray ; E. O'Callaghan

Source :

Schizophrenia research [ 0920-9964 ] ; 1995.

RBID : pubmed:7488569

English descriptors

KwdEn :
- Animals, Disease Models, Animal, Female, Hippocampus (pathology), Influenza A virus, Male, Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (pathology), Pregnancy, Prenatal Exposure Delayed Effects, Pyramidal Cells (pathology).
MESH :
- pathology : Hippocampus, Orthomyxoviridae Infections, Pyramidal Cells.
- Animals, Disease Models, Animal, Female, Influenza A virus, Male, Mice, Mice, Inbred BALB C, Pregnancy, Prenatal Exposure Delayed Effects.

Abstract

Epidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9-16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.

DOI: 10.1016/0920-9964(94)e0082-i
PubMed: 7488569

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pubmed:7488569

Le document en format XML

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<author><name sortKey="Cotter, D" sort="Cotter, D" uniqKey="Cotter D" first="D" last="Cotter">D. Cotter</name>
<affiliation><nlm:affiliation>Cluain Mhuire Family Centre, Blackrock, Co Dublin, Ireland.</nlm:affiliation>
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<author><name sortKey="Takei, N" sort="Takei, N" uniqKey="Takei N" first="N" last="Takei">N. Takei</name>
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<author><name sortKey="Farrell, M" sort="Farrell, M" uniqKey="Farrell M" first="M" last="Farrell">M. Farrell</name>
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<author><name sortKey="Sham, P" sort="Sham, P" uniqKey="Sham P" first="P" last="Sham">P. Sham</name>
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<author><name sortKey="Quinn, P" sort="Quinn, P" uniqKey="Quinn P" first="P" last="Quinn">P. Quinn</name>
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<author><name sortKey="Larkin, C" sort="Larkin, C" uniqKey="Larkin C" first="C" last="Larkin">C. Larkin</name>
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<author><name sortKey="Oxford, J" sort="Oxford, J" uniqKey="Oxford J" first="J" last="Oxford">J. Oxford</name>
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<author><name sortKey="Murray, R M" sort="Murray, R M" uniqKey="Murray R" first="R M" last="Murray">R M Murray</name>
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<author><name sortKey="O Callaghan, E" sort="O Callaghan, E" uniqKey="O Callaghan E" first="E" last="O'Callaghan">E. O'Callaghan</name>
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<term>Influenza A virus</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Orthomyxoviridae Infections (pathology)</term>
<term>Pregnancy</term>
<term>Prenatal Exposure Delayed Effects</term>
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<term>Disease Models, Animal</term>
<term>Female</term>
<term>Influenza A virus</term>
<term>Male</term>
<term>Mice</term>
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<front><div type="abstract" xml:lang="en">Epidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9-16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.</div>
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<Title>Schizophrenia research</Title>
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<ArticleTitle>Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?</ArticleTitle>
<Pagination><MedlinePgn>233-41</MedlinePgn>
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<Abstract><AbstractText>Epidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9-16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.</AbstractText>
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<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Schizophr Res. 1996 Jul;21(1):63-4</RefSource>
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Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?

Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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