Infection of human retinal pigment epithelial cells with influenza A viruses.
Identifieur interne : 000209 ( PubMed/Checkpoint ); précédent : 000208; suivant : 000210Infection of human retinal pigment epithelial cells with influenza A viruses.
Auteurs : Martin Michaelis [Allemagne] ; Janina Geiler ; Denise Klassert ; Hans Wilhelm Doerr ; Jindrich CinatlSource :
- Investigative ophthalmology & visual science [ 1552-5783 ] ; 2009.
Descripteurs français
- KwdFr :
- ARN messager (métabolisme), Antiviraux (pharmacologie), Apoptose, Caspase-3 (métabolisme), Cellules cultivées, Chimiokines (métabolisme), Effet cytopathogène viral, Humains, Interféron de type I (pharmacologie), Interféron gamma (pharmacologie), RT-PCR, Relation dose-effet des médicaments, Ribavirine (pharmacologie), Réplication virale (), Réplication virale (physiologie), Sous-type H1N1 du virus de la grippe A (physiologie), Sous-type H2N2 du virus de la grippe A (physiologie), Sous-type H5N1 du virus de la grippe A (physiologie), Épithélium pigmentaire de la rétine (anatomopathologie), Épithélium pigmentaire de la rétine (virologie).
- MESH :
- anatomopathologie : Épithélium pigmentaire de la rétine.
- métabolisme : ARN messager, Caspase-3, Chimiokines.
- pharmacologie : Antiviraux, Interféron de type I, Interféron gamma, Ribavirine.
- physiologie : Réplication virale, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A.
- virologie : Épithélium pigmentaire de la rétine.
- Apoptose, Cellules cultivées, Effet cytopathogène viral, Humains, RT-PCR, Relation dose-effet des médicaments, Réplication virale.
English descriptors
- KwdEn :
- Antiviral Agents (pharmacology), Apoptosis, Caspase 3 (metabolism), Cells, Cultured, Chemokines (metabolism), Cytopathogenic Effect, Viral, Dose-Response Relationship, Drug, Humans, Influenza A Virus, H1N1 Subtype (physiology), Influenza A Virus, H2N2 Subtype (physiology), Influenza A Virus, H5N1 Subtype (physiology), Interferon Type I (pharmacology), Interferon-gamma (pharmacology), RNA, Messenger (metabolism), Retinal Pigment Epithelium (pathology), Retinal Pigment Epithelium (virology), Reverse Transcriptase Polymerase Chain Reaction, Ribavirin (pharmacology), Virus Replication (drug effects), Virus Replication (physiology).
- MESH :
- chemical , metabolism : Caspase 3, Chemokines, RNA, Messenger.
- chemical , pharmacology : Antiviral Agents, Interferon Type I, Interferon-gamma, Ribavirin.
- drug effects : Virus Replication.
- pathology : Retinal Pigment Epithelium.
- physiology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Virus Replication.
- virology : Retinal Pigment Epithelium.
- Apoptosis, Cells, Cultured, Cytopathogenic Effect, Viral, Dose-Response Relationship, Drug, Humans, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Ocular involvement in influenza A virus diseases is common but usually limited to mild conjunctivitis. Rarely, inflammation of the choriocapillaris may result in atrophia of the retinal pigment epithelium (RPE). Primary human retinal pigment epithelial (RPE) cells were infected with seasonal (H1N1 A/New Caledonia/20/99, H3N2 A/California/7/2004) or highly pathogenic avian H5N1 (A/Thailand/1(Kan-1)/04, A/Vietnam/1203/04, A/Vietnam/1194/04) influenza strains.
DOI: 10.1167/iovs.09-3752
PubMed: 19553611
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:19553611Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Infection of human retinal pigment epithelial cells with influenza A viruses.</title><author><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Medizinische Virologie, Klinikum der J. W. Goethe-Universität, Frankfurt-am-Main, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Medizinische Virologie, Klinikum der J. W. Goethe-Universität, Frankfurt-am-Main</wicri:regionArea><wicri:noRegion>Frankfurt-am-Main</wicri:noRegion><wicri:noRegion>Frankfurt-am-Main</wicri:noRegion><wicri:noRegion>Frankfurt-am-Main</wicri:noRegion></affiliation></author><author><name sortKey="Geiler, Janina" sort="Geiler, Janina" uniqKey="Geiler J" first="Janina" last="Geiler">Janina Geiler</name></author><author><name sortKey="Klassert, Denise" sort="Klassert, Denise" uniqKey="Klassert D" first="Denise" last="Klassert">Denise Klassert</name></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name></author><author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19553611</idno><idno type="pmid">19553611</idno><idno type="doi">10.1167/iovs.09-3752</idno><idno type="wicri:Area/PubMed/Corpus">000228</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000228</idno><idno type="wicri:Area/PubMed/Curation">000228</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000228</idno><idno type="wicri:Area/PubMed/Checkpoint">000209</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000209</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Infection of human retinal pigment epithelial cells with influenza A viruses.</title><author><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Medizinische Virologie, Klinikum der J. W. Goethe-Universität, Frankfurt-am-Main, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Medizinische Virologie, Klinikum der J. W. Goethe-Universität, Frankfurt-am-Main</wicri:regionArea><wicri:noRegion>Frankfurt-am-Main</wicri:noRegion><wicri:noRegion>Frankfurt-am-Main</wicri:noRegion><wicri:noRegion>Frankfurt-am-Main</wicri:noRegion></affiliation></author><author><name sortKey="Geiler, Janina" sort="Geiler, Janina" uniqKey="Geiler J" first="Janina" last="Geiler">Janina Geiler</name></author><author><name sortKey="Klassert, Denise" sort="Klassert, Denise" uniqKey="Klassert D" first="Denise" last="Klassert">Denise Klassert</name></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name></author><author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name></author></analytic><series><title level="j">Investigative ophthalmology & visual science</title><idno type="eISSN">1552-5783</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (pharmacology)</term><term>Apoptosis</term><term>Caspase 3 (metabolism)</term><term>Cells, Cultured</term><term>Chemokines (metabolism)</term><term>Cytopathogenic Effect, Viral</term><term>Dose-Response Relationship, Drug</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (physiology)</term><term>Influenza A Virus, H2N2 Subtype (physiology)</term><term>Influenza A Virus, H5N1 Subtype (physiology)</term><term>Interferon Type I (pharmacology)</term><term>Interferon-gamma (pharmacology)</term><term>RNA, Messenger (metabolism)</term><term>Retinal Pigment Epithelium (pathology)</term><term>Retinal Pigment Epithelium (virology)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Ribavirin (pharmacology)</term><term>Virus Replication (drug effects)</term><term>Virus Replication (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (métabolisme)</term><term>Antiviraux (pharmacologie)</term><term>Apoptose</term><term>Caspase-3 (métabolisme)</term><term>Cellules cultivées</term><term>Chimiokines (métabolisme)</term><term>Effet cytopathogène viral</term><term>Humains</term><term>Interféron de type I (pharmacologie)</term><term>Interféron gamma (pharmacologie)</term><term>RT-PCR</term><term>Relation dose-effet des médicaments</term><term>Ribavirine (pharmacologie)</term><term>Réplication virale ()</term><term>Réplication virale (physiologie)</term><term>Sous-type H1N1 du virus de la grippe A (physiologie)</term><term>Sous-type H2N2 du virus de la grippe A (physiologie)</term><term>Sous-type H5N1 du virus de la grippe A (physiologie)</term><term>Épithélium pigmentaire de la rétine (anatomopathologie)</term><term>Épithélium pigmentaire de la rétine (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Caspase 3</term><term>Chemokines</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Interferon Type I</term><term>Interferon-gamma</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Épithélium pigmentaire de la rétine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Caspase-3</term><term>Chimiokines</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Retinal Pigment Epithelium</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Interféron de type I</term><term>Interféron gamma</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Réplication virale</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Épithélium pigmentaire de la rétine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Retinal Pigment Epithelium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Apoptosis</term><term>Cells, Cultured</term><term>Cytopathogenic Effect, Viral</term><term>Dose-Response Relationship, Drug</term><term>Humans</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term><term>Cellules cultivées</term><term>Effet cytopathogène viral</term><term>Humains</term><term>RT-PCR</term><term>Relation dose-effet des médicaments</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ocular involvement in influenza A virus diseases is common but usually limited to mild conjunctivitis. Rarely, inflammation of the choriocapillaris may result in atrophia of the retinal pigment epithelium (RPE). Primary human retinal pigment epithelial (RPE) cells were infected with seasonal (H1N1 A/New Caledonia/20/99, H3N2 A/California/7/2004) or highly pathogenic avian H5N1 (A/Thailand/1(Kan-1)/04, A/Vietnam/1203/04, A/Vietnam/1194/04) influenza strains.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19553611</PMID><DateCompleted><Year>2009</Year><Month>12</Month><Day>04</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1552-5783</ISSN><JournalIssue CitedMedium="Internet"><Volume>50</Volume><Issue>11</Issue><PubDate><Year>2009</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Investigative ophthalmology & visual science</Title><ISOAbbreviation>Invest. Ophthalmol. Vis. Sci.</ISOAbbreviation></Journal><ArticleTitle>Infection of human retinal pigment epithelial cells with influenza A viruses.</ArticleTitle><Pagination><MedlinePgn>5419-25</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1167/iovs.09-3752</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Ocular involvement in influenza A virus diseases is common but usually limited to mild conjunctivitis. Rarely, inflammation of the choriocapillaris may result in atrophia of the retinal pigment epithelium (RPE). Primary human retinal pigment epithelial (RPE) cells were infected with seasonal (H1N1 A/New Caledonia/20/99, H3N2 A/California/7/2004) or highly pathogenic avian H5N1 (A/Thailand/1(Kan-1)/04, A/Vietnam/1203/04, A/Vietnam/1194/04) influenza strains.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Influenza A virus replication was studied by investigation of cytopathogenic effects, immune staining for influenza A virus nucleoprotein, determination of virus titers, and electron microscopy. Apoptosis induction was examined by immune staining for activated caspase 3 and cleaved PARP. Proinflammatory gene expression was investigated by quantitative PCR.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">H5N1 but not seasonal influenza strains replicated to high titers (>10(8) TCID(50)/mL; 50% tissue culture infectious dose/milliliter) in RPE cells. H5N1 infection resulted in RPE cell apoptosis that was abolished by the antiviral drug ribavirin. Pretreatment with type I interferons (interferon-alpha and -beta) or the type II interferon, (interferon-gamma), inhibited H5N1 replication. Moreover, H5N1 infection induced expression of proinflammatory genes (tumor necrosis factor-alpha, CXCL8, CXCL10, CXCL11, and interleukin-6), which was inhibited by ribavirin in a concentration-dependent manner.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">A novel cell type derived from the central nervous system was permissive to H5N1 influenza virus replication. This findings supports those suggesting H5N1 influenza strains to own a greater potential to spread to nonrespiratory tissues than seasonal human influenza viruses. Moreover, the data warrant the further study of the role of influenza A virus replication in retinal diseases associated with influenza A virus infections.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Michaelis</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institut für Medizinische Virologie, Klinikum der J. W. Goethe-Universität, Frankfurt-am-Main, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geiler</LastName><ForeName>Janina</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Klassert</LastName><ForeName>Denise</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Doerr</LastName><ForeName>Hans Wilhelm</ForeName><Initials>HW</Initials></Author><Author ValidYN="Y"><LastName>Cinatl</LastName><ForeName>Jindrich</ForeName><Initials>J</Initials><Suffix>Jr</Suffix></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>06</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Invest Ophthalmol Vis Sci</MedlineTA><NlmUniqueID>7703701</NlmUniqueID><ISSNLinking>0146-0404</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018925">Chemokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007370">Interferon Type I</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>49717AWG6K</RegistryNumber><NameOfSubstance UI="D012254">Ribavirin</NameOfSubstance></Chemical><Chemical><RegistryNumber>82115-62-6</RegistryNumber><NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber><NameOfSubstance UI="D053148">Caspase 3</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053148" MajorTopicYN="N">Caspase 3</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018925" MajorTopicYN="N">Chemokines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003588" MajorTopicYN="N">Cytopathogenic Effect, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053121" MajorTopicYN="N">Influenza A Virus, H2N2 Subtype</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053124" MajorTopicYN="N">Influenza A Virus, H5N1 Subtype</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007370" MajorTopicYN="N">Interferon Type I</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055213" MajorTopicYN="N">Retinal Pigment Epithelium</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012254" MajorTopicYN="N">Ribavirin</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>6</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>6</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19553611</ArticleId><ArticleId IdType="pii">iovs.09-3752</ArticleId><ArticleId IdType="doi">10.1167/iovs.09-3752</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name><name sortKey="Geiler, Janina" sort="Geiler, Janina" uniqKey="Geiler J" first="Janina" last="Geiler">Janina Geiler</name><name sortKey="Klassert, Denise" sort="Klassert, Denise" uniqKey="Klassert D" first="Denise" last="Klassert">Denise Klassert</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000209 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000209 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:19553611
|texte= Infection of human retinal pigment epithelial cells with influenza A viruses.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:19553611" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |