H2N2V1, PubMed, Checkpoint, bibRecord, 000200

The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus.

Identifieur interne : 000200 ( PubMed/Checkpoint ); précédent : 000199; suivant : 000201

The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus.

Auteurs : Amorsolo L. Suguitan [États-Unis] ; Michael P. Marino ; Purvi D. Desai ; Li-Mei Chen ; Yumiko Matsuoka ; Ruben O. Donis ; Hong Jin ; David E. Swayne ; George Kemble ; Kanta Subbarao

Source :

Virology [ 1096-0341 ] ; 2009.

RBID : pubmed:19833372

Descripteurs français

English descriptors

KwdEn :
- Adaptation, Physiological, Amino Acid Sequence, Animals, Base Sequence, Chickens, Cold Temperature, DNA, Viral, Drug Administration Schedule, Female, Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Influenza A Virus, H5N1 Subtype (physiology), Influenza Vaccines (immunology), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (prevention & control), Recombinant Proteins, Vaccines, Attenuated (immunology), Viral Proteins.
MESH :
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , immunology : Influenza Vaccines, Vaccines, Attenuated.
- chemical : DNA, Viral, Recombinant Proteins, Viral Proteins.
- physiology : Influenza A Virus, H5N1 Subtype.
- prevention & control : Orthomyxoviridae Infections.
- Adaptation, Physiological, Amino Acid Sequence, Animals, Base Sequence, Chickens, Cold Temperature, Drug Administration Schedule, Female, Mice, Mice, Inbred BALB C.

Abstract

A recombinant live attenuated influenza virus DeltaH5N1 vaccine with a modified hemagglutinin (HA) and intact neuraminidase genes from A/Vietnam/1203/04 (H5N1) and six remaining genome segments from A/Ann Arbor/6/60 (H2N2) cold-adapted (AA ca) virus was previously shown to be attenuated in chickens, mice and ferrets. Evaluation of the recombinant H5N1 viruses in mice indicated that three independent factors contributed to the attenuation of the DeltaH5N1 vaccine: the attenuating mutations specified by the AA ca loci had the greatest influence, followed by the deletion of the H5 HA multi-basic cleavage site (MBS), and the constellation effects of the AA genes acting in concert with the H5N1 glycoproteins. Restoring the MBS in the H5 HA of the vaccine virus improved its immunogenicity and efficacy, likely as a consequence of increased virus replication, indicating that removal of the MBS had a deleterious effect on the immunogenicity and efficacy of the DeltaH5N1 vaccine in mice.

DOI: 10.1016/j.virol.2009.09.017
PubMed: 19833372

Affiliations:

États-Unis

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000220
to stream PubMed, to step Curation: 000220

Links to Exploration step

pubmed:19833372

Le document en format XML

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<front><div type="abstract" xml:lang="en">A recombinant live attenuated influenza virus DeltaH5N1 vaccine with a modified hemagglutinin (HA) and intact neuraminidase genes from A/Vietnam/1203/04 (H5N1) and six remaining genome segments from A/Ann Arbor/6/60 (H2N2) cold-adapted (AA ca) virus was previously shown to be attenuated in chickens, mice and ferrets. Evaluation of the recombinant H5N1 viruses in mice indicated that three independent factors contributed to the attenuation of the DeltaH5N1 vaccine: the attenuating mutations specified by the AA ca loci had the greatest influence, followed by the deletion of the H5 HA multi-basic cleavage site (MBS), and the constellation effects of the AA genes acting in concert with the H5N1 glycoproteins. Restoring the MBS in the H5 HA of the vaccine virus improved its immunogenicity and efficacy, likely as a consequence of increased virus replication, indicating that removal of the MBS had a deleterious effect on the immunogenicity and efficacy of the DeltaH5N1 vaccine in mice.</div>
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<Abstract><AbstractText>A recombinant live attenuated influenza virus DeltaH5N1 vaccine with a modified hemagglutinin (HA) and intact neuraminidase genes from A/Vietnam/1203/04 (H5N1) and six remaining genome segments from A/Ann Arbor/6/60 (H2N2) cold-adapted (AA ca) virus was previously shown to be attenuated in chickens, mice and ferrets. Evaluation of the recombinant H5N1 viruses in mice indicated that three independent factors contributed to the attenuation of the DeltaH5N1 vaccine: the attenuating mutations specified by the AA ca loci had the greatest influence, followed by the deletion of the H5 HA multi-basic cleavage site (MBS), and the constellation effects of the AA genes acting in concert with the H5N1 glycoproteins. Restoring the MBS in the H5 HA of the vaccine virus improved its immunogenicity and efficacy, likely as a consequence of increased virus replication, indicating that removal of the MBS had a deleterious effect on the immunogenicity and efficacy of the DeltaH5N1 vaccine in mice.</AbstractText>
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The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus.

The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus.

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