Low-dimensional clustering detects incipient dominant influenza strain clusters.
Identifieur interne : 000179 ( PubMed/Checkpoint ); précédent : 000178; suivant : 000180Low-dimensional clustering detects incipient dominant influenza strain clusters.
Auteurs : Jiankui He [États-Unis] ; Michael W. DeemSource :
- Protein engineering, design & selection : PEDS [ 1741-0134 ] ; 2010.
Descripteurs français
- KwdFr :
- Algorithmes, Analyse de regroupements, Biologie informatique, Flambées de maladies, Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Modèles biologiques, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (), Sous-type H3N2 du virus de la grippe A (génétique), Évolution moléculaire.
- MESH :
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- métabolisme : Glycoprotéine hémagglutinine du virus influenza.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine.
- Algorithmes, Analyse de regroupements, Biologie informatique, Flambées de maladies, Humains, Modèles biologiques, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Évolution moléculaire.
English descriptors
- KwdEn :
- Algorithms, Cluster Analysis, Computational Biology, Disease Outbreaks, Evolution, Molecular, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Humans, Influenza A Virus, H1N1 Subtype (chemistry), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H3N2 Subtype (chemistry), Influenza A Virus, H3N2 Subtype (genetics), Influenza, Human (epidemiology), Influenza, Human (virology), Models, Biological.
- MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus.
- chemistry : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype.
- virology : Influenza, Human.
- Algorithms, Cluster Analysis, Computational Biology, Disease Outbreaks, Evolution, Molecular, Humans, Models, Biological.
Abstract
Influenza has been circulating in the human population and has caused three pandemics in the last century (1918 H1N1, 1957 H2N2 and 1968 H3N2). The 2009 A(H1N1) was classified by World Health Organization as the fourth pandemic. Influenza has a high evolution rate, which makes vaccine design challenging. We here consider an approach for early detection of new dominant strains. By clustering the 2009 A(H1N1) sequence data, we found two main clusters. We then define a metric to detect the emergence of dominant strains. We show on historical H3N2 data that this method is able to identify a cluster around an incipient dominant strain before it becomes dominant. For example, for H3N2 as of 30 March 2009, the method detects the cluster for the new A/British Columbia/RV1222/2009 strain. This strain detection tool would appear to be useful for annual influenza vaccine selection.
DOI: 10.1093/protein/gzq078
PubMed: 21036781
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:21036781Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Low-dimensional clustering detects incipient dominant influenza strain clusters.</title><author><name sortKey="He, Jiankui" sort="He, Jiankui" uniqKey="He J" first="Jiankui" last="He">Jiankui He</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physics & Astronomy, Rice University, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physics & Astronomy, Rice University, Houston, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation></author><author><name sortKey="Deem, Michael W" sort="Deem, Michael W" uniqKey="Deem M" first="Michael W" last="Deem">Michael W. Deem</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:21036781</idno><idno type="pmid">21036781</idno><idno type="doi">10.1093/protein/gzq078</idno><idno type="wicri:Area/PubMed/Corpus">000188</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000188</idno><idno type="wicri:Area/PubMed/Curation">000188</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000188</idno><idno type="wicri:Area/PubMed/Checkpoint">000179</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000179</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Low-dimensional clustering detects incipient dominant influenza strain clusters.</title><author><name sortKey="He, Jiankui" sort="He, Jiankui" uniqKey="He J" first="Jiankui" last="He">Jiankui He</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physics & Astronomy, Rice University, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physics & Astronomy, Rice University, Houston, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation></author><author><name sortKey="Deem, Michael W" sort="Deem, Michael W" uniqKey="Deem M" first="Michael W" last="Deem">Michael W. Deem</name></author></analytic><series><title level="j">Protein engineering, design & selection : PEDS</title><idno type="eISSN">1741-0134</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term><term>Cluster Analysis</term><term>Computational Biology</term><term>Disease Outbreaks</term><term>Evolution, Molecular</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (metabolism)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (chemistry)</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H3N2 Subtype (chemistry)</term><term>Influenza A Virus, H3N2 Subtype (genetics)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Models, Biological</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Algorithmes</term><term>Analyse de regroupements</term><term>Biologie informatique</term><term>Flambées de maladies</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Glycoprotéine hémagglutinine du virus influenza (métabolisme)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Modèles biologiques</term><term>Sous-type H1N1 du virus de la grippe A ()</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H3N2 du virus de la grippe A ()</term><term>Sous-type H3N2 du virus de la grippe A (génétique)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Cluster Analysis</term><term>Computational Biology</term><term>Disease Outbreaks</term><term>Evolution, Molecular</term><term>Humans</term><term>Models, Biological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Algorithmes</term><term>Analyse de regroupements</term><term>Biologie informatique</term><term>Flambées de maladies</term><term>Humains</term><term>Modèles biologiques</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza has been circulating in the human population and has caused three pandemics in the last century (1918 H1N1, 1957 H2N2 and 1968 H3N2). The 2009 A(H1N1) was classified by World Health Organization as the fourth pandemic. Influenza has a high evolution rate, which makes vaccine design challenging. We here consider an approach for early detection of new dominant strains. By clustering the 2009 A(H1N1) sequence data, we found two main clusters. We then define a metric to detect the emergence of dominant strains. We show on historical H3N2 data that this method is able to identify a cluster around an incipient dominant strain before it becomes dominant. For example, for H3N2 as of 30 March 2009, the method detects the cluster for the new A/British Columbia/RV1222/2009 strain. This strain detection tool would appear to be useful for annual influenza vaccine selection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21036781</PMID><DateCompleted><Year>2011</Year><Month>02</Month><Day>24</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1741-0134</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>12</Issue><PubDate><Year>2010</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Protein engineering, design & selection : PEDS</Title><ISOAbbreviation>Protein Eng. Des. Sel.</ISOAbbreviation></Journal><ArticleTitle>Low-dimensional clustering detects incipient dominant influenza strain clusters.</ArticleTitle><Pagination><MedlinePgn>935-46</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/protein/gzq078</ELocationID><Abstract><AbstractText>Influenza has been circulating in the human population and has caused three pandemics in the last century (1918 H1N1, 1957 H2N2 and 1968 H3N2). The 2009 A(H1N1) was classified by World Health Organization as the fourth pandemic. Influenza has a high evolution rate, which makes vaccine design challenging. We here consider an approach for early detection of new dominant strains. By clustering the 2009 A(H1N1) sequence data, we found two main clusters. We then define a metric to detect the emergence of dominant strains. We show on historical H3N2 data that this method is able to identify a cluster around an incipient dominant strain before it becomes dominant. For example, for H3N2 as of 30 March 2009, the method detects the cluster for the new A/British Columbia/RV1222/2009 strain. This strain detection tool would appear to be useful for annual influenza vaccine selection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>He</LastName><ForeName>Jiankui</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Physics & Astronomy, Rice University, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deem</LastName><ForeName>Michael W</ForeName><Initials>MW</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>10</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Protein Eng Des Sel</MedlineTA><NlmUniqueID>101186484</NlmUniqueID><ISSNLinking>1741-0126</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000465" MajorTopicYN="N">Algorithms</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016000" MajorTopicYN="N">Cluster Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019295" MajorTopicYN="N">Computational Biology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="Y">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="N">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>11</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>11</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>2</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21036781</ArticleId><ArticleId IdType="pii">gzq078</ArticleId><ArticleId IdType="doi">10.1093/protein/gzq078</ArticleId><ArticleId IdType="pmc">PMC2978544</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Wkly Epidemiol Rec. 2007 Mar 2;82(9):69-74</Citation><ArticleIdList><ArticleId IdType="pubmed">17333570</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Genet. 2007 Mar;8(3):196-205</Citation><ArticleIdList><ArticleId IdType="pubmed">17262054</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 2008 Feb 29;83(9):77-81</Citation><ArticleIdList><ArticleId IdType="pubmed">18309578</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2008 Apr 18;320(5874):340-6</Citation><ArticleIdList><ArticleId IdType="pubmed">18420927</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2008 Sep 12;26 Suppl 4:D31-4</Citation><ArticleIdList><ArticleId IdType="pubmed">19230156</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 2009 Feb 27;84(9):65-72</Citation><ArticleIdList><ArticleId IdType="pubmed">19248288</ArticleId></ArticleIdList></Reference><Reference><Citation>Influenza Other Respir Viruses. 2008 Jul;2(4):131-4</Citation><ArticleIdList><ArticleId IdType="pubmed">19453464</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2009 Jun 19;324(5934):1557-61</Citation><ArticleIdList><ArticleId IdType="pubmed">19433588</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2009 Jun 25;459(7250):1122-5</Citation><ArticleIdList><ArticleId IdType="pubmed">19516283</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2009 Jul 10;325(5937):197-201</Citation><ArticleIdList><ArticleId IdType="pubmed">19465683</ArticleId></ArticleIdList></Reference><Reference><Citation>Protein Eng Des Sel. 2009 Sep;22(9):543-6</Citation><ArticleIdList><ArticleId IdType="pubmed">19578121</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 2010 Mar 5;85(10):81-92</Citation><ArticleIdList><ArticleId IdType="pubmed">20210260</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13910-3</Citation><ArticleIdList><ArticleId IdType="pubmed">10570172</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 2001 Feb 23;76(8):57</Citation><ArticleIdList><ArticleId IdType="pubmed">11236647</ArticleId></ArticleIdList></Reference><Reference><Citation>J Theor Biol. 2001 Sep 7;212(1):57-69</Citation><ArticleIdList><ArticleId IdType="pubmed">11527445</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6263-8</Citation><ArticleIdList><ArticleId IdType="pubmed">11972025</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2002 Aug 15;35(4):370-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12145718</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2003 Mar 27;422(6930):428-33</Citation><ArticleIdList><ArticleId IdType="pubmed">12660783</ArticleId></ArticleIdList></Reference><Reference><Citation>MMWR Morb Mortal Wkly Rep. 2004 Jan 16;53(1):8-11</Citation><ArticleIdList><ArticleId IdType="pubmed">14724559</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 2004 Feb 27;79(9):85-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15038064</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2004 Jul 16;305(5682):371-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15218094</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 1995 Feb 24;70(8):53-6</Citation><ArticleIdList><ArticleId IdType="pubmed">7537515</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 1996 Feb 23;71(8):57-61</Citation><ArticleIdList><ArticleId IdType="pubmed">8695344</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 1997 Feb 28;72(9):57-61</Citation><ArticleIdList><ArticleId IdType="pubmed">9057482</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7712-8</Citation><ArticleIdList><ArticleId IdType="pubmed">9223253</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 1998 Feb 27;73(9):56-61</Citation><ArticleIdList><ArticleId IdType="pubmed">9523511</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1998 May 8;280(5365):912-5</Citation><ArticleIdList><ArticleId IdType="pubmed">9572737</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 1998 Jul-Sep;4(3):436-41</Citation><ArticleIdList><ArticleId IdType="pubmed">9716966</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 1999 Feb 26;74(8):57-61</Citation><ArticleIdList><ArticleId IdType="pubmed">10079754</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 2005 Feb 25;80(8):65</Citation><ArticleIdList><ArticleId IdType="pubmed">15771205</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2005 Oct 20;437(7062):1162-6</Citation><ArticleIdList><ArticleId IdType="pubmed">16208317</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 2005 Oct 7;80(40):341-2</Citation><ArticleIdList><ArticleId IdType="pubmed">16240984</ArticleId></ArticleIdList></Reference><Reference><Citation>Commun Dis Intell Q Rep. 2006;30(1):137-43</Citation><ArticleIdList><ArticleId IdType="pubmed">16637243</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 2006 Mar 3;81(9):81-2</Citation><ArticleIdList><ArticleId IdType="pubmed">16671217</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2006 May 1;24(18):3881-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16460844</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2008 Jan;82(2):596-601</Citation><ArticleIdList><ArticleId IdType="pubmed">17942553</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Deem, Michael W" sort="Deem, Michael W" uniqKey="Deem M" first="Michael W" last="Deem">Michael W. Deem</name></noCountry><country name="États-Unis"><noRegion><name sortKey="He, Jiankui" sort="He, Jiankui" uniqKey="He J" first="Jiankui" last="He">Jiankui He</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000179 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000179 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:21036781
|texte= Low-dimensional clustering detects incipient dominant influenza strain clusters.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:21036781" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |