Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model.
Identifieur interne : 000178 ( PubMed/Checkpoint ); précédent : 000177; suivant : 000179Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model.
Auteurs : J Theo M. Voeten [Pays-Bas] ; Irina V. Kiseleva ; Harrie L. Glansbeek ; Stephanie M C. Basten ; Sandra K M. Drieszen-Van Der Cruijsen ; Larisa G. Rudenko ; Han Van Den Bosch ; Jacco G M. HeldensSource :
- Archives of virology [ 1432-8798 ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux, Chiens, Embryon de poulet, Encéphale (anatomopathologie), Encéphale (virologie), Femelle, Grippe humaine (), Grippe humaine (anatomopathologie), Grippe humaine (virologie), Humains, Lignée cellulaire, Modèles animaux de maladie humaine, Souris, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (pathogénicité), Sous-type H2N2 du virus de la grippe A (physiologie), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (génétique), Vaccins atténués (immunologie), Virulence, Virus influenza B (génétique), Virus influenza B (immunologie), Virus influenza B (pathogénicité), Virus influenza B (physiologie), Virus recombinants (génétique), Virus recombinants (immunologie), Virus recombinants (pathogénicité), Virus recombinants (physiologie).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués.
- anatomopathologie : Encéphale, Grippe humaine.
- génétique : Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Virus influenza B, Virus recombinants.
- immunologie : Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Virus influenza B, Virus recombinants.
- pathogénicité : Sous-type H2N2 du virus de la grippe A, Virus influenza B, Virus recombinants.
- physiologie : Sous-type H2N2 du virus de la grippe A, Virus influenza B, Virus recombinants.
- virologie : Encéphale, Grippe humaine.
- Animaux, Chiens, Embryon de poulet, Femelle, Grippe humaine, Humains, Lignée cellulaire, Modèles animaux de maladie humaine, Souris, Virulence.
English descriptors
- KwdEn :
- Animals, Brain (pathology), Brain (virology), Cell Line, Chick Embryo, Disease Models, Animal, Dogs, Female, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H2N2 Subtype (pathogenicity), Influenza A Virus, H2N2 Subtype (physiology), Influenza B virus (genetics), Influenza B virus (immunology), Influenza B virus (pathogenicity), Influenza B virus (physiology), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza, Human (pathology), Influenza, Human (prevention & control), Influenza, Human (virology), Mice, Reassortant Viruses (genetics), Reassortant Viruses (immunology), Reassortant Viruses (pathogenicity), Reassortant Viruses (physiology), Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology), Virulence.
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated.
- genetics : Influenza A Virus, H2N2 Subtype, Influenza B virus, Influenza Vaccines, Reassortant Viruses, Vaccines, Attenuated.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza B virus, Influenza Vaccines, Reassortant Viruses, Vaccines, Attenuated.
- pathogenicity : Influenza A Virus, H2N2 Subtype, Influenza B virus, Reassortant Viruses.
- pathology : Brain, Influenza, Human.
- physiology : Influenza A Virus, H2N2 Subtype, Influenza B virus, Reassortant Viruses.
- prevention & control : Influenza, Human.
- virology : Brain, Influenza, Human.
- Animals, Cell Line, Chick Embryo, Disease Models, Animal, Dogs, Female, Humans, Mice, Virulence.
Abstract
Demonstration of the absence of neurovirulent properties of reassortant viruses contained in live attenuated influenza vaccine (LAIV) is a regulatory requirement. A mouse model was used to detect neurovirulent properties of the cold-adapted, temperature-sensitive and attenuated influenza master donor viruses (MDVs) A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortant influenza viruses. A/NWS/33 (H1N1), which is known to be neurovirulent in mice, was used as a positive control. Under conditions where the positive control virus induced symptoms of disease and showed viral replication in the upper respiratory tract as well as in the brain, replication of the influenza master donor viruses and reassortant influenza A and B viruses was limited to the upper respiratory tract where they were administered. None of the mice inoculated with MDVs or reassortant influenza viruses suffered from disease, and no virus or viral replication was observed in the brains of these mice. The results demonstrate the absence of neurovirulent properties of the MDVs and reassortant influenza viruses derived therefrom used in LAIV.
DOI: 10.1007/s00705-010-0719-8
PubMed: 20532926
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:20532926Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model.</title><author><name sortKey="Voeten, J Theo M" sort="Voeten, J Theo M" uniqKey="Voeten J" first="J Theo M" last="Voeten">J Theo M. Voeten</name><affiliation wicri:level="1"><nlm:affiliation>Nobilon Schering-Plough, Wim de Körverstraat 35, Boxmeer, The Netherlands. theo.voeten@sp.nobilon.com</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Nobilon Schering-Plough, Wim de Körverstraat 35, Boxmeer</wicri:regionArea><wicri:noRegion>Boxmeer</wicri:noRegion></affiliation></author><author><name sortKey="Kiseleva, Irina V" sort="Kiseleva, Irina V" uniqKey="Kiseleva I" first="Irina V" last="Kiseleva">Irina V. Kiseleva</name></author><author><name sortKey="Glansbeek, Harrie L" sort="Glansbeek, Harrie L" uniqKey="Glansbeek H" first="Harrie L" last="Glansbeek">Harrie L. Glansbeek</name></author><author><name sortKey="Basten, Stephanie M C" sort="Basten, Stephanie M C" uniqKey="Basten S" first="Stephanie M C" last="Basten">Stephanie M C. Basten</name></author><author><name sortKey="Drieszen Van Der Cruijsen, Sandra K M" sort="Drieszen Van Der Cruijsen, Sandra K M" uniqKey="Drieszen Van Der Cruijsen S" first="Sandra K M" last="Drieszen-Van Der Cruijsen">Sandra K M. Drieszen-Van Der Cruijsen</name></author><author><name sortKey="Rudenko, Larisa G" sort="Rudenko, Larisa G" uniqKey="Rudenko L" first="Larisa G" last="Rudenko">Larisa G. Rudenko</name></author><author><name sortKey="Van Den Bosch, Han" sort="Van Den Bosch, Han" uniqKey="Van Den Bosch H" first="Han" last="Van Den Bosch">Han Van Den Bosch</name></author><author><name sortKey="Heldens, Jacco G M" sort="Heldens, Jacco G M" uniqKey="Heldens J" first="Jacco G M" last="Heldens">Jacco G M. Heldens</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20532926</idno><idno type="pmid">20532926</idno><idno type="doi">10.1007/s00705-010-0719-8</idno><idno type="wicri:Area/PubMed/Corpus">000197</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000197</idno><idno type="wicri:Area/PubMed/Curation">000197</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000197</idno><idno type="wicri:Area/PubMed/Checkpoint">000178</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000178</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model.</title><author><name sortKey="Voeten, J Theo M" sort="Voeten, J Theo M" uniqKey="Voeten J" first="J Theo M" last="Voeten">J Theo M. Voeten</name><affiliation wicri:level="1"><nlm:affiliation>Nobilon Schering-Plough, Wim de Körverstraat 35, Boxmeer, The Netherlands. theo.voeten@sp.nobilon.com</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Nobilon Schering-Plough, Wim de Körverstraat 35, Boxmeer</wicri:regionArea><wicri:noRegion>Boxmeer</wicri:noRegion></affiliation></author><author><name sortKey="Kiseleva, Irina V" sort="Kiseleva, Irina V" uniqKey="Kiseleva I" first="Irina V" last="Kiseleva">Irina V. Kiseleva</name></author><author><name sortKey="Glansbeek, Harrie L" sort="Glansbeek, Harrie L" uniqKey="Glansbeek H" first="Harrie L" last="Glansbeek">Harrie L. Glansbeek</name></author><author><name sortKey="Basten, Stephanie M C" sort="Basten, Stephanie M C" uniqKey="Basten S" first="Stephanie M C" last="Basten">Stephanie M C. Basten</name></author><author><name sortKey="Drieszen Van Der Cruijsen, Sandra K M" sort="Drieszen Van Der Cruijsen, Sandra K M" uniqKey="Drieszen Van Der Cruijsen S" first="Sandra K M" last="Drieszen-Van Der Cruijsen">Sandra K M. Drieszen-Van Der Cruijsen</name></author><author><name sortKey="Rudenko, Larisa G" sort="Rudenko, Larisa G" uniqKey="Rudenko L" first="Larisa G" last="Rudenko">Larisa G. Rudenko</name></author><author><name sortKey="Van Den Bosch, Han" sort="Van Den Bosch, Han" uniqKey="Van Den Bosch H" first="Han" last="Van Den Bosch">Han Van Den Bosch</name></author><author><name sortKey="Heldens, Jacco G M" sort="Heldens, Jacco G M" uniqKey="Heldens J" first="Jacco G M" last="Heldens">Jacco G M. Heldens</name></author></analytic><series><title level="j">Archives of virology</title><idno type="eISSN">1432-8798</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain (pathology)</term><term>Brain (virology)</term><term>Cell Line</term><term>Chick Embryo</term><term>Disease Models, Animal</term><term>Dogs</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype (genetics)</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza A Virus, H2N2 Subtype (pathogenicity)</term><term>Influenza A Virus, H2N2 Subtype (physiology)</term><term>Influenza B virus (genetics)</term><term>Influenza B virus (immunology)</term><term>Influenza B virus (pathogenicity)</term><term>Influenza B virus (physiology)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (pathology)</term><term>Influenza, Human (prevention & control)</term><term>Influenza, Human (virology)</term><term>Mice</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (immunology)</term><term>Reassortant Viruses (pathogenicity)</term><term>Reassortant Viruses (physiology)</term><term>Vaccines, Attenuated (administration & dosage)</term><term>Vaccines, Attenuated (genetics)</term><term>Vaccines, Attenuated (immunology)</term><term>Virulence</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Embryon de poulet</term><term>Encéphale (anatomopathologie)</term><term>Encéphale (virologie)</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (anatomopathologie)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Lignée cellulaire</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Sous-type H2N2 du virus de la grippe A (génétique)</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term><term>Sous-type H2N2 du virus de la grippe A (pathogénicité)</term><term>Sous-type H2N2 du virus de la grippe A (physiologie)</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (génétique)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (administration et posologie)</term><term>Vaccins atténués (génétique)</term><term>Vaccins atténués (immunologie)</term><term>Virulence</term><term>Virus influenza B (génétique)</term><term>Virus influenza B (immunologie)</term><term>Virus influenza B (pathogénicité)</term><term>Virus influenza B (physiologie)</term><term>Virus recombinants (génétique)</term><term>Virus recombinants (immunologie)</term><term>Virus recombinants (pathogénicité)</term><term>Virus recombinants (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza B virus</term><term>Influenza Vaccines</term><term>Reassortant Viruses</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Virus influenza B</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Virus influenza B</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza B virus</term><term>Influenza Vaccines</term><term>Reassortant Viruses</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza B virus</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term><term>Virus influenza B</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term><term>Virus influenza B</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza B virus</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Encéphale</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Brain</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Chick Embryo</term><term>Disease Models, Animal</term><term>Dogs</term><term>Female</term><term>Humans</term><term>Mice</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Embryon de poulet</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Lignée cellulaire</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Demonstration of the absence of neurovirulent properties of reassortant viruses contained in live attenuated influenza vaccine (LAIV) is a regulatory requirement. A mouse model was used to detect neurovirulent properties of the cold-adapted, temperature-sensitive and attenuated influenza master donor viruses (MDVs) A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortant influenza viruses. A/NWS/33 (H1N1), which is known to be neurovirulent in mice, was used as a positive control. Under conditions where the positive control virus induced symptoms of disease and showed viral replication in the upper respiratory tract as well as in the brain, replication of the influenza master donor viruses and reassortant influenza A and B viruses was limited to the upper respiratory tract where they were administered. None of the mice inoculated with MDVs or reassortant influenza viruses suffered from disease, and no virus or viral replication was observed in the brains of these mice. The results demonstrate the absence of neurovirulent properties of the MDVs and reassortant influenza viruses derived therefrom used in LAIV.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20532926</PMID><DateCompleted><Year>2010</Year><Month>10</Month><Day>21</Day></DateCompleted><DateRevised><Year>2010</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-8798</ISSN><JournalIssue CitedMedium="Internet"><Volume>155</Volume><Issue>9</Issue><PubDate><Year>2010</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Archives of virology</Title><ISOAbbreviation>Arch. Virol.</ISOAbbreviation></Journal><ArticleTitle>Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model.</ArticleTitle><Pagination><MedlinePgn>1391-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00705-010-0719-8</ELocationID><Abstract><AbstractText>Demonstration of the absence of neurovirulent properties of reassortant viruses contained in live attenuated influenza vaccine (LAIV) is a regulatory requirement. A mouse model was used to detect neurovirulent properties of the cold-adapted, temperature-sensitive and attenuated influenza master donor viruses (MDVs) A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortant influenza viruses. A/NWS/33 (H1N1), which is known to be neurovirulent in mice, was used as a positive control. Under conditions where the positive control virus induced symptoms of disease and showed viral replication in the upper respiratory tract as well as in the brain, replication of the influenza master donor viruses and reassortant influenza A and B viruses was limited to the upper respiratory tract where they were administered. None of the mice inoculated with MDVs or reassortant influenza viruses suffered from disease, and no virus or viral replication was observed in the brains of these mice. The results demonstrate the absence of neurovirulent properties of the MDVs and reassortant influenza viruses derived therefrom used in LAIV.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Voeten</LastName><ForeName>J Theo M</ForeName><Initials>JT</Initials><AffiliationInfo><Affiliation>Nobilon Schering-Plough, Wim de Körverstraat 35, Boxmeer, The Netherlands. theo.voeten@sp.nobilon.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kiseleva</LastName><ForeName>Irina V</ForeName><Initials>IV</Initials></Author><Author ValidYN="Y"><LastName>Glansbeek</LastName><ForeName>Harrie L</ForeName><Initials>HL</Initials></Author><Author ValidYN="Y"><LastName>Basten</LastName><ForeName>Stephanie M C</ForeName><Initials>SM</Initials></Author><Author ValidYN="Y"><LastName>Drieszen-van der Cruijsen</LastName><ForeName>Sandra K M</ForeName><Initials>SK</Initials></Author><Author ValidYN="Y"><LastName>Rudenko</LastName><ForeName>Larisa G</ForeName><Initials>LG</Initials></Author><Author ValidYN="Y"><LastName>van den Bosch</LastName><ForeName>Han</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Heldens</LastName><ForeName>Jacco G M</ForeName><Initials>JG</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>06</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Austria</Country><MedlineTA>Arch Virol</MedlineTA><NlmUniqueID>7506870</NlmUniqueID><ISSNLinking>0304-8608</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002642" MajorTopicYN="N">Chick Embryo</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053121" MajorTopicYN="N">Influenza A Virus, H2N2 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009981" MajorTopicYN="N">Influenza B virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016865" MajorTopicYN="N">Reassortant Viruses</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014613" MajorTopicYN="N">Vaccines, Attenuated</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>04</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>06</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20532926</ArticleId><ArticleId IdType="doi">10.1007/s00705-010-0719-8</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Basten, Stephanie M C" sort="Basten, Stephanie M C" uniqKey="Basten S" first="Stephanie M C" last="Basten">Stephanie M C. Basten</name><name sortKey="Drieszen Van Der Cruijsen, Sandra K M" sort="Drieszen Van Der Cruijsen, Sandra K M" uniqKey="Drieszen Van Der Cruijsen S" first="Sandra K M" last="Drieszen-Van Der Cruijsen">Sandra K M. Drieszen-Van Der Cruijsen</name><name sortKey="Glansbeek, Harrie L" sort="Glansbeek, Harrie L" uniqKey="Glansbeek H" first="Harrie L" last="Glansbeek">Harrie L. Glansbeek</name><name sortKey="Heldens, Jacco G M" sort="Heldens, Jacco G M" uniqKey="Heldens J" first="Jacco G M" last="Heldens">Jacco G M. Heldens</name><name sortKey="Kiseleva, Irina V" sort="Kiseleva, Irina V" uniqKey="Kiseleva I" first="Irina V" last="Kiseleva">Irina V. Kiseleva</name><name sortKey="Rudenko, Larisa G" sort="Rudenko, Larisa G" uniqKey="Rudenko L" first="Larisa G" last="Rudenko">Larisa G. Rudenko</name><name sortKey="Van Den Bosch, Han" sort="Van Den Bosch, Han" uniqKey="Van Den Bosch H" first="Han" last="Van Den Bosch">Han Van Den Bosch</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Voeten, J Theo M" sort="Voeten, J Theo M" uniqKey="Voeten J" first="J Theo M" last="Voeten">J Theo M. Voeten</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000178 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000178 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:20532926
|texte= Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:20532926" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |