Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes.
Identifieur interne : 000147 ( PubMed/Checkpoint ); précédent : 000146; suivant : 000148Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes.
Auteurs : Ana Clara Monsalvo [Argentine] ; Juan P. Batalle ; M Florencia Lopez ; Jens C. Krause ; Jennifer Klemenc ; Johanna Zea Hernandez ; Bernardo Maskin ; Jimena Bugna ; Carlos Rubinstein ; Leandro Aguilar ; Liliana Dalurzo ; Romina Libster ; Vilma Savy ; Elsa Baumeister ; Liliana Aguilar ; Graciela Cabral ; Julia Font ; Liliana Solari ; Kevin P. Weller ; Joyce Johnson ; Marcela Echavarria ; Kathryn M. Edwards ; James D. Chappell ; James E. Crowe ; John V. Williams ; Guillermina A. Melendi ; Fernando P. PolackSource :
- Nature medicine [ 1546-170X ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (immunologie), Antigènes viraux (immunologie), Complexe antigène-anticorps (immunologie), Complément C3 (analyse), Cytokines (sang), Facteurs de l'âge, Grippe humaine (anatomopathologie), Grippe humaine (immunologie), Grippe humaine (sang), Grippe humaine (virologie), Humains, Interféron alpha (sang), Interféron bêta (sang), Jeune adulte, Poumon (anatomopathologie), Poumon (immunologie), Poumon (virologie), Réactions croisées (immunologie), Sous-type H1N1 du virus de la grippe A (immunologie).
- MESH :
- analyse : Complément C3.
- anatomopathologie : Grippe humaine, Poumon.
- immunologie : Anticorps antiviraux, Antigènes viraux, Complexe antigène-anticorps, Grippe humaine, Poumon, Réactions croisées, Sous-type H1N1 du virus de la grippe A.
- sang : Cytokines, Grippe humaine, Interféron alpha, Interféron bêta.
- virologie : Grippe humaine, Poumon.
- Adolescent, Adulte, Adulte d'âge moyen, Facteurs de l'âge, Humains, Jeune adulte.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Antibodies, Viral (immunology), Antigen-Antibody Complex (immunology), Antigens, Viral (immunology), Complement C3 (analysis), Cross Reactions (immunology), Cytokines (blood), Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza, Human (blood), Influenza, Human (immunology), Influenza, Human (pathology), Influenza, Human (virology), Interferon-alpha (blood), Interferon-beta (blood), Lung (immunology), Lung (pathology), Lung (virology), Middle Aged, Young Adult.
- MESH :
- chemical , analysis : Complement C3.
- chemical , blood : Cytokines, Interferon-alpha, Interferon-beta.
- chemical , immunology : Antibodies, Viral, Antigen-Antibody Complex, Antigens, Viral.
- blood : Influenza, Human.
- immunology : Cross Reactions, Influenza A Virus, H1N1 Subtype, Influenza, Human, Lung.
- pathology : Influenza, Human, Lung.
- virology : Influenza, Human, Lung.
- Adolescent, Adult, Age Factors, Humans, Middle Aged, Young Adult.
Abstract
Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex-mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition--a marker of complement activation mediated by immune complexes--was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics.
DOI: 10.1038/nm.2262
PubMed: 21131958
Affiliations:
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pubmed:21131958Le document en format XML
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<front><div type="abstract" xml:lang="en">Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex-mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition--a marker of complement activation mediated by immune complexes--was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics.</div>
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<DateCompleted><Year>2011</Year>
<Month>03</Month>
<Day>18</Day>
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<Month>11</Month>
<Day>13</Day>
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<Title>Nature medicine</Title>
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<ArticleTitle>Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes.</ArticleTitle>
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<Abstract><AbstractText>Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex-mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition--a marker of complement activation mediated by immune complexes--was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Monsalvo</LastName>
<ForeName>Ana Clara</ForeName>
<Initials>AC</Initials>
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<ForeName>Jens C</ForeName>
<Initials>JC</Initials>
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<ForeName>Jennifer</ForeName>
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<Author ValidYN="Y"><LastName>Hernandez</LastName>
<ForeName>Johanna Zea</ForeName>
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<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20365-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19918065</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Nov 12;361(20):1925-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19815860</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2009;4(12):e8540</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20046873</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Infect Dis. 2010;10:5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20059763</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nephrol Dial Transplant. 2001 Oct;16(10):2058-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11572897</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10736-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12149435</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2002 Sep 16;196(6):859-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12235218</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2004 Sep 15;292(11):1333-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15367555</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2004 Oct 7;431(7009):703-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15470432</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pediatr. 1978 Jul;93(1):28-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">206677</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1986 Dec 15;137(12):3777-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2431043</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1998 Apr;72(4):2871-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9525607</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 1998 Jul;178(1):53-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9652423</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2005 Oct 7;310(5745):77-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16210530</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2005 Dec 15;353(24):2559-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16354892</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2006 Jan;12(1):15-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16494711</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2006 Oct;12(10):1203-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16964257</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2006 Oct 5;443(7111):578-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17006449</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2007 Jan 18;445(7125):319-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17230189</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2007 Apr 1;195(7):1018-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17330793</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12479-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17640882</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2008;4(8):e1000115</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18670648</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2008 Oct 1;198(7):962-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18710327</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2009 Jan;15(1):34-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19079256</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MMWR Morb Mortal Wkly Rep. 2009 May 22;58(19):521-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19478718</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Aug 13;361(7):680-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19564631</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Aug 13;361(7):674-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19564633</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2009 Aug 20;460(7258):1021-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19672242</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Nov 12;361(20):1945-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19745214</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2010 Jan 1;181(1):72-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19875682</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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