Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes.
Identifieur interne : 000182 ( PubMed/Corpus ); précédent : 000181; suivant : 000183Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes.
Auteurs : Ana Clara Monsalvo ; Juan P. Batalle ; M Florencia Lopez ; Jens C. Krause ; Jennifer Klemenc ; Johanna Zea Hernandez ; Bernardo Maskin ; Jimena Bugna ; Carlos Rubinstein ; Leandro Aguilar ; Liliana Dalurzo ; Romina Libster ; Vilma Savy ; Elsa Baumeister ; Liliana Aguilar ; Graciela Cabral ; Julia Font ; Liliana Solari ; Kevin P. Weller ; Joyce Johnson ; Marcela Echavarria ; Kathryn M. Edwards ; James D. Chappell ; James E. Crowe ; John V. Williams ; Guillermina A. Melendi ; Fernando P. PolackSource :
- Nature medicine [ 1546-170X ] ; 2011.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Antibodies, Viral (immunology), Antigen-Antibody Complex (immunology), Antigens, Viral (immunology), Complement C3 (analysis), Cross Reactions (immunology), Cytokines (blood), Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza, Human (blood), Influenza, Human (immunology), Influenza, Human (pathology), Influenza, Human (virology), Interferon-alpha (blood), Interferon-beta (blood), Lung (immunology), Lung (pathology), Lung (virology), Middle Aged, Young Adult.
- MESH :
- chemical , analysis : Complement C3.
- chemical , blood : Cytokines, Interferon-alpha, Interferon-beta.
- chemical , immunology : Antibodies, Viral, Antigen-Antibody Complex, Antigens, Viral.
- blood : Influenza, Human.
- immunology : Cross Reactions, Influenza A Virus, H1N1 Subtype, Influenza, Human, Lung.
- pathology : Influenza, Human, Lung.
- virology : Influenza, Human, Lung.
- Adolescent, Adult, Age Factors, Humans, Middle Aged, Young Adult.
Abstract
Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex-mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition--a marker of complement activation mediated by immune complexes--was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics.
DOI: 10.1038/nm.2262
PubMed: 21131958
Links to Exploration step
pubmed:21131958Le document en format XML
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<front><div type="abstract" xml:lang="en">Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex-mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition--a marker of complement activation mediated by immune complexes--was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics.</div>
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<ArticleTitle>Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes.</ArticleTitle>
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<Abstract><AbstractText>Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex-mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition--a marker of complement activation mediated by immune complexes--was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics.</AbstractText>
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