Influenza A Strain-Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice
Identifieur interne : 000947 ( Pmc/Curation ); précédent : 000946; suivant : 000948Influenza A Strain-Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice
Auteurs : Mutien-Marie Garigliany ; Adélite Habyarimana ; Bénédicte Lambrecht ; Els Van De Paar ; Anne Cornet ; Thierry Van Den Berg ; Daniel DesmechtSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2010.
Abstract
Future treatments may involve customizing treatment to the virus pathotype.
Url:
DOI: 10.3201/eid1604.091061
PubMed: 20350372
PubMed Central: 3321946
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Emerging Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">EID</journal-id><journal-title-group><journal-title>Emerging Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1080-6040</issn><issn pub-type="epub">1080-6059</issn><publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20350372</article-id><article-id pub-id-type="pmc">3321946</article-id><article-id pub-id-type="publisher-id">09-1061</article-id><article-id pub-id-type="doi">10.3201/eid1604.091061</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Influenza A Strain-Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice</article-title><alt-title alt-title-type="running-head">Influenza Strain-Dependent Pathogenesis</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Garigliany</surname><given-names>Mutien-Marie</given-names></name></contrib><contrib contrib-type="author"><name><surname>Habyarimana</surname><given-names>Adélite</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lambrecht</surname><given-names>Bénédicte</given-names></name></contrib><contrib contrib-type="author"><name><surname>Van de Paar</surname><given-names>Els</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cornet</surname><given-names>Anne</given-names></name></contrib><contrib contrib-type="author"><name><surname>van den Berg</surname><given-names>Thierry</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Desmecht</surname><given-names>Daniel</given-names></name></contrib><aff id="aff1">University of Liège, Liège, Belgium (M.-M. Garigliany, E. Van de Paar, A. Cornet, D. Desmecht)</aff><aff id="aff2">Veterinary Agrochemical Center, Brussels, Belgium (A. Habyarimana, B. Lambrecht, T. van den Berg).</aff></contrib-group><author-notes><corresp id="cor1">Address for correspondence: Daniel Desmecht, University of Liège, Department of Pathology, Faculty of Veterinary Medicine, Sart Tilman B43, Liège 4000, Belgium; email: <email xlink:href="daniel.desmecht@ulg.ac.be">daniel.desmecht@ulg.ac.be</email></corresp></author-notes><pub-date pub-type="ppub"><month>4</month><year>2010</year></pub-date><volume>16</volume><issue>4</issue><fpage>595</fpage><lpage>603</lpage><abstract abstract-type="toc"><p>Future treatments may involve customizing treatment to the virus pathotype.</p></abstract><abstract><p>To determine if fatal infections caused by different highly virulent influenza A viruses share the same pathogenesis, we compared 2 different influenza A virus subtypes, H1N1 and H5N1. The subtypes, which had shown no pathogenicity in laboratory mice, were forced to evolve by serial passaging. Although both adapted viruses evoked diffuse alveolar damage and showed a similar 50% mouse lethal dose and the same peak lung concentration, each had a distinct pathologic signature and caused a different course of acute respiratory distress syndrome. In the absence of any virus labeling, a histologist could readily distinguish infections caused by these 2 viruses. The different histologic features described in this study here refute the hypothesis of a single, universal cytokine storm underlying all fatal influenza diseases. Research is thus crucially needed to identify sets of virulence markers and to examine whether treatment should be tailored to the influenza virus pathotype.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>Influenza</kwd><kwd>viruses</kwd><kwd>lung</kwd><kwd>acute respiratory distress syndrome</kwd><kwd>ARDS</kwd><kwd>research</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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