Anti-Influenza Hyperimmune Immunoglobulin Enhances Fc-Functional Antibody Immunity During Human Influenza Infection
Identifieur interne : 000631 ( Pmc/Curation ); précédent : 000630; suivant : 000632Anti-Influenza Hyperimmune Immunoglobulin Enhances Fc-Functional Antibody Immunity During Human Influenza Infection
Auteurs : Hillary A. Vanderven [Australie] ; Kathleen Wragg [Australie] ; Fernanda Ana-Sosa-Batiz [Australie] ; Anne B. Kristensen [Australie] ; Sinthujan Jegaskanda [Australie] ; Adam K. Wheatley [Australie] ; Deborah Wentworth ; Bruce D. Wines [Australie] ; P Mark Hogarth [Australie] ; Steve Rockman [Australie] ; Stephen J. Kent [Australie]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2018.
Abstract
Anti-influenza hyperimmune immunoglobulin (Flu-IVIG) generally contained higher concentrations of influenza-specific Fc-functional antibodies than standard intravenous immunoglobulins against an array of influenza virus strains and subtypes. Passive infusion of Flu-IVIG into influenza-infected patients transiently boosted Fc-functional antibodies early after infusion.
Url:
DOI: 10.1093/infdis/jiy328
PubMed: 29860297
PubMed Central: 6927892
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Deborah Wentworth<affiliation><nlm:aff id="AF0003">Biostatistics Division, University of Minnesota, Minneapolis</nlm:aff><wicri:noCountry code="subfield">Minneapolis</wicri:noCountry></affiliation><affiliation><nlm:aff id="AF0005">Seqirus Ltd, Parkville</nlm:aff><wicri:noCountry code="subfield">Parkville</wicri:noCountry></affiliation><affiliation><nlm:aff id="AF0006">Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Health, Central Clinical School, Monash University</nlm:aff><wicri:noCountry code="subfield">Monash University</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0007">Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria</wicri:regionArea></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti-Influenza Hyperimmune Immunoglobulin Enhances Fc-Functional Antibody Immunity During Human Influenza Infection</title><author><name sortKey="Vanderven, Hillary A" sort="Vanderven, Hillary A" uniqKey="Vanderven H" first="Hillary A" last="Vanderven">Hillary A. Vanderven</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002">Biomedicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Douglas, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Douglas, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Wragg, Kathleen" sort="Wragg, Kathleen" uniqKey="Wragg K" first="Kathleen" last="Wragg">Kathleen Wragg</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Ana Sosa Batiz, Fernanda" sort="Ana Sosa Batiz, Fernanda" uniqKey="Ana Sosa Batiz F" first="Fernanda" last="Ana-Sosa-Batiz">Fernanda Ana-Sosa-Batiz</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Kristensen, Anne B" sort="Kristensen, Anne B" uniqKey="Kristensen A" first="Anne B" last="Kristensen">Anne B. Kristensen</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Jegaskanda, Sinthujan" sort="Jegaskanda, Sinthujan" uniqKey="Jegaskanda S" first="Sinthujan" last="Jegaskanda">Sinthujan Jegaskanda</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Wheatley, Adam K" sort="Wheatley, Adam K" uniqKey="Wheatley A" first="Adam K" last="Wheatley">Adam K. Wheatley</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Wentworth, Deborah" sort="Wentworth, Deborah" uniqKey="Wentworth D" first="Deborah" last="Wentworth">Deborah Wentworth</name><affiliation><nlm:aff id="AF0003">Biostatistics Division, University of Minnesota, Minneapolis</nlm:aff><wicri:noCountry code="subfield">Minneapolis</wicri:noCountry></affiliation></author><author><name sortKey="Wines, Bruce D" sort="Wines, Bruce D" uniqKey="Wines B" first="Bruce D" last="Wines">Bruce D. Wines</name><affiliation wicri:level="3"><nlm:aff id="AF0004">Burnet Institute, Melbourne</nlm:aff><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><wicri:orgArea>Burnet Institute</wicri:orgArea></affiliation></author><author><name sortKey="Hogarth, P Mark" sort="Hogarth, P Mark" uniqKey="Hogarth P" first="P Mark" last="Hogarth">P Mark Hogarth</name><affiliation wicri:level="3"><nlm:aff id="AF0004">Burnet Institute, Melbourne</nlm:aff><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><wicri:orgArea>Burnet Institute</wicri:orgArea></affiliation></author><author><name sortKey="Rockman, Steve" sort="Rockman, Steve" uniqKey="Rockman S" first="Steve" last="Rockman">Steve Rockman</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation><affiliation><nlm:aff id="AF0005">Seqirus Ltd, Parkville</nlm:aff><wicri:noCountry code="subfield">Parkville</wicri:noCountry></affiliation></author><author><name sortKey="Kent, Stephen J" sort="Kent, Stephen J" uniqKey="Kent S" first="Stephen J" last="Kent">Stephen J. Kent</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation><affiliation><nlm:aff id="AF0006">Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Health, Central Clinical School, Monash University</nlm:aff><wicri:noCountry code="subfield">Monash University</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0007">Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29860297</idno><idno type="pmc">6927892</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927892</idno><idno type="RBID">PMC:6927892</idno><idno type="doi">10.1093/infdis/jiy328</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000631</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000631</idno><idno type="wicri:Area/Pmc/Curation">000631</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000631</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anti-Influenza Hyperimmune Immunoglobulin Enhances Fc-Functional Antibody Immunity During Human Influenza Infection</title><author><name sortKey="Vanderven, Hillary A" sort="Vanderven, Hillary A" uniqKey="Vanderven H" first="Hillary A" last="Vanderven">Hillary A. Vanderven</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002">Biomedicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Douglas, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Douglas, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Wragg, Kathleen" sort="Wragg, Kathleen" uniqKey="Wragg K" first="Kathleen" last="Wragg">Kathleen Wragg</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Ana Sosa Batiz, Fernanda" sort="Ana Sosa Batiz, Fernanda" uniqKey="Ana Sosa Batiz F" first="Fernanda" last="Ana-Sosa-Batiz">Fernanda Ana-Sosa-Batiz</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Kristensen, Anne B" sort="Kristensen, Anne B" uniqKey="Kristensen A" first="Anne B" last="Kristensen">Anne B. Kristensen</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Jegaskanda, Sinthujan" sort="Jegaskanda, Sinthujan" uniqKey="Jegaskanda S" first="Sinthujan" last="Jegaskanda">Sinthujan Jegaskanda</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Wheatley, Adam K" sort="Wheatley, Adam K" uniqKey="Wheatley A" first="Adam K" last="Wheatley">Adam K. Wheatley</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Wentworth, Deborah" sort="Wentworth, Deborah" uniqKey="Wentworth D" first="Deborah" last="Wentworth">Deborah Wentworth</name><affiliation><nlm:aff id="AF0003">Biostatistics Division, University of Minnesota, Minneapolis</nlm:aff><wicri:noCountry code="subfield">Minneapolis</wicri:noCountry></affiliation></author><author><name sortKey="Wines, Bruce D" sort="Wines, Bruce D" uniqKey="Wines B" first="Bruce D" last="Wines">Bruce D. Wines</name><affiliation wicri:level="3"><nlm:aff id="AF0004">Burnet Institute, Melbourne</nlm:aff><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><wicri:orgArea>Burnet Institute</wicri:orgArea></affiliation></author><author><name sortKey="Hogarth, P Mark" sort="Hogarth, P Mark" uniqKey="Hogarth P" first="P Mark" last="Hogarth">P Mark Hogarth</name><affiliation wicri:level="3"><nlm:aff id="AF0004">Burnet Institute, Melbourne</nlm:aff><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><wicri:orgArea>Burnet Institute</wicri:orgArea></affiliation></author><author><name sortKey="Rockman, Steve" sort="Rockman, Steve" uniqKey="Rockman S" first="Steve" last="Rockman">Steve Rockman</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation><affiliation><nlm:aff id="AF0005">Seqirus Ltd, Parkville</nlm:aff><wicri:noCountry code="subfield">Parkville</wicri:noCountry></affiliation></author><author><name sortKey="Kent, Stephen J" sort="Kent, Stephen J" uniqKey="Kent S" first="Stephen J" last="Kent">Stephen J. Kent</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea></affiliation><affiliation><nlm:aff id="AF0006">Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Health, Central Clinical School, Monash University</nlm:aff><wicri:noCountry code="subfield">Monash University</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0007">Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Anti-influenza hyperimmune immunoglobulin (Flu-IVIG) generally contained higher concentrations of influenza-specific Fc-functional antibodies than standard intravenous immunoglobulins against an array of influenza virus strains and subtypes. Passive infusion of Flu-IVIG into influenza-infected patients transiently boosted Fc-functional antibodies early after infusion.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">jid</journal-id><journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">0022-1899</issn><issn pub-type="epub">1537-6613</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>US</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29860297</article-id><article-id pub-id-type="pmc">6927892</article-id><article-id pub-id-type="doi">10.1093/infdis/jiy328</article-id><article-id pub-id-type="publisher-id">jiy328</article-id><article-categories><subj-group subj-group-type="heading"><subject>Major Articles and Brief Reports</subject><subj-group subj-group-type="category-toc-heading"><subject>Pathogenesis and Host Response</subject></subj-group></subj-group></article-categories><title-group><article-title>Anti-Influenza Hyperimmune Immunoglobulin Enhances Fc-Functional Antibody Immunity During Human Influenza Infection</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Vanderven</surname><given-names>Hillary A</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Wragg</surname><given-names>Kathleen</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Ana-Sosa-Batiz</surname><given-names>Fernanda</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Kristensen</surname><given-names>Anne B</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Jegaskanda</surname><given-names>Sinthujan</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Wheatley</surname><given-names>Adam K</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Wentworth</surname><given-names>Deborah</given-names></name><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Wines</surname><given-names>Bruce D</given-names></name><xref ref-type="aff" rid="AF0004">4</xref></contrib><contrib contrib-type="author"><name><surname>Hogarth</surname><given-names>P Mark</given-names></name><xref ref-type="aff" rid="AF0004">4</xref></contrib><contrib contrib-type="author"><name><surname>Rockman</surname><given-names>Steve</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0005">5</xref></contrib><contrib contrib-type="author"><name><surname>Kent</surname><given-names>Stephen J</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0006">6</xref><xref ref-type="aff" rid="AF0007">7</xref><xref ref-type="corresp" rid="c1"></xref><pmc-comment>skent@unimelb.edu.au </pmc-comment>
</contrib><contrib contrib-type="author"><collab>INSIGHT FLU005 Pilot Study Writing Group
<contrib-group><contrib contrib-type="author"><name><surname>Emery</surname><given-names>Sean</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lane</surname><given-names>H Clifford</given-names></name></contrib><contrib contrib-type="author"><name><surname>Amin</surname><given-names>Janaki</given-names></name></contrib><contrib contrib-type="author"><name><surname>Davey</surname><given-names>Richard T</given-names><suffix>Jr</suffix></name></contrib><contrib contrib-type="author"><name><surname>Markowitz</surname><given-names>Norman P</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pett</surname><given-names>Sarah L</given-names></name></contrib><contrib contrib-type="author"><name><surname>Beigel</surname><given-names>John</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gardner</surname><given-names>Edward</given-names></name></contrib><contrib contrib-type="author"><name><surname>Temesgen</surname><given-names>Zelalem</given-names></name></contrib></contrib-group></collab><xref ref-type="author-notes" rid="fn-0001"></xref></contrib></contrib-group><aff id="AF0001"><label>1</label>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia</aff><aff id="AF0002"><label>2</label>Biomedicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Douglas, Queensland, Australia</aff><aff id="AF0003"><label>3</label>Biostatistics Division, University of Minnesota, Minneapolis</aff><aff id="AF0004"><label>4</label>Burnet Institute, Melbourne</aff><aff id="AF0005"><label>5</label>Seqirus Ltd, Parkville</aff><aff id="AF0006"><label>6</label>Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Health, Central Clinical School, Monash University</aff><aff id="AF0007"><label>7</label>Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria, Australia</aff><author-notes><fn id="fn-0001"><p>Members of the INSIGHT FLU005 Pilot Study Writing Group are listed in the Notes.</p></fn><corresp id="c1">Correspondence: S. J. Kent, MD, PhD, Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia (<email>skent@unimelb.edu.au</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>11</month><year>2018</year></pub-date><pub-date pub-type="epub" iso-8601-date="2018-05-31"><day>31</day><month>5</month><year>2018</year></pub-date><volume>218</volume><issue>9</issue><fpage>1383</fpage><lpage>1393</lpage><history><date date-type="received"><day>26</day><month>2</month><year>2018</year></date><date date-type="accepted"><day>30</day><month>5</month><year>2018</year></date></history><permissions><copyright-statement>© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</copyright-statement><copyright-year>2018</copyright-year><license license-type="oup-standard" xlink:href="https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model"><license-p>This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (<ext-link ext-link-type="uri" xlink:href="https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model">https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model</ext-link>)</license-p></license></permissions><self-uri xlink:href="jiy328.pdf"></self-uri><abstract abstract-type="teaser"><p>Anti-influenza hyperimmune immunoglobulin (Flu-IVIG) generally contained higher concentrations of influenza-specific Fc-functional antibodies than standard intravenous immunoglobulins against an array of influenza virus strains and subtypes. Passive infusion of Flu-IVIG into influenza-infected patients transiently boosted Fc-functional antibodies early after infusion.</p></abstract><abstract><title>Abstract</title><sec id="s1"><title>Background</title><p>New treatments for severe influenza are needed. Passive transfer of influenza-specific hyperimmune pooled immunoglobulin (Flu-IVIG) boosts neutralizing antibody responses to past strains in influenza-infected subjects. The effect of Flu-IVIG on antibodies with Fc-mediated functions, which may target diverse influenza strains, is unclear.</p></sec><sec id="s2"><title>Methods</title><p>We studied the capacity of Flu-IVIG, relative to standard IVIG, to bind to Fcγ receptors and mediate antibody-dependent cellular cytotoxicity in vitro. The effect of Flu-IVIG infusion, compared to placebo infusion, was examined in serial plasma samples from 24 subjects with confirmed influenza infection in the INSIGHT FLU005 pilot study.</p></sec><sec id="s3"><title>Results</title><p>Flu-IVIG contains higher concentrations of Fc-functional antibodies than IVIG against a diverse range of influenza hemagglutinins. Following infusion of Flu-IVIG into influenza-infected subjects, a transient increase in Fc-functional antibodies was present for 1–3 days against infecting and noninfecting strains of influenza.</p></sec><sec id="s4"><title>Conclusions</title><p>Flu-IVIG contains antibodies with Fc-mediated functions against influenza virus, and passive transfer of Flu-IVIG increases anti-influenza Fc-functional antibodies in the plasma of influenza-infected subjects. Enhancement of Fc-functional antibodies to a diverse range of influenza strains suggests that Flu-IVIG infusion could prove useful in the context of novel influenza virus infections, when there may be minimal or no neutralizing antibodies in the Flu-IVIG preparation.</p></sec></abstract><kwd-group><kwd>influenza</kwd><kwd>immunoglobulin</kwd><kwd>ADCC</kwd><kwd>Fc receptor</kwd><kwd>passive transfer</kwd></kwd-group><funding-group><award-group award-type="grant"><funding-source><named-content content-type="funder-name">NIH</named-content><named-content content-type="funder-identifier">10.13039/100000002</named-content></funding-source></award-group></funding-group><counts><page-count count="11"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Anti-Influenza Hyperimmune Immunoglobulin Enhances Fc-Functional Antibody Immunity During Human Influenza Infection
}}
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