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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Infection of the Upper Respiratory Tract with Seasonal Influenza A(H3N2) Virus Induces Protective Immunity in Ferrets against Infection with A(H1N1)pdm09 Virus after Intranasal, but Not Intratracheal, Inoculation</title>
<author><name sortKey="Bodewes, Rogier" sort="Bodewes, Rogier" uniqKey="Bodewes R" first="Rogier" last="Bodewes">Rogier Bodewes</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kreijtz, Joost H C M" sort="Kreijtz, Joost H C M" uniqKey="Kreijtz J" first="Joost H. C. M." last="Kreijtz">Joost H. C. M. Kreijtz</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hillaire, Marine L B" sort="Hillaire, Marine L B" uniqKey="Hillaire M" first="Marine L. B." last="Hillaire">Marine L. B. Hillaire</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vogelzang Van Trierum, Stella E" sort="Vogelzang Van Trierum, Stella E" uniqKey="Vogelzang Van Trierum S" first="Stella E." last="Vogelzang-Van Trierum">Stella E. Vogelzang-Van Trierum</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nieuwkoop, Nella J" sort="Nieuwkoop, Nella J" uniqKey="Nieuwkoop N" first="Nella J." last="Nieuwkoop">Nella J. Nieuwkoop</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Run, Peter" sort="Van Run, Peter" uniqKey="Van Run P" first="Peter" last="Van Run">Peter Van Run</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">ViroClinics Biosciences BV, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">ViroClinics Biosciences BV, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23365444</idno>
<idno type="pmc">3624397</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624397</idno>
<idno type="RBID">PMC:3624397</idno>
<idno type="doi">10.1128/JVI.02536-12</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000663</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000663</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Infection of the Upper Respiratory Tract with Seasonal Influenza A(H3N2) Virus Induces Protective Immunity in Ferrets against Infection with A(H1N1)pdm09 Virus after Intranasal, but Not Intratracheal, Inoculation</title>
<author><name sortKey="Bodewes, Rogier" sort="Bodewes, Rogier" uniqKey="Bodewes R" first="Rogier" last="Bodewes">Rogier Bodewes</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kreijtz, Joost H C M" sort="Kreijtz, Joost H C M" uniqKey="Kreijtz J" first="Joost H. C. M." last="Kreijtz">Joost H. C. M. Kreijtz</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hillaire, Marine L B" sort="Hillaire, Marine L B" uniqKey="Hillaire M" first="Marine L. B." last="Hillaire">Marine L. B. Hillaire</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vogelzang Van Trierum, Stella E" sort="Vogelzang Van Trierum, Stella E" uniqKey="Vogelzang Van Trierum S" first="Stella E." last="Vogelzang-Van Trierum">Stella E. Vogelzang-Van Trierum</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nieuwkoop, Nella J" sort="Nieuwkoop, Nella J" uniqKey="Nieuwkoop N" first="Nella J." last="Nieuwkoop">Nella J. Nieuwkoop</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Run, Peter" sort="Van Run, Peter" uniqKey="Van Run P" first="Peter" last="Van Run">Peter Van Run</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">ViroClinics Biosciences BV, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name>
<affiliation><nlm:aff id="aff1">Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">ViroClinics Biosciences BV, Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The clinical symptoms caused by infection with influenza A virus vary widely and depend on the strain causing the infection, the dose and route of inoculation, and the presence of preexisting immunity. In most cases, seasonal influenza A viruses cause relatively mild upper respiratory tract disease, while sometimes patients develop an acute severe pneumonia. Heterosubtypic immunity induced by previous infections with influenza A viruses may dampen the development of clinical symptoms caused by infection with influenza A viruses of another subtype, as is the case during influenza pandemics. Here we show that ferrets acquire protective immunity after infection of the upper respiratory tract with a seasonal influenza A(H3N2) virus against subsequent infection with influenza A(H1N1)pdm09 virus inoculated by the intranasal route. However, protective heterosubtypic immunity was afforded locally, since the prior infection with the A(H3N2) virus did not provide protection against the development of pneumonia induced after intratracheal inoculation with the A(H1N1)pdm09 virus. Interestingly, some of these animals developed more severe disease than that observed in naïve control animals. These findings are of interest in light of the development of so-called universal influenza vaccines that aim at the induction of cross-reactive T cell responses.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Virol</journal-id>
<journal-id journal-id-type="hwp">jvi</journal-id>
<journal-id journal-id-type="pmc">jvi</journal-id>
<journal-id journal-id-type="publisher-id">JVI</journal-id>
<journal-title-group><journal-title>Journal of Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0022-538X</issn>
<issn pub-type="epub">1098-5514</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
<publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23365444</article-id>
<article-id pub-id-type="pmc">3624397</article-id>
<article-id pub-id-type="publisher-id">02536-12</article-id>
<article-id pub-id-type="doi">10.1128/JVI.02536-12</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject>
</subj-group>
</article-categories>
<title-group><article-title>Infection of the Upper Respiratory Tract with Seasonal Influenza A(H3N2) Virus Induces Protective Immunity in Ferrets against Infection with A(H1N1)pdm09 Virus after Intranasal, but Not Intratracheal, Inoculation</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Bodewes</surname>
<given-names>Rogier</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kreijtz</surname>
<given-names>Joost H. C. M.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Amerongen</surname>
<given-names>Geert</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hillaire</surname>
<given-names>Marine L. B.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vogelzang-van Trierum</surname>
<given-names>Stella E.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nieuwkoop</surname>
<given-names>Nella J.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Run</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kuiken</surname>
<given-names>Thijs</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fouchier</surname>
<given-names>Ron A. M.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Osterhaus</surname>
<given-names>Albert D. M. E.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>b</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Rimmelzwaan</surname>
<given-names>Guus F.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>b</sup>
</xref>
</contrib>
<aff id="aff1"><label>a</label>
Viroscience Lab, Erasmus MC, Rotterdam, Netherlands</aff>
<aff id="aff2"><label>b</label>
ViroClinics Biosciences BV, Rotterdam, Netherlands</aff>
</contrib-group>
<author-notes><corresp>Address correspondence to Guus F. Rimmelzwaan, <email>g.rimmelzwaan@erasmusmc.nl</email>
.</corresp>
<fn fn-type="equal"><p>R.B. and J.H.C.M.K. contributed equally to this article.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>4</month>
<year>2013</year>
</pub-date>
<volume>87</volume>
<issue>8</issue>
<fpage>4293</fpage>
<lpage>4301</lpage>
<history><date date-type="received"><day>17</day>
<month>9</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>25</day>
<month>1</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2013, American Society for Microbiology. All Rights Reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>American Society for Microbiology</copyright-holder>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjv00813004293.pdf"></self-uri>
<abstract><p>The clinical symptoms caused by infection with influenza A virus vary widely and depend on the strain causing the infection, the dose and route of inoculation, and the presence of preexisting immunity. In most cases, seasonal influenza A viruses cause relatively mild upper respiratory tract disease, while sometimes patients develop an acute severe pneumonia. Heterosubtypic immunity induced by previous infections with influenza A viruses may dampen the development of clinical symptoms caused by infection with influenza A viruses of another subtype, as is the case during influenza pandemics. Here we show that ferrets acquire protective immunity after infection of the upper respiratory tract with a seasonal influenza A(H3N2) virus against subsequent infection with influenza A(H1N1)pdm09 virus inoculated by the intranasal route. However, protective heterosubtypic immunity was afforded locally, since the prior infection with the A(H3N2) virus did not provide protection against the development of pneumonia induced after intratracheal inoculation with the A(H1N1)pdm09 virus. Interestingly, some of these animals developed more severe disease than that observed in naïve control animals. These findings are of interest in light of the development of so-called universal influenza vaccines that aim at the induction of cross-reactive T cell responses.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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