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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The TLR4-TRIF Pathway Protects against H5N1 Influenza Virus Infection</title><author><name sortKey="Shinya, Kyoko" sort="Shinya, Kyoko" uniqKey="Shinya K" first="Kyoko" last="Shinya">Kyoko Shinya</name><affiliation><nlm:aff id="aff1">Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan</nlm:aff></affiliation></author><author><name sortKey="Ito, Mutsumi" sort="Ito, Mutsumi" uniqKey="Ito M" first="Mutsumi" last="Ito">Mutsumi Ito</name><affiliation><nlm:aff id="aff2">Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Makino, Akiko" sort="Makino, Akiko" uniqKey="Makino A" first="Akiko" last="Makino">Akiko Makino</name><affiliation><nlm:aff id="aff1">Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Motoko" sort="Tanaka, Motoko" uniqKey="Tanaka M" first="Motoko" last="Tanaka">Motoko Tanaka</name><affiliation><nlm:aff id="aff1">Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan</nlm:aff></affiliation></author><author><name sortKey="Miyake, Kensuke" sort="Miyake, Kensuke" uniqKey="Miyake K" first="Kensuke" last="Miyake">Kensuke Miyake</name><affiliation><nlm:aff id="aff3">Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Eisfeld, Amie J" sort="Eisfeld, Amie J" uniqKey="Eisfeld A" first="Amie J." last="Eisfeld">Amie J. Eisfeld</name><affiliation><nlm:aff id="aff4">Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA</nlm:aff></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><nlm:aff id="aff1">Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22031950</idno><idno type="pmc">3255869</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255869</idno><idno type="RBID">PMC:3255869</idno><idno type="doi">10.1128/JVI.06168-11</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000640</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000640</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The TLR4-TRIF Pathway Protects against H5N1 Influenza Virus Infection</title><author><name sortKey="Shinya, Kyoko" sort="Shinya, Kyoko" uniqKey="Shinya K" first="Kyoko" last="Shinya">Kyoko Shinya</name><affiliation><nlm:aff id="aff1">Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan</nlm:aff></affiliation></author><author><name sortKey="Ito, Mutsumi" sort="Ito, Mutsumi" uniqKey="Ito M" first="Mutsumi" last="Ito">Mutsumi Ito</name><affiliation><nlm:aff id="aff2">Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Makino, Akiko" sort="Makino, Akiko" uniqKey="Makino A" first="Akiko" last="Makino">Akiko Makino</name><affiliation><nlm:aff id="aff1">Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Motoko" sort="Tanaka, Motoko" uniqKey="Tanaka M" first="Motoko" last="Tanaka">Motoko Tanaka</name><affiliation><nlm:aff id="aff1">Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan</nlm:aff></affiliation></author><author><name sortKey="Miyake, Kensuke" sort="Miyake, Kensuke" uniqKey="Miyake K" first="Kensuke" last="Miyake">Kensuke Miyake</name><affiliation><nlm:aff id="aff3">Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Eisfeld, Amie J" sort="Eisfeld, Amie J" uniqKey="Eisfeld A" first="Amie J." last="Eisfeld">Amie J. Eisfeld</name><affiliation><nlm:aff id="aff4">Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA</nlm:aff></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><nlm:aff id="aff1">Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Prestimulation of the TLR4 pathway with lipopolysaccharide (LPS) protects mice from lethal infection with H5N1 influenza virus. Here, we reveal that the TLR4-TRIF pathway is required for this protective effect by using mice whose TLR4-related molecules were knocked out. Microarray analysis of primary mouse lung culture cells that were LPS pretreated and infected with an H5N1 virus indicated that TLR3 mRNA was upregulated. Primary lung culture cells of TLR3 knockout mice showed no response to LPS pretreatment against H5N1 virus infection, suggesting that TLR3 is also involved in the preventive effect of LPS. Our data suggest that the TLR4-TRIF axis has an important role in stimulating protective innate immunity against H5N1 influenza A virus infection and that TLR3 signaling is involved in this pathway.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="hwp">jvi</journal-id><journal-id journal-id-type="pmc">jvi</journal-id><journal-id journal-id-type="publisher-id">JVI</journal-id><journal-title-group><journal-title>Journal of Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22031950</article-id><article-id pub-id-type="pmc">3255869</article-id><article-id pub-id-type="publisher-id">6168-11</article-id><article-id pub-id-type="doi">10.1128/JVI.06168-11</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject></subj-group></article-categories><title-group><article-title>The TLR4-TRIF Pathway Protects against H5N1 Influenza Virus Infection</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Shinya</surname><given-names>Kyoko</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ito</surname><given-names>Mutsumi</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Makino</surname><given-names>Akiko</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tanaka</surname><given-names>Motoko</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Miyake</surname><given-names>Kensuke</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Eisfeld</surname><given-names>Amie J.</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Kawaoka</surname><given-names>Yoshihiro</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="aff" rid="aff4"><sup>d</sup></xref><xref ref-type="aff" rid="aff5"><sup>e</sup></xref><xref ref-type="aff" rid="aff6"><sup>f</sup></xref></contrib><aff id="aff1"><label>a</label>Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan</aff><aff id="aff2"><label>b</label>Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan</aff><aff id="aff3"><label>c</label>Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan</aff><aff id="aff4"><label>d</label>Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA</aff><aff id="aff5"><label>e</label>International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan</aff><aff id="aff6"><label>f</label>ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan</aff></contrib-group><author-notes><corresp>Address correspondence to Yoshihiro Kawaoka, <email>kawaokay@svm.vetmed.wisc.edu</email>.</corresp><fn fn-type="equal"><p>K.S. and M.I. contributed equally to this work.</p></fn></author-notes><pub-date pub-type="ppub"><month>1</month><year>2012</year></pub-date><volume>86</volume><issue>1</issue><fpage>19</fpage><lpage>24</lpage><history><date date-type="received"><day>29</day><month>8</month><year>2011</year></date><date date-type="accepted"><day>17</day><month>10</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2012, American Society for Microbiology. All Rights Reserved.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>American Society for Microbiology</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjv00112000019.pdf"></self-uri><abstract><p>Prestimulation of the TLR4 pathway with lipopolysaccharide (LPS) protects mice from lethal infection with H5N1 influenza virus. Here, we reveal that the TLR4-TRIF pathway is required for this protective effect by using mice whose TLR4-related molecules were knocked out. Microarray analysis of primary mouse lung culture cells that were LPS pretreated and infected with an H5N1 virus indicated that TLR3 mRNA was upregulated. Primary lung culture cells of TLR3 knockout mice showed no response to LPS pretreatment against H5N1 virus infection, suggesting that TLR3 is also involved in the preventive effect of LPS. Our data suggest that the TLR4-TRIF axis has an important role in stimulating protective innate immunity against H5N1 influenza A virus infection and that TLR3 signaling is involved in this pathway.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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