Serveur d'exploration H2N2

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<title xml:lang="en">Human Infection with an Avian H9N2 Influenza A Virus in Hong Kong in 2003</title>
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<title xml:lang="en" level="a" type="main">Human Infection with an Avian H9N2 Influenza A Virus in Hong Kong in 2003</title>
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<name sortKey="Butt, K M" sort="Butt, K M" uniqKey="Butt K" first="K. M." last="Butt">K. M. Butt</name>
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<name sortKey="Leung, Y H Connie" sort="Leung, Y H Connie" uniqKey="Leung Y" first="Y. H. Connie" last="Leung">Y. H. Connie Leung</name>
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<name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name>
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<p>Avian H9N2 influenza A virus has caused repeated human infections in Asia since 1998. Here we report that an H9N2 influenza virus infected a 5-year-old child in Hong Kong in 2003. To identify the possible source of the infection, the human isolate and other H9N2 influenza viruses isolated from Hong Kong poultry markets from January to October 2003 were genetically and antigenically characterized. The findings of this study show that the human H9N2 influenza virus, A/Hong Kong/2108/03, is of purely avian origin and is closely related to some viruses circulating in poultry in the markets of Hong Kong. The continued presence of H9N2 influenza viruses in poultry markets in southern China increases the likelihood of avian-to-human interspecies transmission.</p>
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<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<journal-id journal-id-type="nlm-ta">J Clin Microbiol</journal-id>
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<journal-title>Journal of Clinical Microbiology</journal-title>
<issn pub-type="ppub">0095-1137</issn>
<issn pub-type="epub">1098-660X</issn>
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<article-id pub-id-type="doi">10.1128/JCM.43.11.5760-5767.2005</article-id>
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<subject>Virology</subject>
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<article-title>Human Infection with an Avian H9N2 Influenza A Virus in Hong Kong in 2003</article-title>
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<name>
<surname>Butt</surname>
<given-names>K. M.</given-names>
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<contrib contrib-type="author">
<name>
<surname>Smith</surname>
<given-names>Gavin J. D.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Honglin</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhang</surname>
<given-names>L. J.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Leung</surname>
<given-names>Y. H. Connie</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Xu</surname>
<given-names>K. M.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lim</surname>
<given-names>Wilina</given-names>
</name>
<xref ref-type="aff" rid="aff1">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Webster</surname>
<given-names>Robert G.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff1">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yuen</surname>
<given-names>K. Y.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Peiris</surname>
<given-names>J. S. Malik</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Guan</surname>
<given-names>Yi</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff1">2</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
</contrib-group>
<aff id="aff1">Department of Microbiology, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, People's Republic of China,
<label>1</label>
Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, Shantou, Guangdong 515031, People's Republic of China,
<label>2</label>
Virus Unit, Department of Health, Hong Kong SAR, People's Republic of China,
<label>3</label>
Virology Division, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105
<label>4</label>
</aff>
<author-notes>
<fn id="cor1">
<label>*</label>
<p>Corresponding author. Mailing address: Department of Microbiology, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, People's Republic of China. Phone: 2819-9829. Fax: 2819-9827. E-mail:
<email>yguan@hkucc.hku.hk</email>
.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub">
<month>11</month>
<year>2005</year>
</pub-date>
<volume>43</volume>
<issue>11</issue>
<fpage>5760</fpage>
<lpage>5767</lpage>
<history>
<date date-type="received">
<day>26</day>
<month>4</month>
<year>2005</year>
</date>
<date date-type="rev-recd">
<day>19</day>
<month>7</month>
<year>2005</year>
</date>
<date date-type="accepted">
<day>13</day>
<month>8</month>
<year>2005</year>
</date>
</history>
<copyright-year>2005</copyright-year>
<abstract>
<p>Avian H9N2 influenza A virus has caused repeated human infections in Asia since 1998. Here we report that an H9N2 influenza virus infected a 5-year-old child in Hong Kong in 2003. To identify the possible source of the infection, the human isolate and other H9N2 influenza viruses isolated from Hong Kong poultry markets from January to October 2003 were genetically and antigenically characterized. The findings of this study show that the human H9N2 influenza virus, A/Hong Kong/2108/03, is of purely avian origin and is closely related to some viruses circulating in poultry in the markets of Hong Kong. The continued presence of H9N2 influenza viruses in poultry markets in southern China increases the likelihood of avian-to-human interspecies transmission.</p>
</abstract>
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