Serveur d'exploration H2N2

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<title xml:lang="en">Laboratory-Based Surveillance and Molecular Epidemiology of Influenza Virus in Taiwan</title>
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<name sortKey="Shih, Shin Ru" sort="Shih, Shin Ru" uniqKey="Shih S" first="Shin-Ru" last="Shih">Shin-Ru Shih</name>
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<name sortKey="Chen, Guang Wu" sort="Chen, Guang Wu" uniqKey="Chen G" first="Guang-Wu" last="Chen">Guang-Wu Chen</name>
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<name sortKey="Yang, Ching Chun" sort="Yang, Ching Chun" uniqKey="Yang C" first="Ching-Chun" last="Yang">Ching-Chun Yang</name>
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<name sortKey="Yang, Weng Zhi" sort="Yang, Weng Zhi" uniqKey="Yang W" first="Weng-Zhi" last="Yang">Weng-Zhi Yang</name>
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<name sortKey="Liu, Ding Ping" sort="Liu, Ding Ping" uniqKey="Liu D" first="Ding-Ping" last="Liu">Ding-Ping Liu</name>
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<name sortKey="Lin, Jih Hui" sort="Lin, Jih Hui" uniqKey="Lin J" first="Jih-Hui" last="Lin">Jih-Hui Lin</name>
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<name sortKey="Chiu, Shu Chun" sort="Chiu, Shu Chun" uniqKey="Chiu S" first="Shu-Chun" last="Chiu">Shu-Chun Chiu</name>
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<name sortKey="Chen, Haur Young" sort="Chen, Haur Young" uniqKey="Chen H" first="Haur-Young" last="Chen">Haur-Young Chen</name>
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<name sortKey="Tsao, Kuo Chien" sort="Tsao, Kuo Chien" uniqKey="Tsao K" first="Kuo-Chien" last="Tsao">Kuo-Chien Tsao</name>
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<author>
<name sortKey="Huang, Chung Guei" sort="Huang, Chung Guei" uniqKey="Huang C" first="Chung-Guei" last="Huang">Chung-Guei Huang</name>
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<name sortKey="Huang, Ya Ling" sort="Huang, Ya Ling" uniqKey="Huang Y" first="Ya-Ling" last="Huang">Ya-Ling Huang</name>
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<author>
<name sortKey="Mok, Chee Keng" sort="Mok, Chee Keng" uniqKey="Mok C" first="Chee-Keng" last="Mok">Chee-Keng Mok</name>
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<author>
<name sortKey="Chen, Chi Jene" sort="Chen, Chi Jene" uniqKey="Chen C" first="Chi-Jene" last="Chen">Chi-Jene Chen</name>
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<name sortKey="Lin, Tzou Yien" sort="Lin, Tzou Yien" uniqKey="Lin T" first="Tzou-Yien" last="Lin">Tzou-Yien Lin</name>
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<author>
<name sortKey="Wang, Jen Ren" sort="Wang, Jen Ren" uniqKey="Wang J" first="Jen-Ren" last="Wang">Jen-Ren Wang</name>
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<author>
<name sortKey="Kao, Chuan Liang" sort="Kao, Chuan Liang" uniqKey="Kao C" first="Chuan-Liang" last="Kao">Chuan-Liang Kao</name>
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<author>
<name sortKey="Lin, Kwei Hsian" sort="Lin, Kwei Hsian" uniqKey="Lin K" first="Kwei-Hsian" last="Lin">Kwei-Hsian Lin</name>
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<author>
<name sortKey="Chen, Li Kuang" sort="Chen, Li Kuang" uniqKey="Chen L" first="Li-Kuang" last="Chen">Li-Kuang Chen</name>
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<author>
<name sortKey="Eng, Hock Liew" sort="Eng, Hock Liew" uniqKey="Eng H" first="Hock-Liew" last="Eng">Hock-Liew Eng</name>
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<name sortKey="Liu, Yung Ching" sort="Liu, Yung Ching" uniqKey="Liu Y" first="Yung-Ching" last="Liu">Yung-Ching Liu</name>
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<author>
<name sortKey="Chen, Po Yen" sort="Chen, Po Yen" uniqKey="Chen P" first="Po-Yen" last="Chen">Po-Yen Chen</name>
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<name sortKey="Lin, Jen Shiou" sort="Lin, Jen Shiou" uniqKey="Lin J" first="Jen-Shiou" last="Lin">Jen-Shiou Lin</name>
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<name sortKey="Wang, Jen Hsien" sort="Wang, Jen Hsien" uniqKey="Wang J" first="Jen-Hsien" last="Wang">Jen-Hsien Wang</name>
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<name sortKey="Lin, Cheng Wen" sort="Lin, Cheng Wen" uniqKey="Lin C" first="Cheng-Wen" last="Lin">Cheng-Wen Lin</name>
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<author>
<name sortKey="Chan, Yu Jiun" sort="Chan, Yu Jiun" uniqKey="Chan Y" first="Yu-Jiun" last="Chan">Yu-Jiun Chan</name>
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<author>
<name sortKey="Lu, Jang Jih" sort="Lu, Jang Jih" uniqKey="Lu J" first="Jang-Jih" last="Lu">Jang-Jih Lu</name>
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<name sortKey="Hsiung, Chao A" sort="Hsiung, Chao A" uniqKey="Hsiung C" first="Chao A." last="Hsiung">Chao A. Hsiung</name>
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<author>
<name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name>
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<author>
<name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name>
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<title xml:lang="en" level="a" type="main">Laboratory-Based Surveillance and Molecular Epidemiology of Influenza Virus in Taiwan</title>
<author>
<name sortKey="Shih, Shin Ru" sort="Shih, Shin Ru" uniqKey="Shih S" first="Shin-Ru" last="Shih">Shin-Ru Shih</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chen, Guang Wu" sort="Chen, Guang Wu" uniqKey="Chen G" first="Guang-Wu" last="Chen">Guang-Wu Chen</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yang, Ching Chun" sort="Yang, Ching Chun" uniqKey="Yang C" first="Ching-Chun" last="Yang">Ching-Chun Yang</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yang, Weng Zhi" sort="Yang, Weng Zhi" uniqKey="Yang W" first="Weng-Zhi" last="Yang">Weng-Zhi Yang</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Liu, Ding Ping" sort="Liu, Ding Ping" uniqKey="Liu D" first="Ding-Ping" last="Liu">Ding-Ping Liu</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lin, Jih Hui" sort="Lin, Jih Hui" uniqKey="Lin J" first="Jih-Hui" last="Lin">Jih-Hui Lin</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chiu, Shu Chun" sort="Chiu, Shu Chun" uniqKey="Chiu S" first="Shu-Chun" last="Chiu">Shu-Chun Chiu</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chen, Haur Young" sort="Chen, Haur Young" uniqKey="Chen H" first="Haur-Young" last="Chen">Haur-Young Chen</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tsao, Kuo Chien" sort="Tsao, Kuo Chien" uniqKey="Tsao K" first="Kuo-Chien" last="Tsao">Kuo-Chien Tsao</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Huang, Chung Guei" sort="Huang, Chung Guei" uniqKey="Huang C" first="Chung-Guei" last="Huang">Chung-Guei Huang</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Huang, Ya Ling" sort="Huang, Ya Ling" uniqKey="Huang Y" first="Ya-Ling" last="Huang">Ya-Ling Huang</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mok, Chee Keng" sort="Mok, Chee Keng" uniqKey="Mok C" first="Chee-Keng" last="Mok">Chee-Keng Mok</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chen, Chi Jene" sort="Chen, Chi Jene" uniqKey="Chen C" first="Chi-Jene" last="Chen">Chi-Jene Chen</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lin, Tzou Yien" sort="Lin, Tzou Yien" uniqKey="Lin T" first="Tzou-Yien" last="Lin">Tzou-Yien Lin</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wang, Jen Ren" sort="Wang, Jen Ren" uniqKey="Wang J" first="Jen-Ren" last="Wang">Jen-Ren Wang</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kao, Chuan Liang" sort="Kao, Chuan Liang" uniqKey="Kao C" first="Chuan-Liang" last="Kao">Chuan-Liang Kao</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lin, Kwei Hsian" sort="Lin, Kwei Hsian" uniqKey="Lin K" first="Kwei-Hsian" last="Lin">Kwei-Hsian Lin</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chen, Li Kuang" sort="Chen, Li Kuang" uniqKey="Chen L" first="Li-Kuang" last="Chen">Li-Kuang Chen</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Eng, Hock Liew" sort="Eng, Hock Liew" uniqKey="Eng H" first="Hock-Liew" last="Eng">Hock-Liew Eng</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Liu, Yung Ching" sort="Liu, Yung Ching" uniqKey="Liu Y" first="Yung-Ching" last="Liu">Yung-Ching Liu</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chen, Po Yen" sort="Chen, Po Yen" uniqKey="Chen P" first="Po-Yen" last="Chen">Po-Yen Chen</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lin, Jen Shiou" sort="Lin, Jen Shiou" uniqKey="Lin J" first="Jen-Shiou" last="Lin">Jen-Shiou Lin</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wang, Jen Hsien" sort="Wang, Jen Hsien" uniqKey="Wang J" first="Jen-Hsien" last="Wang">Jen-Hsien Wang</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lin, Cheng Wen" sort="Lin, Cheng Wen" uniqKey="Lin C" first="Cheng-Wen" last="Lin">Cheng-Wen Lin</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chan, Yu Jiun" sort="Chan, Yu Jiun" uniqKey="Chan Y" first="Yu-Jiun" last="Chan">Yu-Jiun Chan</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lu, Jang Jih" sort="Lu, Jang Jih" uniqKey="Lu J" first="Jang-Jih" last="Lu">Jang-Jih Lu</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hsiung, Chao A" sort="Hsiung, Chao A" uniqKey="Hsiung C" first="Chao A." last="Hsiung">Chao A. Hsiung</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Journal of Clinical Microbiology</title>
<idno type="ISSN">0095-1137</idno>
<idno type="eISSN">1098-660X</idno>
<imprint>
<date when="2005">2005</date>
</imprint>
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<front>
<div type="abstract" xml:lang="en">
<p>A laboratory-based surveillance network of 11 clinical virological laboratories for influenza viruses was established in Taiwan under the coordination of the Center for Disease Control and Prevention (CDC), Taiwan. From October 2000 to March 2004, 3,244 influenza viruses were isolated, including 1,969 influenza A and 1,275 influenza B viruses. The influenza infections usually occurred frequently in winter in the northern hemisphere. However, the influenza seasonality in Taiwan was not clear during the four seasons under investigation. For example, the influenza A viruses peaked during the winters of 2001, 2002, and 2003. However, some isolated peaks were also found in the summer and fall (June to November) of 2001 and 2002. An unusual peak of influenza B also occurred in the summer of 2002 (June to August). Phylogenetic analysis shows that influenza A isolates from the same year were often grouped together. However, influenza B isolates from the year 2002 clustered into different groups, and the data indicate that both B/Victoria/2/87-like and B/Yamagata/16/88-like lineages of influenza B viruses were cocirculating. Sequence comparison of epidemic strains versus vaccine strains shows that many vaccine-like Taiwanese strains were circulating at least 2 years before the vaccine strains were introduced. No clear seasonality of influenza reports in Taiwan occurred in contrast to other more continental regions.</p>
</div>
</front>
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<pmc article-type="research-article">
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<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">J Clin Microbiol</journal-id>
<journal-id journal-id-type="publisher-id">jcm</journal-id>
<journal-title>Journal of Clinical Microbiology</journal-title>
<issn pub-type="ppub">0095-1137</issn>
<issn pub-type="epub">1098-660X</issn>
<publisher>
<publisher-name>American Society for Microbiology</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">15814980</article-id>
<article-id pub-id-type="pmc">1081360</article-id>
<article-id pub-id-type="publisher-id">1617-04</article-id>
<article-id pub-id-type="doi">10.1128/JCM.43.4.1651-1661.2005</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Virology</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Laboratory-Based Surveillance and Molecular Epidemiology of Influenza Virus in Taiwan</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Shih</surname>
<given-names>Shin-Ru</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Guang-Wu</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yang</surname>
<given-names>Ching-Chun</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yang</surname>
<given-names>Weng-Zhi</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Liu</surname>
<given-names>Ding-Ping</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lin</surname>
<given-names>Jih-Hui</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chiu</surname>
<given-names>Shu-Chun</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Haur-Young</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tsao</surname>
<given-names>Kuo-Chien</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Huang</surname>
<given-names>Chung-Guei</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Huang</surname>
<given-names>Ya-Ling</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mok</surname>
<given-names>Chee-Keng</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Chi-Jene</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lin</surname>
<given-names>Tzou-Yien</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wang</surname>
<given-names>Jen-Ren</given-names>
</name>
<xref ref-type="aff" rid="aff1">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kao</surname>
<given-names>Chuan-Liang</given-names>
</name>
<xref ref-type="aff" rid="aff1">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lin</surname>
<given-names>Kwei-Hsian</given-names>
</name>
<xref ref-type="aff" rid="aff1">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Li-Kuang</given-names>
</name>
<xref ref-type="aff" rid="aff1">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Eng</surname>
<given-names>Hock-Liew</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Liu</surname>
<given-names>Yung-Ching</given-names>
</name>
<xref ref-type="aff" rid="aff1">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Po-Yen</given-names>
</name>
<xref ref-type="aff" rid="aff1">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lin</surname>
<given-names>Jen-Shiou</given-names>
</name>
<xref ref-type="aff" rid="aff1">8</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wang</surname>
<given-names>Jen-Hsien</given-names>
</name>
<xref ref-type="aff" rid="aff1">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lin</surname>
<given-names>Cheng-Wen</given-names>
</name>
<xref ref-type="aff" rid="aff1">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chan</surname>
<given-names>Yu-Jiun</given-names>
</name>
<xref ref-type="aff" rid="aff1">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lu</surname>
<given-names>Jang-Jih</given-names>
</name>
<xref ref-type="aff" rid="aff1">10</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hsiung</surname>
<given-names>Chao A.</given-names>
</name>
<xref ref-type="aff" rid="aff1">11</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Pei-Jer</given-names>
</name>
<xref ref-type="aff" rid="aff1">4</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Su</surname>
<given-names>Ih-Jen</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
<xref ref-type="aff" rid="aff1">11</xref>
<xref ref-type="corresp" rid="cor2">*</xref>
</contrib>
</contrib-group>
<aff id="aff1">Chang Gung Memorial Hospital & Chang Gung University,
<label>1</label>
National Health Research Institutes,
<label>11</label>
Center for Disease Control and Prevention,
<label>2</label>
National Taiwan University Hospital,
<label>4</label>
Veterans General Hospital,
<label>7</label>
Tri-Service General Hospital, Taipei,
<label>10</label>
National Cheng Kung University Hospital, Tainan,
<label>3</label>
Kaohsiung Medical University, Kaohsiung,
<label>5</label>
Buddhist Tzu Chi General Hospital, Hualien,
<label>6</label>
Changhua Christian Hospital, Changhua,
<label>8</label>
China Medical University Hospital, TaichungTaiwan
<label>9</label>
</aff>
<author-notes>
<fn id="cor1">
<label>*</label>
<p>Corresponding author. Mailing address for Ih-Jen Su: Division of Clinical Research, NHRI, 138, Shen-Li Rd., Tainan, Taiwan. Phone: 886-6-3028045. Fax: 886-6-3028046. E-mail:
<email>suihjen@nhri.org.tw</email>
.</p>
</fn>
<fn id="cor2">
<label>*</label>
<p>Corresponding author. Mailing address for Pei-Jer Chen: Graduate Institute, National Taiwan University Medical College, 1, Jen-Ai Rd., Taipei, Taiwan. Phone: 886-2-23123456, ext. 7311. Fax: 886-2-23709820. E-mail:
<email>peijer@ha.mc.ntu.edu.tw</email>
.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub">
<month>4</month>
<year>2005</year>
</pub-date>
<volume>43</volume>
<issue>4</issue>
<fpage>1651</fpage>
<lpage>1661</lpage>
<history>
<date date-type="received">
<day>31</day>
<month>8</month>
<year>2004</year>
</date>
<date date-type="rev-recd">
<day>23</day>
<month>9</month>
<year>2004</year>
</date>
<date date-type="accepted">
<day>22</day>
<month>11</month>
<year>2004</year>
</date>
</history>
<copyright-statement>Copyright © 2005, American Society for Microbiology</copyright-statement>
<copyright-year>2005</copyright-year>
<abstract>
<p>A laboratory-based surveillance network of 11 clinical virological laboratories for influenza viruses was established in Taiwan under the coordination of the Center for Disease Control and Prevention (CDC), Taiwan. From October 2000 to March 2004, 3,244 influenza viruses were isolated, including 1,969 influenza A and 1,275 influenza B viruses. The influenza infections usually occurred frequently in winter in the northern hemisphere. However, the influenza seasonality in Taiwan was not clear during the four seasons under investigation. For example, the influenza A viruses peaked during the winters of 2001, 2002, and 2003. However, some isolated peaks were also found in the summer and fall (June to November) of 2001 and 2002. An unusual peak of influenza B also occurred in the summer of 2002 (June to August). Phylogenetic analysis shows that influenza A isolates from the same year were often grouped together. However, influenza B isolates from the year 2002 clustered into different groups, and the data indicate that both B/Victoria/2/87-like and B/Yamagata/16/88-like lineages of influenza B viruses were cocirculating. Sequence comparison of epidemic strains versus vaccine strains shows that many vaccine-like Taiwanese strains were circulating at least 2 years before the vaccine strains were introduced. No clear seasonality of influenza reports in Taiwan occurred in contrast to other more continental regions.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>

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