Perspectives on pandemics : A research agenda
Identifieur interne : 000083 ( PascalFrancis/Checkpoint ); précédent : 000082; suivant : 000084Perspectives on pandemics : A research agenda
Auteurs : E. D. Kilbourne [États-Unis]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 1997.
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- Pascal (Inist)
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- topic : Homme, Historique.
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Abstract
During the 20th century, indisputable pandemics of influenza occurred in 1918, 1957, and 1968. The pandemics of 1957 (A/H2N2) and 1968 (A/H3N2) were associated with major antigenic changes in the virus, probably reflecting introduction by recombination of animal virus genes. The 1918 epidemic is beyond the reach of modern virology but, based on seroarcheology, appears to have been caused by a virus very similar to present swine (A/H1N1) influenza viruses. Changes in both principal antigens of the A/H1N1 subtype in 1947 resulted in total vaccine failure and pandemic spread of virus. On the basis of three periods of prevalence in the 20th century, A/H1N1 may be the "default" human virus, although the 39-year persistence of A/H3N2 to the present challenges this view. Only H1, H2, and H3 and N1 and N2 antigens have been found in human influenza viruses, but virologic history is too brief to preclude the contribution of other antigens to future pandemics.
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D." last="Kilbourne">E. D. Kilbourne</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, New York Medical College</s1><s2>Valhalla, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="1997">1997</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case history</term><term>Epidemiology</term><term>Human</term><term>Influenza</term><term>Perspective</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Grippe</term><term>Homme</term><term>Epidémiologie</term><term>Historique</term><term>Perspective</term><term>Pandémie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Historique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the 20th century, indisputable pandemics of influenza occurred in 1918, 1957, and 1968. The pandemics of 1957 (A/H2N2) and 1968 (A/H3N2) were associated with major antigenic changes in the virus, probably reflecting introduction by recombination of animal virus genes. The 1918 epidemic is beyond the reach of modern virology but, based on seroarcheology, appears to have been caused by a virus very similar to present swine (A/H1N1) influenza viruses. Changes in both principal antigens of the A/H1N1 subtype in 1947 resulted in total vaccine failure and pandemic spread of virus. On the basis of three periods of prevalence in the 20th century, A/H1N1 may be the "default" human virus, although the 39-year persistence of A/H3N2 to the present challenges this view. Only H1, H2, and H3 and N1 and N2 antigens have been found in human influenza viruses, but virologic history is too brief to preclude the contribution of other antigens to future pandemics.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-1899</s0></fA01><fA02 i1="01"><s0>JIDIAQ</s0></fA02><fA03 i2="1"><s0>J. infect. dis.</s0></fA03><fA05><s2>176</s2></fA05><fA06><s3>SUP1</s3></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Perspectives on pandemics : A research agenda</s1></fA08><fA11 i1="01" i2="1"><s1>KILBOURNE (E. 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All rights reserved.</s1></fA44><fA45><s0>23 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>97-0460472</s0></fA47><fA60><s1>P</s1><s2>C</s2></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>The Journal of infectious diseases</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>During the 20th century, indisputable pandemics of influenza occurred in 1918, 1957, and 1968. The pandemics of 1957 (A/H2N2) and 1968 (A/H3N2) were associated with major antigenic changes in the virus, probably reflecting introduction by recombination of animal virus genes. The 1918 epidemic is beyond the reach of modern virology but, based on seroarcheology, appears to have been caused by a virus very similar to present swine (A/H1N1) influenza viruses. Changes in both principal antigens of the A/H1N1 subtype in 1947 resulted in total vaccine failure and pandemic spread of virus. On the basis of three periods of prevalence in the 20th century, A/H1N1 may be the "default" human virus, although the 39-year persistence of A/H3N2 to the present challenges this view. Only H1, H2, and H3 and N1 and N2 antigens have been found in human influenza viruses, but virologic history is too brief to preclude the contribution of other antigens to future pandemics.</s0></fC01><fC02 i1="01" i2="X"><s0>002A05C06</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Grippe</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Influenza</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Gripe</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Homme</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Human</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Hombre</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Epidémiologie</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Epidemiology</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Epidemiología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Historique</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Case history</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="GER"><s0>Entwicklungsgeschichte</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Histórica</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Perspective</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Perspective</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Perspectiva</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Pandémie</s0><s4>INC</s4><s5>91</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0></fC07><fN21><s1>279</s1></fN21></pA><pR><fA30 i1="01" i2="1" l="ENG"><s1>Pandemic Influenza: Confronting a Re-emergent Threat</s1><s3>Bethesda, Maryland USA</s3><s4>1995-12-11</s4></fA30></pR></standard></inist><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Kilbourne, E D" sort="Kilbourne, E D" uniqKey="Kilbourne E" first="E. D." last="Kilbourne">E. D. Kilbourne</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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