H2N2V1, PascalFrancis, Checkpoint, bibRecord, 000008

Upstream start codon in segment 4 of North American H2 avian influenza A viruses

Identifieur interne : 000008 ( PascalFrancis/Checkpoint ); précédent : 000007; suivant : 000009

Upstream start codon in segment 4 of North American H2 avian influenza A viruses

Auteurs : Geneviève Girard [Pays-Bas] ; Alexander P. Gultyaev [Pays-Bas] ; René C. L. Olsthoorn [Pays-Bas]

Source :

Infection, genetics and evolution : (Print) [ 1567-1348 ] ; 2011.

RBID : Pascal:11-0148190

Descripteurs français

Pascal (Inist)
- Grippe aviaire, Grippe A, Codon, Hémagglutinine, Virus grippal A, Epidémiologie moléculaire.

English descriptors

KwdEn :
- Avian influenza, Codon, Hemagglutinin, Influenza A, Influenza A virus, Molecular epidemiology.

Abstract

H2N2 influenza A virus was the cause of the 1957 pandemic. Due to its constant presence in birds, the H2 subtype remains a topic of interest. In this work, comparison of H2 leader sequences of influenza A segment 4 revealed the presence of an upstream in-frame start codon in a majority of North American avian strains. This AUG is located seven codons upstream of the conventional start codon and is in a good Kozak context. In vivo experiments, using a luciferase reporter gene fused to leader sequences derived from North American avian H2 strains, support the efficient use of the upstream start codon. These results were corroborated by in vitro translation data using full-length segment 4 mRNA. Phylogenic analyses indicate that the upstream AUG, first detected in 1976, is stably nested in the North American avian lineage of H2 strains nowadays. The possible consequences of the upstream AUG are discussed.

Affiliations:

Pays-Bas

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Pascal:11-0148190

Le document en format XML

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Upstream start codon in segment 4 of North American H2 avian influenza A viruses

Upstream start codon in segment 4 of North American H2 avian influenza A viruses

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri