[Testing of apathogenic influenza virus H5N3 as a poultry live vaccine].
Identifieur interne : 000C49 ( Ncbi/Merge ); précédent : 000C48; suivant : 000C50[Testing of apathogenic influenza virus H5N3 as a poultry live vaccine].
Auteurs : E Y Boravleva ; I A Chvala ; N F Lomakina ; P I Repin ; N S Mudrak ; L G Rudenko ; A S Gambaryan ; V V DryginSource :
- Voprosy virusologii [ 0507-4088 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Grippe chez les oiseaux, Maladies de la volaille, Poulets, Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A.
- virologie : Poulets.
- Animaux, Grippe chez les oiseaux, Maladies de la volaille, Souris.
English descriptors
- KwdEn :
- Animals, Chickens (immunology), Chickens (virology), Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza in Birds (immunology), Influenza in Birds (prevention & control), Mice, Poultry Diseases (immunology), Poultry Diseases (prevention & control), Vaccines, Attenuated (immunology).
- MESH :
- chemical , immunology : Influenza Vaccines, Vaccines, Attenuated.
- immunology : Chickens, Influenza A virus, Influenza in Birds, Poultry Diseases.
- prevention & control : Influenza in Birds, Poultry Diseases.
- virology : Chickens.
- Animals, Mice.
Abstract
Four H5N2 experimental vaccine strains and the apathogenic wild duck H5N3 influenza virus A/duck/ Moscow/4182/2010 (dk/4182) were tested as a live poultry vaccine. Experimental strains had the hemagglutinin of the A/Vietnam/1203/04 strain lacking the polybasic HA cleavage site or the hemagglutinin from attenuated virus (Ku/ at) that was derived from the highly pathogenic influenza virus A/chicken/Kurgan/3/2005 (H5N1). The hemagglutinin of the Ku-at has the amino acid substitutions Asp54/Asn and Lys222/Thr in HA1 and Val48/Ile and Lys131/Thr in HA2, while maintaining the polybasic HA cleavage site at an invariable level. The other genes of these experimental strains were from the H2N2 cold-adapted master strain A/Leningrad/134/17/57 (VN-Len and Ku-Len) or from the apathogenic H6N2 virus A/gull/Moscow/3100/2006 (VN-Gull and Ku-Gull). A single immunization of mice with all tested strains elicited a high level of serum antibodies and provided complete protection against the challenge with the lethal dose of A/chicken/Kurgan/3/05. The pathogenicity indexes of the Ku-at and the other strains for chicken were virtually zero, whereas the index of the parent H5N1 virus A/chicken/Kurgan/3/2005 was 2.98. Intravenous, intranasal, and aerosol routes of vaccination were compared. It was shown that the strain dk/4182 was totally apathogenic for one-day-old chicken and provided complete protection against the highly pathogenic H5N1 virus.
PubMed: 26665435
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pubmed:26665435Le document en format XML
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<author><name sortKey="Chvala, I A" sort="Chvala, I A" uniqKey="Chvala I" first="I A" last="Chvala">I A Chvala</name>
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<author><name sortKey="Lomakina, N F" sort="Lomakina, N F" uniqKey="Lomakina N" first="N F" last="Lomakina">N F Lomakina</name>
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<series><title level="j">Voprosy virusologii</title>
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<term>Influenza A virus (immunology)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza in Birds (immunology)</term>
<term>Influenza in Birds (prevention & control)</term>
<term>Mice</term>
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<term>Grippe chez les oiseaux ()</term>
<term>Grippe chez les oiseaux (immunologie)</term>
<term>Maladies de la volaille ()</term>
<term>Maladies de la volaille (immunologie)</term>
<term>Poulets (immunologie)</term>
<term>Poulets (virologie)</term>
<term>Souris</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins atténués (immunologie)</term>
<term>Virus de la grippe A (immunologie)</term>
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<term>Maladies de la volaille</term>
<term>Poulets</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Virus de la grippe A</term>
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<term>Mice</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Grippe chez les oiseaux</term>
<term>Maladies de la volaille</term>
<term>Souris</term>
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<front><div type="abstract" xml:lang="en">Four H5N2 experimental vaccine strains and the apathogenic wild duck H5N3 influenza virus A/duck/ Moscow/4182/2010 (dk/4182) were tested as a live poultry vaccine. Experimental strains had the hemagglutinin of the A/Vietnam/1203/04 strain lacking the polybasic HA cleavage site or the hemagglutinin from attenuated virus (Ku/ at) that was derived from the highly pathogenic influenza virus A/chicken/Kurgan/3/2005 (H5N1). The hemagglutinin of the Ku-at has the amino acid substitutions Asp54/Asn and Lys222/Thr in HA1 and Val48/Ile and Lys131/Thr in HA2, while maintaining the polybasic HA cleavage site at an invariable level. The other genes of these experimental strains were from the H2N2 cold-adapted master strain A/Leningrad/134/17/57 (VN-Len and Ku-Len) or from the apathogenic H6N2 virus A/gull/Moscow/3100/2006 (VN-Gull and Ku-Gull). A single immunization of mice with all tested strains elicited a high level of serum antibodies and provided complete protection against the challenge with the lethal dose of A/chicken/Kurgan/3/05. The pathogenicity indexes of the Ku-at and the other strains for chicken were virtually zero, whereas the index of the parent H5N1 virus A/chicken/Kurgan/3/2005 was 2.98. Intravenous, intranasal, and aerosol routes of vaccination were compared. It was shown that the strain dk/4182 was totally apathogenic for one-day-old chicken and provided complete protection against the highly pathogenic H5N1 virus.</div>
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<Abstract><AbstractText>Four H5N2 experimental vaccine strains and the apathogenic wild duck H5N3 influenza virus A/duck/ Moscow/4182/2010 (dk/4182) were tested as a live poultry vaccine. Experimental strains had the hemagglutinin of the A/Vietnam/1203/04 strain lacking the polybasic HA cleavage site or the hemagglutinin from attenuated virus (Ku/ at) that was derived from the highly pathogenic influenza virus A/chicken/Kurgan/3/2005 (H5N1). The hemagglutinin of the Ku-at has the amino acid substitutions Asp54/Asn and Lys222/Thr in HA1 and Val48/Ile and Lys131/Thr in HA2, while maintaining the polybasic HA cleavage site at an invariable level. The other genes of these experimental strains were from the H2N2 cold-adapted master strain A/Leningrad/134/17/57 (VN-Len and Ku-Len) or from the apathogenic H6N2 virus A/gull/Moscow/3100/2006 (VN-Gull and Ku-Gull). A single immunization of mice with all tested strains elicited a high level of serum antibodies and provided complete protection against the challenge with the lethal dose of A/chicken/Kurgan/3/05. The pathogenicity indexes of the Ku-at and the other strains for chicken were virtually zero, whereas the index of the parent H5N1 virus A/chicken/Kurgan/3/2005 was 2.98. Intravenous, intranasal, and aerosol routes of vaccination were compared. It was shown that the strain dk/4182 was totally apathogenic for one-day-old chicken and provided complete protection against the highly pathogenic H5N1 virus.</AbstractText>
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