[Testing of apathogenic influenza virus H5N3 as a poultry live vaccine].
Identifieur interne : 000057 ( PubMed/Curation ); précédent : 000056; suivant : 000058[Testing of apathogenic influenza virus H5N3 as a poultry live vaccine].
Auteurs : E Y Boravleva ; I A Chvala ; N F Lomakina ; P I Repin ; N S Mudrak ; L G Rudenko ; A S Gambaryan ; V V DryginSource :
- Voprosy virusologii [ 0507-4088 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Grippe chez les oiseaux, Maladies de la volaille, Poulets, Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A.
- virologie : Poulets.
- Animaux, Grippe chez les oiseaux, Maladies de la volaille, Souris.
English descriptors
- KwdEn :
- Animals, Chickens (immunology), Chickens (virology), Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza in Birds (immunology), Influenza in Birds (prevention & control), Mice, Poultry Diseases (immunology), Poultry Diseases (prevention & control), Vaccines, Attenuated (immunology).
- MESH :
- chemical , immunology : Influenza Vaccines, Vaccines, Attenuated.
- immunology : Chickens, Influenza A virus, Influenza in Birds, Poultry Diseases.
- prevention & control : Influenza in Birds, Poultry Diseases.
- virology : Chickens.
- Animals, Mice.
Abstract
Four H5N2 experimental vaccine strains and the apathogenic wild duck H5N3 influenza virus A/duck/ Moscow/4182/2010 (dk/4182) were tested as a live poultry vaccine. Experimental strains had the hemagglutinin of the A/Vietnam/1203/04 strain lacking the polybasic HA cleavage site or the hemagglutinin from attenuated virus (Ku/ at) that was derived from the highly pathogenic influenza virus A/chicken/Kurgan/3/2005 (H5N1). The hemagglutinin of the Ku-at has the amino acid substitutions Asp54/Asn and Lys222/Thr in HA1 and Val48/Ile and Lys131/Thr in HA2, while maintaining the polybasic HA cleavage site at an invariable level. The other genes of these experimental strains were from the H2N2 cold-adapted master strain A/Leningrad/134/17/57 (VN-Len and Ku-Len) or from the apathogenic H6N2 virus A/gull/Moscow/3100/2006 (VN-Gull and Ku-Gull). A single immunization of mice with all tested strains elicited a high level of serum antibodies and provided complete protection against the challenge with the lethal dose of A/chicken/Kurgan/3/05. The pathogenicity indexes of the Ku-at and the other strains for chicken were virtually zero, whereas the index of the parent H5N1 virus A/chicken/Kurgan/3/2005 was 2.98. Intravenous, intranasal, and aerosol routes of vaccination were compared. It was shown that the strain dk/4182 was totally apathogenic for one-day-old chicken and provided complete protection against the highly pathogenic H5N1 virus.
PubMed: 26665435
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uniqKey="Gambaryan A" first="A S" last="Gambaryan">A S Gambaryan</name></author><author><name sortKey="Drygin, V V" sort="Drygin, V V" uniqKey="Drygin V" first="V V" last="Drygin">V V Drygin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26665435</idno><idno type="pmid">26665435</idno><idno type="wicri:Area/PubMed/Corpus">000057</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000057</idno><idno type="wicri:Area/PubMed/Curation">000057</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000057</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Testing of apathogenic influenza virus H5N3 as a poultry live vaccine].</title><author><name sortKey="Boravleva, E Y" sort="Boravleva, E Y" uniqKey="Boravleva E" first="E Y" last="Boravleva">E Y Boravleva</name></author><author><name sortKey="Chvala, I A" sort="Chvala, I A" uniqKey="Chvala I" first="I A" last="Chvala">I A Chvala</name></author><author><name sortKey="Lomakina, N F" sort="Lomakina, N F" uniqKey="Lomakina N" first="N F" last="Lomakina">N F Lomakina</name></author><author><name sortKey="Repin, P I" sort="Repin, P I" uniqKey="Repin P" first="P I" last="Repin">P I Repin</name></author><author><name sortKey="Mudrak, N S" sort="Mudrak, N S" uniqKey="Mudrak N" first="N S" last="Mudrak">N S Mudrak</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author><author><name sortKey="Gambaryan, A S" sort="Gambaryan, A S" uniqKey="Gambaryan A" first="A S" last="Gambaryan">A S Gambaryan</name></author><author><name sortKey="Drygin, V V" sort="Drygin, V V" uniqKey="Drygin V" first="V V" last="Drygin">V V Drygin</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno><imprint><date when="2015" 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(immunologie)</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Maladies de la volaille</term><term>Poulets</term><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Chickens</term><term>Influenza A virus</term><term>Influenza in Birds</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza in Birds</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poulets</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chickens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Grippe chez les oiseaux</term><term>Maladies de la volaille</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Four H5N2 experimental vaccine strains and the apathogenic wild duck H5N3 influenza virus A/duck/ Moscow/4182/2010 (dk/4182) were tested as a live poultry vaccine. Experimental strains had the hemagglutinin of the A/Vietnam/1203/04 strain lacking the polybasic HA cleavage site or the hemagglutinin from attenuated virus (Ku/ at) that was derived from the highly pathogenic influenza virus A/chicken/Kurgan/3/2005 (H5N1). The hemagglutinin of the Ku-at has the amino acid substitutions Asp54/Asn and Lys222/Thr in HA1 and Val48/Ile and Lys131/Thr in HA2, while maintaining the polybasic HA cleavage site at an invariable level. The other genes of these experimental strains were from the H2N2 cold-adapted master strain A/Leningrad/134/17/57 (VN-Len and Ku-Len) or from the apathogenic H6N2 virus A/gull/Moscow/3100/2006 (VN-Gull and Ku-Gull). A single immunization of mice with all tested strains elicited a high level of serum antibodies and provided complete protection against the challenge with the lethal dose of A/chicken/Kurgan/3/05. The pathogenicity indexes of the Ku-at and the other strains for chicken were virtually zero, whereas the index of the parent H5N1 virus A/chicken/Kurgan/3/2005 was 2.98. Intravenous, intranasal, and aerosol routes of vaccination were compared. It was shown that the strain dk/4182 was totally apathogenic for one-day-old chicken and provided complete protection against the highly pathogenic H5N1 virus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26665435</PMID><DateCompleted><Year>2015</Year><Month>12</Month><Day>29</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0507-4088</ISSN><JournalIssue CitedMedium="Print"><Volume>60</Volume><Issue>4</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>Voprosy virusologii</Title><ISOAbbreviation>Vopr. Virusol.</ISOAbbreviation></Journal><ArticleTitle>[Testing of apathogenic influenza virus H5N3 as a poultry live vaccine].</ArticleTitle><Pagination><MedlinePgn>44-9</MedlinePgn></Pagination><Abstract><AbstractText>Four H5N2 experimental vaccine strains and the apathogenic wild duck H5N3 influenza virus A/duck/ Moscow/4182/2010 (dk/4182) were tested as a live poultry vaccine. Experimental strains had the hemagglutinin of the A/Vietnam/1203/04 strain lacking the polybasic HA cleavage site or the hemagglutinin from attenuated virus (Ku/ at) that was derived from the highly pathogenic influenza virus A/chicken/Kurgan/3/2005 (H5N1). The hemagglutinin of the Ku-at has the amino acid substitutions Asp54/Asn and Lys222/Thr in HA1 and Val48/Ile and Lys131/Thr in HA2, while maintaining the polybasic HA cleavage site at an invariable level. The other genes of these experimental strains were from the H2N2 cold-adapted master strain A/Leningrad/134/17/57 (VN-Len and Ku-Len) or from the apathogenic H6N2 virus A/gull/Moscow/3100/2006 (VN-Gull and Ku-Gull). A single immunization of mice with all tested strains elicited a high level of serum antibodies and provided complete protection against the challenge with the lethal dose of A/chicken/Kurgan/3/05. The pathogenicity indexes of the Ku-at and the other strains for chicken were virtually zero, whereas the index of the parent H5N1 virus A/chicken/Kurgan/3/2005 was 2.98. Intravenous, intranasal, and aerosol routes of vaccination were compared. It was shown that the strain dk/4182 was totally apathogenic for one-day-old chicken and provided complete protection against the highly pathogenic H5N1 virus.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Boravleva</LastName><ForeName>E Y</ForeName><Initials>EY</Initials></Author><Author ValidYN="Y"><LastName>Chvala</LastName><ForeName>I A</ForeName><Initials>IA</Initials></Author><Author ValidYN="Y"><LastName>Lomakina</LastName><ForeName>N F</ForeName><Initials>NF</Initials></Author><Author ValidYN="Y"><LastName>Repin</LastName><ForeName>P I</ForeName><Initials>PI</Initials></Author><Author ValidYN="Y"><LastName>Mudrak</LastName><ForeName>N S</ForeName><Initials>NS</Initials></Author><Author ValidYN="Y"><LastName>Rudenko</LastName><ForeName>L G</ForeName><Initials>LG</Initials></Author><Author ValidYN="Y"><LastName>Gambaryan</LastName><ForeName>A S</ForeName><Initials>AS</Initials></Author><Author ValidYN="Y"><LastName>Drygin</LastName><ForeName>V V</ForeName><Initials>VV</Initials></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Vopr Virusol</MedlineTA><NlmUniqueID>0417337</NlmUniqueID><ISSNLinking>0507-4088</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002645" MajorTopicYN="Y">Chickens</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="Y">Influenza in Birds</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011201" MajorTopicYN="Y">Poultry Diseases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014613" MajorTopicYN="N">Vaccines, Attenuated</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26665435</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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