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Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus

Identifieur interne : 000C21 ( Ncbi/Curation ); précédent : 000C20; suivant : 000C22

Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus

Auteurs : Sjouke Van Poucke [Belgique] ; Jennifer Doedt [Allemagne] ; Jan Baumann [Allemagne] ; Yu Qiu [Belgique] ; Tatyana Matrosovich [Allemagne] ; Hans-Dieter Klenk [Allemagne] ; Kristien Van Reeth [Belgique] ; Mikhail Matrosovich [Allemagne]

Source :

Journal of Virology [ 0022-538X ] ; 2015.

RBID : PMC:4645308

Abstract

Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645308

DOI: 10.1128/JVI.01292-15
PubMed: 26378170
PubMed Central: 4645308

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PMC:4645308

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.</p>
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Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus

Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus

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Abstract

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