Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus
Identifieur interne : 000366 ( Pmc/Checkpoint ); précédent : 000365; suivant : 000367Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus
Auteurs : Sjouke Van Poucke [Belgique] ; Jennifer Doedt [Allemagne] ; Jan Baumann [Allemagne] ; Yu Qiu [Belgique] ; Tatyana Matrosovich [Allemagne] ; Hans-Dieter Klenk [Allemagne] ; Kristien Van Reeth [Belgique] ; Mikhail Matrosovich [Allemagne]Source :
- Journal of Virology [ 0022-538X ] ; 2015.
Abstract
Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.
Url:
DOI: 10.1128/JVI.01292-15
PubMed: 26378170
PubMed Central: 4645308
Affiliations:
- Allemagne, Belgique
- District de Giessen, Hesse (Land), Province de Flandre-Orientale, Région flamande
- Gand, Marbourg
- Université de Gand
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<front><div type="abstract" xml:lang="en"><p>Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.</p>
</div>
</front>
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<pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Virol</journal-id>
<journal-id journal-id-type="hwp">jvi</journal-id>
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<title-group><article-title>Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus</article-title>
<alt-title alt-title-type="running-head">Changes in the HA of the 1968 Pandemic Influenza Virus</alt-title>
<alt-title alt-title-type="short-authors">Van Poucke et al.</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Van Poucke</surname>
<given-names>Sjouke</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
<xref ref-type="author-notes" rid="fn1">*</xref>
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<contrib contrib-type="author"><name><surname>Doedt</surname>
<given-names>Jennifer</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>b</sup>
</xref>
<xref ref-type="author-notes" rid="fn1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baumann</surname>
<given-names>Jan</given-names>
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<xref ref-type="aff" rid="aff2"><sup>b</sup>
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<contrib contrib-type="author"><name><surname>Qiu</surname>
<given-names>Yu</given-names>
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<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
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<contrib contrib-type="author"><name><surname>Matrosovich</surname>
<given-names>Tatyana</given-names>
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<xref ref-type="aff" rid="aff2"><sup>b</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klenk</surname>
<given-names>Hans-Dieter</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>b</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Van Reeth</surname>
<given-names>Kristien</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
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<contrib contrib-type="author" corresp="yes"><name><surname>Matrosovich</surname>
<given-names>Mikhail</given-names>
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<xref ref-type="aff" rid="aff2"><sup>b</sup>
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<aff id="aff1"><label>a</label>
Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium</aff>
<aff id="aff2"><label>b</label>
Institute of Virology, Philipps University, Marburg, Germany</aff>
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<author-notes><corresp id="cor1">Address correspondence to Kristien Van Reeth, kristien. <email>vanreeth@ugent.be</email>
, or Mikhail Matrosovich, <email>M.Matrosovich@gmail.com</email>
.</corresp>
<fn id="fn1" fn-type="present-address"><label>*</label>
<p>Present address: Sjouke Van Poucke, Merial NV, Diegem, Belgium; Jennifer Doedt, Sividon Diagnostics GmbH, Cologne, Germany.</p>
</fn>
<fn fn-type="equal"><p>K.V.R. and M.M. contributed equally to this article.</p>
</fn>
<fn fn-type="other"><p><bold>Citation</bold>
Van Poucke S, Doedt J, Baumann J, Qiu Y, Matrosovich T, Klenk H-D, Van Reeth K, Matrosovich M. 2015. Role of substitutions in the hemagglutinin in the emergence of the 1968 pandemic influenza virus. J Virol 89:12211–12216. doi:<ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1128/JVI.01292-15">10.1128/JVI.01292-15</ext-link>
.</p>
</fn>
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<month>9</month>
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<pub-date pub-type="collection"><day>1</day>
<month>12</month>
<year>2015</year>
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<volume>89</volume>
<issue>23</issue>
<fpage>12211</fpage>
<lpage>12216</lpage>
<history><date date-type="received"><day>22</day>
<month>5</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>2</day>
<month>9</month>
<year>2015</year>
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<permissions><copyright-statement>Copyright © 2015, American Society for Microbiology. All Rights Reserved.</copyright-statement>
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<abstract><p>Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.</p>
</abstract>
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