Evaluation of Three Live Attenuated H2 Pandemic Influenza Vaccine Candidates in Mice and Ferrets
Identifieur interne : 000995 ( Ncbi/Curation ); précédent : 000994; suivant : 000996Evaluation of Three Live Attenuated H2 Pandemic Influenza Vaccine Candidates in Mice and Ferrets
Auteurs : Grace L. Chen [États-Unis] ; Elaine W. Lamirande [États-Unis] ; Xing Cheng [États-Unis] ; Fernando Torres-Velez [États-Unis] ; Marlene Orandle [États-Unis] ; Hong Jin [États-Unis] ; George Kemble [États-Unis] ; Kanta Subbarao [États-Unis]Source :
- Journal of Virology [ 0022-538X ] ; 2014.
Descripteurs français
- KwdFr :
- Alignement de séquences, Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Anticorps neutralisants (immunologie), Anticorps neutralisants (sang), Données de séquences moléculaires, Femelle, Furets, Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (immunologie), Infections de l'appareil respiratoire (), Infections de l'appareil respiratoire (anatomopathologie), Infections de l'appareil respiratoire (immunologie), Infections de l'appareil respiratoire (virologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Réactions croisées (immunologie), Réplication virale, Souris, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Séquence d'acides aminés, Vaccins antigrippaux (immunologie), Vaccins atténués (immunologie), Virus recombinants (génétique), Virus recombinants (immunologie).
- MESH :
- anatomopathologie : Infections de l'appareil respiratoire, Infections à Orthomyxoviridae.
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H2N2 du virus de la grippe A, Virus recombinants.
- immunologie : Anticorps antiviraux, Anticorps neutralisants, Glycoprotéine hémagglutinine du virus influenza, Infections de l'appareil respiratoire, Infections à Orthomyxoviridae, Réactions croisées, Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Virus recombinants.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- virologie : Infections de l'appareil respiratoire.
- Alignement de séquences, Animaux, Données de séquences moléculaires, Femelle, Furets, Glycoprotéine hémagglutinine du virus influenza, Infections de l'appareil respiratoire, Infections à Orthomyxoviridae, Réplication virale, Souris, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Neutralizing (blood), Antibodies, Neutralizing (immunology), Antibodies, Viral (blood), Antibodies, Viral (immunology), Cross Reactions (immunology), Female, Ferrets, Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza Vaccines (immunology), Mice, Molecular Sequence Data, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (prevention & control), Reassortant Viruses (genetics), Reassortant Viruses (immunology), Respiratory Tract Infections (immunology), Respiratory Tract Infections (pathology), Respiratory Tract Infections (prevention & control), Respiratory Tract Infections (virology), Sequence Alignment, Vaccines, Attenuated (immunology), Virus Replication.
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Vaccines, Attenuated.
- genetics : Influenza A Virus, H2N2 Subtype, Reassortant Viruses.
- immunology : Cross Reactions, Influenza A Virus, H2N2 Subtype, Orthomyxoviridae Infections, Reassortant Viruses, Respiratory Tract Infections.
- pathology : Orthomyxoviridae Infections, Respiratory Tract Infections.
- prevention & control : Orthomyxoviridae Infections, Respiratory Tract Infections.
- virology : Respiratory Tract Infections.
- Amino Acid Sequence, Animals, Female, Ferrets, Mice, Molecular Sequence Data, Sequence Alignment, Virus Replication.
Abstract
H2 influenza viruses have not circulated in humans since 1968, and therefore a significant portion of the population would be susceptible to infection should H2 influenza viruses reemerge. H2 influenza viruses continue to circulate in avian reservoirs worldwide, and these reservoirs are a potential source from which these viruses could emerge. Three reassortant cold-adapted (ca) H2 pandemic influenza vaccine candidates with hemagglutinin (HA) and neuraminidase (NA) genes derived from the wild-type A/Japan/305/1957 (H2N2) (Jap/57), A/mallard/6750/1978 (H2N2) (mal/78), or A/swine/MO/4296424/2006 (H2N3) (sw/06) viruses and the internal protein gene segments from the A/Ann Arbor/6/60 ca virus were generated by plasmid-based reverse genetics (Jap/57 ca, mal/78 ca, and sw/06 ca, respectively). The vaccine candidates exhibited the
Url:
DOI: 10.1128/JVI.01829-13
PubMed: 24371061
PubMed Central: 3958078
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PMC:3958078Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Antibodies, Neutralizing (blood)</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Cross Reactions (immunology)</term>
<term>Female</term>
<term>Ferrets</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (chemistry)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Influenza A Virus, H2N2 Subtype (genetics)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Orthomyxoviridae Infections (immunology)</term>
<term>Orthomyxoviridae Infections (pathology)</term>
<term>Orthomyxoviridae Infections (prevention & control)</term>
<term>Reassortant Viruses (genetics)</term>
<term>Reassortant Viruses (immunology)</term>
<term>Respiratory Tract Infections (immunology)</term>
<term>Respiratory Tract Infections (pathology)</term>
<term>Respiratory Tract Infections (prevention & control)</term>
<term>Respiratory Tract Infections (virology)</term>
<term>Sequence Alignment</term>
<term>Vaccines, Attenuated (immunology)</term>
<term>Virus Replication</term>
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<term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps antiviraux (sang)</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Anticorps neutralisants (sang)</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Furets</term>
<term>Glycoprotéine hémagglutinine du virus influenza ()</term>
<term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Infections de l'appareil respiratoire ()</term>
<term>Infections de l'appareil respiratoire (anatomopathologie)</term>
<term>Infections de l'appareil respiratoire (immunologie)</term>
<term>Infections de l'appareil respiratoire (virologie)</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (anatomopathologie)</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
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<term>Réplication virale</term>
<term>Souris</term>
<term>Sous-type H2N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Séquence d'acides aminés</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins atténués (immunologie)</term>
<term>Virus recombinants (génétique)</term>
<term>Virus recombinants (immunologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
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<term>Antibodies, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Influenza Vaccines</term>
<term>Vaccines, Attenuated</term>
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<term>Infections à Orthomyxoviridae</term>
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<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Virus recombinants</term>
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<term>Anticorps neutralisants</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Infections de l'appareil respiratoire</term>
<term>Infections à Orthomyxoviridae</term>
<term>Réactions croisées</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Virus recombinants</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cross Reactions</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Orthomyxoviridae Infections</term>
<term>Reassortant Viruses</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Orthomyxoviridae Infections</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term>
<term>Respiratory Tract Infections</term>
</keywords>
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<term>Anticorps neutralisants</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Tract Infections</term>
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<term>Animals</term>
<term>Female</term>
<term>Ferrets</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Sequence Alignment</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Furets</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Infections de l'appareil respiratoire</term>
<term>Infections à Orthomyxoviridae</term>
<term>Réplication virale</term>
<term>Souris</term>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>H2 influenza viruses have not circulated in humans since 1968, and therefore a significant portion of the population would be susceptible to infection should H2 influenza viruses reemerge. H2 influenza viruses continue to circulate in avian reservoirs worldwide, and these reservoirs are a potential source from which these viruses could emerge. Three reassortant cold-adapted (ca) H2 pandemic influenza vaccine candidates with hemagglutinin (HA) and neuraminidase (NA) genes derived from the wild-type A/Japan/305/1957 (H2N2) (Jap/57), A/mallard/6750/1978 (H2N2) (mal/78), or A/swine/MO/4296424/2006 (H2N3) (sw/06) viruses and the internal protein gene segments from the A/Ann Arbor/6/60 ca virus were generated by plasmid-based reverse genetics (Jap/57 ca, mal/78 ca, and sw/06 ca, respectively). The vaccine candidates exhibited the <italic>in vitro</italic>
phenotypes of temperature sensitivity and cold adaptation and were restricted in replication in the respiratory tract of ferrets. In mice and ferrets, the vaccines elicited neutralizing antibodies and conferred protection against homologous wild-type virus challenge. Of the three candidates, the sw/06 ca vaccine elicited cross-reactive antibodies and provided significant protection against the greatest number of heterologous viruses. These observations suggest that the sw/06 ca vaccine should be further evaluated in a clinical trial as an H2 pandemic influenza vaccine candidate.</p>
<p><bold>IMPORTANCE</bold>
Influenza pandemics arise when novel influenza viruses are introduced into a population with little prior immunity to the new virus and often result in higher rates of illness and death than annual seasonal influenza epidemics. An influenza H2 subtype virus caused a pandemic in 1957, and H2 viruses circulated in humans till 1968. H2 influenza viruses continue to circulate in birds, and the development of an H2 influenza vaccine candidate is therefore considered a priority in preparing for future pandemics. However, we cannot predict whether a human H2 virus will reemerge or a novel avian H2 virus will emerge. We identified three viruses as suitable candidates for further evaluation as vaccines to protect against H2 influenza viruses and evaluated the immune responses and protection that these three vaccines provided in mice and ferrets.</p>
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