Evaluation of three live attenuated H2 pandemic influenza vaccine candidates in mice and ferrets.
Identifieur interne : 000094 ( PubMed/Checkpoint ); précédent : 000093; suivant : 000095Evaluation of three live attenuated H2 pandemic influenza vaccine candidates in mice and ferrets.
Auteurs : Grace L. Chen [États-Unis] ; Elaine W. Lamirande ; Xing Cheng ; Fernando Torres-Velez ; Marlene Orandle ; Hong Jin ; George Kemble ; Kanta SubbaraoSource :
- Journal of virology [ 1098-5514 ] ; 2014.
Descripteurs français
- KwdFr :
- Alignement de séquences, Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Anticorps neutralisants (immunologie), Anticorps neutralisants (sang), Données de séquences moléculaires, Femelle, Furets, Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (immunologie), Infections de l'appareil respiratoire (), Infections de l'appareil respiratoire (anatomopathologie), Infections de l'appareil respiratoire (immunologie), Infections de l'appareil respiratoire (virologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Réactions croisées (immunologie), Réplication virale, Souris, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Séquence d'acides aminés, Vaccins antigrippaux (immunologie), Vaccins atténués (immunologie), Virus recombinants (génétique), Virus recombinants (immunologie).
- MESH :
- anatomopathologie : Infections de l'appareil respiratoire, Infections à Orthomyxoviridae.
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H2N2 du virus de la grippe A, Virus recombinants.
- immunologie : Anticorps antiviraux, Anticorps neutralisants, Glycoprotéine hémagglutinine du virus influenza, Infections de l'appareil respiratoire, Infections à Orthomyxoviridae, Réactions croisées, Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Virus recombinants.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- virologie : Infections de l'appareil respiratoire.
- Alignement de séquences, Animaux, Données de séquences moléculaires, Femelle, Furets, Glycoprotéine hémagglutinine du virus influenza, Infections de l'appareil respiratoire, Infections à Orthomyxoviridae, Réplication virale, Souris, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Neutralizing (blood), Antibodies, Neutralizing (immunology), Antibodies, Viral (blood), Antibodies, Viral (immunology), Cross Reactions (immunology), Female, Ferrets, Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza Vaccines (immunology), Mice, Molecular Sequence Data, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (prevention & control), Reassortant Viruses (genetics), Reassortant Viruses (immunology), Respiratory Tract Infections (immunology), Respiratory Tract Infections (pathology), Respiratory Tract Infections (prevention & control), Respiratory Tract Infections (virology), Sequence Alignment, Vaccines, Attenuated (immunology), Virus Replication.
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Vaccines, Attenuated.
- genetics : Influenza A Virus, H2N2 Subtype, Reassortant Viruses.
- immunology : Cross Reactions, Influenza A Virus, H2N2 Subtype, Orthomyxoviridae Infections, Reassortant Viruses, Respiratory Tract Infections.
- pathology : Orthomyxoviridae Infections, Respiratory Tract Infections.
- prevention & control : Orthomyxoviridae Infections, Respiratory Tract Infections.
- virology : Respiratory Tract Infections.
- Amino Acid Sequence, Animals, Female, Ferrets, Mice, Molecular Sequence Data, Sequence Alignment, Virus Replication.
Abstract
H2 influenza viruses have not circulated in humans since 1968, and therefore a significant portion of the population would be susceptible to infection should H2 influenza viruses reemerge. H2 influenza viruses continue to circulate in avian reservoirs worldwide, and these reservoirs are a potential source from which these viruses could emerge. Three reassortant cold-adapted (ca) H2 pandemic influenza vaccine candidates with hemagglutinin (HA) and neuraminidase (NA) genes derived from the wild-type A/Japan/305/1957 (H2N2) (Jap/57), A/mallard/6750/1978 (H2N2) (mal/78), or A/swine/MO/4296424/2006 (H2N3) (sw/06) viruses and the internal protein gene segments from the A/Ann Arbor/6/60 ca virus were generated by plasmid-based reverse genetics (Jap/57 ca, mal/78 ca, and sw/06 ca, respectively). The vaccine candidates exhibited the in vitro phenotypes of temperature sensitivity and cold adaptation and were restricted in replication in the respiratory tract of ferrets. In mice and ferrets, the vaccines elicited neutralizing antibodies and conferred protection against homologous wild-type virus challenge. Of the three candidates, the sw/06 ca vaccine elicited cross-reactive antibodies and provided significant protection against the greatest number of heterologous viruses. These observations suggest that the sw/06 ca vaccine should be further evaluated in a clinical trial as an H2 pandemic influenza vaccine candidate.
DOI: 10.1128/JVI.01829-13
PubMed: 24371061
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:24371061Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of three live attenuated H2 pandemic influenza vaccine candidates in mice and ferrets.</title><author><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L" last="Chen">Grace L. Chen</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name></author><author><name sortKey="Cheng, Xing" sort="Cheng, Xing" uniqKey="Cheng X" first="Xing" last="Cheng">Xing Cheng</name></author><author><name sortKey="Torres Velez, Fernando" sort="Torres Velez, Fernando" uniqKey="Torres Velez F" first="Fernando" last="Torres-Velez">Fernando Torres-Velez</name></author><author><name sortKey="Orandle, Marlene" sort="Orandle, Marlene" uniqKey="Orandle M" first="Marlene" last="Orandle">Marlene Orandle</name></author><author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name></author><author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24371061</idno><idno type="pmid">24371061</idno><idno type="doi">10.1128/JVI.01829-13</idno><idno type="wicri:Area/PubMed/Corpus">000108</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000108</idno><idno type="wicri:Area/PubMed/Curation">000108</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000108</idno><idno type="wicri:Area/PubMed/Checkpoint">000094</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000094</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evaluation of three live attenuated H2 pandemic influenza vaccine candidates in mice and ferrets.</title><author><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L" last="Chen">Grace L. Chen</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name></author><author><name sortKey="Cheng, Xing" sort="Cheng, Xing" uniqKey="Cheng X" first="Xing" last="Cheng">Xing Cheng</name></author><author><name sortKey="Torres Velez, Fernando" sort="Torres Velez, Fernando" uniqKey="Torres Velez F" first="Fernando" last="Torres-Velez">Fernando Torres-Velez</name></author><author><name sortKey="Orandle, Marlene" sort="Orandle, Marlene" uniqKey="Orandle M" first="Marlene" last="Orandle">Marlene Orandle</name></author><author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name></author><author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Neutralizing (immunology)</term><term>Antibodies, Viral (blood)</term><term>Antibodies, Viral (immunology)</term><term>Cross Reactions (immunology)</term><term>Female</term><term>Ferrets</term><term>Hemagglutinin Glycoproteins, Influenza Virus (chemistry)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Influenza A Virus, H2N2 Subtype (genetics)</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Mice</term><term>Molecular Sequence Data</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (pathology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (immunology)</term><term>Respiratory Tract Infections (immunology)</term><term>Respiratory Tract Infections (pathology)</term><term>Respiratory Tract Infections (prevention & control)</term><term>Respiratory Tract Infections (virology)</term><term>Sequence Alignment</term><term>Vaccines, Attenuated (immunology)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (immunologie)</term><term>Anticorps neutralisants (sang)</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Furets</term><term>Glycoprotéine hémagglutinine du virus influenza ()</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term><term>Infections de l'appareil respiratoire ()</term><term>Infections de l'appareil respiratoire (anatomopathologie)</term><term>Infections de l'appareil respiratoire (immunologie)</term><term>Infections de l'appareil respiratoire (virologie)</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (anatomopathologie)</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Réactions croisées (immunologie)</term><term>Réplication virale</term><term>Souris</term><term>Sous-type H2N2 du virus de la grippe A (génétique)</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term><term>Séquence d'acides aminés</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (immunologie)</term><term>Virus recombinants (génétique)</term><term>Virus recombinants (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Infections de l'appareil respiratoire</term><term>Infections à Orthomyxoviridae</term><term>Réactions croisées</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cross Reactions</term><term>Influenza A Virus, H2N2 Subtype</term><term>Orthomyxoviridae Infections</term><term>Reassortant Viruses</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Orthomyxoviridae Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Female</term><term>Ferrets</term><term>Mice</term><term>Molecular Sequence Data</term><term>Sequence Alignment</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Furets</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Infections de l'appareil respiratoire</term><term>Infections à Orthomyxoviridae</term><term>Réplication virale</term><term>Souris</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">H2 influenza viruses have not circulated in humans since 1968, and therefore a significant portion of the population would be susceptible to infection should H2 influenza viruses reemerge. H2 influenza viruses continue to circulate in avian reservoirs worldwide, and these reservoirs are a potential source from which these viruses could emerge. Three reassortant cold-adapted (ca) H2 pandemic influenza vaccine candidates with hemagglutinin (HA) and neuraminidase (NA) genes derived from the wild-type A/Japan/305/1957 (H2N2) (Jap/57), A/mallard/6750/1978 (H2N2) (mal/78), or A/swine/MO/4296424/2006 (H2N3) (sw/06) viruses and the internal protein gene segments from the A/Ann Arbor/6/60 ca virus were generated by plasmid-based reverse genetics (Jap/57 ca, mal/78 ca, and sw/06 ca, respectively). The vaccine candidates exhibited the in vitro phenotypes of temperature sensitivity and cold adaptation and were restricted in replication in the respiratory tract of ferrets. In mice and ferrets, the vaccines elicited neutralizing antibodies and conferred protection against homologous wild-type virus challenge. Of the three candidates, the sw/06 ca vaccine elicited cross-reactive antibodies and provided significant protection against the greatest number of heterologous viruses. These observations suggest that the sw/06 ca vaccine should be further evaluated in a clinical trial as an H2 pandemic influenza vaccine candidate.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24371061</PMID><DateCompleted><Year>2014</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-5514</ISSN><JournalIssue CitedMedium="Internet"><Volume>88</Volume><Issue>5</Issue><PubDate><Year>2014</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Journal of virology</Title><ISOAbbreviation>J. Virol.</ISOAbbreviation></Journal><ArticleTitle>Evaluation of three live attenuated H2 pandemic influenza vaccine candidates in mice and ferrets.</ArticleTitle><Pagination><MedlinePgn>2867-76</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1128/JVI.01829-13</ELocationID><Abstract><AbstractText Label="UNLABELLED">H2 influenza viruses have not circulated in humans since 1968, and therefore a significant portion of the population would be susceptible to infection should H2 influenza viruses reemerge. H2 influenza viruses continue to circulate in avian reservoirs worldwide, and these reservoirs are a potential source from which these viruses could emerge. Three reassortant cold-adapted (ca) H2 pandemic influenza vaccine candidates with hemagglutinin (HA) and neuraminidase (NA) genes derived from the wild-type A/Japan/305/1957 (H2N2) (Jap/57), A/mallard/6750/1978 (H2N2) (mal/78), or A/swine/MO/4296424/2006 (H2N3) (sw/06) viruses and the internal protein gene segments from the A/Ann Arbor/6/60 ca virus were generated by plasmid-based reverse genetics (Jap/57 ca, mal/78 ca, and sw/06 ca, respectively). The vaccine candidates exhibited the in vitro phenotypes of temperature sensitivity and cold adaptation and were restricted in replication in the respiratory tract of ferrets. In mice and ferrets, the vaccines elicited neutralizing antibodies and conferred protection against homologous wild-type virus challenge. Of the three candidates, the sw/06 ca vaccine elicited cross-reactive antibodies and provided significant protection against the greatest number of heterologous viruses. These observations suggest that the sw/06 ca vaccine should be further evaluated in a clinical trial as an H2 pandemic influenza vaccine candidate.</AbstractText><AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">Influenza pandemics arise when novel influenza viruses are introduced into a population with little prior immunity to the new virus and often result in higher rates of illness and death than annual seasonal influenza epidemics. An influenza H2 subtype virus caused a pandemic in 1957, and H2 viruses circulated in humans till 1968. H2 influenza viruses continue to circulate in birds, and the development of an H2 influenza vaccine candidate is therefore considered a priority in preparing for future pandemics. However, we cannot predict whether a human H2 virus will reemerge or a novel avian H2 virus will emerge. We identified three viruses as suitable candidates for further evaluation as vaccines to protect against H2 influenza viruses and evaluated the immune responses and protection that these three vaccines provided in mice and ferrets.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Grace L</ForeName><Initials>GL</Initials><AffiliationInfo><Affiliation>Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lamirande</LastName><ForeName>Elaine W</ForeName><Initials>EW</Initials></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Xing</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Torres-Velez</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Orandle</LastName><ForeName>Marlene</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Hong</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Kemble</LastName><ForeName>George</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Subbarao</LastName><ForeName>Kanta</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>12</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Virol</MedlineTA><NlmUniqueID>0113724</NlmUniqueID><ISSNLinking>0022-538X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057134">Antibodies, Neutralizing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057134" MajorTopicYN="N">Antibodies, Neutralizing</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003429" MajorTopicYN="N">Cross Reactions</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005289" MajorTopicYN="N">Ferrets</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053121" MajorTopicYN="N">Influenza A Virus, H2N2 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016865" MajorTopicYN="N">Reassortant Viruses</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014613" MajorTopicYN="N">Vaccines, Attenuated</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>12</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>12</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24371061</ArticleId><ArticleId IdType="pii">JVI.01829-13</ArticleId><ArticleId IdType="doi">10.1128/JVI.01829-13</ArticleId><ArticleId IdType="pmc">PMC3958078</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Virology. 1978 Jun 1;87(1):13-20</Citation><ArticleIdList><ArticleId IdType="pubmed">664248</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hyg (Lond). 1977 Oct;79(2):203-8</Citation><ArticleIdList><ArticleId IdType="pubmed">269196</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1989 Nov;63(11):4603-8</Citation><ArticleIdList><ArticleId IdType="pubmed">2795713</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 1993 Jun;194(2):781-8</Citation><ArticleIdList><ArticleId IdType="pubmed">7684877</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Virol. 1994;135(1-2):101-14</Citation><ArticleIdList><ArticleId IdType="pubmed">8198436</ArticleId></ArticleIdList></Reference><Reference><Citation>Avian Dis. 2007 Mar;51(1 Suppl):425-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17494599</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2007 Nov;3(11):e167</Citation><ArticleIdList><ArticleId IdType="pubmed">17997603</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2007 Dec 17;25(52):8664-72</Citation><ArticleIdList><ArticleId IdType="pubmed">18031873</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20949-54</Citation><ArticleIdList><ArticleId IdType="pubmed">18093945</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Genes. 2008 Aug;37(1):16-21</Citation><ArticleIdList><ArticleId IdType="pubmed">18454312</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2008 Aug 15;378(1):123-32</Citation><ArticleIdList><ArticleId IdType="pubmed">18585748</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2010 Mar 1;398(1):109-14</Citation><ArticleIdList><ArticleId IdType="pubmed">20034647</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Aug;84(15):7695-702</Citation><ArticleIdList><ArticleId IdType="pubmed">20504935</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2011 Mar 10;471(7337):157-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21390107</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2012 Mar;86(5):2780-6</Citation><ArticleIdList><ArticleId IdType="pubmed">22190726</ArticleId></ArticleIdList></Reference><Reference><Citation>Influenza Other Respir Viruses. 2013 Jan;7(1):66-73</Citation><ArticleIdList><ArticleId IdType="pubmed">22417012</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 1999 Dec;80 ( Pt 12):3167-71</Citation><ArticleIdList><ArticleId IdType="pubmed">10567648</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 1999 Dec 10;18(9-10):899-906</Citation><ArticleIdList><ArticleId IdType="pubmed">10580204</ArticleId></ArticleIdList></Reference><Reference><Citation>Bull World Health Organ. 1999;77(10):820-8</Citation><ArticleIdList><ArticleId IdType="pubmed">10593030</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pediatr. 2000 Feb;136(2):168-75</Citation><ArticleIdList><ArticleId IdType="pubmed">10657821</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Virol. 2000;145(6):1059-66</Citation><ArticleIdList><ArticleId IdType="pubmed">10948982</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 1982 Mar;145(3):320-30</Citation><ArticleIdList><ArticleId IdType="pubmed">6977595</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Cheng, Xing" sort="Cheng, Xing" uniqKey="Cheng X" first="Xing" last="Cheng">Xing Cheng</name><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name><name sortKey="Orandle, Marlene" sort="Orandle, Marlene" uniqKey="Orandle M" first="Marlene" last="Orandle">Marlene Orandle</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Torres Velez, Fernando" sort="Torres Velez, Fernando" uniqKey="Torres Velez F" first="Fernando" last="Torres-Velez">Fernando Torres-Velez</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L" last="Chen">Grace L. Chen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000094 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000094 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:24371061
|texte= Evaluation of three live attenuated H2 pandemic influenza vaccine candidates in mice and ferrets.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:24371061" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |