Vaccination with inactivated influenza A virus during pregnancy protects neonatal mice against lethal challenge by influenza A viruses representing three subtypes.
Identifieur interne : 000818 ( Ncbi/Curation ); précédent : 000817; suivant : 000819Vaccination with inactivated influenza A virus during pregnancy protects neonatal mice against lethal challenge by influenza A viruses representing three subtypes.
Auteurs : I N Mbawuike [États-Unis] ; H R Six ; T R Cate ; R B CouchSource :
- Journal of virology [ 0022-538X ] ; 1990.
Descripteurs français
- KwdFr :
- Animaux, Animaux nouveau-nés, Anticorps antiviraux (analyse), Femelle, Gestation animale (immunologie), Grossesse, Immunité acquise d'origine maternelle, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Lignées consanguines de souris, Réactions croisées, Souris, Spécificité d'espèce, Tests de neutralisation, Vaccination, Vaccins atténués, Virus de la grippe A (immunologie).
- MESH :
- analyse : Anticorps antiviraux.
- immunologie : Gestation animale, Infections à Orthomyxoviridae, Virus de la grippe A.
- Animaux, Animaux nouveau-nés, Femelle, Grossesse, Immunité acquise d'origine maternelle, Infections à Orthomyxoviridae, Lignées consanguines de souris, Réactions croisées, Souris, Spécificité d'espèce, Tests de neutralisation, Vaccination, Vaccins atténués.
English descriptors
- KwdEn :
- Animals, Animals, Newborn, Antibodies, Viral (analysis), Cross Reactions, Female, Immunity, Maternally-Acquired, Influenza A virus (immunology), Mice, Mice, Inbred Strains, Neutralization Tests, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Pregnancy, Pregnancy, Animal (immunology), Species Specificity, Vaccination, Vaccines, Attenuated.
- MESH :
- chemical , analysis : Antibodies, Viral.
- immunology : Influenza A virus, Orthomyxoviridae Infections, Pregnancy, Animal.
- prevention & control : Orthomyxoviridae Infections.
- Animals, Animals, Newborn, Cross Reactions, Female, Immunity, Maternally-Acquired, Mice, Mice, Inbred Strains, Neutralization Tests, Pregnancy, Species Specificity, Vaccination, Vaccines, Attenuated.
Abstract
A single intraperitoneal injection of pregnant mice with a monovalent Formalin-inactivated influenza A virus vaccine protected their offspring against a lethal challenge dose of the same influenza A virus H3N2, H2N2, and H1N1 subtypes, as well as against challenge with the other two subtypes. Degree of protection was vaccine dose related. Cross-fostering of neonates indicated that protection was conferred by breast milk antibodies. Serum virus-specific neutralizing antibodies in the mothers and neonates correlated with resistance to vaccine virus, but were detected against other subtypes only in a complement enhancement test or when high doses of vaccine were given.
PubMed: 2304146
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pubmed:2304146Le document en format XML
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
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<wicri:cityArea>Influenza Research Center, Baylor College of Medicine, Houston</wicri:cityArea>
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<term>Cross Reactions</term>
<term>Female</term>
<term>Immunity, Maternally-Acquired</term>
<term>Influenza A virus (immunology)</term>
<term>Mice</term>
<term>Mice, Inbred Strains</term>
<term>Neutralization Tests</term>
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<term>Orthomyxoviridae Infections (prevention & control)</term>
<term>Pregnancy</term>
<term>Pregnancy, Animal (immunology)</term>
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<term>Vaccines, Attenuated</term>
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<term>Animaux nouveau-nés</term>
<term>Anticorps antiviraux (analyse)</term>
<term>Femelle</term>
<term>Gestation animale (immunologie)</term>
<term>Grossesse</term>
<term>Immunité acquise d'origine maternelle</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Lignées consanguines de souris</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Spécificité d'espèce</term>
<term>Tests de neutralisation</term>
<term>Vaccination</term>
<term>Vaccins atténués</term>
<term>Virus de la grippe A (immunologie)</term>
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<term>Infections à Orthomyxoviridae</term>
<term>Virus de la grippe A</term>
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<term>Orthomyxoviridae Infections</term>
<term>Pregnancy, Animal</term>
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<term>Cross Reactions</term>
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<term>Immunity, Maternally-Acquired</term>
<term>Mice</term>
<term>Mice, Inbred Strains</term>
<term>Neutralization Tests</term>
<term>Pregnancy</term>
<term>Species Specificity</term>
<term>Vaccination</term>
<term>Vaccines, Attenuated</term>
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<term>Animaux nouveau-nés</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Immunité acquise d'origine maternelle</term>
<term>Infections à Orthomyxoviridae</term>
<term>Lignées consanguines de souris</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Spécificité d'espèce</term>
<term>Tests de neutralisation</term>
<term>Vaccination</term>
<term>Vaccins atténués</term>
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<front><div type="abstract" xml:lang="en">A single intraperitoneal injection of pregnant mice with a monovalent Formalin-inactivated influenza A virus vaccine protected their offspring against a lethal challenge dose of the same influenza A virus H3N2, H2N2, and H1N1 subtypes, as well as against challenge with the other two subtypes. Degree of protection was vaccine dose related. Cross-fostering of neonates indicated that protection was conferred by breast milk antibodies. Serum virus-specific neutralizing antibodies in the mothers and neonates correlated with resistance to vaccine virus, but were detected against other subtypes only in a complement enhancement test or when high doses of vaccine were given.</div>
</front>
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