Differential response of respiratory dendritic cell subsets to influenza virus infection.
Identifieur interne : 000279 ( Ncbi/Curation ); précédent : 000278; suivant : 000280Differential response of respiratory dendritic cell subsets to influenza virus infection.
Auteurs : Xueli Hao [États-Unis] ; Taeg S. Kim ; Thomas J. BracialeSource :
- Journal of virology [ 1098-5514 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Antigènes CD (analyse), Appareil respiratoire (immunologie), Appareil respiratoire (virologie), Cellules dendritiques (), Cellules dendritiques (immunologie), Cytokines (biosynthèse), Cytométrie en flux, Femelle, Infections à Orthomyxoviridae (immunologie), Intégrines alpha (analyse), Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A (immunologie).
- MESH :
- analyse : Antigènes CD, Intégrines alpha.
- biosynthèse : Cytokines.
- immunologie : Appareil respiratoire, Cellules dendritiques, Infections à Orthomyxoviridae, Sous-type H2N2 du virus de la grippe A.
- virologie : Appareil respiratoire.
- Animaux, Cellules dendritiques, Cytométrie en flux, Femelle, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals, Antigens, CD (analysis), CD11b Antigen (analysis), CD11c Antigen (analysis), Cytokines (biosynthesis), Dendritic Cells (chemistry), Dendritic Cells (immunology), Female, Flow Cytometry, Influenza A Virus, H2N2 Subtype (immunology), Integrin alpha Chains (analysis), Leukocyte Common Antigens (analysis), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (immunology), Respiratory System (immunology), Respiratory System (virology).
- MESH :
- chemical , analysis : Antigens, CD, CD11b Antigen, CD11c Antigen, Integrin alpha Chains, Leukocyte Common Antigens.
- chemical , biosynthesis : Cytokines.
- chemistry : Dendritic Cells.
- immunology : Dendritic Cells, Influenza A Virus, H2N2 Subtype, Orthomyxoviridae Infections, Respiratory System.
- virology : Respiratory System.
- Animals, Female, Flow Cytometry, Mice, Mice, Inbred BALB C.
Abstract
Dendritic cells (DC) are believed to play an important role in the initiation of innate and adaptive immune responses to infection, including respiratory tract infections, where respiratory DC (RDC) perform this role. In this report, we examined the susceptibilities of isolated murine RDC to influenza virus infection in vitro and the effect of the multiplicity of infection (MOI) on costimulatory ligand upregulation and inflammatory cytokine/chemokine production after infection. We found that the efficiency of influenza virus infection of RDC increased with increasing MOIs. Furthermore, distinct subpopulations of RDC differed in their susceptibilities to influenza virus infection and in the magnitude/tempo of costimulatory ligand expression. Additional characterization of the CD11c-positive (CD11c(+)) RDC revealed that the identifiable subsets of RDC differed in susceptibility to infection, with CD11c(+) CD103(+) DC exhibiting the greatest susceptibility, CD11c(+) CD11b(hi) DC exhibiting intermediate susceptibility, and CD11c(+) B220(+) plasmacytoid DC (pDC) exhibiting the least susceptibility to infection. A companion analysis of the in vivo susceptibilities of these RDC subsets to influenza virus revealed a corresponding infection pattern. The three RDC subsets displayed different patterns of cytokine/chemokine production in response to influenza virus infection in vitro: pDC were the predominant producers of most cytokines examined, while CD103(+) DC and CD11b(hi) DC produced elevated levels of the murine chemokine CXCL1 (KC), interleukin 12p40, and RANTES in response to influenza virus infection. Our results indicate that RDC are targets of influenza virus infection and that distinct RDC subsets differ in their susceptibilities and responses to infection.
DOI: 10.1128/JVI.02367-07
PubMed: 18353940
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000264
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000264
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000240
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000279
Links to Exploration step
pubmed:18353940Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential response of respiratory dendritic cell subsets to influenza virus infection.</title><author><name sortKey="Hao, Xueli" sort="Hao, Xueli" uniqKey="Hao X" first="Xueli" last="Hao">Xueli Hao</name><affiliation wicri:level="1"><nlm:affiliation>Carter Immunology Center, UVA, P.O. Box 801386, Charlottesville, VA 22908, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Carter Immunology Center, UVA, P.O. Box 801386, Charlottesville, VA 22908</wicri:regionArea><wicri:noRegion>VA 22908</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Taeg S" sort="Kim, Taeg S" uniqKey="Kim T" first="Taeg S" last="Kim">Taeg S. Kim</name></author><author><name sortKey="Braciale, Thomas J" sort="Braciale, Thomas J" uniqKey="Braciale T" first="Thomas J" last="Braciale">Thomas J. Braciale</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18353940</idno><idno type="pmid">18353940</idno><idno type="doi">10.1128/JVI.02367-07</idno><idno type="wicri:Area/PubMed/Corpus">000264</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000264</idno><idno type="wicri:Area/PubMed/Curation">000264</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000264</idno><idno type="wicri:Area/PubMed/Checkpoint">000240</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000240</idno><idno type="wicri:Area/Ncbi/Merge">000279</idno><idno type="wicri:Area/Ncbi/Curation">000279</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Differential response of respiratory dendritic cell subsets to influenza virus infection.</title><author><name sortKey="Hao, Xueli" sort="Hao, Xueli" uniqKey="Hao X" first="Xueli" last="Hao">Xueli Hao</name><affiliation wicri:level="1"><nlm:affiliation>Carter Immunology Center, UVA, P.O. Box 801386, Charlottesville, VA 22908, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Carter Immunology Center, UVA, P.O. Box 801386, Charlottesville, VA 22908</wicri:regionArea><wicri:noRegion>VA 22908</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Taeg S" sort="Kim, Taeg S" uniqKey="Kim T" first="Taeg S" last="Kim">Taeg S. Kim</name></author><author><name sortKey="Braciale, Thomas J" sort="Braciale, Thomas J" uniqKey="Braciale T" first="Thomas J" last="Braciale">Thomas J. Braciale</name></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, CD (analysis)</term><term>CD11b Antigen (analysis)</term><term>CD11c Antigen (analysis)</term><term>Cytokines (biosynthesis)</term><term>Dendritic Cells (chemistry)</term><term>Dendritic Cells (immunology)</term><term>Female</term><term>Flow Cytometry</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Integrin alpha Chains (analysis)</term><term>Leukocyte Common Antigens (analysis)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (immunology)</term><term>Respiratory System (immunology)</term><term>Respiratory System (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes CD (analyse)</term><term>Appareil respiratoire (immunologie)</term><term>Appareil respiratoire (virologie)</term><term>Cellules dendritiques ()</term><term>Cellules dendritiques (immunologie)</term><term>Cytokines (biosynthèse)</term><term>Cytométrie en flux</term><term>Femelle</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Intégrines alpha (analyse)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, CD</term><term>CD11b Antigen</term><term>CD11c Antigen</term><term>Integrin alpha Chains</term><term>Leukocyte Common Antigens</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes CD</term><term>Intégrines alpha</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Dendritic Cells</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Cellules dendritiques</term><term>Infections à Orthomyxoviridae</term><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dendritic Cells</term><term>Influenza A Virus, H2N2 Subtype</term><term>Orthomyxoviridae Infections</term><term>Respiratory System</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Flow Cytometry</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules dendritiques</term><term>Cytométrie en flux</term><term>Femelle</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dendritic cells (DC) are believed to play an important role in the initiation of innate and adaptive immune responses to infection, including respiratory tract infections, where respiratory DC (RDC) perform this role. In this report, we examined the susceptibilities of isolated murine RDC to influenza virus infection in vitro and the effect of the multiplicity of infection (MOI) on costimulatory ligand upregulation and inflammatory cytokine/chemokine production after infection. We found that the efficiency of influenza virus infection of RDC increased with increasing MOIs. Furthermore, distinct subpopulations of RDC differed in their susceptibilities to influenza virus infection and in the magnitude/tempo of costimulatory ligand expression. Additional characterization of the CD11c-positive (CD11c(+)) RDC revealed that the identifiable subsets of RDC differed in susceptibility to infection, with CD11c(+) CD103(+) DC exhibiting the greatest susceptibility, CD11c(+) CD11b(hi) DC exhibiting intermediate susceptibility, and CD11c(+) B220(+) plasmacytoid DC (pDC) exhibiting the least susceptibility to infection. A companion analysis of the in vivo susceptibilities of these RDC subsets to influenza virus revealed a corresponding infection pattern. The three RDC subsets displayed different patterns of cytokine/chemokine production in response to influenza virus infection in vitro: pDC were the predominant producers of most cytokines examined, while CD103(+) DC and CD11b(hi) DC produced elevated levels of the murine chemokine CXCL1 (KC), interleukin 12p40, and RANTES in response to influenza virus infection. Our results indicate that RDC are targets of influenza virus infection and that distinct RDC subsets differ in their susceptibilities and responses to infection.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000279 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000279 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:18353940
|texte= Differential response of respiratory dendritic cell subsets to influenza virus infection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:18353940" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |