Thujaplicin-copper chelates inhibit replication of human influenza viruses.
Identifieur interne : 001376 ( Ncbi/Checkpoint ); précédent : 001375; suivant : 001377Thujaplicin-copper chelates inhibit replication of human influenza viruses.
Auteurs : D. Miyamoto [Japon] ; Y. Kusagaya ; N. Endo ; A. Sometani ; S. Takeo ; T. Suzuki ; Y. Arima ; K. Nakajima ; Y. SuzukiSource :
- Antiviral research [ 0166-3542 ] ; 1998.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (), Antiviraux (pharmacologie), Apoptose (), Chiens, Chélateurs (), Cuivre (), Humains, Lignée cellulaire, Monoterpènes, Méthode des plages virales, Réplication virale (), Survie cellulaire (), Tropolone (), Tropolone (analogues et dérivés), Tropolone (pharmacologie), Virus de la grippe A (), Virus de la grippe A (physiologie).
- MESH :
- analogues et dérivés : Tropolone.
- pharmacologie : Antiviraux, Tropolone.
- physiologie : Virus de la grippe A.
- Animaux, Antiviraux, Apoptose, Chiens, Chélateurs, Cuivre, Humains, Lignée cellulaire, Monoterpènes, Méthode des plages virales, Réplication virale, Survie cellulaire, Tropolone, Virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Apoptosis (drug effects), Cell Line, Cell Survival (drug effects), Chelating Agents (chemistry), Copper (chemistry), Dogs, Humans, Influenza A virus (drug effects), Influenza A virus (physiology), Monoterpenes, Tropolone (analogs & derivatives), Tropolone (chemistry), Tropolone (pharmacology), Viral Plaque Assay, Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Tropolone.
- chemical , chemistry : Antiviral Agents, Chelating Agents, Copper, Tropolone.
- chemical , pharmacology : Antiviral Agents, Tropolone.
- drug effects : Apoptosis, Cell Survival, Influenza A virus, Virus Replication.
- physiology : Influenza A virus.
- Animals, Cell Line, Dogs, Humans, Monoterpenes, Viral Plaque Assay.
Abstract
The effects of alpha-, beta- and gamma-thujaplicins and six of their metal chelates on human influenza virus-induced apoptosis in Madin-Darby canine kidney (MDCK) cells were examined by DNA fragmentation and flow cytometry. Among the compounds tested, thujaplicin copper chelates inhibited apoptosis induced in the infected MDCK cells with influenza A/PR/8/34(H1N1), A/Shingapol/1/57(H2N2), A/Aichi/2/68(H3N2) and B/Lee/40 viruses, at concentrations of more than 5 microM. These results indicate that the copper chelates inhibit influenza virus-induced apoptosis and that the inhibitory effects may be independent of influenza virus subtype or types. Furthermore, the copper chelates also inhibited the release of the viruses from the infected MDCK cells during apoptosis. The anti-apoptotic effects of the copper chelates may occur 2 4 h postinfection, suggesting that the copper chelates affect MDCK cells directly in the early stage of influenza virus-induced apoptosis. In this study, we demonstrated that thujaplicin-copper chelates inhibit influenza virus-induced apoptosis of MDCK cells and also inhibit virus replication and release from the infected cells.
DOI: 10.1016/s0166-3542(98)00034-5
PubMed: 9806486
Affiliations:
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pubmed:9806486Le document en format XML
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Endo</name></author><author><name sortKey="Sometani, A" sort="Sometani, A" uniqKey="Sometani A" first="A" last="Sometani">A. Sometani</name></author><author><name sortKey="Takeo, S" sort="Takeo, S" uniqKey="Takeo S" first="S" last="Takeo">S. Takeo</name></author><author><name sortKey="Suzuki, T" sort="Suzuki, T" uniqKey="Suzuki T" first="T" last="Suzuki">T. Suzuki</name></author><author><name sortKey="Arima, Y" sort="Arima, Y" uniqKey="Arima Y" first="Y" last="Arima">Y. Arima</name></author><author><name sortKey="Nakajima, K" sort="Nakajima, K" uniqKey="Nakajima K" first="K" last="Nakajima">K. Nakajima</name></author><author><name sortKey="Suzuki, Y" sort="Suzuki, Y" uniqKey="Suzuki Y" first="Y" last="Suzuki">Y. 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Miyamoto</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences</wicri:regionArea><wicri:noRegion>School of Pharmaceutical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Kusagaya, Y" sort="Kusagaya, Y" uniqKey="Kusagaya Y" first="Y" last="Kusagaya">Y. Kusagaya</name></author><author><name sortKey="Endo, N" sort="Endo, N" uniqKey="Endo N" first="N" last="Endo">N. Endo</name></author><author><name sortKey="Sometani, A" sort="Sometani, A" uniqKey="Sometani A" first="A" last="Sometani">A. Sometani</name></author><author><name sortKey="Takeo, S" sort="Takeo, S" uniqKey="Takeo S" first="S" last="Takeo">S. Takeo</name></author><author><name sortKey="Suzuki, T" sort="Suzuki, T" uniqKey="Suzuki T" first="T" last="Suzuki">T. Suzuki</name></author><author><name sortKey="Arima, Y" sort="Arima, Y" uniqKey="Arima Y" first="Y" last="Arima">Y. Arima</name></author><author><name sortKey="Nakajima, K" sort="Nakajima, K" uniqKey="Nakajima K" first="K" last="Nakajima">K. Nakajima</name></author><author><name sortKey="Suzuki, Y" sort="Suzuki, Y" uniqKey="Suzuki Y" first="Y" last="Suzuki">Y. Suzuki</name></author></analytic><series><title level="j">Antiviral research</title><idno type="ISSN">0166-3542</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Cell Line</term><term>Cell Survival (drug effects)</term><term>Chelating Agents (chemistry)</term><term>Copper (chemistry)</term><term>Dogs</term><term>Humans</term><term>Influenza A virus (drug effects)</term><term>Influenza A virus (physiology)</term><term>Monoterpenes</term><term>Tropolone (analogs & derivatives)</term><term>Tropolone (chemistry)</term><term>Tropolone (pharmacology)</term><term>Viral Plaque Assay</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Apoptose ()</term><term>Chiens</term><term>Chélateurs ()</term><term>Cuivre ()</term><term>Humains</term><term>Lignée cellulaire</term><term>Monoterpènes</term><term>Méthode des plages virales</term><term>Réplication virale ()</term><term>Survie cellulaire ()</term><term>Tropolone ()</term><term>Tropolone (analogues et dérivés)</term><term>Tropolone (pharmacologie)</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Tropolone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Chelating Agents</term><term>Copper</term><term>Tropolone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Tropolone</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Tropolone</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Cell Survival</term><term>Influenza A virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Tropolone</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Dogs</term><term>Humans</term><term>Monoterpenes</term><term>Viral Plaque Assay</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antiviraux</term><term>Apoptose</term><term>Chiens</term><term>Chélateurs</term><term>Cuivre</term><term>Humains</term><term>Lignée cellulaire</term><term>Monoterpènes</term><term>Méthode des plages virales</term><term>Réplication virale</term><term>Survie cellulaire</term><term>Tropolone</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of alpha-, beta- and gamma-thujaplicins and six of their metal chelates on human influenza virus-induced apoptosis in Madin-Darby canine kidney (MDCK) cells were examined by DNA fragmentation and flow cytometry. Among the compounds tested, thujaplicin copper chelates inhibited apoptosis induced in the infected MDCK cells with influenza A/PR/8/34(H1N1), A/Shingapol/1/57(H2N2), A/Aichi/2/68(H3N2) and B/Lee/40 viruses, at concentrations of more than 5 microM. These results indicate that the copper chelates inhibit influenza virus-induced apoptosis and that the inhibitory effects may be independent of influenza virus subtype or types. Furthermore, the copper chelates also inhibited the release of the viruses from the infected MDCK cells during apoptosis. The anti-apoptotic effects of the copper chelates may occur 2 4 h postinfection, suggesting that the copper chelates affect MDCK cells directly in the early stage of influenza virus-induced apoptosis. In this study, we demonstrated that thujaplicin-copper chelates inhibit influenza virus-induced apoptosis of MDCK cells and also inhibit virus replication and release from the infected cells.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Arima, Y" sort="Arima, Y" uniqKey="Arima Y" first="Y" last="Arima">Y. Arima</name><name sortKey="Endo, N" sort="Endo, N" uniqKey="Endo N" first="N" last="Endo">N. Endo</name><name sortKey="Kusagaya, Y" sort="Kusagaya, Y" uniqKey="Kusagaya Y" first="Y" last="Kusagaya">Y. Kusagaya</name><name sortKey="Nakajima, K" sort="Nakajima, K" uniqKey="Nakajima K" first="K" last="Nakajima">K. Nakajima</name><name sortKey="Sometani, A" sort="Sometani, A" uniqKey="Sometani A" first="A" last="Sometani">A. Sometani</name><name sortKey="Suzuki, T" sort="Suzuki, T" uniqKey="Suzuki T" first="T" last="Suzuki">T. Suzuki</name><name sortKey="Suzuki, Y" sort="Suzuki, Y" uniqKey="Suzuki Y" first="Y" last="Suzuki">Y. Suzuki</name><name sortKey="Takeo, S" sort="Takeo, S" uniqKey="Takeo S" first="S" last="Takeo">S. Takeo</name></noCountry><country name="Japon"><noRegion><name sortKey="Miyamoto, D" sort="Miyamoto, D" uniqKey="Miyamoto D" first="D" last="Miyamoto">D. Miyamoto</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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