Thujaplicin-copper chelates inhibit replication of human influenza viruses.
Identifieur interne : 000379 ( PubMed/Corpus ); précédent : 000378; suivant : 000380Thujaplicin-copper chelates inhibit replication of human influenza viruses.
Auteurs : D. Miyamoto ; Y. Kusagaya ; N. Endo ; A. Sometani ; S. Takeo ; T. Suzuki ; Y. Arima ; K. Nakajima ; Y. SuzukiSource :
- Antiviral research [ 0166-3542 ] ; 1998.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Apoptosis (drug effects), Cell Line, Cell Survival (drug effects), Chelating Agents (chemistry), Copper (chemistry), Dogs, Humans, Influenza A virus (drug effects), Influenza A virus (physiology), Monoterpenes, Tropolone (analogs & derivatives), Tropolone (chemistry), Tropolone (pharmacology), Viral Plaque Assay, Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Tropolone.
- chemical , chemistry : Antiviral Agents, Chelating Agents, Copper, Tropolone.
- chemical , pharmacology : Antiviral Agents, Tropolone.
- drug effects : Apoptosis, Cell Survival, Influenza A virus, Virus Replication.
- physiology : Influenza A virus.
- Animals, Cell Line, Dogs, Humans, Monoterpenes, Viral Plaque Assay.
Abstract
The effects of alpha-, beta- and gamma-thujaplicins and six of their metal chelates on human influenza virus-induced apoptosis in Madin-Darby canine kidney (MDCK) cells were examined by DNA fragmentation and flow cytometry. Among the compounds tested, thujaplicin copper chelates inhibited apoptosis induced in the infected MDCK cells with influenza A/PR/8/34(H1N1), A/Shingapol/1/57(H2N2), A/Aichi/2/68(H3N2) and B/Lee/40 viruses, at concentrations of more than 5 microM. These results indicate that the copper chelates inhibit influenza virus-induced apoptosis and that the inhibitory effects may be independent of influenza virus subtype or types. Furthermore, the copper chelates also inhibited the release of the viruses from the infected MDCK cells during apoptosis. The anti-apoptotic effects of the copper chelates may occur 2 4 h postinfection, suggesting that the copper chelates affect MDCK cells directly in the early stage of influenza virus-induced apoptosis. In this study, we demonstrated that thujaplicin-copper chelates inhibit influenza virus-induced apoptosis of MDCK cells and also inhibit virus replication and release from the infected cells.
DOI: 10.1016/s0166-3542(98)00034-5
PubMed: 9806486
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Thujaplicin-copper chelates inhibit replication of human influenza viruses.</title><author><name sortKey="Miyamoto, D" sort="Miyamoto, D" uniqKey="Miyamoto D" first="D" last="Miyamoto">D. Miyamoto</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Kusagaya, Y" sort="Kusagaya, Y" uniqKey="Kusagaya Y" first="Y" last="Kusagaya">Y. Kusagaya</name></author><author><name sortKey="Endo, N" sort="Endo, N" uniqKey="Endo N" first="N" last="Endo">N. Endo</name></author><author><name sortKey="Sometani, A" sort="Sometani, A" uniqKey="Sometani A" first="A" last="Sometani">A. Sometani</name></author><author><name sortKey="Takeo, S" sort="Takeo, S" uniqKey="Takeo S" first="S" last="Takeo">S. Takeo</name></author><author><name sortKey="Suzuki, T" sort="Suzuki, T" uniqKey="Suzuki T" first="T" last="Suzuki">T. Suzuki</name></author><author><name sortKey="Arima, Y" sort="Arima, Y" uniqKey="Arima Y" first="Y" last="Arima">Y. Arima</name></author><author><name sortKey="Nakajima, K" sort="Nakajima, K" uniqKey="Nakajima K" first="K" last="Nakajima">K. Nakajima</name></author><author><name sortKey="Suzuki, Y" sort="Suzuki, Y" uniqKey="Suzuki Y" first="Y" last="Suzuki">Y. Suzuki</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9806486</idno><idno type="pmid">9806486</idno><idno type="doi">10.1016/s0166-3542(98)00034-5</idno><idno type="wicri:Area/PubMed/Corpus">000379</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000379</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Thujaplicin-copper chelates inhibit replication of human influenza viruses.</title><author><name sortKey="Miyamoto, D" sort="Miyamoto, D" uniqKey="Miyamoto D" first="D" last="Miyamoto">D. Miyamoto</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Kusagaya, Y" sort="Kusagaya, Y" uniqKey="Kusagaya Y" first="Y" last="Kusagaya">Y. Kusagaya</name></author><author><name sortKey="Endo, N" sort="Endo, N" uniqKey="Endo N" first="N" last="Endo">N. Endo</name></author><author><name sortKey="Sometani, A" sort="Sometani, A" uniqKey="Sometani A" first="A" last="Sometani">A. Sometani</name></author><author><name sortKey="Takeo, S" sort="Takeo, S" uniqKey="Takeo S" first="S" last="Takeo">S. Takeo</name></author><author><name sortKey="Suzuki, T" sort="Suzuki, T" uniqKey="Suzuki T" first="T" last="Suzuki">T. Suzuki</name></author><author><name sortKey="Arima, Y" sort="Arima, Y" uniqKey="Arima Y" first="Y" last="Arima">Y. Arima</name></author><author><name sortKey="Nakajima, K" sort="Nakajima, K" uniqKey="Nakajima K" first="K" last="Nakajima">K. Nakajima</name></author><author><name sortKey="Suzuki, Y" sort="Suzuki, Y" uniqKey="Suzuki Y" first="Y" last="Suzuki">Y. Suzuki</name></author></analytic><series><title level="j">Antiviral research</title><idno type="ISSN">0166-3542</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Cell Line</term><term>Cell Survival (drug effects)</term><term>Chelating Agents (chemistry)</term><term>Copper (chemistry)</term><term>Dogs</term><term>Humans</term><term>Influenza A virus (drug effects)</term><term>Influenza A virus (physiology)</term><term>Monoterpenes</term><term>Tropolone (analogs & derivatives)</term><term>Tropolone (chemistry)</term><term>Tropolone (pharmacology)</term><term>Viral Plaque Assay</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Tropolone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Chelating Agents</term><term>Copper</term><term>Tropolone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Tropolone</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Cell Survival</term><term>Influenza A virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Dogs</term><term>Humans</term><term>Monoterpenes</term><term>Viral Plaque Assay</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of alpha-, beta- and gamma-thujaplicins and six of their metal chelates on human influenza virus-induced apoptosis in Madin-Darby canine kidney (MDCK) cells were examined by DNA fragmentation and flow cytometry. Among the compounds tested, thujaplicin copper chelates inhibited apoptosis induced in the infected MDCK cells with influenza A/PR/8/34(H1N1), A/Shingapol/1/57(H2N2), A/Aichi/2/68(H3N2) and B/Lee/40 viruses, at concentrations of more than 5 microM. These results indicate that the copper chelates inhibit influenza virus-induced apoptosis and that the inhibitory effects may be independent of influenza virus subtype or types. Furthermore, the copper chelates also inhibited the release of the viruses from the infected MDCK cells during apoptosis. The anti-apoptotic effects of the copper chelates may occur 2 4 h postinfection, suggesting that the copper chelates affect MDCK cells directly in the early stage of influenza virus-induced apoptosis. In this study, we demonstrated that thujaplicin-copper chelates inhibit influenza virus-induced apoptosis of MDCK cells and also inhibit virus replication and release from the infected cells.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9806486</PMID><DateCompleted><Year>1999</Year><Month>01</Month><Day>08</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0166-3542</ISSN><JournalIssue CitedMedium="Print"><Volume>39</Volume><Issue>2</Issue><PubDate><Year>1998</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Antiviral research</Title><ISOAbbreviation>Antiviral Res.</ISOAbbreviation></Journal><ArticleTitle>Thujaplicin-copper chelates inhibit replication of human influenza viruses.</ArticleTitle><Pagination><MedlinePgn>89-100</MedlinePgn></Pagination><Abstract><AbstractText>The effects of alpha-, beta- and gamma-thujaplicins and six of their metal chelates on human influenza virus-induced apoptosis in Madin-Darby canine kidney (MDCK) cells were examined by DNA fragmentation and flow cytometry. Among the compounds tested, thujaplicin copper chelates inhibited apoptosis induced in the infected MDCK cells with influenza A/PR/8/34(H1N1), A/Shingapol/1/57(H2N2), A/Aichi/2/68(H3N2) and B/Lee/40 viruses, at concentrations of more than 5 microM. These results indicate that the copper chelates inhibit influenza virus-induced apoptosis and that the inhibitory effects may be independent of influenza virus subtype or types. Furthermore, the copper chelates also inhibited the release of the viruses from the infected MDCK cells during apoptosis. The anti-apoptotic effects of the copper chelates may occur 2 4 h postinfection, suggesting that the copper chelates affect MDCK cells directly in the early stage of influenza virus-induced apoptosis. In this study, we demonstrated that thujaplicin-copper chelates inhibit influenza virus-induced apoptosis of MDCK cells and also inhibit virus replication and release from the infected cells.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Miyamoto</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kusagaya</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Endo</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Sometani</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Takeo</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Suzuki</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Arima</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Nakajima</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Suzuki</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Antiviral Res</MedlineTA><NlmUniqueID>8109699</NlmUniqueID><ISSNLinking>0166-3542</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C116333">2-hydroxy-5-isopropyl- 2,4,6-cycloheptatrienone</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002614">Chelating Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D039821">Monoterpenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>789U1901C5</RegistryNumber><NameOfSubstance UI="D003300">Copper</NameOfSubstance></Chemical><Chemical><RegistryNumber>7L6DL16P1T</RegistryNumber><NameOfSubstance UI="D014334">Tropolone</NameOfSubstance></Chemical><Chemical><RegistryNumber>U5335D6EBI</RegistryNumber><NameOfSubstance UI="C009479">beta-thujaplicin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002614" MajorTopicYN="N">Chelating Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003300" MajorTopicYN="N">Copper</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D039821" MajorTopicYN="Y">Monoterpenes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014334" MajorTopicYN="N">Tropolone</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010948" MajorTopicYN="N">Viral Plaque Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug 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