Nucleotide sequence analysis of the nucleoprotein gene of an avian and a human influenza virus strain identifies two classes of nucleoproteins.
Identifieur interne : 001086 ( Ncbi/Checkpoint ); précédent : 001085; suivant : 001087Nucleotide sequence analysis of the nucleoprotein gene of an avian and a human influenza virus strain identifies two classes of nucleoproteins.
Auteurs : A J Buckler-White ; B R MurphySource :
- Virology [ 0042-6822 ] ; 1986.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , classification : Nucleoproteins, Viral Proteins.
- genetics : Influenza A virus, Nucleoproteins, RNA, Viral, Viral Proteins.
- Amino Acid Sequence, Base Sequence, Biological Evolution, Genes, Viral, Sequence Homology, Nucleic Acid.
Abstract
The nucleotide sequences of RNA segment 5 of an avian influenza A virus, A/Mallard/NY/6750/78 (H2N2), and a human influenza A virus, A/Udorn/307/72 (H3N2), were determined and the deduced amino acid sequences of the nucleoprotein (NP) of these viruses were compared to two other avian and two other human influenza A NP sequences. The results indicated that there are separate classes of avian and human influenza A NP genes that can be distinguished on the basis of sites containing amino acids specific for avian and human influenza viruses and also by amino acid composition. The human influenza A virus NP genes appear to follow a linear pathway of evolution with the greatest homology (96.9%) between A/NT/60/68 (H3N2) and A/Udorn/72, isolated only 4 years apart, and the least homology (91.1%) between A/PR/8/34 (H1N1) and A/Udorn/72, isolated 38 years apart. Furthermore, 84% of the nucleotide substitutions between A/PR/8/34 and A/NT/60/68 are preserved in the NP gene of the A/Udorn/72 strain. In contrast, a distinct linear pathway is not present in the avian influenza NP genes since the homology (90.3%) between the two avian influenza viruses A/Parrot/Ulster/73 (H7N1) and A/Mallard/78 isolated only 5 years apart is not significantly greater than the homology (90.1%) between strains A/FPV/Rostock/34 and A/Mallard/78 isolated 44 years apart and only 49% of the nucleotide substitutions between A/FPV/34 and A/Parrot/73 are found in A/Mallard/78. A determination of the rate of evolution of the human influenza A virus NP genes suggested that there were a greater number of nucleotide substitutions per year during the first several years immediately following the emergence of a new subtype in 1968.
DOI: 10.1016/0042-6822(86)90198-4
PubMed: 3788059
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nucleotide sequence analysis of the nucleoprotein gene of an avian and a human influenza virus strain identifies two classes of nucleoproteins.</title><author><name sortKey="Buckler White, A J" sort="Buckler White, A J" uniqKey="Buckler White A" first="A J" last="Buckler-White">A J Buckler-White</name></author><author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1986">1986</date><idno type="RBID">pubmed:3788059</idno><idno type="pmid">3788059</idno><idno type="doi">10.1016/0042-6822(86)90198-4</idno><idno type="wicri:Area/PubMed/Corpus">000491</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000491</idno><idno type="wicri:Area/PubMed/Curation">000491</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000491</idno><idno type="wicri:Area/PubMed/Checkpoint">000436</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000436</idno><idno type="wicri:Area/Ncbi/Merge">001086</idno><idno type="wicri:Area/Ncbi/Curation">001086</idno><idno type="wicri:Area/Ncbi/Checkpoint">001086</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nucleotide sequence analysis of the nucleoprotein gene of an avian and a human influenza virus strain identifies two classes of nucleoproteins.</title><author><name sortKey="Buckler White, A J" sort="Buckler White, A J" uniqKey="Buckler White A" first="A J" last="Buckler-White">A J Buckler-White</name></author><author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><imprint><date when="1986" type="published">1986</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Base Sequence</term><term>Biological Evolution</term><term>Genes, Viral</term><term>Influenza A virus (genetics)</term><term>Nucleoproteins (classification)</term><term>Nucleoproteins (genetics)</term><term>RNA, Viral (genetics)</term><term>Sequence Homology, Nucleic Acid</term><term>Viral Proteins (classification)</term><term>Viral Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>Gènes viraux</term><term>Nucléoprotéines ()</term><term>Nucléoprotéines (génétique)</term><term>Protéines virales ()</term><term>Protéines virales (génétique)</term><term>Similitude de séquences d'acides nucléiques</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Virus de la grippe A (génétique)</term><term>Évolution biologique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Nucleoproteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term><term>Nucleoproteins</term><term>RNA, Viral</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Nucléoprotéines</term><term>Protéines virales</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Base Sequence</term><term>Biological Evolution</term><term>Genes, Viral</term><term>Sequence Homology, Nucleic Acid</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Gènes viraux</term><term>Nucléoprotéines</term><term>Protéines virales</term><term>Similitude de séquences d'acides nucléiques</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Évolution biologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The nucleotide sequences of RNA segment 5 of an avian influenza A virus, A/Mallard/NY/6750/78 (H2N2), and a human influenza A virus, A/Udorn/307/72 (H3N2), were determined and the deduced amino acid sequences of the nucleoprotein (NP) of these viruses were compared to two other avian and two other human influenza A NP sequences. The results indicated that there are separate classes of avian and human influenza A NP genes that can be distinguished on the basis of sites containing amino acids specific for avian and human influenza viruses and also by amino acid composition. The human influenza A virus NP genes appear to follow a linear pathway of evolution with the greatest homology (96.9%) between A/NT/60/68 (H3N2) and A/Udorn/72, isolated only 4 years apart, and the least homology (91.1%) between A/PR/8/34 (H1N1) and A/Udorn/72, isolated 38 years apart. Furthermore, 84% of the nucleotide substitutions between A/PR/8/34 and A/NT/60/68 are preserved in the NP gene of the A/Udorn/72 strain. In contrast, a distinct linear pathway is not present in the avian influenza NP genes since the homology (90.3%) between the two avian influenza viruses A/Parrot/Ulster/73 (H7N1) and A/Mallard/78 isolated only 5 years apart is not significantly greater than the homology (90.1%) between strains A/FPV/Rostock/34 and A/Mallard/78 isolated 44 years apart and only 49% of the nucleotide substitutions between A/FPV/34 and A/Parrot/73 are found in A/Mallard/78. A determination of the rate of evolution of the human influenza A virus NP genes suggested that there were a greater number of nucleotide substitutions per year during the first several years immediately following the emergence of a new subtype in 1968.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Buckler White, A J" sort="Buckler White, A J" uniqKey="Buckler White A" first="A J" last="Buckler-White">A J Buckler-White</name><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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