Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans
Identifieur interne : 000C45 ( Ncbi/Checkpoint ); précédent : 000C44; suivant : 000C46Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans
Auteurs : Zhong-Wei Zhang [République populaire de Chine] ; Ting Liu [République populaire de Chine] ; Jian Zeng [République populaire de Chine] ; Yang-Er Chen [République populaire de Chine, Suède] ; Ming Yuan [République populaire de Chine, États-Unis] ; Da-Wei Zhang [République populaire de Chine, États-Unis] ; Feng Zhu [République populaire de Chine] ; Shu Yuan [République populaire de Chine]Source :
- Infectious Diseases of Poverty [ 2049-9957 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN messager (), ARN messager (génétique), ARN viral, Alignement de séquences, Animaux, Biologie informatique, Conformation d'acide nucléique, Données de séquences moléculaires, Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (génétique), Grippe humaine (transmission), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Mutation, Pandémies, Phylogénie, Protéines virales (génétique), RNA replicase (génétique), Régions 5' non traduites, Séquence d'acides aminés, Virus de la grippe A (), Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité).
- MESH :
- génétique : ARN messager, Glycoprotéine hémagglutinine du virus influenza, Protéines virales, RNA replicase, Virus de la grippe A.
- pathogénicité : Virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine.
- ARN messager, ARN viral, Alignement de séquences, Animaux, Biologie informatique, Conformation d'acide nucléique, Données de séquences moléculaires, Glycoprotéine hémagglutinine du virus influenza, Humains, Mutation, Pandémies, Phylogénie, Régions 5' non traduites, Séquence d'acides aminés, Virus de la grippe A.
English descriptors
- KwdEn :
- 5' Untranslated Regions, Amino Acid Sequence, Animals, Computational Biology, Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Humans, Influenza A virus (classification), Influenza A virus (genetics), Influenza A virus (pathogenicity), Influenza, Human (epidemiology), Influenza, Human (transmission), Influenza, Human (virology), Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Pandemics, Phylogeny, RNA Replicase (genetics), RNA, Messenger (chemistry), RNA, Messenger (genetics), RNA, Viral, Sequence Alignment, Viral Proteins (genetics).
- MESH :
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus, RNA, Messenger.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, RNA Replicase, RNA, Messenger, Viral Proteins.
- chemical : 5' Untranslated Regions, RNA, Viral.
- classification : Influenza A virus.
- epidemiology : Influenza, Human.
- genetics : Influenza A virus.
- pathogenicity : Influenza A virus.
- transmission : Influenza, Human.
- virology : Influenza, Human.
- Amino Acid Sequence, Animals, Computational Biology, Humans, Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Pandemics, Phylogeny, Sequence Alignment.
Abstract
In recent years, avian influenza viruses (AIVs) have seriously threatened human health. Questions such as: why do AIVs infect humans?, how quickly can an AIV become pandemic?, and which virus is the most dangerous? cannot be sufficiently answered using current bioinformatic studies.
Secondary structures and energies of representative 5′-untranslated region (UTR) of the
The simplicity of the secondary structure of the 5′-UTR of the
Some high-virulent strains of avian influenza might emerge in the next two to three years. The H2N2 subtype, once disappeared in humans, may stage a comeback. The current outbreak of H7N9 may become pandemic and cause even more deaths, if one or two bases are substituted in the 5′-UTR sequence of the
The online version of this article (doi:10.1186/s40249-015-0083-8) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s40249-015-0083-8
PubMed: 26612517
PubMed Central: 4661964
Affiliations:
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PMC:4661964Le document en format XML
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<term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term>
<term>Humans</term>
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<term>RNA Replicase (genetics)</term>
<term>RNA, Messenger (chemistry)</term>
<term>RNA, Messenger (genetics)</term>
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<term>Sequence Alignment</term>
<term>Viral Proteins (genetics)</term>
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<term>Biologie informatique</term>
<term>Conformation d'acide nucléique</term>
<term>Données de séquences moléculaires</term>
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<term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term>
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<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Mutation</term>
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<term>Phylogénie</term>
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<term>RNA replicase (génétique)</term>
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<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (pathogénicité)</term>
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<term>RNA, Messenger</term>
<term>Viral Proteins</term>
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<term>RNA, Viral</term>
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<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Protéines virales</term>
<term>RNA replicase</term>
<term>Virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
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<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Computational Biology</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
<term>Nucleic Acid Conformation</term>
<term>Pandemics</term>
<term>Phylogeny</term>
<term>Sequence Alignment</term>
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<keywords scheme="MESH" xml:lang="fr"><term>ARN messager</term>
<term>ARN viral</term>
<term>Alignement de séquences</term>
<term>Animaux</term>
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<term>Conformation d'acide nucléique</term>
<term>Données de séquences moléculaires</term>
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<term>Mutation</term>
<term>Pandémies</term>
<term>Phylogénie</term>
<term>Régions 5' non traduites</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>In recent years, avian influenza viruses (AIVs) have seriously threatened human health. Questions such as: why do AIVs infect humans?, how quickly can an AIV become pandemic?, and which virus is the most dangerous? cannot be sufficiently answered using current bioinformatic studies.</p>
</sec>
<sec><title>Method</title>
<p>Secondary structures and energies of representative 5′-untranslated region (UTR) of the <italic>HA</italic>
gene were calculated. Then their secondary structures and energies were re-calculated after one or two nucleotide substitutions were introduced into the <italic>HA</italic>
5′-UTR. Phylogenetic trees on the basis of hemagglutinin (HA) and polymerase basic protein 2 (PB2) amino acid sequences and <italic>HA</italic>
5′-UTR nucleotide sequences were constructed. The connection between the energy and translation efficiency of 5′-UTR was confirmed by <italic>in vitro</italic>
coupled transcription/translation assay.</p>
</sec>
<sec><title>Results</title>
<p>The simplicity of the secondary structure of the 5′-UTR of the <italic>HA</italic>
gene determines the overall virus replication rate and transmission potential. Point mutation assays show that the 5′-UTR sequences of the <italic>HA</italic>
gene in the influenza subtypes H2N2, H3N2, and H7N9 have greater variation potentials than other virus subtypes.</p>
</sec>
<sec><title>Conclusion</title>
<p>Some high-virulent strains of avian influenza might emerge in the next two to three years. The H2N2 subtype, once disappeared in humans, may stage a comeback. The current outbreak of H7N9 may become pandemic and cause even more deaths, if one or two bases are substituted in the 5′-UTR sequence of the <italic>HA</italic>
gene.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s40249-015-0083-8) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<affiliations><list><country><li>République populaire de Chine</li>
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</record>
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