H2N2V1, PubMed, Checkpoint, bibRecord, 000062

Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans.

Identifieur interne : 000062 ( PubMed/Checkpoint ); précédent : 000061; suivant : 000063

Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans.

Auteurs : Zhong-Wei Zhang [République populaire de Chine] ; Ting Liu [République populaire de Chine] ; Jian Zeng [République populaire de Chine] ; Yang-Er Chen [République populaire de Chine] ; Ming Yuan [République populaire de Chine] ; Da-Wei Zhang [République populaire de Chine] ; Feng Zhu [République populaire de Chine] ; Shu Yuan [République populaire de Chine]

Source :

Infectious diseases of poverty [ 2095-5162 ] ; 2015.

RBID : pubmed:26612517

Descripteurs français

KwdFr :
- ARN messager (), ARN messager (génétique), ARN viral, Alignement de séquences, Animaux, Biologie informatique, Conformation d'acide nucléique, Données de séquences moléculaires, Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (génétique), Grippe humaine (transmission), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Mutation, Pandémies, Phylogénie, Protéines virales (génétique), RNA replicase (génétique), Régions 5' non traduites, Séquence d'acides aminés, Virus de la grippe A (), Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité).
MESH :
- génétique : ARN messager, Glycoprotéine hémagglutinine du virus influenza, Protéines virales, RNA replicase, Virus de la grippe A.
- pathogénicité : Virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine.
- ARN messager, ARN viral, Alignement de séquences, Animaux, Biologie informatique, Conformation d'acide nucléique, Données de séquences moléculaires, Glycoprotéine hémagglutinine du virus influenza, Humains, Mutation, Pandémies, Phylogénie, Régions 5' non traduites, Séquence d'acides aminés, Virus de la grippe A.

English descriptors

KwdEn :
- 5' Untranslated Regions, Amino Acid Sequence, Animals, Computational Biology, Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Humans, Influenza A virus (classification), Influenza A virus (genetics), Influenza A virus (pathogenicity), Influenza, Human (epidemiology), Influenza, Human (transmission), Influenza, Human (virology), Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Pandemics, Phylogeny, RNA Replicase (genetics), RNA, Messenger (chemistry), RNA, Messenger (genetics), RNA, Viral, Sequence Alignment, Viral Proteins (genetics).
MESH :
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus, RNA, Messenger.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, RNA Replicase, RNA, Messenger, Viral Proteins.
- chemical : 5' Untranslated Regions, RNA, Viral.
- classification : Influenza A virus.
- epidemiology : Influenza, Human.
- genetics : Influenza A virus.
- pathogenicity : Influenza A virus.
- transmission : Influenza, Human.
- virology : Influenza, Human.
- Amino Acid Sequence, Animals, Computational Biology, Humans, Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Pandemics, Phylogeny, Sequence Alignment.

Abstract

In recent years, avian influenza viruses (AIVs) have seriously threatened human health. Questions such as: why do AIVs infect humans?, how quickly can an AIV become pandemic?, and which virus is the most dangerous? cannot be sufficiently answered using current bioinformatic studies.

DOI: 10.1186/s40249-015-0083-8
PubMed: 26612517

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000059
to stream PubMed, to step Curation: 000059

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pubmed:26612517

Le document en format XML

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<front><div type="abstract" xml:lang="en">In recent years, avian influenza viruses (AIVs) have seriously threatened human health. Questions such as: why do AIVs infect humans?, how quickly can an AIV become pandemic?, and which virus is the most dangerous? cannot be sufficiently answered using current bioinformatic studies.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26612517</PMID>
<DateCompleted><Year>2016</Year>
<Month>04</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2095-5162</ISSN>
<JournalIssue CitedMedium="Print"><Volume>4</Volume>
<PubDate><Year>2015</Year>
<Month>Nov</Month>
<Day>27</Day>
</PubDate>
</JournalIssue>
<Title>Infectious diseases of poverty</Title>
<ISOAbbreviation>Infect Dis Poverty</ISOAbbreviation>
</Journal>
<ArticleTitle>Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans.</ArticleTitle>
<Pagination><MedlinePgn>50</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s40249-015-0083-8</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In recent years, avian influenza viruses (AIVs) have seriously threatened human health. Questions such as: why do AIVs infect humans?, how quickly can an AIV become pandemic?, and which virus is the most dangerous? cannot be sufficiently answered using current bioinformatic studies.</AbstractText>
<AbstractText Label="METHOD" NlmCategory="METHODS">Secondary structures and energies of representative 5'-untranslated region (UTR) of the HA gene were calculated. Then their secondary structures and energies were re-calculated after one or two nucleotide substitutions were introduced into the HA 5'-UTR. Phylogenetic trees on the basis of hemagglutinin (HA) and polymerase basic protein 2 (PB2) amino acid sequences and HA 5'-UTR nucleotide sequences were constructed. The connection between the energy and translation efficiency of 5'-UTR was confirmed by in vitro coupled transcription/translation assay.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The simplicity of the secondary structure of the 5'-UTR of the HA gene determines the overall virus replication rate and transmission potential. Point mutation assays show that the 5'-UTR sequences of the HA gene in the influenza subtypes H2N2, H3N2, and H7N9 have greater variation potentials than other virus subtypes.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Some high-virulent strains of avian influenza might emerge in the next two to three years. The H2N2 subtype, once disappeared in humans, may stage a comeback. The current outbreak of H7N9 may become pandemic and cause even more deaths, if one or two bases are substituted in the 5'-UTR sequence of the HA gene.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Zhong-Wei</ForeName>
<Initials>ZW</Initials>
<AffiliationInfo><Affiliation>College of Resources Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China. zzwzhang@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Ting</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Sichuan Kelun Pharmaceutical Comp. Ltd., Chengdu, 610072, China. 191202430@q.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zeng</LastName>
<ForeName>Jian</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>College of Resources Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China. doplin@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yang-Er</ForeName>
<Initials>YE</Initials>
<AffiliationInfo><Affiliation>Bioinformatic Study Centre, College of Life Sciences, Sichuan Agricultural University, Ya'an, 625014, China. anty9826@163.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Plant Physiology, Umeå University, SE-901 87, Umeå, Sweden. anty9826@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yuan</LastName>
<ForeName>Ming</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Bioinformatic Study Centre, College of Life Sciences, Sichuan Agricultural University, Ya'an, 625014, China. yuanmingsicau@126.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Boyce Thompson Institute, Cornell University, Ithaca, NY, 14850, USA. yuanmingsicau@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Da-Wei</ForeName>
<Initials>DW</Initials>
<AffiliationInfo><Affiliation>College of Life Sciences, Sichuan University, Chengdu, 610064, China. yuanmiao1892@163.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, 50011, USA. yuanmiao1892@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Feng</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>College of Life Sciences, Sichuan University, Chengdu, 610064, China. zhufeng1361@163.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, 225009, China. zhufeng1361@163.com.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Shu</ForeName>
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<affiliations><list><country><li>République populaire de Chine</li>
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Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans.

Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans.

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