Designing vaccines for pandemic influenza
Identifieur interne : 000416 ( Ncbi/Checkpoint ); précédent : 000415; suivant : 000417Designing vaccines for pandemic influenza
Auteurs : T. Horimoto [Japon] ; Yoshihiro Kawaoka [Japon, États-Unis]Source :
- Current topics in microbiology and immunology [ 0070-217X ] ; 2009.
Abstract
Recent outbreaks of highly pathogenic avian influenza A virus infections (including those of the H5N1 subtype) in poultry and in humans (through contact with infected birds) have raised concerns that a new influenza pandemic will soon occur. Effective vaccines against H5N1 virus are, therefore, urgently needed. Reverse genetics-based inactivated vaccines have been prepared according to WHO recommendations and licensed in several countries following their assessment in clinical trials. However, the effectiveness of these vaccines in a pandemic is not guaranteed. We must, therefore, continue to develop alternative pandemic vaccine strategies. Here, we review the current strategies for the development of H5N1 influenza vaccines, as well as some future directions for vaccine development.
Url:
DOI: 10.1007/978-3-540-92165-3_8
PubMed: 19768405
PubMed Central: 6133292
Affiliations:
- Japon, États-Unis
- Région de Kantō, Wisconsin
- Madison (Wisconsin), Tokyo
- Université de Tokyo, Université du Wisconsin à Madison
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PMC:6133292Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Recent outbreaks of highly pathogenic avian influenza A virus infections (including those of the H5N1 subtype) in poultry and in humans (through contact with infected birds) have raised concerns that a new influenza pandemic will soon occur. Effective vaccines against H5N1 virus are, therefore, urgently needed. Reverse genetics-based inactivated vaccines have been prepared according to WHO recommendations and licensed in several countries following their assessment in clinical trials. However, the effectiveness of these vaccines in a pandemic is not guaranteed. We must, therefore, continue to develop alternative pandemic vaccine strategies. Here, we review the current strategies for the development of H5N1 influenza vaccines, as well as some future directions for vaccine development.</p>
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