Designing vaccines for pandemic influenza
Identifieur interne : 000416 ( Ncbi/Merge ); précédent : 000415; suivant : 000417Designing vaccines for pandemic influenza
Auteurs : T. Horimoto [Japon] ; Yoshihiro Kawaoka [Japon, États-Unis]Source :
- Current topics in microbiology and immunology [ 0070-217X ] ; 2009.
Abstract
Recent outbreaks of highly pathogenic avian influenza A virus infections (including those of the H5N1 subtype) in poultry and in humans (through contact with infected birds) have raised concerns that a new influenza pandemic will soon occur. Effective vaccines against H5N1 virus are, therefore, urgently needed. Reverse genetics-based inactivated vaccines have been prepared according to WHO recommendations and licensed in several countries following their assessment in clinical trials. However, the effectiveness of these vaccines in a pandemic is not guaranteed. We must, therefore, continue to develop alternative pandemic vaccine strategies. Here, we review the current strategies for the development of H5N1 influenza vaccines, as well as some future directions for vaccine development.
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DOI: 10.1007/978-3-540-92165-3_8
PubMed: 19768405
PubMed Central: 6133292
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Horimoto</name><affiliation wicri:level="4"><nlm:aff id="A1">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kawaoka, Y" sort="Kawaoka, Y" uniqKey="Kawaoka Y" first="Y." last="Kawaoka">Yoshihiro Kawaoka</name><affiliation wicri:level="4"><nlm:aff id="A1">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author></analytic><series><title level="j">Current topics in microbiology and immunology</title><idno type="ISSN">0070-217X</idno><idno type="eISSN">2196-9965</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Recent outbreaks of highly pathogenic avian influenza A virus infections (including those of the H5N1 subtype) in poultry and in humans (through contact with infected birds) have raised concerns that a new influenza pandemic will soon occur. Effective vaccines against H5N1 virus are, therefore, urgently needed. Reverse genetics-based inactivated vaccines have been prepared according to WHO recommendations and licensed in several countries following their assessment in clinical trials. However, the effectiveness of these vaccines in a pandemic is not guaranteed. We must, therefore, continue to develop alternative pandemic vaccine strategies. Here, we review the current strategies for the development of H5N1 influenza vaccines, as well as some future directions for vaccine development.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0110513</journal-id><journal-id journal-id-type="pubmed-jr-id">3237</journal-id><journal-id journal-id-type="nlm-ta">Curr Top Microbiol Immunol</journal-id><journal-id journal-id-type="iso-abbrev">Curr. Top. Microbiol. Immunol.</journal-id><journal-title-group><journal-title>Current topics in microbiology and immunology</journal-title></journal-title-group><issn pub-type="ppub">0070-217X</issn><issn pub-type="epub">2196-9965</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19768405</article-id><article-id pub-id-type="pmc">6133292</article-id><article-id pub-id-type="doi">10.1007/978-3-540-92165-3_8</article-id><article-id pub-id-type="manuscript">NIHMS979084</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Designing vaccines for pandemic influenza</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Horimoto</surname><given-names>T.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kawaoka</surname><given-names>Y.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan</aff><aff id="A2"><label>2</label>International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan</aff><aff id="A3"><label>3</label>Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA</aff><pub-date pub-type="nihms-submitted"><day>5</day><month>7</month><year>2018</year></pub-date><pub-date pub-type="ppub"><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>9</month><year>2018</year></pub-date><volume>333</volume><fpage>165</fpage><lpage>176</lpage><pmc-comment>elocation-id from pubmed: 10.1007/978-3-540-92165-3_8</pmc-comment>
<abstract><p id="P1">Recent outbreaks of highly pathogenic avian influenza A virus infections (including those of the H5N1 subtype) in poultry and in humans (through contact with infected birds) have raised concerns that a new influenza pandemic will soon occur. Effective vaccines against H5N1 virus are, therefore, urgently needed. Reverse genetics-based inactivated vaccines have been prepared according to WHO recommendations and licensed in several countries following their assessment in clinical trials. However, the effectiveness of these vaccines in a pandemic is not guaranteed. We must, therefore, continue to develop alternative pandemic vaccine strategies. Here, we review the current strategies for the development of H5N1 influenza vaccines, as well as some future directions for vaccine development.</p></abstract></article-meta></front></pmc><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Région de Kantō</li><li>Wisconsin</li></region><settlement><li>Madison (Wisconsin)</li><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li><li>Université du Wisconsin à Madison</li></orgName></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Horimoto, T" sort="Horimoto, T" uniqKey="Horimoto T" first="T." last="Horimoto">T. Horimoto</name></region><name sortKey="Kawaoka, Y" sort="Kawaoka, Y" uniqKey="Kawaoka Y" first="Y." last="Kawaoka">Yoshihiro Kawaoka</name><name sortKey="Kawaoka, Y" sort="Kawaoka, Y" uniqKey="Kawaoka Y" first="Y." last="Kawaoka">Yoshihiro Kawaoka</name></country><country name="États-Unis"><region name="Wisconsin"><name sortKey="Kawaoka, Y" sort="Kawaoka, Y" uniqKey="Kawaoka Y" first="Y." last="Kawaoka">Yoshihiro Kawaoka</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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